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Items: 27

1.

Rational design of cationic lipids for siRNA delivery.

Semple SC, Akinc A, Chen J, Sandhu AP, Mui BL, Cho CK, Sah DW, Stebbing D, Crosley EJ, Yaworski E, Hafez IM, Dorkin JR, Qin J, Lam K, Rajeev KG, Wong KF, Jeffs LB, Nechev L, Eisenhardt ML, Jayaraman M, Kazem M, Maier MA, Srinivasulu M, Weinstein MJ, Chen Q, Alvarez R, Barros SA, De S, Klimuk SK, Borland T, Kosovrasti V, Cantley WL, Tam YK, Manoharan M, Ciufolini MA, Tracy MA, de Fougerolles A, MacLachlan I, Cullis PR, Madden TD, Hope MJ.

Nat Biotechnol. 2010 Feb;28(2):172-6. doi: 10.1038/nbt.1602. Epub 2010 Jan 17.

PMID:
20081866
2.

Therapeutic integration of c-myc and bcl-2 antisense molecules with docetaxel in a preclinical model of hormone-refractory prostate cancer.

Leonetti C, Biroccio A, D'Angelo C, Semple SC, Scarsella M, Zupi G.

Prostate. 2007 Sep 15;67(13):1475-85.

PMID:
17654511
3.

Characterization of the drug retention and pharmacokinetic properties of liposomal nanoparticles containing dihydrosphingomyelin.

Johnston MJ, Semple SC, Klimuk SK, Ansell S, Maurer N, Cullis PR.

Biochim Biophys Acta. 2007 May;1768(5):1121-7. Epub 2007 Feb 1.

4.

Therapeutically optimized rates of drug release can be achieved by varying the drug-to-lipid ratio in liposomal vincristine formulations.

Johnston MJ, Semple SC, Klimuk SK, Edwards K, Eisenhardt ML, Leng EC, Karlsson G, Yanko D, Cullis PR.

Biochim Biophys Acta. 2006 Jan;1758(1):55-64. Epub 2006 Feb 3.

5.

Liposome-encapsulated vincristine, vinblastine and vinorelbine: a comparative study of drug loading and retention.

Zhigaltsev IV, Maurer N, Akhong QF, Leone R, Leng E, Wang J, Semple SC, Cullis PR.

J Control Release. 2005 May 5;104(1):103-11. Epub 2005 Mar 2.

PMID:
15866338
6.

Optimization and characterization of a sphingomyelin/cholesterol liposome formulation of vinorelbine with promising antitumor activity.

Semple SC, Leone R, Wang J, Leng EC, Klimuk SK, Eisenhardt ML, Yuan ZN, Edwards K, Maurer N, Hope MJ, Cullis PR, Ahkong QF.

J Pharm Sci. 2005 May;94(5):1024-38.

PMID:
15793796
7.
8.

Immunogenicity and rapid blood clearance of liposomes containing polyethylene glycol-lipid conjugates and nucleic Acid.

Semple SC, Harasym TO, Clow KA, Ansell SM, Klimuk SK, Hope MJ.

J Pharmacol Exp Ther. 2005 Mar;312(3):1020-6. Epub 2004 Nov 3.

PMID:
15525796
9.

Role of c-myc protein in hormone refractory prostate carcinoma: cellular response to paclitaxel.

Cassinelli G, Supino R, Zuco V, Lanzi C, Scovassi AI, Semple SC, Zunino F.

Biochem Pharmacol. 2004 Sep 1;68(5):923-31.

PMID:
15294455
10.

High efficiency entrapment of antisense oligonucleotides in liposomes.

Stuart DD, Semple SC, Allen TM.

Methods Enzymol. 2004;387:171-88. No abstract available.

PMID:
15172164
11.

In vivo administration of liposomal vincristine sensitizes drug-resistant human solid tumors.

Leonetti C, Scarsella M, Semple SC, Molinari A, D'Angelo C, Stoppacciaro A, Biroccio A, Zupi G.

Int J Cancer. 2004 Jul 10;110(5):767-74.

12.

Epicutaneous application of CpG oligodeoxynucleotides with peptide or protein antigen promotes the generation of CTL.

Klimuk SK, Najar HM, Semple SC, Aslanian S, Dutz JP.

J Invest Dermatol. 2004 Apr;122(4):1042-9.

13.

Targeted liposomal c-myc antisense oligodeoxynucleotides induce apoptosis and inhibit tumor growth and metastases in human melanoma models.

Pastorino F, Brignole C, Marimpietri D, Pagnan G, Morando A, Ribatti D, Semple SC, Gambini C, Allen TM, Ponzoni M.

Clin Cancer Res. 2003 Oct 1;9(12):4595-605.

14.

Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles.

Mui B, Raney SG, Semple SC, Hope MJ.

J Pharmacol Exp Ther. 2001 Sep;298(3):1185-92.

PMID:
11504819
15.

Encapsulation of c-myc antisense oligodeoxynucleotides in lipid particles improves antitumoral efficacy in vivo in a human melanoma line.

Leonetti C, Biroccio A, Benassi B, Stringaro A, Stoppacciaro A, Semple SC, Zupi G.

Cancer Gene Ther. 2001 Jun;8(6):459-68.

16.

Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures.

Semple SC, Klimuk SK, Harasym TO, Dos Santos N, Ansell SM, Wong KF, Maurer N, Stark H, Cullis PR, Hope MJ, Scherrer P.

Biochim Biophys Acta. 2001 Feb 9;1510(1-2):152-66.

17.

Spontaneous entrapment of polynucleotides upon electrostatic interaction with ethanol-destabilized cationic liposomes.

Maurer N, Wong KF, Stark H, Louie L, McIntosh D, Wong T, Scherrer P, Semple SC, Cullis PR.

Biophys J. 2001 May;80(5):2310-26.

18.

Interactions of liposomes and lipid-based carrier systems with blood proteins: Relation to clearance behaviour in vivo.

Cullis PR, Chonn A, Semple SC.

Adv Drug Deliv Rev. 1998 Jun 8;32(1-2):3-17.

PMID:
10837632
19.

Enhanced anti-inflammatory activity of a liposomal intercellular adhesion molecule-1 antisense oligodeoxynucleotide in an acute model of contact hypersensitivity.

Klimuk SK, Semple SC, Nahirney PN, Mullen MC, Bennett CF, Scherrer P, Hope MJ.

J Pharmacol Exp Ther. 2000 Feb;292(2):480-8.

PMID:
10640283
20.

Lipid-based formulations of antisense oligonucleotides for systemic delivery applications.

Semple SC, Klimuk SK, Harasym TO, Hope MJ.

Methods Enzymol. 2000;313:322-41. No abstract available.

PMID:
10595364
21.

Application of oligo-(14-amino-3,6,9,12-tetraoxatetradecanoic acid) lipid conjugates as steric barrier molecules in liposomal formulations.

Ansell SM, Kojic LD, Hankins JS, Sekirov L, Boey A, Lee DK, Bennett AR, Klimuk SK, Harasym TO, Dos Santos N, Semple SC.

Bioconjug Chem. 1999 Jul-Aug;10(4):653-66.

PMID:
10411464
22.

Contact hypersensitivity: a simple model for the characterization of disease-site targeting by liposomes.

Klimuk SK, Semple SC, Scherrer P, Hope MJ.

Biochim Biophys Acta. 1999 Mar 4;1417(2):191-201.

23.

Influence of dose on liposome clearance: critical role of blood proteins.

Oja CD, Semple SC, Chonn A, Cullis PR.

Biochim Biophys Acta. 1996 May 22;1281(1):31-7.

24.

Influence of cholesterol on the association of plasma proteins with liposomes.

Semple SC, Chonn A, Cullis PR.

Biochemistry. 1996 Feb 27;35(8):2521-5.

PMID:
8611555
26.

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