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Items: 35


MicroRNA-155 Expression Is Enhanced by T-cell Receptor Stimulation Strength and Correlates with Improved Tumor Control in Melanoma.

Martinez-Usatorre A, Sempere LF, Carmona SJ, Carretero-Iglesia L, Monnot G, Speiser DE, Rufer N, Donda A, Zehn D, Jandus C, Romero P.

Cancer Immunol Res. 2019 Jun;7(6):1013-1024. doi: 10.1158/2326-6066.CIR-18-0504. Epub 2019 May 1.


Celebrating 25 Years of MicroRNA Research: From Discovery to Clinical Application.

Sempere LF.

Int J Mol Sci. 2019 Apr 23;20(8). pii: E1987. doi: 10.3390/ijms20081987.


Exosomal MicroRNAs in Breast Cancer towards Diagnostic and Therapeutic Applications.

Sempere LF, Keto J, Fabbri M.

Cancers (Basel). 2017 Jun 24;9(7). pii: E71. doi: 10.3390/cancers9070071. Review.


A Uniform System for the Annotation of Vertebrate microRNA Genes and the Evolution of the Human microRNAome.

Fromm B, Billipp T, Peck LE, Johansen M, Tarver JE, King BL, Newcomb JM, Sempere LF, Flatmark K, Hovig E, Peterson KJ.

Annu Rev Genet. 2015;49:213-42. doi: 10.1146/annurev-genet-120213-092023. Epub 2015 Oct 14. Review.


Segment and fit thresholding: a new method for image analysis applied to microarray and immunofluorescence data.

Ensink E, Sinha J, Sinha A, Tang H, Calderone HM, Hostetter G, Winter J, Cherba D, Brand RE, Allen PJ, Sempere LF, Haab BB.

Anal Chem. 2015 Oct 6;87(19):9715-21. doi: 10.1021/acs.analchem.5b03159. Epub 2015 Sep 11.


Critical analysis of the potential for microRNA biomarkers in breast cancer management.

Graveel CR, Calderone HM, Westerhuis JJ, Winn ME, Sempere LF.

Breast Cancer (Dove Med Press). 2015 Feb 23;7:59-79. doi: 10.2147/BCTT.S43799. eCollection 2015. Review.


MIR21 is differentially expressed in the lymphoid tissue and modulated by stromal signalling in chronic lymphocytic leukaemia.

Danilova OV, Paiva C, Kaur P, Kamal A, Sempere LF, Danilov AV.

Br J Haematol. 2015 Jul;170(2):272-5. doi: 10.1111/bjh.13282. Epub 2015 Jan 29. No abstract available.


Expression of tumor suppressive microRNA-34a is associated with a reduced risk of bladder cancer recurrence.

Andrew AS, Marsit CJ, Schned AR, Seigne JD, Kelsey KT, Moore JH, Perreard L, Karagas MR, Sempere LF.

Int J Cancer. 2015 Sep 1;137(5):1158-66. doi: 10.1002/ijc.29413. Epub 2015 Feb 25.


Stromal expression of miR-21 identifies high-risk group in triple-negative breast cancer.

MacKenzie TA, Schwartz GN, Calderone HM, Graveel CR, Winn ME, Hostetter G, Wells WA, Sempere LF.

Am J Pathol. 2014 Dec;184(12):3217-25. doi: 10.1016/j.ajpath.2014.08.020. Epub 2014 Nov 6.


Tissue slide-based microRNA characterization of tumors: how detailed could diagnosis become for cancer medicine?

Sempere LF.

Expert Rev Mol Diagn. 2014 Sep;14(7):853-69. doi: 10.1586/14737159.2014.944507. Epub 2014 Aug 4. Review.


VISTA is a novel broad-spectrum negative checkpoint regulator for cancer immunotherapy.

Lines JL, Sempere LF, Broughton T, Wang L, Noelle R.

Cancer Immunol Res. 2014 Jun;2(6):510-7. doi: 10.1158/2326-6066.CIR-14-0072.


VISTA is an immune checkpoint molecule for human T cells.

Lines JL, Pantazi E, Mak J, Sempere LF, Wang L, O'Connell S, Ceeraz S, Suriawinata AA, Yan S, Ernstoff MS, Noelle R.

Cancer Res. 2014 Apr 1;74(7):1924-32. doi: 10.1158/0008-5472.CAN-13-1504. Erratum in: Cancer Res. 2014 Jun 1;74(11):3195.


A method for conducting highly sensitive microRNA in situ hybridization and immunohistochemical analysis in pancreatic cancer.

Sempere LF, Korc M.

Methods Mol Biol. 2013;980:43-59. doi: 10.1007/978-1-62703-287-2_4.


ΔNp63α-mediated activation of bone morphogenetic protein signaling governs stem cell activity and plasticity in normal and malignant mammary epithelial cells.

Balboni AL, Hutchinson JA, DeCastro AJ, Cherukuri P, Liby K, Sporn MB, Schwartz GN, Wells WA, Sempere LF, Yu PB, DiRenzo J.

Cancer Res. 2013 Jan 15;73(2):1020-30. doi: 10.1158/0008-5472.CAN-12-2862. Epub 2012 Dec 14.


Good things come in small packages: Therapeutic anti-tumor immunity induced by microRNA nanoparticles.

Cubillos-Ruiz JR, Sempere LF, Conejo-Garcia JR.

Oncoimmunology. 2012 Sep 1;1(6):968-970.


Recent advances in miRNA-based diagnostic applications.

Sempere LF.

Expert Rev Mol Diagn. 2012 Jul;12(6):557-9. doi: 10.1586/erm.12.47.


Reprogramming tumor-associated dendritic cells in vivo using miRNA mimetics triggers protective immunity against ovarian cancer.

Cubillos-Ruiz JR, Baird JR, Tesone AJ, Rutkowski MR, Scarlett UK, Camposeco-Jacobs AL, Anadon-Arnillas J, Harwood NM, Korc M, Fiering SN, Sempere LF, Conejo-Garcia JR.

Cancer Res. 2012 Apr 1;72(7):1683-93. doi: 10.1158/0008-5472.CAN-11-3160. Epub 2012 Feb 3.


Integrating contextual miRNA and protein signatures for diagnostic and treatment decisions in cancer.

Sempere LF.

Expert Rev Mol Diagn. 2011 Nov;11(8):813-27. doi: 10.1586/erm.11.69. Review.


MicroRNA-10b expression correlates with response to neoadjuvant therapy and survival in pancreatic ductal adenocarcinoma.

Preis M, Gardner TB, Gordon SR, Pipas JM, Mackenzie TA, Klein EE, Longnecker DS, Gutmann EJ, Sempere LF, Korc M.

Clin Cancer Res. 2011 Sep 1;17(17):5812-21. doi: 10.1158/1078-0432.CCR-11-0695. Epub 2011 Jun 7.


A novel 3-dimensional culture system uncovers growth stimulatory actions by TGFβ in pancreatic cancer cells.

Sempere LF, Gunn JR, Korc M.

Cancer Biol Ther. 2011 Aug 1;12(3):198-207. Epub 2011 Aug 1.


Involvement of microRNAs in lung cancer biology and therapy.

Liu X, Sempere LF, Guo Y, Korc M, Kauppinen S, Freemantle SJ, Dmitrovsky E.

Transl Res. 2011 Apr;157(4):200-8. doi: 10.1016/j.trsl.2011.01.001. Epub 2011 Feb 4. Review.


Fluorescence-based codetection with protein markers reveals distinct cellular compartments for altered MicroRNA expression in solid tumors.

Sempere LF, Preis M, Yezefski T, Ouyang H, Suriawinata AA, Silahtaroglu A, Conejo-Garcia JR, Kauppinen S, Wells W, Korc M.

Clin Cancer Res. 2010 Aug 15;16(16):4246-55. doi: 10.1158/1078-0432.CCR-10-1152. Epub 2010 Aug 3.


MicroRNA-31 functions as an oncogenic microRNA in mouse and human lung cancer cells by repressing specific tumor suppressors.

Liu X, Sempere LF, Ouyang H, Memoli VA, Andrew AS, Luo Y, Demidenko E, Korc M, Shi W, Preis M, Dragnev KH, Li H, Direnzo J, Bak M, Freemantle SJ, Kauppinen S, Dmitrovsky E.

J Clin Invest. 2010 Apr;120(4):1298-309. doi: 10.1172/JCI39566. Epub 2010 Mar 8.


Tumor-suppressive microRNAs in Lung cancer: diagnostic and therapeutic opportunities.

Sempere LF, Liu X, Dmitrovsky E.

ScientificWorldJournal. 2009 Jul 13;9:626-8. doi: 10.1100/tsw.2009.88.


Uncovering growth-suppressive MicroRNAs in lung cancer.

Liu X, Sempere LF, Galimberti F, Freemantle SJ, Black C, Dragnev KH, Ma Y, Fiering S, Memoli V, Li H, DiRenzo J, Korc M, Cole CN, Bak M, Kauppinen S, Dmitrovsky E.

Clin Cancer Res. 2009 Feb 15;15(4):1177-83. doi: 10.1158/1078-0432.CCR-08-1355.


UBE1L causes lung cancer growth suppression by targeting cyclin D1.

Feng Q, Sekula D, Guo Y, Liu X, Black CC, Galimberti F, Shah SJ, Sempere LF, Memoli V, Andersen JB, Hassel BA, Dragnev K, Dmitrovsky E.

Mol Cancer Ther. 2008 Dec;7(12):3780-8. doi: 10.1158/1535-7163.MCT-08-0753.


Shining the spotlight on shed KRAS in pancreatic cancer.

Sempere LF, Korc M.

Cancer Biol Ther. 2008 Mar;7(3):361-3. No abstract available.


MicroRNAs and the advent of vertebrate morphological complexity.

Heimberg AM, Sempere LF, Moy VN, Donoghue PC, Peterson KJ.

Proc Natl Acad Sci U S A. 2008 Feb 26;105(8):2946-50. doi: 10.1073/pnas.0712259105. Epub 2008 Feb 14.


Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer.

Sempere LF, Christensen M, Silahtaroglu A, Bak M, Heath CV, Schwartz G, Wells W, Kauppinen S, Cole CN.

Cancer Res. 2007 Dec 15;67(24):11612-20.


Phylogenetic distribution of microRNAs supports the basal position of acoel flatworms and the polyphyly of Platyhelminthes.

Sempere LF, Martinez P, Cole C, Baguñà J, Peterson KJ.

Evol Dev. 2007 Sep-Oct;9(5):409-15.


The phylogenetic distribution of metazoan microRNAs: insights into evolutionary complexity and constraint.

Sempere LF, Cole CN, McPeek MA, Peterson KJ.

J Exp Zool B Mol Dev Evol. 2006 Nov 15;306(6):575-88.


Expression profiling of mammalian microRNAs uncovers a subset of brain-expressed microRNAs with possible roles in murine and human neuronal differentiation.

Sempere LF, Freemantle S, Pitha-Rowe I, Moss E, Dmitrovsky E, Ambros V.

Genome Biol. 2004;5(3):R13. Epub 2004 Feb 16.


The expression of the let-7 small regulatory RNA is controlled by ecdysone during metamorphosis in Drosophila melanogaster.

Sempere LF, Dubrovsky EB, Dubrovskaya VA, Berger EM, Ambros V.

Dev Biol. 2002 Apr 1;244(1):170-9.

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