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Items: 35

1.

Structure, Regulation, and Inhibition of the Quorum-Sensing Signal Integrator LuxO.

Boyaci H, Shah T, Hurley A, Kokona B, Li Z, Ventocilla C, Jeffrey PD, Semmelhack MF, Fairman R, Bassler BL, Hughson FM.

PLoS Biol. 2016 May 24;14(5):e1002464. doi: 10.1371/journal.pbio.1002464. eCollection 2016 May.

2.

Modulating Vibrio cholerae quorum-sensing-controlled communication using autoinducer-loaded nanoparticles.

Lu HD, Spiegel AC, Hurley A, Perez LJ, Maisel K, Ensign LM, Hanes J, Bassler BL, Semmelhack MF, Prud'homme RK.

Nano Lett. 2015 Apr 8;15(4):2235-41. doi: 10.1021/acs.nanolett.5b00151. Epub 2015 Mar 3.

3.

Development of potent inhibitors of pyocyanin production in Pseudomonas aeruginosa.

Miller LC, O'Loughlin CT, Zhang Z, Siryaporn A, Silpe JE, Bassler BL, Semmelhack MF.

J Med Chem. 2015 Feb 12;58(3):1298-306. doi: 10.1021/jm5015082. Epub 2015 Feb 3.

4.

Caenorhabditis elegans recognizes a bacterial quorum-sensing signal molecule through the AWCON neuron.

Werner KM, Perez LJ, Ghosh R, Semmelhack MF, Bassler BL.

J Biol Chem. 2014 Sep 19;289(38):26566-73. doi: 10.1074/jbc.M114.573832. Epub 2014 Aug 4.

5.

Highly Potent, Chemically Stable Quorum Sensing Agonists for Vibrio Cholerae.

Perez LJ, Karagounis TK, Hurley A, Bassler BL, Semmelhack MF.

Chem Sci. 2014 Jan 1;5(1):151-155.

6.

Synthesis and biological evaluation of bis-CNB-GABA, a photoactivatable neurotransmitter with low receptor interference and chemical two-photon uncaging properties.

Shi DD, Trigo FF, Semmelhack MF, Wang SS.

J Am Chem Soc. 2014 Feb 5;136(5):1976-81. doi: 10.1021/ja411082f. Epub 2014 Jan 27.

7.

A quorum-sensing inhibitor blocks Pseudomonas aeruginosa virulence and biofilm formation.

O'Loughlin CT, Miller LC, Siryaporn A, Drescher K, Semmelhack MF, Bassler BL.

Proc Natl Acad Sci U S A. 2013 Oct 29;110(44):17981-6. doi: 10.1073/pnas.1316981110. Epub 2013 Oct 18.

8.

Role of the CAI-1 fatty acid tail in the Vibrio cholerae quorum sensing response.

Perez LJ, Ng WL, Marano P, Brook K, Bassler BL, Semmelhack MF.

J Med Chem. 2012 Nov 26;55(22):9669-81. doi: 10.1021/jm300908t. Epub 2012 Nov 8.

9.

Identification of small molecules that antagonize diguanylate cyclase enzymes to inhibit biofilm formation.

Sambanthamoorthy K, Sloup RE, Parashar V, Smith JM, Kim EE, Semmelhack MF, Neiditch MB, Waters CM.

Antimicrob Agents Chemother. 2012 Oct;56(10):5202-11. doi: 10.1128/AAC.01396-12. Epub 2012 Jul 30.

10.

Broad spectrum pro-quorum-sensing molecules as inhibitors of virulence in vibrios.

Ng WL, Perez L, Cong J, Semmelhack MF, Bassler BL.

PLoS Pathog. 2012;8(6):e1002767. doi: 10.1371/journal.ppat.1002767. Epub 2012 Jun 28.

11.

Small molecule probes of the receptor binding site in the Vibrio cholerae CAI-1 quorum sensing circuit.

Bolitho ME, Perez LJ, Koch MJ, Ng WL, Bassler BL, Semmelhack MF.

Bioorg Med Chem. 2011 Nov 15;19(22):6906-18. doi: 10.1016/j.bmc.2011.09.021. Epub 2011 Sep 17.

12.

Identification of a novel benzimidazole that inhibits bacterial biofilm formation in a broad-spectrum manner.

Sambanthamoorthy K, Gokhale AA, Lao W, Parashar V, Neiditch MB, Semmelhack MF, Lee I, Waters CM.

Antimicrob Agents Chemother. 2011 Sep;55(9):4369-78. doi: 10.1128/AAC.00583-11. Epub 2011 Jun 27.

13.

Processing the interspecies quorum-sensing signal autoinducer-2 (AI-2): characterization of phospho-(S)-4,5-dihydroxy-2,3-pentanedione isomerization by LsrG protein.

Marques JC, Lamosa P, Russell C, Ventura R, Maycock C, Semmelhack MF, Miller ST, Xavier KB.

J Biol Chem. 2011 May 20;286(20):18331-43. doi: 10.1074/jbc.M111.230227. Epub 2011 Mar 30.

14.

The structural basis for tight control of PP2A methylation and function by LCMT-1.

Stanevich V, Jiang L, Satyshur KA, Li Y, Jeffrey PD, Li Z, Menden P, Semmelhack MF, Xing Y.

Mol Cell. 2011 Feb 4;41(3):331-42. doi: 10.1016/j.molcel.2010.12.030.

15.

Signal production and detection specificity in Vibrio CqsA/CqsS quorum-sensing systems.

Ng WL, Perez LJ, Wei Y, Kraml C, Semmelhack MF, Bassler BL.

Mol Microbiol. 2011 Mar;79(6):1407-17. doi: 10.1111/j.1365-2958.2011.07548.x. Epub 2011 Jan 26.

16.

The free and bound forms of Lpp occupy distinct subcellular locations in Escherichia coli.

Cowles CE, Li Y, Semmelhack MF, Cristea IM, Silhavy TJ.

Mol Microbiol. 2011 Mar;79(5):1168-81. doi: 10.1111/j.1365-2958.2011.07539.x. Epub 2011 Jan 24.

17.

Mechanism of Vibrio cholerae autoinducer-1 biosynthesis.

Wei Y, Perez LJ, Ng WL, Semmelhack MF, Bassler BL.

ACS Chem Biol. 2011 Apr 15;6(4):356-65. doi: 10.1021/cb1003652. Epub 2011 Jan 13.

18.

Probing bacterial transmembrane histidine kinase receptor-ligand interactions with natural and synthetic molecules.

Ng WL, Wei Y, Perez LJ, Cong J, Long T, Koch M, Semmelhack MF, Wingreen NS, Bassler BL.

Proc Natl Acad Sci U S A. 2010 Mar 23;107(12):5575-80. doi: 10.1073/pnas.1001392107. Epub 2010 Mar 8.

19.

The Vibrio cholerae quorum-sensing autoinducer CAI-1: analysis of the biosynthetic enzyme CqsA.

Kelly RC, Bolitho ME, Higgins DA, Lu W, Ng WL, Jeffrey PD, Rabinowitz JD, Semmelhack MF, Hughson FM, Bassler BL.

Nat Chem Biol. 2009 Dec;5(12):891-5. doi: 10.1038/nchembio.237. Epub 2009 Oct 18.

20.

The major Vibrio cholerae autoinducer and its role in virulence factor production.

Higgins DA, Pomianek ME, Kraml CM, Taylor RK, Semmelhack MF, Bassler BL.

Nature. 2007 Dec 6;450(7171):883-6. Epub 2007 Nov 14.

PMID:
18004304
21.

The quorum-sensing molecule autoinducer 2 regulates motility and flagellar morphogenesis in Helicobacter pylori.

Rader BA, Campagna SR, Semmelhack MF, Bassler BL, Guillemin K.

J Bacteriol. 2007 Sep;189(17):6109-17. Epub 2007 Jun 22.

22.

Making bacteria behave: new agonists and antagonists of quorum sensing.

Pomianek ME, Semmelhack MF.

ACS Chem Biol. 2007 May 22;2(5):293-5.

PMID:
17518429
23.

Phosphorylation and processing of the quorum-sensing molecule autoinducer-2 in enteric bacteria.

Xavier KB, Miller ST, Lu W, Kim JH, Rabinowitz J, Pelczer I, Semmelhack MF, Bassler BL.

ACS Chem Biol. 2007 Feb 20;2(2):128-36. Epub 2007 Mar 2.

PMID:
17274596
24.

Synthesis of plakortone B and analogs.

Semmelhack MF, Hooley RJ, Kraml CM.

Org Lett. 2006 Nov 9;8(23):5203-6.

PMID:
17078678
25.

Autoinducer 2: a concentration-dependent signal for mutualistic bacterial biofilm growth.

Rickard AH, Palmer RJ Jr, Blehert DS, Campagna SR, Semmelhack MF, Egland PG, Bassler BL, Kolenbrander PE.

Mol Microbiol. 2006 Jun;60(6):1446-56.

26.

Accelerated arene ligand exchange in the (Arene)Cr(CO)2L series.

Semmelhack MF, Chlenov A, Ho DM.

J Am Chem Soc. 2005 Jun 1;127(21):7759-73.

PMID:
15913366
27.

An expeditious synthesis of DPD and boron binding studies.

Semmelhack MF, Campagna SR, Federle MJ, Bassler BL.

Org Lett. 2005 Feb 17;7(4):569-72.

PMID:
15704896
28.

Salmonella typhimurium recognizes a chemically distinct form of the bacterial quorum-sensing signal AI-2.

Miller ST, Xavier KB, Campagna SR, Taga ME, Semmelhack MF, Bassler BL, Hughson FM.

Mol Cell. 2004 Sep 10;15(5):677-87.

29.

Boron binding with the quorum sensing signal AI-2 and analogues.

Semmelhack MF, Campagna SR, Hwa C, Federle MJ, Bassler BL.

Org Lett. 2004 Jul 22;6(15):2635-7.

PMID:
15255709
30.

Conformational control in activation of an enediyne.

Semmelhack MF, Wu L, Pascal RA Jr, Ho DM.

J Am Chem Soc. 2003 Sep 3;125(35):10496-7.

PMID:
12940713
31.

Molecular targeting of inhibitor of apoptosis proteins based on small molecule mimics of natural binding partners.

Kipp RA, Case MA, Wist AD, Cresson CM, Carrell M, Griner E, Wiita A, Albiniak PA, Chai J, Shi Y, Semmelhack MF, McLendon GL.

Biochemistry. 2002 Jun 11;41(23):7344-9.

PMID:
12044166
32.

Accelerated arene ligand exchange in areneCr(CO(3)) complexes.

Semmelhack MF, Chlenov A, Wu L, Ho D.

J Am Chem Soc. 2001 Aug 29;123(34):8438-9. No abstract available.

PMID:
11516310
33.

Synthesis of the amino sugar from C-1027.

Semmelhack MF, Jiang Y, Ho D.

Org Lett. 2001 Jul 26;3(15):2403-6.

PMID:
11463327
34.

Total synthesis of the Cephalotaxus alkaloids. A problem in nucleophilic aromatic substitution.

Semmelhack MF, Chong BP, Stauffer RD, Rogerson TD, Chong A, Jones LD.

J Am Chem Soc. 1975 Apr 30;97(9):2507-16. No abstract available.

PMID:
1133420
35.

Total synthesis of cephalotaxus alkaloids.

Semmelhack MF, Chong BP, Jones LD.

J Am Chem Soc. 1972 Nov 29;94(24):8629-30. No abstract available.

PMID:
4638998

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