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Picornaviruses and RNA Metabolism: Local and Global Effects of Infection.

Holmes AC, Semler BL.

J Virol. 2019 Oct 15;93(21). pii: e02088-17. doi: 10.1128/JVI.02088-17. Print 2019 Nov 1. Review.


Enterovirus Persistence in Cardiac Cells of Patients With Idiopathic Dilated Cardiomyopathy Is Linked to 5' Terminal Genomic RNA-Deleted Viral Populations With Viral-Encoded Proteinase Activities.

Bouin A, Gretteau PA, Wehbe M, Renois F, N'Guyen Y, Lévêque N, Vu MN, Tracy S, Chapman NM, Bruneval P, Fornes P, Semler BL, Andreoletti L.

Circulation. 2019 May 14;139(20):2326-2338. doi: 10.1161/CIRCULATIONAHA.118.035966.


Exploitation of nuclear functions by human rhinovirus, a cytoplasmic RNA virus.

Flather D, Nguyen JHC, Semler BL, Gershon PD.

PLoS Pathog. 2018 Aug 24;14(8):e1007277. doi: 10.1371/journal.ppat.1007277. eCollection 2018 Aug.


VPg unlinkase/TDP2 in cardiovirus infected cells: Re-localization and proteolytic cleavage.

Maciejewski S, Ullmer W, Semler BL.

Virology. 2018 Mar;516:139-146. doi: 10.1016/j.virol.2018.01.010. Epub 2018 Jan 30.


Functional Consequences of RNA 5'-Terminal Deletions on Coxsackievirus B3 RNA Replication and Ribonucleoprotein Complex Formation.

Lévêque N, Garcia M, Bouin A, Nguyen JHC, Tran GP, Andreoletti L, Semler BL.

J Virol. 2017 Jul 27;91(16). pii: e00423-17. doi: 10.1128/JVI.00423-17. Print 2017 Aug 15.


Mammalian Polycistronic mRNAs and Disease.

Karginov TA, Pastor DPH, Semler BL, Gomez CM.

Trends Genet. 2017 Feb;33(2):129-142. doi: 10.1016/j.tig.2016.11.007. Epub 2016 Dec 21. Review.


Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways.

Ullmer W, Semler BL.

Viruses. 2016 Dec 20;8(12). pii: E335. doi: 10.3390/v8120335. Review.


Viral Determinants of miR-122-Independent Hepatitis C Virus Replication.

Hopcraft SE, Azarm KD, Israelow B, Lévêque N, Schwarz MC, Hsu TH, Chambers MT, Sourisseau M, Semler BL, Evans MJ.

mSphere. 2015 Nov 25;1(1). pii: e00009-15. doi: 10.1128/mSphere.00009-15. eCollection 2016 Jan-Feb.


Generation of Recombinant Polioviruses Harboring RNA Affinity Tags in the 5' and 3' Noncoding Regions of Genomic RNAs.

Flather D, Cathcart AL, Cruz C, Baggs E, Ngo T, Gershon PD, Semler BL.

Viruses. 2016 Feb 4;8(2). pii: E39. doi: 10.3390/v8020039.


Construction of a subgenomic CV-B3 replicon expressing emerald green fluorescent protein to assess viral replication of a cardiotropic enterovirus strain in cultured human cells.

Wehbe M, Huguenin A, Leveque N, Semler BL, Hamze M, Andreoletti L, Bouin A.

J Virol Methods. 2016 Apr;230:1-8. doi: 10.1016/j.jviromet.2016.01.005. Epub 2016 Jan 19.


Divergent Requirement for a DNA Repair Enzyme during Enterovirus Infections.

Maciejewski S, Nguyen JH, Gómez-Herreros F, Cortés-Ledesma F, Caldecott KW, Semler BL.

MBio. 2015 Dec 29;7(1):e01931-15. doi: 10.1128/mBio.01931-15.


Picornaviruses and nuclear functions: targeting a cellular compartment distinct from the replication site of a positive-strand RNA virus.

Flather D, Semler BL.

Front Microbiol. 2015 Jun 18;6:594. doi: 10.3389/fmicb.2015.00594. eCollection 2015. Review.


A 21st century perspective of poliovirus replication.

Lévêque N, Semler BL.

PLoS Pathog. 2015 Jun 4;11(6):e1004825. doi: 10.1371/journal.ppat.1004825. eCollection 2015 Jun. Review. No abstract available.


A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1.

Tsai BP, Jimenez J, Lim S, Fitzgerald KD, Zhang M, Chuah CT, Axelrod H, Wilson L, Ong ST, Semler BL, Waterman ML.

Open Biol. 2014 Nov;4(11):140180. doi: 10.1098/rsob.140180.


Differential restriction patterns of mRNA decay factor AUF1 during picornavirus infections.

Cathcart AL, Semler BL.

J Gen Virol. 2014 Jul;95(Pt 7):1488-92. doi: 10.1099/vir.0.064501-0. Epub 2014 Apr 10.


In memoriam John J. Holland (1929-2013): a pioneer in molecular virology.

Spindler KR, Semler BL.

J Virol. 2014 Jun;88(11):5903-5. doi: 10.1128/JVI.00653-14. Epub 2014 Mar 12. No abstract available.


Revelations from a bicistronic calcium channel gene.

Du X, Semler BL, Gomez CM.

Cell Cycle. 2014;13(6):875-6. doi: 10.4161/cc.28199. Epub 2014 Feb 14. No abstract available.


Differential cleavage of IRES trans-acting factors (ITAFs) in cells infected by human rhinovirus.

Chase AJ, Semler BL.

Virology. 2014 Jan 20;449:35-44. doi: 10.1016/j.virol.2013.10.030. Epub 2013 Nov 21.


Inhibition of poliovirus-induced cleavage of cellular protein PCBP2 reduces the levels of viral RNA replication.

Chase AJ, Daijogo S, Semler BL.

J Virol. 2014 Mar;88(6):3192-201. doi: 10.1128/JVI.02503-13. Epub 2013 Dec 26.


Modification of picornavirus genomic RNA using 'click' chemistry shows that unlinking of the VPg peptide is dispensable for translation and replication of the incoming viral RNA.

Langereis MA, Feng Q, Nelissen FH, Virgen-Slane R, van der Heden van Noort GJ, Maciejewski S, Filippov DV, Semler BL, van Delft FL, van Kuppeveld FJ.

Nucleic Acids Res. 2014 Feb;42(4):2473-82. doi: 10.1093/nar/gkt1162. Epub 2013 Nov 15.


Cellular mRNA decay protein AUF1 negatively regulates enterovirus and human rhinovirus infections.

Cathcart AL, Rozovics JM, Semler BL.

J Virol. 2013 Oct;87(19):10423-34. doi: 10.1128/JVI.01049-13. Epub 2013 Jul 31.


Poliovirus infection induces the co-localization of cellular protein SRp20 with TIA-1, a cytoplasmic stress granule protein.

Fitzgerald KD, Semler BL.

Virus Res. 2013 Sep;176(1-2):223-31. doi: 10.1016/j.virusres.2013.06.012. Epub 2013 Jul 2.


Methods to study RNA virus molecular biology.

Semler BL, Whelan SP.

Methods. 2013 Feb;59(2):165-6. doi: 10.1016/j.ymeth.2013.02.013. No abstract available.


Viral proteinase requirements for the nucleocytoplasmic relocalization of cellular splicing factor SRp20 during picornavirus infections.

Fitzgerald KD, Chase AJ, Cathcart AL, Tran GP, Semler BL.

J Virol. 2013 Mar;87(5):2390-400. doi: 10.1128/JVI.02396-12. Epub 2012 Dec 19.


MDA5 detects the double-stranded RNA replicative form in picornavirus-infected cells.

Feng Q, Hato SV, Langereis MA, Zoll J, Virgen-Slane R, Peisley A, Hur S, Semler BL, van Rij RP, van Kuppeveld FJ.

Cell Rep. 2012 Nov 29;2(5):1187-96. doi: 10.1016/j.celrep.2012.10.005. Epub 2012 Nov 8.


Picornavirus modification of a host mRNA decay protein.

Rozovics JM, Chase AJ, Cathcart AL, Chou W, Gershon PD, Palusa S, Wilusz J, Semler BL.

MBio. 2012 Nov 6;3(6):e00431-12. doi: 10.1128/mBio.00431-12.


An RNA virus hijacks an incognito function of a DNA repair enzyme.

Virgen-Slane R, Rozovics JM, Fitzgerald KD, Ngo T, Chou W, van der Heden van Noort GJ, Filippov DV, Gershon PD, Semler BL.

Proc Natl Acad Sci U S A. 2012 Sep 4;109(36):14634-9. doi: 10.1073/pnas.1208096109. Epub 2012 Aug 20.


SARS coronavirus nsp1 protein induces template-dependent endonucleolytic cleavage of mRNAs: viral mRNAs are resistant to nsp1-induced RNA cleavage.

Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S.

PLoS Pathog. 2011 Dec;7(12):e1002433. doi: 10.1371/journal.ppat.1002433. Epub 2011 Dec 8.


Re-localization of cellular protein SRp20 during poliovirus infection: bridging a viral IRES to the host cell translation apparatus.

Fitzgerald KD, Semler BL.

PLoS Pathog. 2011 Jul;7(7):e1002127. doi: 10.1371/journal.ppat.1002127. Epub 2011 Jul 14.


Mechanistic intersections between picornavirus translation and RNA replication.

Daijogo S, Semler BL.

Adv Virus Res. 2011;80:1-24. doi: 10.1016/B978-0-12-385987-7.00001-4. Review.


Engineered picornavirus VPg-RNA substrates: analysis of a tyrosyl-RNA phosphodiesterase activity.

Rozovics JM, Virgen-Slane R, Semler BL.

PLoS One. 2011 Mar 7;6(3):e16559. doi: 10.1371/journal.pone.0016559.


Alphacoronavirus transmissible gastroenteritis virus nsp1 protein suppresses protein translation in mammalian cells and in cell-free HeLa cell extracts but not in rabbit reticulocyte lysate.

Huang C, Lokugamage KG, Rozovics JM, Narayanan K, Semler BL, Makino S.

J Virol. 2011 Jan;85(1):638-43. doi: 10.1128/JVI.01806-10. Epub 2010 Nov 3.


Stress-inducible alternative translation initiation of human cytomegalovirus latency protein pUL138.

Grainger L, Cicchini L, Rak M, Petrucelli A, Fitzgerald KD, Semler BL, Goodrum F.

J Virol. 2010 Sep;84(18):9472-86. doi: 10.1128/JVI.00855-10. Epub 2010 Jun 30.


Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins.

Brunner JE, Ertel KJ, Rozovics JM, Semler BL.

Virology. 2010 May 10;400(2):240-7. doi: 10.1016/j.virol.2010.01.031. Epub 2010 Mar 1.


Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates.

Ertel KJ, Brunner JE, Semler BL.

J Virol. 2010 May;84(9):4229-42. doi: 10.1128/JVI.02198-09. Epub 2010 Feb 17.


Bridging IRES elements in mRNAs to the eukaryotic translation apparatus.

Fitzgerald KD, Semler BL.

Biochim Biophys Acta. 2009 Sep-Oct;1789(9-10):518-28. doi: 10.1016/j.bbagrm.2009.07.004. Epub 2009 Jul 23. Review.


The linker domain of poly(rC) binding protein 2 is a major determinant in poliovirus cap-independent translation.

Sean P, Nguyen JH, Semler BL.

Virology. 2008 Sep 1;378(2):243-53. doi: 10.1016/j.virol.2008.05.007. Epub 2008 Jul 25.


School nursing offers a zest for life and learning.

Semler B.

Aust Nurs J. 2008 May;15(10):20. No abstract available.


Coxsackievirus B RNA replication: lessons from poliovirus.

Sean P, Semler BL.

Curr Top Microbiol Immunol. 2008;323:89-121. Review.


IRES-mediated pathways to polysomes: nuclear versus cytoplasmic routes.

Semler BL, Waterman ML.

Trends Microbiol. 2008 Jan;16(1):1-5.


Cellular protein modification by poliovirus: the two faces of poly(rC)-binding protein.

Perera R, Daijogo S, Walter BL, Nguyen JH, Semler BL.

J Virol. 2007 Sep;81(17):8919-32. Epub 2007 Jun 20.


A nucleo-cytoplasmic SR protein functions in viral IRES-mediated translation initiation.

Bedard KM, Daijogo S, Semler BL.

EMBO J. 2007 Jan 24;26(2):459-67. Epub 2006 Dec 21.


An authentic 3' noncoding region is necessary for efficient poliovirus replication.

Brown DM, Cornell CT, Tran GP, Nguyen JH, Semler BL.

J Virol. 2005 Sep;79(18):11962-73.


An internal ribosome entry site mediates translation of lymphoid enhancer factor-1.

Jimenez J, Jang GM, Semler BL, Waterman ML.

RNA. 2005 Sep;11(9):1385-99.


Resistance is futile.

Semler BL.

Nat Genet. 2005 Jul;37(7):665-6. No abstract available.


Allosteric effects of ligands and mutations on poliovirus RNA-dependent RNA polymerase.

Boerner JE, Lyle JM, Daijogo S, Semler BL, Schultz SC, Kirkegaard K, Richards OC.

J Virol. 2005 Jun;79(12):7803-11.

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