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Items: 28


Efficacy and Pharmacokinetics of Glecaprevir and Pibrentasvir With Concurrent Use of Acid-Reducing Agents in Patients With Chronic HCV Infection.

Flamm S, Reddy KR, Zadeikis N, Hassanein T, Bacon BR, Maieron A, Zeuzem S, Bourliere M, Calleja JL, Kosloski MP, Oberoi RK, Lin CW, Yu Y, Lovell S, Semizarov D, Mensa FJ.

Clin Gastroenterol Hepatol. 2019 Feb;17(3):527-535.e6. doi: 10.1016/j.cgh.2018.07.003. Epub 2018 Sep 10.


Mcl-1 is critical for survival in a subgroup of non-small-cell lung cancer cell lines.

Zhang H, Guttikonda S, Roberts L, Uziel T, Semizarov D, Elmore SW, Leverson JD, Lam LT.

Oncogene. 2011 Apr 21;30(16):1963-8. doi: 10.1038/onc.2010.559. Epub 2010 Dec 6.


A microRNA screen to identify modulators of sensitivity to BCL2 inhibitor ABT-263 (navitoclax).

Lam LT, Lu X, Zhang H, Lesniewski R, Rosenberg S, Semizarov D.

Mol Cancer Ther. 2010 Nov;9(11):2943-50. doi: 10.1158/1535-7163.MCT-10-0427. Epub 2010 Sep 9.


An algorithm for classifying tumors based on genomic aberrations and selecting representative tumor models.

Lu X, Zhang K, Van Sant C, Coon J, Semizarov D.

BMC Med Genomics. 2010 Jun 22;3:23. doi: 10.1186/1755-8794-3-23.


Acquired resistance to combination treatment with temozolomide and ABT-888 is mediated by both base excision repair and homologous recombination DNA repair pathways.

Liu X, Han EK, Anderson M, Shi Y, Semizarov D, Wang G, McGonigal T, Roberts L, Lasko L, Palma J, Zhu GD, Penning T, Rosenberg S, Giranda VL, Luo Y, Leverson J, Johnson EF, Shoemaker AR.

Mol Cancer Res. 2009 Oct;7(10):1686-92. doi: 10.1158/1541-7786.MCR-09-0299. Epub 2009 Oct 13.


Identification of genes that confer tumor cell resistance to the aurora B kinase inhibitor, AZD1152.

Guo J, Anderson MG, Tapang P, Palma JP, Rodriguez LE, Niquette A, Li J, Bouska JJ, Wang G, Semizarov D, Albert DH, Donawho CK, Glaser KB, Shah OJ.

Pharmacogenomics J. 2009 Apr;9(2):90-102. doi: 10.1038/tpj.2008.20. Epub 2009 Feb 3.


Integrative genomic analysis of small-cell lung carcinoma reveals correlates of sensitivity to bcl-2 antagonists and uncovers novel chromosomal gains.

Olejniczak ET, Van Sant C, Anderson MG, Wang G, Tahir SK, Sauter G, Lesniewski R, Semizarov D.

Mol Cancer Res. 2007 Apr;5(4):331-9.


Endothelin signaling in osteoblasts: global genome view and implication of the calcineurin/NFAT pathway.

Van Sant C, Wang G, Anderson MG, Trask OJ, Lesniewski R, Semizarov D.

Mol Cancer Ther. 2007 Jan;6(1):253-61.


Evaluating hypoxia-inducible factor-1alpha as a cancer therapeutic target via inducible RNA interference in vivo.

Li L, Lin X, Staver M, Shoemaker A, Semizarov D, Fesik SW, Shen Y.

Cancer Res. 2005 Aug 15;65(16):7249-58.


Novel indication for cancer therapy: Chk1 inhibition sensitizes tumor cells to antimitotics.

Xiao Z, Xue J, Semizarov D, Sowin TJ, Rosenberg SH, Zhang H.

Int J Cancer. 2005 Jul 1;115(4):528-38.


siRNA-mediated gene silencing: a global genome view.

Semizarov D, Kroeger P, Fesik S.

Nucleic Acids Res. 2004 Jul 22;32(13):3836-45. Print 2004.


Specificity of short interfering RNA determined through gene expression signatures.

Semizarov D, Frost L, Sarthy A, Kroeger P, Halbert DN, Fesik SW.

Proc Natl Acad Sci U S A. 2003 May 27;100(11):6347-52. Epub 2003 May 13.


[Synthesis and substrate properties of modified nucleoside 5'-triphosphates mimicking dATP in the reactions of DNA synthesis catalyzed by DNA polymerases].

Sharkin IuA, Semizarov DG, Viktorova LS, Kukhanova MK.

Bioorg Khim. 2001 Sep-Oct;27(5):383-92. Russian.


Human DNA polymerases and retroviral reverse transcriptases: selectivity in respect to dNTPs modified at triphosphate residues.

Victorova LS, Semizarov DG, Shirokova EA, Alexandrova LA, Arzumanov AA, Jasko MV, Krayevsky AA.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):1031-2. No abstract available.


Reasons and limits of substrate activity of modified L-dNTP in DNA biosynthesis.

Krayevsky AA, Dyatkina NB, Semizarov DG, Victorova LS, Shirokova EA, Theil F, Von Janta Lipinski MJ, Gosselin G, Imbach JL.

Nucleosides Nucleotides. 1999 Apr-May;18(4-5):863-4.


A lineage-specific protein kinase crucial for myeloid maturation.

Semizarov D, Glesne D, Laouar A, Schiebel K, Huberman E.

Proc Natl Acad Sci U S A. 1998 Dec 22;95(26):15412-7.


Effect of P-chirality of oligo(deoxyribonucleoside phosphorothioate)s on the activity of terminal deoxyribonucleotidyl transferase.

Koziołkiewicz M, Maciaszek A, Stec WJ, Semizarov D, Victorova L, Krayevsky A.

FEBS Lett. 1998 Aug 28;434(1-2):77-82.


Stereoisomers of deoxynucleoside 5'-triphosphates as substrates for template-dependent and -independent DNA polymerases.

Semizarov DG, Arzumanov AA, Dyatkina NB, Meyer A, Vichier-Guerre S, Gosselin G, Rayner B, Imbach JL, Krayevsky AA.

J Biol Chem. 1997 Apr 4;272(14):9556-60.


Gamma-phosphate-substituted 2'-deoxynucleoside 5'-triphosphates as substrates for DNA polymerases.

Arzumanov AA, Semizarov DG, Victorova LS, Dyatkina NB, Krayevsky AA.

J Biol Chem. 1996 Oct 4;271(40):24389-94.


[Synthesis and some biochemical properties of phosphonyl acyclic analogs of 2'-deoxyadenosine nucleotides].

Malakhov DV, Semizarov DG, Ias'ko MV.

Bioorg Khim. 1995 Jul;21(7):539-44. Russian.


[New nucleotide inhibitors of human DNA polymerase alpha].

Semizarov DG, Ias'ko MV, Kukhanova MK, Kraevskiĭ AA.

Mol Biol (Mosk). 1995 May-Jun;29(3):689-700. Russian.


[Study of reverse transcriptase selectivity. Substrate properties of new 2',3'-unsaturated acyclic nucleotide analogs].

Shirokova EA, Shipitsyn AV, Semizarov DG.

Mol Biol (Mosk). 1995 Mar-Apr;29(2):461-71. Russian.


New modified substrates for discriminating between human DNA polymerases alpha and epsilon.

Jasko MV, Semizarov DG, Victorova LS, Mozzherin DJu, Krayevsky AA, Kukhanova MK.

FEBS Lett. 1995 Jan 2;357(1):23-6.


[3'-(Tetrazol-2''-yl-3'-deoxythymidine and its 5''-substituted form: synthesis and conformation in the crystalline state. Substrate properties of 3'-(tetrazol-2''-yl)-3'-deoxythymidine-5'-triphosphate in relation to DNA polymerases].

Ostrovskiĭ VA, Studentsov EP, Poplavskiĭ VS, Ivanov NV, Gurskaia GV, Zavodnik VE, Ias'ko MV, Semizarov DG.

Bioorg Khim. 1995 Jan;21(1):49-54. Russian.


Selectivity of DNA polymerases toward alpha and beta nucleotide substrates of D and L series.

Semizarov DG, Victorova LS, Dyatkina NB, von Janta-Lipinski M, Krayevsky AA.

FEBS Lett. 1994 Nov 7;354(2):187-90.


Novel acyclic nucleotides and nucleoside 5'-triphosphates imitating 2',3'-dideoxy-2',3'-didehydronucleotides: synthesis and biological properties.

Shirokova EA, Tarussova NB, Shipitsin AV, Semizarov DG, Krayevsky AA.

J Med Chem. 1994 Oct 28;37(22):3739-48.


[Modified nucleoside-5'-triphosphates with an additional conjugated through the 2'-3'-fused ring as DNA polymerase substrates].

Semizarov DG, Viktorova LS, Kraevskiĭ AA, Kukhanova MK.

Mol Biol (Mosk). 1994 Jan-Feb;28(1):113-26. Russian.


Modified nucleoside 5'-triphosphates containing 2',3'-fused three-membered rings as substrates for different DNA polymerases.

Semizarov DG, Victorova LS, Krayevsky AA, Kukhanova MK.

FEBS Lett. 1993 Jul 19;327(1):45-8.

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