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SEMG1/2 augment energy metabolism of tumor cells.
Shuvalov O, Kizenko A, Petukhov A, Fedorova O, Daks A, Bottrill A, Snezhkina AV, Kudryavtseva AV, Barlev N. Shuvalov O, et al. Cell Death Dis. 2020 Dec 11;11(12):1047. doi: 10.1038/s41419-020-03251-w. Cell Death Dis. 2020. PMID: 33311447 Free PMC article.
SEMG1 and SEMG2 genes belong to the family of cancer-testis antigens (CTAs), whose expression normally is restricted to male germ cells but is often restored in various malignancies. High levels of SEMG1 and SEMG2 expression are detected in prostate, renal, and lung …
SEMG1 and SEMG2 genes belong to the family of cancer-testis antigens (CTAs), whose expression normally is restricted to male germ cel …
SEMG1 may be the candidate gene for idiopathic asthenozoospermia.
Yu Q, Zhou Q, Wei Q, Li J, Feng C, Mao X. Yu Q, et al. Andrologia. 2014 Mar;46(2):158-66. doi: 10.1111/and.12064. Epub 2013 Jan 7. Andrologia. 2014. PMID: 23289976
We used Finding Associated Concepts with Text Analysis to match the specially expressed genes against the MEDLINE database and found SEMG1 and PGAP1 were related to male fertility. Validation of the microarray data of SEMG1 was carried out using real-time PCR. Our s …
We used Finding Associated Concepts with Text Analysis to match the specially expressed genes against the MEDLINE database and found SEMG …
Expressions of miR-525-3p and its target gene SEMG1 in the spermatozoa of patients with asthenozoospermia.
Zhou QZ, Guo XB, Zhang WS, Zhou JH, Yang C, Bian J, Chen MK, Guo WB, Wang P, Qi T, Wang CY, Yang JK, Liu CD. Zhou QZ, et al. Andrology. 2019 Mar;7(2):220-227. doi: 10.1111/andr.12573. Epub 2018 Dec 21. Andrology. 2019. PMID: 30575326 Free PMC article.
OBJECTIVES: To study the molecular mechanism of high expression of SEMG1 gene and its potential roles in AZS. MATERIALS AND METHODS: Western blot and real-time PCR were used to detect the expression levels of SEMG1 protein and mRNA in the ejaculated spermatozoa from …
OBJECTIVES: To study the molecular mechanism of high expression of SEMG1 gene and its potential roles in AZS. MATERIALS AND METHODS: …
[Effects of silencing the SEMG1 protein on the cycle and apoptosis of GC-1 spg cells].
Guo XB, Zhai JW, Yang JK, Lü XY, Cai ZX, Huang ZP, Liu CD, Zhou QZ. Guo XB, et al. Zhonghua Nan Ke Xue. 2020 Sep;26(9):771-776. Zhonghua Nan Ke Xue. 2020. PMID: 33377697 Chinese.
METHODS: SEMG1-specific siRNA was transfected into GC-1 spg cells by lipofectamine 2000 (the siRNA-SEMG1 group), the relative expression levels of the SEMG1 protein in the GC-1 spg cells of the siRNA-SEMG1, blank control and negative control groups wer …
METHODS: SEMG1-specific siRNA was transfected into GC-1 spg cells by lipofectamine 2000 (the siRNA-SEMG1 group), the relative …
Human Semenogelin 1 Promotes Sperm Survival in the Mouse Female Reproductive Tract.
Sakaguchi D, Miyado K, Iwamoto T, Okada H, Yoshida K, Kang W, Suzuki M, Yoshida M, Kawano N. Sakaguchi D, et al. Int J Mol Sci. 2020 May 31;21(11):3961. doi: 10.3390/ijms21113961. Int J Mol Sci. 2020. PMID: 32486486 Free PMC article.
The effect of SEMG1 on intrauterine sperm survival was comparable with that of SVS2. For clinical applications, three potentially sperm-protecting polypeptides that are easy to handle were designed from SEMG1, but their individual use was unable to mimic the ability …
The effect of SEMG1 on intrauterine sperm survival was comparable with that of SVS2. For clinical applications, three potentially spe …
Expression Analysis of the CRISP2, CATSPER1, PATE1 and SEMG1 in the Sperm of Men with Idiopathic Asthenozoospermia.
Heidary Z, Zaki-Dizaji M, Saliminejad K, Khorramkhorshid HR. Heidary Z, et al. J Reprod Infertil. 2019 Apr-Jun;20(2):70-75. J Reprod Infertil. 2019. PMID: 31058050 Free PMC article.
BACKGROUND: The purpose of this study was to analyze the expression level of CRISP2, CATSPER1, PATE1 and SEMG1 genes in the sperm of men with asthenozoospermia (AZS). AZS is a cause of infertility in men in which the motility of the sperm is reduced. ...Mann-Whitney test w …
BACKGROUND: The purpose of this study was to analyze the expression level of CRISP2, CATSPER1, PATE1 and SEMG1 genes in the sperm of …
Interactions of the male contraceptive target EPPIN with semenogelin-1 and small organic ligands.
Gomes AAS, Santos NCM, Rosa LR, Borges RJ, Fontes MRM, Hamil KG, O'Rand MG, Silva EJR. Gomes AAS, et al. Sci Rep. 2023 Sep 1;13(1):14382. doi: 10.1038/s41598-023-41365-1. Sci Rep. 2023. PMID: 37658081 Free PMC article.
EPPIN interacts with the semen coagulum protein semenogelin-1 (SEMG1) on the sperm surface, leading to transient inhibition of sperm motility after ejaculation. Small organic molecules targeting EPPIN's SEMG1-binding are under development as male contraceptives. Her …
EPPIN interacts with the semen coagulum protein semenogelin-1 (SEMG1) on the sperm surface, leading to transient inhibition of sperm …
Loss of calcium in human spermatozoa via EPPIN, the semenogelin receptor.
O'Rand MG, Widgren EE. O'Rand MG, et al. Biol Reprod. 2012 Feb 29;86(2):55. doi: 10.1095/biolreprod.111.094227. Print 2012 Feb. Biol Reprod. 2012. PMID: 22075473 Free PMC article.
However, the exact steps through which the EPPIN-SEMG1 complex exerts its effect on internal calcium levels are unknown. Anti-EPPIN antibodies can substitute for SEMG1, and, therefore, small-molecular weight compounds that mimic anti-EPPIN binding should be able to …
However, the exact steps through which the EPPIN-SEMG1 complex exerts its effect on internal calcium levels are unknown. Anti-EPPIN a …
Interacting proteins on human spermatozoa: adaptive evolution of the binding of semenogelin I to EPPIN.
Silva EJ, Hamil KG, O'Rand MG. Silva EJ, et al. PLoS One. 2013 Dec 2;8(12):e82014. doi: 10.1371/journal.pone.0082014. eCollection 2013. PLoS One. 2013. PMID: 24312623 Free PMC article.
Semenogelin I (SEMG1) is found in human semen coagulum and on the surface of spermatozoa bound to EPPIN. ...Our results indicate that some amino acid residues of SEMG1 and EPPIN possess a remarkable deficiency of variation among hominoid primates. ...
Semenogelin I (SEMG1) is found in human semen coagulum and on the surface of spermatozoa bound to EPPIN. ...Our results indicate that …
Blocking serine protease activity prevents semenogelin degradation leading to hyperviscous semen in humans.
Anamthathmakula P, Erickson JA, Winuthayanon W. Anamthathmakula P, et al. Biol Reprod. 2022 May 17;106(5):879-887. doi: 10.1093/biolre/ioac023. Biol Reprod. 2022. PMID: 35098308 Free PMC article.
Therefore, to determine whether inhibition of PSA activity alone could disrupt SEMG1 degradation and contribute to hyperviscous semen, a neutralizing PSA antibody was used. We found that PSA antibody effectively prevented SEMG1 degradation with a subtle impact on sp …
Therefore, to determine whether inhibition of PSA activity alone could disrupt SEMG1 degradation and contribute to hyperviscous semen …
57 results