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Items: 27

1.

Mechanism of Selective Enzyme Inhibition through Uncompetitive Regulation of an Allosteric Agonist.

Boulton S, Selvaratnam R, Blondeau JP, Lezoualc'h F, Melacini G.

J Am Chem Soc. 2018 Aug 1;140(30):9624-9637. doi: 10.1021/jacs.8b05044. Epub 2018 Jul 17.

PMID:
30016089
2.

What's a Lab to Do During and After a Hurricane?

Rodriguez F, Selvaratnam R, Mann P, Kalariya R, Petersen JR.

Lab Med. 2018 Mar 21;49(2):e23-e28. doi: 10.1093/labmed/lmy006.

PMID:
29538693
3.

Hurricanes: Are You Prepared?

Rodriguez FH Jr, Petersen J, Selvaratnam R, Mann P, Hoyne JB.

Lab Med. 2018 Mar 21;49(2):e18-e22. doi: 10.1093/labmed/lmy001.

PMID:
29481622
4.

Implementation of the NMR CHEmical Shift Covariance Analysis (CHESCA): A Chemical Biologist's Approach to Allostery.

Boulton S, Selvaratnam R, Ahmed R, Melacini G.

Methods Mol Biol. 2018;1688:391-405. doi: 10.1007/978-1-4939-7386-6_18.

PMID:
29151219
5.

A Newborn with Distended Abdomen.

Selvaratnam R, Karger AB.

Clin Chem. 2016 Aug;62(8):1061-4. doi: 10.1373/clinchem.2015.251231. No abstract available.

6.

Mechanism of cAMP Partial Agonism in Protein Kinase G (PKG).

VanSchouwen B, Selvaratnam R, Giri R, Lorenz R, Herberg FW, Kim C, Melacini G.

J Biol Chem. 2015 Nov 27;290(48):28631-41. doi: 10.1074/jbc.M115.685305. Epub 2015 Sep 14.

7.

A tool set to map allosteric networks through the NMR chemical shift covariance analysis.

Boulton S, Akimoto M, Selvaratnam R, Bashiri A, Melacini G.

Sci Rep. 2014 Dec 8;4:7306. doi: 10.1038/srep07306.

8.

A mechanism for the auto-inhibition of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel opening and its relief by cAMP.

Akimoto M, Zhang Z, Boulton S, Selvaratnam R, VanSchouwen B, Gloyd M, Accili EA, Lange OF, Melacini G.

J Biol Chem. 2014 Aug 8;289(32):22205-20. doi: 10.1074/jbc.M114.572164. Epub 2014 May 30.

9.

Tapping the translation potential of cAMP signalling: molecular basis for selectivity in cAMP agonism and antagonism as revealed by NMR.

Boulton S, Akimoto M, VanSchouwen B, Moleschi K, Selvaratnam R, Giri R, Melacini G.

Biochem Soc Trans. 2014 Apr;42(2):302-7. doi: 10.1042/BST20130282. Review.

PMID:
24646235
10.

Allosteric linkers in cAMP signalling.

Akimoto M, Moleschi K, Boulton S, VanSchouwen B, Selvaratnam R, Taylor SS, Melacini G.

Biochem Soc Trans. 2014 Feb;42(1):139-44. doi: 10.1042/BST20130257. Review.

11.

A novel non-canonical forkhead-associated (FHA) domain-binding interface mediates the interaction between Rad53 and Dbf4 proteins.

Matthews LA, Selvaratnam R, Jones DR, Akimoto M, McConkey BJ, Melacini G, Duncker BP, Guarné A.

J Biol Chem. 2014 Jan 31;289(5):2589-99. doi: 10.1074/jbc.M113.517060. Epub 2013 Nov 27.

12.

Structural basis for cyclic-nucleotide selectivity and cGMP-selective activation of PKG I.

Huang GY, Kim JJ, Reger AS, Lorenz R, Moon EW, Zhao C, Casteel DE, Bertinetti D, Vanschouwen B, Selvaratnam R, Pflugrath JW, Sankaran B, Melacini G, Herberg FW, Kim C.

Structure. 2014 Jan 7;22(1):116-24. doi: 10.1016/j.str.2013.09.021. Epub 2013 Nov 14.

13.

Ultrasonic and densimetric characterization of the association of cyclic AMP with the cAMP-binding domain of the exchange protein EPAC1.

Son I, Selvaratnam R, Dubins DN, Melacini G, Chalikian TV.

J Phys Chem B. 2013 Sep 19;117(37):10779-84. doi: 10.1021/jp406451p. Epub 2013 Sep 10.

PMID:
23968295
14.

Signaling through dynamic linkers as revealed by PKA.

Akimoto M, Selvaratnam R, McNicholl ET, Verma G, Taylor SS, Melacini G.

Proc Natl Acad Sci U S A. 2013 Aug 27;110(35):14231-6. doi: 10.1073/pnas.1312644110. Epub 2013 Aug 14.

15.

The auto-inhibitory role of the EPAC hinge helix as mapped by NMR.

Selvaratnam R, Mazhab-Jafari MT, Das R, Melacini G.

PLoS One. 2012;7(11):e48707. doi: 10.1371/journal.pone.0048707. Epub 2012 Nov 21.

16.

The projection analysis of NMR chemical shifts reveals extended EPAC autoinhibition determinants.

Selvaratnam R, VanSchouwen B, Fogolari F, Mazhab-Jafari MT, Das R, Melacini G.

Biophys J. 2012 Feb 8;102(3):630-9. doi: 10.1016/j.bpj.2011.12.030. Epub 2012 Feb 7.

17.

cAMP-dependent allostery and dynamics in Epac: an NMR view.

Selvaratnam R, Akimoto M, VanSchouwen B, Melacini G.

Biochem Soc Trans. 2012 Feb;40(1):219-23. doi: 10.1042/BST20110628. Review.

PMID:
22260694
18.

Noradrenergic modulation of hypoglossal motoneuron excitability: developmental and putative state-dependent mechanisms.

Funk GD, Zwicker JD, Selvaratnam R, Robinson DM.

Arch Ital Biol. 2011 Dec 1;149(4):426-53. doi: 10.4449/aib.v149i4.1271. Review.

PMID:
22205594
19.

A rare cause of acute chest pain in a young adult.

Selvaratnam R, Srirangalingam U, Mclean E, Lang-Lazdunski L, Goulden P.

Clin Med (Lond). 2011 Jun;11(3):265-7. No abstract available.

PMID:
21902082
20.

Role of dynamics in the autoinhibition and activation of the exchange protein directly activated by cyclic AMP (EPAC).

VanSchouwen B, Selvaratnam R, Fogolari F, Melacini G.

J Biol Chem. 2011 Dec 9;286(49):42655-69. doi: 10.1074/jbc.M111.277723. Epub 2011 Aug 26.

21.

A case of hiccoughs.

Srirangalingam U, Selvaratnam R, Monson JP, Grossman AB.

Clin Med (Lond). 2011 Aug;11(4):366-8. No abstract available. Erratum in: Clin Med. 2011 Oct;11(5):475.

PMID:
21853836
22.

Mapping allostery through the covariance analysis of NMR chemical shifts.

Selvaratnam R, Chowdhury S, VanSchouwen B, Melacini G.

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6133-8. doi: 10.1073/pnas.1017311108. Epub 2011 Mar 28.

23.

Thrombolysis beyond 3 hours for acute ischaemic stroke.

Selvaratnam R, Srirangalingam U, Ahmad S, Goulden P.

Emerg Med J. 2009 Oct;26(10):756-7. doi: 10.1136/emj.2008.070540.

PMID:
19773512
24.

Dynamically driven ligand selectivity in cyclic nucleotide binding domains.

Das R, Chowdhury S, Mazhab-Jafari MT, Sildas S, Selvaratnam R, Melacini G.

J Biol Chem. 2009 Aug 28;284(35):23682-96. doi: 10.1074/jbc.M109.011700. Epub 2009 Apr 29.

25.

Entropy-driven cAMP-dependent allosteric control of inhibitory interactions in exchange proteins directly activated by cAMP.

Das R, Mazhab-Jafari MT, Chowdhury S, SilDas S, Selvaratnam R, Melacini G.

J Biol Chem. 2008 Jul 11;283(28):19691-703. doi: 10.1074/jbc.M802164200. Epub 2008 Apr 14.

26.

Nutritional status and productivity of Sri Lankan tea pluckers.

Selvaratnam RR, de Silva LD, Pathmeswaran A, de Silva NR.

Ceylon Med J. 2003 Dec;48(4):114-8.

PMID:
15125401
27.

Impact of mass chemotherapy for the control of filariasis on geohelminth infections in Sri Lanka.

De Silva NR, Pathmeswaran A, Fernando SD, Weerasinghe CR, Selvaratnam RR, Padmasiri EA, Montresor A.

Ann Trop Med Parasitol. 2003 Jun;97(4):421-5. No abstract available.

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