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RTD-1 therapeutically normalizes synovial gene signatures in rat autoimmune arthritis and suppresses proinflammatory mediators in RA synovial fibroblasts.

Tongaonkar P, Punj V, Subramanian A, Tran DQ, Trinh KK, Schaal JB, Laragione T, Ouellette AJ, Gulko PS, Selsted ME.

Physiol Genomics. 2019 Dec 1;51(12):657-667. doi: 10.1152/physiolgenomics.00066.2019. Epub 2019 Nov 25.


Rhesus Theta Defensin 1 Promotes Long Term Survival in Systemic Candidiasis by Host Directed Mechanisms.

Basso V, Tran DQ, Schaal JB, Tran P, Eriguchi Y, Ngole D, Cabebe AE, Park AY, Beringer PM, Ouellette AJ, Selsted ME.

Sci Rep. 2019 Nov 15;9(1):16905. doi: 10.1038/s41598-019-53402-z.


Essential role of IFN-γ in T cell-associated intestinal inflammation.

Eriguchi Y, Nakamura K, Yokoi Y, Sugimoto R, Takahashi S, Hashimoto D, Teshima T, Ayabe T, Selsted ME, Ouellette AJ.

JCI Insight. 2018 Sep 20;3(18). pii: 121886. doi: 10.1172/jci.insight.121886. eCollection 2018 Sep 20.


Fungicidal Potency and Mechanisms of θ-Defensins against Multidrug-Resistant Candida Species.

Basso V, Garcia A, Tran DQ, Schaal JB, Tran P, Ngole D, Aqeel Y, Tongaonkar P, Ouellette AJ, Selsted ME.

Antimicrob Agents Chemother. 2018 May 25;62(6). pii: e00111-18. doi: 10.1128/AAC.00111-18. Print 2018 Jun.


Macrocyclic θ-defensins suppress tumor necrosis factor-α (TNF-α) shedding by inhibition of TNF-α-converting enzyme.

Schaal JB, Maretzky T, Tran DQ, Tran PA, Tongaonkar P, Blobel CP, Ouellette AJ, Selsted ME.

J Biol Chem. 2018 Feb 23;293(8):2725-2734. doi: 10.1074/jbc.RA117.000793. Epub 2018 Jan 9.


Suppression and resolution of autoimmune arthritis by rhesus θ-defensin-1, an immunomodulatory macrocyclic peptide.

Schaal JB, Tran DQ, Subramanian A, Patel R, Laragione T, Roberts KD, Trinh K, Tongaonkar P, Tran PA, Minond D, Fields GB, Beringer P, Ouellette AJ, Gulko PS, Selsted ME.

PLoS One. 2017 Nov 16;12(11):e0187868. doi: 10.1371/journal.pone.0187868. eCollection 2017.


Rhesus θ-Defensin-1 Attenuates Endotoxin-induced Acute Lung Injury by Inhibiting Proinflammatory Cytokines and Neutrophil Recruitment.

Jayne JG, Bensman TJ, Schaal JB, Park AYJ, Kimura E, Tran D, Selsted ME, Beringer PM.

Am J Respir Cell Mol Biol. 2018 Mar;58(3):310-319. doi: 10.1165/rcmb.2016-0428OC.


Efficacy of Rhesus Theta-Defensin-1 in Experimental Models of Pseudomonas aeruginosa Lung Infection and Inflammation.

Bensman TJ, Jayne JG, Sun M, Kimura E, Meinert J, Wang JC, Schaal JB, Tran D, Rao AP, Akbari O, Selsted ME, Beringer PM.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00154-17. doi: 10.1128/AAC.00154-17. Print 2017 Aug.


Rhesus θ-defensin-1 (RTD-1) exhibits in vitro and in vivo activity against cystic fibrosis strains of Pseudomonas aeruginosa.

Beringer PM, Bensman TJ, Ho H, Agnello M, Denovel N, Nguyen A, Wong-Beringer A, She R, Tran DQ, Moskowitz SM, Selsted ME.

J Antimicrob Chemother. 2016 Jan;71(1):181-8. doi: 10.1093/jac/dkv301. Epub 2015 Oct 3.


Rhesus macaque θ-defensin RTD-1 inhibits proinflammatory cytokine secretion and gene expression by inhibiting the activation of NF-κB and MAPK pathways.

Tongaonkar P, Trinh KK, Schaal JB, Tran D, Gulko PS, Ouellette AJ, Selsted ME.

J Leukoc Biol. 2015 Dec;98(6):1061-70. doi: 10.1189/jlb.3A0315-102R. Epub 2015 Aug 12.


θ-Defensin RTD-1 improves insulin action and normalizes plasma glucose and FFA levels in diet-induced obese rats.

Oh YT, Tran D, Buchanan TA, Selsted ME, Youn JH.

Am J Physiol Endocrinol Metab. 2015 Jul 15;309(2):E154-60. doi: 10.1152/ajpendo.00131.2015. Epub 2015 May 19.


Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes.

Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG.

Antibiotics (Basel). 2014;3(4):617-31. doi: 10.3390/antibiotics3040617.


Differential Susceptibility of Bacteria to Mouse Paneth Cell α-Defensins under Anaerobic Conditions.

Mastroianni JR, Lu W, Selsted ME, Ouellette AJ.

Antibiotics (Basel). 2014;3(4):493-508.


Hydrophobic determinants of α-defensin bactericidal activity.

Tai KP, Le VV, Selsted ME, Ouellette AJ.

Infect Immun. 2014 Jun;82(6):2195-202. doi: 10.1128/IAI.01414-13. Epub 2014 Mar 10.


Microbicidal effects of α- and θ-defensins against antibiotic-resistant Staphylococcus aureus and Pseudomonas aeruginosa.

Tai KP, Kamdar K, Yamaki J, Le VV, Tran D, Tran P, Selsted ME, Ouellette AJ, Wong-Beringer A.

Innate Immun. 2015 Jan;21(1):17-29. doi: 10.1177/1753425913514784. Epub 2013 Dec 17.


Rhesus macaque theta defensins suppress inflammatory cytokines and enhance survival in mouse models of bacteremic sepsis.

Schaal JB, Tran D, Tran P, Ösapay G, Trinh K, Roberts KD, Brasky KM, Tongaonkar P, Ouellette AJ, Selsted ME.

PLoS One. 2012;7(12):e51337. doi: 10.1371/journal.pone.0051337. Epub 2012 Dec 6.


Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.


Immunology. HD6 defensin nanonets.

Ouellette AJ, Selsted ME.

Science. 2012 Jul 27;337(6093):420-1. doi: 10.1126/science.1225906. No abstract available.


θ-Defensins: cyclic peptides with endless potential.

Lehrer RI, Cole AM, Selsted ME.

J Biol Chem. 2012 Aug 3;287(32):27014-9. doi: 10.1074/jbc.R112.346098. Epub 2012 Jun 14.


High fidelity processing and activation of the human α-defensin HNP1 precursor by neutrophil elastase and proteinase 3.

Tongaonkar P, Golji AE, Tran P, Ouellette AJ, Selsted ME.

PLoS One. 2012;7(3):e32469. doi: 10.1371/journal.pone.0032469. Epub 2012 Mar 20.


Alternative luminal activation mechanisms for paneth cell α-defensins.

Mastroianni JR, Costales JK, Zaksheske J, Selsted ME, Salzman NH, Ouellette AJ.

J Biol Chem. 2012 Mar 30;287(14):11205-12. doi: 10.1074/jbc.M111.333559. Epub 2012 Feb 13.


RTD-1mimic containing γPNA scaffold exhibits broad-spectrum antibacterial activities.

Rapireddy S, Nhon L, Meehan RE, Franks J, Stolz DB, Tran D, Selsted ME, Ly DH.

J Am Chem Soc. 2012 Mar 7;134(9):4041-4. doi: 10.1021/ja211867j. Epub 2012 Feb 22.


Cycloquest: identification of cyclopeptides via database search of their mass spectra against genome databases.

Mohimani H, Liu WT, Mylne JS, Poth AG, Colgrave ML, Tran D, Selsted ME, Dorrestein PC, Pevzner PA.

J Proteome Res. 2011 Oct 7;10(10):4505-12. doi: 10.1021/pr200323a. Epub 2011 Sep 7. Erratum in: J Proteome Res. 2011 Dec 2;10(12):5575.


Criterion for amino acid composition of defensins and antimicrobial peptides based on geometry of membrane destabilization.

Schmidt NW, Mishra A, Lai GH, Davis M, Sanders LK, Tran D, Garcia A, Tai KP, McCray PB, Ouellette AJ, Selsted ME, Wong GC.

J Am Chem Soc. 2011 May 4;133(17):6720-7. doi: 10.1021/ja200079a. Epub 2011 Apr 7.


Rhesus macaque θ-defensin isoforms: expression, antimicrobial activities, and demonstration of a prominent role in neutrophil granule microbicidal activities.

Tongaonkar P, Tran P, Roberts K, Schaal J, Osapay G, Tran D, Ouellette AJ, Selsted ME.

J Leukoc Biol. 2011 Feb;89(2):283-90. doi: 10.1189/jlb.0910535. Epub 2010 Nov 17.


Cyclic and acyclic defensins inhibit human immunodeficiency virus type-1 replication by different mechanisms.

Seidel A, Ye Y, de Armas LR, Soto M, Yarosh W, Marcsisin RA, Tran D, Selsted ME, Camerini D.

PLoS One. 2010 Mar 17;5(3):e9737. doi: 10.1371/journal.pone.0009737.


Rhesus theta-defensin prevents death in a mouse model of severe acute respiratory syndrome coronavirus pulmonary disease.

Wohlford-Lenane CL, Meyerholz DK, Perlman S, Zhou H, Tran D, Selsted ME, McCray PB Jr.

J Virol. 2009 Nov;83(21):11385-90. doi: 10.1128/JVI.01363-09. Epub 2009 Aug 26.


SDF2L1, a component of the endoplasmic reticulum chaperone complex, differentially interacts with {alpha}-, {beta}-, and {theta}-defensin propeptides.

Tongaonkar P, Selsted ME.

J Biol Chem. 2009 Feb 27;284(9):5602-9. doi: 10.1074/jbc.M806664200. Epub 2008 Dec 24.


The cell-penetrating peptide, Pep-1, has activity against intracellular chlamydial growth but not extracellular forms of Chlamydia trachomatis.

Park N, Yamanaka K, Tran D, Chandrangsu P, Akers JC, de Leon JC, Morrissette NS, Selsted ME, Tan M.

J Antimicrob Chemother. 2009 Jan;63(1):115-23. doi: 10.1093/jac/dkn436. Epub 2008 Oct 27.


Synthesis, structure, and activities of an oral mucosal alpha-defensin from rhesus macaque.

Vasudevan S, Yuan J, Osapay G, Tran P, Tai K, Liang W, Kumar V, Selsted ME, Cocco MJ.

J Biol Chem. 2008 Dec 19;283(51):35869-77. doi: 10.1074/jbc.M806915200. Epub 2008 Oct 17.


Isolation, synthesis, and antimicrobial activities of naturally occurring theta-defensin isoforms from baboon leukocytes.

Garcia AE, Osapay G, Tran PA, Yuan J, Selsted ME.

Infect Immun. 2008 Dec;76(12):5883-91. doi: 10.1128/IAI.01100-08. Epub 2008 Oct 13.


Microbicidal properties and cytocidal selectivity of rhesus macaque theta defensins.

Tran D, Tran P, Roberts K, Osapay G, Schaal J, Ouellette A, Selsted ME.

Antimicrob Agents Chemother. 2008 Mar;52(3):944-53. Epub 2007 Dec 26.


A pocket guide to explorations of the defensin field.

Selsted ME.

Curr Pharm Des. 2007;13(30):3061-4.


Mammalian defensins in the antimicrobial immune response.

Selsted ME, Ouellette AJ.

Nat Immunol. 2005 Jun;6(6):551-7. Review.


Quantitative interactions between cryptdin-4 amino terminal variants and membranes.

Satchell DP, Sheynis T, Kolusheva S, Cummings J, Vanderlick TK, Jelinek R, Selsted ME, Ouellette AJ.

Peptides. 2003 Nov;24(11):1795-805.


Paneth cell alpha-defensins from rhesus macaque small intestine.

Tanabe H, Yuan J, Zaragoza MM, Dandekar S, Henschen-Edman A, Selsted ME, Ouellette AJ.

Infect Immun. 2004 Mar;72(3):1470-8.


Structure-activity determinants in paneth cell alpha-defensins: loss-of-function in mouse cryptdin-4 by charge-reversal at arginine residue positions.

Tanabe H, Qu X, Weeks CS, Cummings JE, Kolusheva S, Walsh KB, Jelinek R, Vanderlick TK, Selsted ME, Ouellette AJ.

J Biol Chem. 2004 Mar 19;279(12):11976-83. Epub 2003 Dec 31.


Alpha-defensin expression during myelopoiesis: identification of cis and trans elements that regulate expression of NP-3 in rat promyelocytes.

Yamamoto CM, Banaiee N, Yount NY, Patel B, Selsted ME.

J Leukoc Biol. 2004 Feb;75(2):332-41. Epub 2003 Nov 21.


alpha-Defensins can have anti-HIV activity but are not CD8 cell anti-HIV factors.

Mackewicz CE, Yuan J, Tran P, Diaz L, Mack E, Selsted ME, Levy JA.

AIDS. 2003 Sep 26;17(14):F23-32. Erratum in: AIDS. 2003 Sep 26;17(14):F31.


Susceptibility of human and murine Chlamydia trachomatis serovars to granulocyte- and epithelium-derived antimicrobial peptides.

Chong-Cerrillo C, Selsted ME, Peterson EM, de la Maza LM.

J Pept Res. 2003 May;61(5):237-42.


Antimicrobial peptides from human platelets.

Tang YQ, Yeaman MR, Selsted ME.

Infect Immun. 2002 Dec;70(12):6524-33.


Antimicrobial properties of the Escherichia coli R1 plasmid host killing peptide.

Pecota DC, Osapay G, Selsted ME, Wood TK.

J Biotechnol. 2003 Jan 9;100(1):1-12.


Cryptdin 3 forms anion selective channels in cytoplasmic membranes of human embryonic kidney cells.

Yue G, Merlin D, Selsted ME, Lencer WI, Madara JL, Eaton DC.

Am J Physiol Gastrointest Liver Physiol. 2002 May;282(5):G757-65.


Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria.

Ayabe T, Satchell DP, Wilson CL, Parks WC, Selsted ME, Ouellette AJ.

Nat Immunol. 2000 Aug;1(2):113-8.


Cryptdin-3 induces novel apical conductance(s) in Cl- secretory, including cystic fibrosis, epithelia.

Merlin D, Yue G, Lencer WI, Selsted ME, Madara JL.

Am J Physiol Cell Physiol. 2001 Feb;280(2):C296-302.


Human neutrophil-mediated nonoxidative antifungal activity against Cryptococcus neoformans.

Mambula SS, Simons ER, Hastey R, Selsted ME, Levitz SM.

Infect Immun. 2000 Nov;68(11):6257-64.

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