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Items: 45

1.

Mouse model of Gram-negative prosthetic joint infection reveals therapeutic targets.

Thompson JM, Miller RJ, Ashbaugh AG, Dillen CA, Pickett JE, Wang Y, Ortines RV, Sterling RS, Francis KP, Bernthal NM, Cohen TS, Tkaczyk C, Yu L, Stover CK, DiGiandomenico A, Sellman BR, Thorek DL, Miller LS.

JCI Insight. 2018 Sep 6;3(17). pii: 121737. doi: 10.1172/jci.insight.121737. [Epub ahead of print]

2.

Alanine Scanning Mutagenesis of the MEDI4893 (Suvratoxumab) Epitope Reduces Alpha Toxin Lytic Activity In Vitro and Staphylococcus aureus Fitness in Infection Models.

Tkaczyk C, Semenova E, Shi YY, Rosenthal K, Oganesyan V, Warrener P, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01033-18. doi: 10.1128/AAC.01033-18. Print 2018 Nov.

3.

The Neutrophilic Response to Pseudomonas Damages the Airway Barrier, Promoting Infection by Klebsiella pneumoniae.

Jones-Nelson O, Hilliard JJ, DiGiandomenico A, Warrener P, Alfaro A, Cheng L, Stover CK, Cohen TS, Sellman BR.

Am J Respir Cell Mol Biol. 2018 Dec;59(6):745-756. doi: 10.1165/rcmb.2018-0107OC.

PMID:
30109945
4.

α-Toxin Induces Platelet Aggregation and Liver Injury during Staphylococcus aureus Sepsis.

Surewaard BGJ, Thanabalasuriar A, Zeng Z, Tkaczyk C, Cohen TS, Bardoel BW, Jorch SK, Deppermann C, Bubeck Wardenburg J, Davis RP, Jenne CN, Stover KC, Sellman BR, Kubes P.

Cell Host Microbe. 2018 Aug 8;24(2):271-284.e3. doi: 10.1016/j.chom.2018.06.017. Epub 2018 Jul 19.

PMID:
30033122
5.

Molecularly specific detection of bacterial lipoteichoic acid for diagnosis of prosthetic joint infection of the bone.

Pickett JE, Thompson JM, Sadowska A, Tkaczyk C, Sellman BR, Minola A, Corti D, Lanzavecchia A, Miller LS, Thorek DL.

Bone Res. 2018 Apr 25;6:13. doi: 10.1038/s41413-018-0014-y. eCollection 2018.

6.

Alpha-Toxin Contributes to Biofilm Formation among Staphylococcus aureus Wound Isolates.

Anderson MJ, Schaaf E, Breshears LM, Wallis HW, Johnson JR, Tkaczyk C, Sellman BR, Sun J, Peterson ML.

Toxins (Basel). 2018 Apr 16;10(4). pii: E157. doi: 10.3390/toxins10040157.

7.

S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking.

Cohen TS, Boland ML, Boland BB, Takahashi V, Tovchigrechko A, Lee Y, Wilde AD, Mazaitis MJ, Jones-Nelson O, Tkaczyk C, Raja R, Stover CK, Sellman BR.

Cell Rep. 2018 Feb 27;22(9):2431-2441. doi: 10.1016/j.celrep.2018.02.027.

8.

MEDI3902 Correlates of Protection against Severe Pseudomonas aeruginosa Pneumonia in a Rabbit Acute Pneumonia Model.

Le HN, Quetz JS, Tran VG, Le VTM, Aguiar-Alves F, Pinheiro MG, Cheng L, Yu L, Sellman BR, Stover CK, DiGiandomenico A, Diep BA.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e02565-17. doi: 10.1128/AAC.02565-17. Print 2018 May.

9.

Serum biomarker profiles suggest that atopic dermatitis is a systemic disease.

Thijs JL, Strickland I, Bruijnzeel-Koomen CAFM, Nierkens S, Giovannone B, Knol EF, Csomor E, Sellman BR, Mustelin T, Sleeman MA, de Bruin-Weller MS, Herath A, Drylewicz J, May RD, Hijnen D.

J Allergy Clin Immunol. 2018 Apr;141(4):1523-1526. doi: 10.1016/j.jaci.2017.12.991. Epub 2018 Feb 2. No abstract available.

PMID:
29410314
10.

Neutralizing Alpha-Toxin Accelerates Healing of Staphylococcus aureus-Infected Wounds in Nondiabetic and Diabetic Mice.

Ortines RV, Liu H, Cheng LI, Cohen TS, Lawlor H, Gami A, Wang Y, Dillen CA, Archer NK, Miller RJ, Ashbaugh AG, Pinsker BL, Marchitto MC, Tkaczyk C, Stover CK, Sellman BR, Miller LS.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02288-17. doi: 10.1128/AAC.02288-17. Print 2018 Mar.

11.

Prevalence of IgG and Neutralizing Antibodies against Staphylococcus aureus Alpha-Toxin in Healthy Human Subjects and Diverse Patient Populations.

Wu Y, Liu X, Akhgar A, Li JJ, Mok H, Sellman BR, Yu L, Roskos LK, Esser MT, Ruzin A.

Infect Immun. 2018 Feb 20;86(3). pii: e00671-17. doi: 10.1128/IAI.00671-17. Print 2018 Mar.

12.

Mouse model of hematogenous implant-related Staphylococcus aureus biofilm infection reveals therapeutic targets.

Wang Y, Cheng LI, Helfer DR, Ashbaugh AG, Miller RJ, Tzomides AJ, Thompson JM, Ortines RV, Tsai AS, Liu H, Dillen CA, Archer NK, Cohen TS, Tkaczyk C, Stover CK, Sellman BR, Miller LS.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5094-E5102. doi: 10.1073/pnas.1703427114. Epub 2017 Jun 12.

13.

Multimechanistic Monoclonal Antibodies (MAbs) Targeting Staphylococcus aureus Alpha-Toxin and Clumping Factor A: Activity and Efficacy Comparisons of a MAb Combination and an Engineered Bispecific Antibody Approach.

Tkaczyk C, Kasturirangan S, Minola A, Jones-Nelson O, Gunter V, Shi YY, Rosenthal K, Aleti V, Semenova E, Warrener P, Tabor D, Stover CK, Corti D, Rainey G, Sellman BR.

Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00629-17. doi: 10.1128/AAC.00629-17. Print 2017 Aug.

14.

Anti-LPS antibodies protect against Klebsiella pneumoniae by empowering neutrophil-mediated clearance without neutralizing TLR4.

Cohen TS, Pelletier M, Cheng L, Pennini ME, Bonnell J, Cvitkovic R, Chang CS, Xiao X, Cameroni E, Corti D, Semenova E, Warrener P, Sellman BR, Suzich J, Wang Q, Stover CK.

JCI Insight. 2017 May 4;2(9). pii: 92774. doi: 10.1172/jci.insight.92774. [Epub ahead of print]

15.

Bispecific antibody targets multiple Pseudomonas aeruginosa evasion mechanisms in the lung vasculature.

Thanabalasuriar A, Surewaard BG, Willson ME, Neupane AS, Stover CK, Warrener P, Wilson G, Keller AE, Sellman BR, DiGiandomenico A, Kubes P.

J Clin Invest. 2017 Jun 1;127(6):2249-2261. doi: 10.1172/JCI89652. Epub 2017 May 2.

16.

Moving toward endotypes in atopic dermatitis: Identification of patient clusters based on serum biomarker analysis.

Thijs JL, Strickland I, Bruijnzeel-Koomen CAFM, Nierkens S, Giovannone B, Csomor E, Sellman BR, Mustelin T, Sleeman MA, de Bruin-Weller MS, Herath A, Drylewicz J, May RD, Hijnen D.

J Allergy Clin Immunol. 2017 Sep;140(3):730-737. doi: 10.1016/j.jaci.2017.03.023. Epub 2017 Apr 13. Erratum in: J Allergy Clin Immunol. 2018 Aug;142(2):714.

PMID:
28412391
17.

Effects of Tedizolid Phosphate on Survival Outcomes and Suppression of Production of Staphylococcal Toxins in a Rabbit Model of Methicillin-Resistant Staphylococcus aureus Necrotizing Pneumonia.

Le VT, Le HN, Pinheiro MG, Hahn KJ, Dinh ML, Larson KB, Flanagan SD, Badiou C, Lina G, Tkaczyk C, Sellman BR, Diep BA.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02734-16. doi: 10.1128/AAC.02734-16. Print 2017 Apr.

18.

Targeting Alpha Toxin To Mitigate Its Lethal Toxicity in Ferret and Rabbit Models of Staphylococcus aureus Necrotizing Pneumonia.

Diep BA, Hilliard JJ, Le VT, Tkaczyk C, Le HN, Tran VG, Rao RL, Dip EC, Pereira-Franchi EP, Cha P, Jacobson S, Broome R, Cheng LI, Weiss W, Prokai L, Nguyen V, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02456-16. doi: 10.1128/AAC.02456-16. Print 2017 Apr.

19.

The complex biology and contribution of Staphylococcus aureus in atopic dermatitis, current and future therapies.

Hepburn L, Hijnen DJ, Sellman BR, Mustelin T, Sleeman MA, May RD, Strickland I.

Br J Dermatol. 2017 Jul;177(1):63-71. doi: 10.1111/bjd.15139. Epub 2017 Jun 11. Review.

PMID:
27779765
20.

S. aureus blocks efferocytosis of neutrophils by macrophages through the activity of its virulence factor alpha toxin.

Cohen TS, Jones-Nelson O, Hotz M, Cheng L, Miller LS, Suzich J, Stover CK, Sellman BR.

Sci Rep. 2016 Oct 14;6:35466. doi: 10.1038/srep35466.

21.

IVIG-mediated protection against necrotizing pneumonia caused by MRSA.

Diep BA, Le VT, Badiou C, Le HN, Pinheiro MG, Duong AH, Wang X, Dip EC, Aguiar-Alves F, Basuino L, Marbach H, Mai TT, Sarda MN, Kajikawa O, Matute-Bello G, Tkaczyk C, Rasigade JP, Sellman BR, Chambers HF, Lina G.

Sci Transl Med. 2016 Sep 21;8(357):357ra124. doi: 10.1126/scitranslmed.aag1153.

PMID:
27655850
22.

Critical Role of Alpha-Toxin and Protective Effects of Its Neutralization by a Human Antibody in Acute Bacterial Skin and Skin Structure Infections.

Le VT, Tkaczyk C, Chau S, Rao RL, Dip EC, Pereira-Franchi EP, Cheng L, Lee S, Koelkebeck H, Hilliard JJ, Yu XQ, Datta V, Nguyen V, Weiss W, Prokai L, O'Day T, Stover CK, Sellman BR, Diep BA.

Antimicrob Agents Chemother. 2016 Sep 23;60(10):5640-8. doi: 10.1128/AAC.00710-16. Print 2016 Oct.

23.

Targeting Alpha Toxin and ClfA with a Multimechanistic Monoclonal-Antibody-Based Approach for Prophylaxis of Serious Staphylococcus aureus Disease.

Tkaczyk C, Hamilton MM, Sadowska A, Shi Y, Chang CS, Chowdhury P, Buonapane R, Xiao X, Warrener P, Mediavilla J, Kreiswirth B, Suzich J, Stover CK, Sellman BR.

MBio. 2016 Jun 28;7(3). pii: e00528-16. doi: 10.1128/mBio.00528-16.

24.

Staphylococcus aureus Alpha-Toxin Is Conserved among Diverse Hospital Respiratory Isolates Collected from a Global Surveillance Study and Is Neutralized by Monoclonal Antibody MEDI4893.

Tabor DE, Yu L, Mok H, Tkaczyk C, Sellman BR, Wu Y, Oganesyan V, Slidel T, Jafri H, McCarthy M, Bradford P, Esser MT.

Antimicrob Agents Chemother. 2016 Aug 22;60(9):5312-21. doi: 10.1128/AAC.00357-16. Print 2016 Sep.

25.

Staphylococcus aureus α toxin potentiates opportunistic bacterial lung infections.

Cohen TS, Hilliard JJ, Jones-Nelson O, Keller AE, O'Day T, Tkaczyk C, DiGiandomenico A, Hamilton M, Pelletier M, Wang Q, Diep BA, Le VT, Cheng L, Suzich J, Stover CK, Sellman BR.

Sci Transl Med. 2016 Mar 9;8(329):329ra31. doi: 10.1126/scitranslmed.aad9922.

PMID:
26962155
26.

Antibacterial monoclonal antibodies: the next generation?

DiGiandomenico A, Sellman BR.

Curr Opin Microbiol. 2015 Oct;27:78-85. doi: 10.1016/j.mib.2015.07.014. Epub 2015 Aug 25. Review.

PMID:
26302478
27.

MEDI4893* Promotes Survival and Extends the Antibiotic Treatment Window in a Staphylococcus aureus Immunocompromised Pneumonia Model.

Hua L, Cohen TS, Shi Y, Datta V, Hilliard JJ, Tkaczyk C, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2015 Aug;59(8):4526-32. doi: 10.1128/AAC.00510-15. Epub 2015 May 18.

28.

Differential expression and roles of Staphylococcus aureus virulence determinants during colonization and disease.

Jenkins A, Diep BA, Mai TT, Vo NH, Warrener P, Suzich J, Stover CK, Sellman BR.

MBio. 2015 Feb 17;6(1):e02272-14. doi: 10.1128/mBio.02272-14.

29.

Characterization of alpha-toxin hla gene variants, alpha-toxin expression levels, and levels of antibody to alpha-toxin in hemodialysis and postsurgical patients with Staphylococcus aureus bacteremia.

Sharma-Kuinkel BK, Wu Y, Tabor DE, Mok H, Sellman BR, Jenkins A, Yu L, Jafri HS, Rude TH, Ruffin F, Schell WA, Park LP, Yan Q, Thaden JT, Messina JA, Fowler VG Jr, Esser MT.

J Clin Microbiol. 2015 Jan;53(1):227-36. doi: 10.1128/JCM.02023-14. Epub 2014 Nov 12.

30.

A multifunctional bispecific antibody protects against Pseudomonas aeruginosa.

DiGiandomenico A, Keller AE, Gao C, Rainey GJ, Warrener P, Camara MM, Bonnell J, Fleming R, Bezabeh B, Dimasi N, Sellman BR, Hilliard J, Guenther CM, Datta V, Zhao W, Gao C, Yu XQ, Suzich JA, Stover CK.

Sci Transl Med. 2014 Nov 12;6(262):262ra155. doi: 10.1126/scitranslmed.3009655.

31.

Anti-alpha-toxin monoclonal antibody and antibiotic combination therapy improves disease outcome and accelerates healing in a Staphylococcus aureus dermonecrosis model.

Hilliard JJ, Datta V, Tkaczyk C, Hamilton M, Sadowska A, Jones-Nelson O, O'Day T, Weiss WJ, Szarka S, Nguyen V, Prokai L, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2015 Jan;59(1):299-309. doi: 10.1128/AAC.03918-14. Epub 2014 Oct 27.

32.

Mechanisms of neutralization of a human anti-α-toxin antibody.

Oganesyan V, Peng L, Damschroder MM, Cheng L, Sadowska A, Tkaczyk C, Sellman BR, Wu H, Dall'Acqua WF.

J Biol Chem. 2014 Oct 24;289(43):29874-80. doi: 10.1074/jbc.M114.601328. Epub 2014 Sep 10.

33.

Assessment of an anti-alpha-toxin monoclonal antibody for prevention and treatment of Staphylococcus aureus-induced pneumonia.

Hua L, Hilliard JJ, Shi Y, Tkaczyk C, Cheng LI, Yu X, Datta V, Ren S, Feng H, Zinsou R, Keller A, O'Day T, Du Q, Cheng L, Damschroder M, Robbie G, Suzich J, Stover CK, Sellman BR.

Antimicrob Agents Chemother. 2014;58(2):1108-17. doi: 10.1128/AAC.02190-13. Epub 2013 Dec 2.

34.

Staphylococcus aureus alpha toxin suppresses effective innate and adaptive immune responses in a murine dermonecrosis model.

Tkaczyk C, Hamilton MM, Datta V, Yang XP, Hilliard JJ, Stephens GL, Sadowska A, Hua L, O'Day T, Suzich J, Stover CK, Sellman BR.

PLoS One. 2013 Oct 2;8(10):e75103. doi: 10.1371/journal.pone.0075103. eCollection 2013.

35.

Identification of anti-alpha toxin monoclonal antibodies that reduce the severity of Staphylococcus aureus dermonecrosis and exhibit a correlation between affinity and potency.

Tkaczyk C, Hua L, Varkey R, Shi Y, Dettinger L, Woods R, Barnes A, MacGill RS, Wilson S, Chowdhury P, Stover CK, Sellman BR.

Clin Vaccine Immunol. 2012 Mar;19(3):377-85. doi: 10.1128/CVI.05589-11. Epub 2012 Jan 11.

36.

Heterogeneous in vivo expression of clumping factor A and capsular polysaccharide by Staphylococcus aureus: implications for vaccine design.

Nanra JS, Timofeyeva Y, Buitrago SM, Sellman BR, Dilts DA, Fink P, Nunez L, Hagen M, Matsuka YV, Mininni T, Zhu D, Pavliak V, Green BA, Jansen KU, Anderson AS.

Vaccine. 2009 May 26;27(25-26):3276-80. doi: 10.1016/j.vaccine.2009.01.062. Epub 2009 Feb 5.

PMID:
19200819
37.

Expression of Staphylococcus epidermidis SdrG increases following exposure to an in vivo environment.

Sellman BR, Timofeyeva Y, Nanra J, Scott A, Fulginiti JP, Matsuka YV, Baker SM.

Infect Immun. 2008 Jul;76(7):2950-7. doi: 10.1128/IAI.00055-08. Epub 2008 Apr 21.

38.

Identification of immunogenic and serum binding proteins of Staphylococcus epidermidis.

Sellman BR, Howell AP, Kelly-Boyd C, Baker SM.

Infect Immun. 2005 Oct;73(10):6591-600.

39.

2001: a year of major advances in anthrax toxin research.

Mourez M, Lacy DB, Cunningham K, Legmann R, Sellman BR, Mogridge J, Collier RJ.

Trends Microbiol. 2002 Jun;10(6):287-93. Review.

PMID:
12088665
40.

Designing a polyvalent inhibitor of anthrax toxin.

Mourez M, Kane RS, Mogridge J, Metallo S, Deschatelets P, Sellman BR, Whitesides GM, Collier RJ.

Nat Biotechnol. 2001 Oct;19(10):958-61.

PMID:
11581662
41.

Dominant-negative mutants of a toxin subunit: an approach to therapy of anthrax.

Sellman BR, Mourez M, Collier RJ.

Science. 2001 Apr 27;292(5517):695-7.

42.

Point mutations in anthrax protective antigen that block translocation.

Sellman BR, Nassi S, Collier RJ.

J Biol Chem. 2001 Mar 16;276(11):8371-6. Epub 2000 Dec 11.

43.

Expression and properties of an aerolysin--Clostridium septicum alpha toxin hybrid protein.

Diep DB, Nelson KL, Lawrence TS, Sellman BR, Tweten RK, Buckley JT.

Mol Microbiol. 1999 Feb;31(3):785-94.

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