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Items: 1 to 50 of 210


A Semi-High-Throughput Adaptation of the NADH-Coupled ATPase Assay for Screening Small Molecule Inhibitors.

Radnai L, Stremel RF, Sellers JR, Rumbaugh G, Miller CA.

J Vis Exp. 2019 Aug 17;(150). doi: 10.3791/60017.


Perfringolysin O-Induced Plasma Membrane Pores Trigger Actomyosin Remodeling and Endoplasmic Reticulum Redistribution.

Brito C, Mesquita FS, Bleck CKE, Sellers JR, Cabanes D, Sousa S.

Toxins (Basel). 2019 Jul 17;11(7). pii: E419. doi: 10.3390/toxins11070419.


Remarkable Rigidity of the Single α-Helical Domain of Myosin-VI As Revealed by NMR Spectroscopy.

Barnes CA, Shen Y, Ying J, Takagi Y, Torchia DA, Sellers JR, Bax A.

J Am Chem Soc. 2019 Jun 5;141(22):9004-9017. doi: 10.1021/jacs.9b03116. Epub 2019 May 23.


Nonmuscle myosin-2 isoforms.

Sellers JR, Heissler SM.

Curr Biol. 2019 Apr 22;29(8):R275-R278. doi: 10.1016/j.cub.2019.03.022.


Multiple S100 protein isoforms and C-terminal phosphorylation contribute to the paralog-selective regulation of nonmuscle myosin 2 filaments.

Ecsédi P, Billington N, Pálfy G, Gógl G, Kiss B, Bulyáki É, Bodor A, Sellers JR, Nyitray L.

J Biol Chem. 2018 Sep 21;293(38):14850-14867. doi: 10.1074/jbc.RA118.004277. Epub 2018 Aug 7.


Dissecting myosin-5B mechanosensitivity and calcium regulation at the single molecule level.

Gardini L, Heissler SM, Arbore C, Yang Y, Sellers JR, Pavone FS, Capitanio M.

Nat Commun. 2018 Jul 20;9(1):2844. doi: 10.1038/s41467-018-05251-z.


Affimer proteins for F-actin: novel affinity reagents that label F-actin in live and fixed cells.

Lopata A, Hughes R, Tiede C, Heissler SM, Sellers JR, Knight PJ, Tomlinson D, Peckham M.

Sci Rep. 2018 Apr 26;8(1):6572. doi: 10.1038/s41598-018-24953-4.


Quantitative mass imaging of single biological macromolecules.

Young G, Hundt N, Cole D, Fineberg A, Andrecka J, Tyler A, Olerinyova A, Ansari A, Marklund EG, Collier MP, Chandler SA, Tkachenko O, Allen J, Crispin M, Billington N, Takagi Y, Sellers JR, Eichmann C, Selenko P, Frey L, Riek R, Galpin MR, Struwe WB, Benesch JLP, Kukura P.

Science. 2018 Apr 27;360(6387):423-427. doi: 10.1126/science.aar5839.


Bipolar filaments of human nonmuscle myosin 2-A and 2-B have distinct motile and mechanical properties.

Melli L, Billington N, Sun SA, Bird JE, Nagy A, Friedman TB, Takagi Y, Sellers JR.

Elife. 2018 Feb 8;7. pii: e32871. doi: 10.7554/eLife.32871.


Mechanistic insights into the active site and allosteric communication pathways in human nonmuscle myosin-2C.

Chinthalapudi K, Heissler SM, Preller M, Sellers JR, Manstein DJ.

Elife. 2017 Dec 19;6. pii: e32742. doi: 10.7554/eLife.32742.


Kinetic signatures of myosin-5B, the motor involved in microvillus inclusion disease.

Heissler SM, Chinthalapudi K, Sellers JR.

J Biol Chem. 2017 Nov 3;292(44):18372-18385. doi: 10.1074/jbc.M117.801456. Epub 2017 Sep 7.


Effect of ATP and regulatory light-chain phosphorylation on the polymerization of mammalian nonmuscle myosin II.

Liu X, Billington N, Shu S, Yu SH, Piszczek G, Sellers JR, Korn ED.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):E6516-E6525. doi: 10.1073/pnas.1702375114. Epub 2017 Jul 24.


Correction to Enthalpies and Entropies of Adsorption on Well-Defined Oxide Surfaces: Experimental Measurements.

Campbell CT, Sellers JRV.

Chem Rev. 2017 May 10;117(9):6632. doi: 10.1021/acs.chemrev.7b00175. Epub 2017 Apr 10. No abstract available.


Re-evaluating the roles of myosin 18Aα and F-actin in determining Golgi morphology.

Bruun K, Beach JR, Heissler SM, Remmert K, Sellers JR, Hammer JA.

Cytoskeleton (Hoboken). 2017 May;74(5):205-218. doi: 10.1002/cm.21364. Epub 2017 May 10.


Drosophila non-muscle myosin II motor activity determines the rate of tissue folding.

Vasquez CG, Heissler SM, Billington N, Sellers JR, Martin AC.

Elife. 2016 Dec 30;5. pii: e20828. doi: 10.7554/eLife.20828.


Self-organization of actin networks by a monomeric myosin.

Saczko-Brack D, Warchol E, Rogez B, Kröss M, Heissler SM, Sellers JR, Batters C, Veigel C.

Proc Natl Acad Sci U S A. 2016 Dec 27;113(52):E8387-E8395. doi: 10.1073/pnas.1612719113. Epub 2016 Dec 12.


Local pulsatile contractions are an intrinsic property of the myosin 2A motor in the cortical cytoskeleton of adherent cells.

Baird MA, Billington N, Wang A, Adelstein RS, Sellers JR, Fischer RS, Waterman CM.

Mol Biol Cell. 2017 Jan 15;28(2):240-251. doi: 10.1091/mbc.E16-05-0335. Epub 2016 Nov 23.


Interferometric Scattering Microscopy for the Study of Molecular Motors.

Andrecka J, Takagi Y, Mickolajczyk KJ, Lippert LG, Sellers JR, Hancock WO, Goldman YE, Kukura P.

Methods Enzymol. 2016;581:517-539. doi: 10.1016/bs.mie.2016.08.016. Epub 2016 Oct 10.


Mammalian Nonmuscle Myosin II Binds to Anionic Phospholipids with Concomitant Dissociation of the Regulatory Light Chain.

Liu X, Shu S, Billington N, Williamson CD, Yu S, Brzeska H, Donaldson JG, Sellers JR, Korn ED.

J Biol Chem. 2016 Nov 25;291(48):24828-24837. Epub 2016 Oct 3.


Mechanisms and Functional Diversity of Macromolecular Remodeling by ATP-Dependent Motors.

Martin A, Berger JM, Sellers JR, Ostankovitch M.

J Mol Biol. 2016 May 8;428(9 Pt B):1819-21. doi: 10.1016/j.jmb.2016.04.008. No abstract available.


Kinetic Adaptations of Myosins for Their Diverse Cellular Functions.

Heissler SM, Sellers JR.

Traffic. 2016 Aug;17(8):839-59. doi: 10.1111/tra.12388. Epub 2016 Mar 31. Review.


The Arf GTPase-activating Protein, ASAP1, Binds Nonmuscle Myosin 2A to Control Remodeling of the Actomyosin Network.

Chen PW, Jian X, Heissler SM, Le K, Luo R, Jenkins LM, Nagy A, Moss J, Sellers JR, Randazzo PA.

J Biol Chem. 2016 Apr 1;291(14):7517-26. doi: 10.1074/jbc.M115.701292. Epub 2016 Feb 17.


Various Themes of Myosin Regulation.

Heissler SM, Sellers JR.

J Mol Biol. 2016 May 8;428(9 Pt B):1927-46. doi: 10.1016/j.jmb.2016.01.022. Epub 2016 Jan 28. Review.


Myosin light chains: Teaching old dogs new tricks.

Heissler SM, Sellers JR.

Bioarchitecture. 2014;4(6):169-88. doi: 10.1080/19490992.2015.1054092. Review.


Rho kinase as a target for cerebral vascular disorders.

Bond LM, Sellers JR, McKerracher L.

Future Med Chem. 2015;7(8):1039-53. doi: 10.4155/fmc.15.45. Review.


Ankyrin domain of myosin 16 influences motor function and decreases protein phosphatase catalytic activity.

Kengyel A, Bécsi B, Kónya Z, Sellers JR, Erdődi F, Nyitrai M.

Eur Biophys J. 2015 May;44(4):207-18. doi: 10.1007/s00249-015-1015-z. Epub 2015 Mar 17.


Myosin 18A coassembles with nonmuscle myosin 2 to form mixed bipolar filaments.

Billington N, Beach JR, Heissler SM, Remmert K, Guzik-Lendrum S, Nagy A, Takagi Y, Shao L, Li D, Yang Y, Zhang Y, Barzik M, Betzig E, Hammer JA 3rd, Sellers JR.

Curr Biol. 2015 Mar 30;25(7):942-8. doi: 10.1016/j.cub.2015.02.012. Epub 2015 Mar 5.


Structural dynamics of myosin 5 during processive motion revealed by interferometric scattering microscopy.

Andrecka J, Ortega Arroyo J, Takagi Y, de Wit G, Fineberg A, MacKinnon L, Young G, Sellers JR, Kukura P.

Elife. 2015 Mar 6;4. doi: 10.7554/eLife.05413.


Four things to know about myosin light chains as reporters for non-muscle myosin-2 dynamics in live cells.

Heissler SM, Sellers JR.

Cytoskeleton (Hoboken). 2015 Feb;72(2):65-70. doi: 10.1002/cm.21212.


Kinetic characterization of the sole nonmuscle myosin-2 from the model organism Drosophila melanogaster.

Heissler SM, Chinthalapudi K, Sellers JR.

FASEB J. 2015 Apr;29(4):1456-66. doi: 10.1096/fj.14-266742. Epub 2015 Jan 30.


Chaperone-enhanced purification of unconventional myosin 15, a molecular motor specialized for stereocilia protein trafficking.

Bird JE, Takagi Y, Billington N, Strub MP, Sellers JR, Friedman TB.

Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12390-5. doi: 10.1073/pnas.1409459111. Epub 2014 Aug 11.


Use of fluorescent techniques to study the in vitro movement of myosins.

Toepfer C, Sellers JR.

Exp Suppl. 2014;105:193-210. doi: 10.1007/978-3-0348-0856-9_9. Review.


Regulation of nonmuscle myosin II by tropomyosin.

Barua B, Nagy A, Sellers JR, Hitchcock-DeGregori SE.

Biochemistry. 2014 Jun 24;53(24):4015-24. doi: 10.1021/bi500162z. Epub 2014 Jun 12.


Myosin-10 produces its power-stroke in two phases and moves processively along a single actin filament under low load.

Takagi Y, Farrow RE, Billington N, Nagy A, Batters C, Yang Y, Sellers JR, Molloy JE.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1833-42. doi: 10.1073/pnas.1320122111. Epub 2014 Apr 21.


To understand muscle you must take it apart.

Batters C, Veigel C, Homsher E, Sellers JR.

Front Physiol. 2014 Mar 11;5:90. doi: 10.3389/fphys.2014.00090. eCollection 2014. Review.


Label-free, all-optical detection, imaging, and tracking of a single protein.

Ortega Arroyo J, Andrecka J, Spillane KM, Billington N, Takagi Y, Sellers JR, Kukura P.

Nano Lett. 2014;14(4):2065-70. doi: 10.1021/nl500234t. Epub 2014 Mar 21.


Adsorption calorimetry during metal vapor deposition on single crystal surfaces: increased flux, reduced optical radiation, and real-time flux and reflectivity measurements.

Sellers JR, James TE, Hemmingson SL, Farmer JA, Campbell CT.

Rev Sci Instrum. 2013 Dec;84(12):123901. doi: 10.1063/1.4832980.


Characterization of three full-length human nonmuscle myosin II paralogs.

Billington N, Wang A, Mao J, Adelstein RS, Sellers JR.

J Biol Chem. 2013 Nov 15;288(46):33398-410. doi: 10.1074/jbc.M113.499848. Epub 2013 Sep 26.


Actin structure-dependent stepping of myosin 5a and 10 during processive movement.

Bao J, Huck D, Gunther LK, Sellers JR, Sakamoto T.

PLoS One. 2013 Sep 19;8(9):e74936. doi: 10.1371/journal.pone.0074936. eCollection 2013.


Kinetic characterization of the ATPase and actin-activated ATPase activities of Acanthamoeba castellanii myosin-2.

Heissler SM, Liu X, Korn ED, Sellers JR.

J Biol Chem. 2013 Sep 13;288(37):26709-20. doi: 10.1074/jbc.M113.485946. Epub 2013 Jul 29.


Loss of actomyosin regulation in distal arthrogryposis myopathy due to mutant myosin binding protein-C slow.

Ackermann MA, Patel PD, Valenti J, Takagi Y, Homsher E, Sellers JR, Kontrogianni-Konstantopoulos A.

FASEB J. 2013 Aug;27(8):3217-28. doi: 10.1096/fj.13-228882. Epub 2013 May 8. Erratum in: FASEB J. 2018 Mar;32(3):1729-1730.


A subdomain interaction at the base of the lever allosterically tunes the mechanochemical mechanism of myosin 5a.

Nagy NT, Chakraborty S, Harami GM, Sellers JR, Sakamoto T, Kovács M.

PLoS One. 2013 May 1;8(5):e62640. doi: 10.1371/journal.pone.0062640. Print 2013.


Myosin regulatory light chain (RLC) phosphorylation change as a modulator of cardiac muscle contraction in disease.

Toepfer C, Caorsi V, Kampourakis T, Sikkel MB, West TG, Leung MC, Al-Saud SA, MacLeod KT, Lyon AR, Marston SB, Sellers JR, Ferenczi MA.

J Biol Chem. 2013 May 10;288(19):13446-54. doi: 10.1074/jbc.M113.455444. Epub 2013 Mar 25.


Enthalpies and entropies of adsorption on well-defined oxide surfaces: experimental measurements.

Campbell CT, Sellers JR.

Chem Rev. 2013 Jun 12;113(6):4106-35. doi: 10.1021/cr300329s. Epub 2013 Feb 26. No abstract available. Erratum in: Chem Rev. 2013 Aug 14;113(8):6902. Chem Rev. 2017 May 10;117(9):6632.


Mammalian myosin-18A, a highly divergent myosin.

Guzik-Lendrum S, Heissler SM, Billington N, Takagi Y, Yang Y, Knight PJ, Homsher E, Sellers JR.

J Biol Chem. 2013 Mar 29;288(13):9532-48. doi: 10.1074/jbc.M112.441238. Epub 2013 Feb 4.


Kinetic characterization of nonmuscle myosin IIb at the single molecule level.

Nagy A, Takagi Y, Billington N, Sun SA, Hong DK, Homsher E, Wang A, Sellers JR.

J Biol Chem. 2013 Jan 4;288(1):709-22. doi: 10.1074/jbc.M112.424671. Epub 2012 Nov 12.


The entropies of adsorbed molecules.

Campbell CT, Sellers JR.

J Am Chem Soc. 2012 Oct 31;134(43):18109-15. doi: 10.1021/ja3080117. Epub 2012 Oct 17. Erratum in: J Am Chem Soc. 2013 Sep 18;135(37):13998.


Dynamic exchange of myosin VI on endocytic structures.

Bond LM, Arden SD, Kendrick-Jones J, Buss F, Sellers JR.

J Biol Chem. 2012 Nov 9;287(46):38637-46. doi: 10.1074/jbc.M112.373969. Epub 2012 Sep 19.


Temperature dependent measurements reveal similarities between muscle and non-muscle myosin motility.

Yengo CM, Takagi Y, Sellers JR.

J Muscle Res Cell Motil. 2012 Dec;33(6):385-94. doi: 10.1007/s10974-012-9316-7. Epub 2012 Aug 29.

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