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Patterns of substrate affinity, competition and degradation kinetics underlie biological activity of thalidomide analogs.

Sperling AS, Burgess M, Keshishian H, Gasser JA, Bhatt S, Jan M, Słabicki M, Sellar RS, Fink EC, Miller PG, Liddicoat BJ, Sievers QL, Sharma R, Adams DN, Olesinski EA, Fulciniti M, Udeshi ND, Kuhn E, Letai A, Munshi NC, Carr SA, Ebert BL.

Blood. 2019 May 1. pii: blood.2019000789. doi: 10.1182/blood.2019000789. [Epub ahead of print]


Jak-ing Up the Plaque's Lipid Core…and Even More.

Libby P, Molinaro R, Sellar RS, Ebert BL.

Circ Res. 2018 Nov 9;123(11):1180-1182. doi: 10.1161/CIRCRESAHA.118.314074. No abstract available.


Post-mortem magnetic resonance imaging in patients with suspected prion disease: Pathological confirmation, sensitivity, specificity and observer reliability. A national registry.

Gibson LM, Chappell FM, Summers D, Collie DA, Sellar R, Best J, Knight R, Ironside JW, Wardlaw JM.

PLoS One. 2018 Aug 7;13(8):e0201434. doi: 10.1371/journal.pone.0201434. eCollection 2018.


Predicting progression to AML.

Sellar RS, Jaiswal S, Ebert BL.

Nat Med. 2018 Jul;24(7):904-906. doi: 10.1038/s41591-018-0114-7. No abstract available.


PPM1D-truncating mutations confer resistance to chemotherapy and sensitivity to PPM1D inhibition in hematopoietic cells.

Kahn JD, Miller PG, Silver AJ, Sellar RS, Bhatt S, Gibson C, McConkey M, Adams D, Mar B, Mertins P, Fereshetian S, Krug K, Zhu H, Letai A, Carr SA, Doench J, Jaiswal S, Ebert BL.

Blood. 2018 Sep 13;132(11):1095-1105. doi: 10.1182/blood-2018-05-850339. Epub 2018 Jun 28.


Relapse in teenage and young adult patients treated on a paediatric minimal residual disease stratified ALL treatment protocol is associated with a poor outcome: results from UKALL2003.

Sellar RS, Rowntree C, Vora AJ, Furness CL, Goulden N, Mitchell C, Moorman AV, Hough R.

Br J Haematol. 2018 May;181(4):515-522. doi: 10.1111/bjh.15208. Epub 2018 Apr 24.


Immunophenotypic analysis of cell cycle status in acute myeloid leukaemia: relationship to cytogenetics, genotype and clinical outcome.

Sellar RS, Gale RE, Khwaja A, Garbowski M, Loddo M, Stoeber K, Williams GH, Linch DC.

Br J Haematol. 2018 May;181(4):486-494. doi: 10.1111/bjh.15211. Epub 2018 Apr 20.


Increased neutrophil extracellular trap formation promotes thrombosis in myeloproliferative neoplasms.

Wolach O, Sellar RS, Martinod K, Cherpokova D, McConkey M, Chappell RJ, Silver AJ, Adams D, Castellano CA, Schneider RK, Padera RF, DeAngelo DJ, Wadleigh M, Steensma DP, Galinsky I, Stone RM, Genovese G, McCarroll SA, Iliadou B, Hultman C, Neuberg D, Mullally A, Wagner DD, Ebert BL.

Sci Transl Med. 2018 Apr 11;10(436). pii: eaan8292. doi: 10.1126/scitranslmed.aan8292.



Charrot SC, Sellar RS, Manson JJ.

Br J Hosp Med (Lond). 2017 Oct 2;78(10):C147-C151. doi: 10.12968/hmed.2017.78.10.C147. No abstract available.


Angiographic and clinical outcomes of balloon remodeling versus unassisted coil embolization in the ruptured aneurysm cohort of the GEL THE NEC study.

Dabus G, Brinjikji W, Amar AP, Delgado Almandoz JE, Diaz OM, Jabbour P, Hanel R, Hui F, Kelly M, Layton KF, Miller JW, Levy EI, Moran CJ, Suh DC, Woo H, Sellar R, Hoh B, Evans A, Kallmes DF.

J Neurointerv Surg. 2018 May;10(5):446-450. doi: 10.1136/neurintsurg-2017-013326. Epub 2017 Aug 18.


Targeting Aberrant Signaling in Myeloid Malignancies: Promise Versus Reality.

Sellar R, Losman JA.

Hematol Oncol Clin North Am. 2017 Aug;31(4):565-576. doi: 10.1016/j.hoc.2017.04.001. Epub 2017 May 17. Review.


The clinico-radiological paradox of cognitive function and MRI burden of white matter lesions in people with multiple sclerosis: A systematic review and meta-analysis.

Mollison D, Sellar R, Bastin M, Mollison D, Chandran S, Wardlaw J, Connick P.

PLoS One. 2017 May 15;12(5):e0177727. doi: 10.1371/journal.pone.0177727. eCollection 2017. Review.


Spinal cord arteriovenous shunts of the ventral (anterior) sulcus: anatomical, clinical, and therapeutic considerations.

Roccatagliata L, Kominami S, Krajina A, Sellar R, Soderman M, Van den Berg R, Desal H, Condette-Auliac S, Rodesch G.

Neuroradiology. 2017 Mar;59(3):289-296. doi: 10.1007/s00234-017-1789-z. Epub 2017 Mar 1.


Impact of Alemtuzumab Scheduling on Graft-versus-Host Disease after Unrelated Donor Fludarabine and Melphalan Allografts.

Green K, Pearce K, Sellar RS, Jardine L, Nicolson PLR, Nagra S, Bigley V, Jackson G, Dickinson AM, Thomson K, Mackinnon S, Craddock C, Peggs KS, Collin M.

Biol Blood Marrow Transplant. 2017 May;23(5):805-812. doi: 10.1016/j.bbmt.2017.02.007. Epub 2017 Feb 14.


Safety results from the treatment of 109 cerebral aneurysms using the Woven EndoBridge technique: preliminary results in the United Kingdom.

Lawson A, Molyneux A, Sellar R, Lamin S, Thomas A, Gholkar A, Patankar T.

J Neurosurg. 2018 Jan;128(1):144-153. doi: 10.3171/2016.9.JNS152849. Epub 2017 Feb 3.


GEL THE NEC: a prospective registry evaluating the safety, ease of use, and efficacy of the HydroSoft coil as a finishing device.

Brinjikji W, Amar AP, Delgado Almandoz JE, Diaz O, Jabbour P, Hanel R, Hui F, Kelly M, Layton KD, Miller JW, Levy E, Moran C, Suh DC, Woo H, Sellar R, Ho B, Evans A, Kallmes DF.

J Neurointerv Surg. 2018 Jan;10(1):83-87. doi: 10.1136/neurintsurg-2016-012915. Epub 2017 Jan 30.


Arterial Obstruction on Computed Tomographic or Magnetic Resonance Angiography and Response to Intravenous Thrombolytics in Ischemic Stroke.

Mair G, von Kummer R, Adami A, White PM, Adams ME, Yan B, Demchuk AM, Farrall AJ, Sellar RJ, Sakka E, Palmer J, Perry D, Lindley RI, Sandercock PA, Wardlaw JM; IST-3 Collaborative Group.

Stroke. 2017 Feb;48(2):353-360. doi: 10.1161/STROKEAHA.116.015164. Epub 2016 Dec 22.


Cell cycle status in AML blast cells from peripheral blood, bone marrow aspirates and trephines and implications for biological studies and treatment.

Sellar RS, Fraser L, Khwaja A, Gale RE, Marafioti T, Akarca A, Hubank M, Brooks T, Stoeber K, Williams G, Linch DC.

Br J Haematol. 2016 Jul;174(2):275-9. doi: 10.1111/bjh.14055. Epub 2016 Apr 8.


A donor-specific epigenetic classifier for acute graft-versus-host disease severity in hematopoietic stem cell transplantation.

Paul DS, Jones A, Sellar RS, Mayor NP, Feber A, Webster AP, Afonso N, Sergeant R, Szydlo RM, Apperley JF, Widschwendter M, Mackinnon S, Marsh SG, Madrigal JA, Rakyan VK, Peggs KS, Beck S.

Genome Med. 2015 Dec 15;7:128. doi: 10.1186/s13073-015-0246-z.


Intracranial Carotid Calcification on Cranial Computed Tomography: Visual Scoring Methods, Semiautomated Scores, and Volume Measurements in Patients With Stroke.

Subedi D, Zishan US, Chappell F, Gregoriades ML, Sudlow C, Sellar R, Wardlaw J.

Stroke. 2015 Sep;46(9):2504-9. doi: 10.1161/STROKEAHA.115.009716. Epub 2015 Aug 6.


HydroCoils Are Associated with Lower Angiographic Recurrence Rates Than Are Bare Platinum Coils in Treatment of "Difficult-to-Treat" Aneurysms: A Post Hoc Subgroup Analysis of the HELPS Trial.

Brinjikji W, White PM, Nahser H, Wardlaw J, Sellar R, Gholkar A, Cloft HJ, Kallmes DF.

AJNR Am J Neuroradiol. 2015 Sep;36(9):1689-94. doi: 10.3174/ajnr.A4349. Epub 2015 Jul 30.


HydroCoils reduce recurrence rates in recently ruptured medium-sized intracranial aneurysms: a subgroup analysis of the HELPS trial.

Brinjikji W, White PM, Nahser H, Wardlaw J, Sellar R, Cloft HJ, Kallmes DF.

AJNR Am J Neuroradiol. 2015 Jun;36(6):1136-41. doi: 10.3174/ajnr.A4266. Epub 2015 Mar 12.


BRAF(V600E) mutations are found in Richter syndrome and may allow targeted therapy in a subset of patients.

Sellar RS, Fend F, Akarca AU, Agostinelli C, Shende V, Quintanilla-Martínez L, Stein H, Pileri SA, Linch D, Marafioti T.

Br J Haematol. 2015 Jul;170(2):282-5. doi: 10.1111/bjh.13291. Epub 2015 Mar 10. No abstract available.


CMV promotes recipient T-cell immunity following reduced-intensity T-cell-depleted HSCT, significantly modulating chimerism status.

Sellar RS, Vargas FA, Henry JY, Verfuerth S, Charrot S, Beaton B, Chakraverty R, Quezada SA, Mackinnon S, Thomson KJ, Peggs KS.

Blood. 2015 Jan 22;125(4):731-9. doi: 10.1182/blood-2014-07-589150. Epub 2014 Dec 12.


Observer reliability of CT angiography in the assessment of acute ischaemic stroke: data from the Third International Stroke Trial.

Mair G, von Kummer R, Adami A, White PM, Adams ME, Yan B, Demchuk AM, Farrall AJ, Sellar RJ, Ramaswamy R, Mollison D, Boyd EV, Rodrigues MA, Samji K, Baird AJ, Cohen G, Sakka E, Palmer J, Perry D, Lindley R, Sandercock PA, Wardlaw JM; IST-3 Collaborative Group.

Neuroradiology. 2015 Jan;57(1):1-9. doi: 10.1007/s00234-014-1441-0. Epub 2014 Oct 7.


Outcome after surgical or conservative management of cerebral cavernous malformations.

Moultrie F, Horne MA, Josephson CB, Hall JM, Counsell CE, Bhattacharya JJ, Papanastassiou V, Sellar RJ, Warlow CP, Murray GD, Al-Shahi Salman R; Scottish Audit of Intracranial Vascular Malformations (SAIVMs) steering committee and collaborators.

Neurology. 2014 Aug 12;83(7):582-9. doi: 10.1212/WNL.0000000000000684. Epub 2014 Jul 3.


PIM and AKT kinase inhibitors show synergistic cytotoxicity in acute myeloid leukaemia that is associated with convergence on mTOR and MCL1 pathways.

Meja K, Stengel C, Sellar R, Huszar D, Davies BR, Gale RE, Linch DC, Khwaja A.

Br J Haematol. 2014 Oct;167(1):69-79. doi: 10.1111/bjh.13013. Epub 2014 Jun 30.


Therapeutic strategies for cytomegalovirus infection in haematopoietic transplant recipients: a focused update.

Sellar RS, Peggs KS.

Expert Opin Biol Ther. 2014 Aug;14(8):1121-6. doi: 10.1517/14712598.2014.908847. Epub 2014 Apr 25. Review.


Outcome after conservative management or intervention for unruptured brain arteriovenous malformations.

Al-Shahi Salman R, White PM, Counsell CE, du Plessis J, van Beijnum J, Josephson CB, Wilkinson T, Wedderburn CJ, Chandy Z, St George EJ, Sellar RJ, Warlow CP; Scottish Audit of Intracranial Vascular Malformations Collaborators.

JAMA. 2014 Apr 23-30;311(16):1661-9. doi: 10.1001/jama.2014.3200.


Science applications of a multispectral microscopic imager for the astrobiological exploration of Mars.

Núñez JI, Farmer JD, Sellar RG, Swayze GA, Blaney DL.

Astrobiology. 2014 Feb;14(2):132-69. doi: 10.1089/ast.2013.1079.


The importance of relative mutant level for evaluating impact on outcome of KIT, FLT3 and CBL mutations in core-binding factor acute myeloid leukemia.

Allen C, Hills RK, Lamb K, Evans C, Tinsley S, Sellar R, O'Brien M, Yin JL, Burnett AK, Linch DC, Gale RE.

Leukemia. 2013 Sep;27(9):1891-901. doi: 10.1038/leu.2013.186. Epub 2013 Jun 20.


Best evidence: comments on meta-analysis of coiling versus clipping.

Sellar RJ, White P.

AJNR Am J Neuroradiol. 2013 Jul;34(7):1385-6. doi: 10.3174/ajnr.A3404. Epub 2013 Apr 4. No abstract available.


Recent progress in managing graft-versus-host disease and viral infections following allogeneic stem cell transplantation.

Sellar RS, Peggs KS.

Future Oncol. 2012 Dec;8(12):1549-65. doi: 10.2217/fon.12.153. Review.


Seizure risk with AVM treatment or conservative management: prospective, population-based study.

Josephson CB, Bhattacharya JJ, Counsell CE, Papanastassiou V, Ritchie V, Roberts R, Sellar R, Warlow CP, Al-Shahi Salman R; Scottish Audit of Intracranial Vascular Malformations (SAIVMs) steering committee and collaborators.

Neurology. 2012 Aug 7;79(6):500-7. Epub 2012 Jul 3.


Therapeutic strategies for the prevention and treatment of cytomegalovirus infection.

Sellar RS, Peggs KS.

Expert Opin Biol Ther. 2012 Sep;12(9):1161-72. doi: 10.1517/14712598.2012.693471. Epub 2012 Jun 1. Review.


Evidence for clinical activity of artesunate in multidrug-resistant herpes simplex infection following HSCT.

Sellar RS, Ward KN, Thomson KJ, Peggs KS.

Bone Marrow Transplant. 2012 Nov;47(11):1482-3. doi: 10.1038/bmt.2012.46. Epub 2012 Mar 19. No abstract available.


The role of virus-specific adoptive T-cell therapy in hematopoietic transplantation.

Sellar RS, Peggs KS.

Cytotherapy. 2012 Apr;14(4):391-400. doi: 10.3109/14653249.2012.662769. Review.


Untreated clinical course of cerebral cavernous malformations: a prospective, population-based cohort study.

Al-Shahi Salman R, Hall JM, Horne MA, Moultrie F, Josephson CB, Bhattacharya JJ, Counsell CE, Murray GD, Papanastassiou V, Ritchie V, Roberts RC, Sellar RJ, Warlow CP; Scottish Audit of Intracranial Vascular Malformations (SAIVMs) collaborators.

Lancet Neurol. 2012 Mar;11(3):217-24. doi: 10.1016/S1474-4422(12)70004-2. Epub 2012 Jan 31.


Management of multidrug-resistant viruses in the immunocompromised host.

Sellar RS, Peggs KS.

Br J Haematol. 2012 Mar;156(5):559-72. doi: 10.1111/j.1365-2141.2011.08988.x. Epub 2011 Dec 22. Review.


Redefining transplant in acute leukemia.

Sellar R, Goldstone AH, Lazarus HM.

Curr Treat Options Oncol. 2011 Dec;12(4):312-28. doi: 10.1007/s11864-011-0166-0.


Hydrogel-coated coils versus bare platinum coils for the endovascular treatment of intracranial aneurysms (HELPS): a randomised controlled trial.

White PM, Lewis SC, Gholkar A, Sellar RJ, Nahser H, Cognard C, Forrester L, Wardlaw JM; HELPS trial collaborators.

Lancet. 2011 May 14;377(9778):1655-62. doi: 10.1016/S0140-6736(11)60408-X.


Elevated GnRH receptor expression plus GnRH agonist treatment inhibits the growth of a subset of papillomavirus 18-immortalized human prostate cells.

Morgan K, Stavrou E, Leighton SP, Miller N, Sellar R, Millar RP.

Prostate. 2011 Jun 15;71(9):915-28. doi: 10.1002/pros.21308. Epub 2010 Dec 6.


Unlocking the 'locked-in syndrome'.

Shanmuganathan M, Warlow CP, Al-Shahi Salman R, Keston P, Sellar RJ, Fouyas IP.

Br J Neurosurg. 2011 Feb;25(1):109-10. doi: 10.3109/02688697.2010.542838.


Transplants for the old but not for the young?--The enigma of adult ALL.

Sellar RS, Goldstone AH.

Biol Blood Marrow Transplant. 2011 Jan;17(1 Suppl):S71-5. doi: 10.1016/j.bbmt.2010.11.015. Review. No abstract available.


[Therapy of lymph node tuberculosis].

Sellar RS, Corbett EL, D'Sa S, Linch DC, Ardeshna KM.

Praxis (Bern 1994). 2010 Aug 25;99(17):1043-6. doi: 10.1024/1661-8157/a000242. German. No abstract available.


Significant aortic coarctation presenting as subarachnoid hemorrhage in the adult.

Martin R, Sellar R, Dawson D.

J Am Coll Cardiol. 2010 Apr 6;55(14):e25. doi: 10.1016/j.jacc.2009.10.067. No abstract available.


Treatment for lymph node tuberculosis.

Sellar RS, Corbett EL, D'Sa S, Linch DC, Ardeshna KM.

BMJ. 2010 Mar 10;340:c63. doi: 10.1136/bmj.c63. No abstract available.


Subarachnoid haemorrhage in undiagnosed secondary hypertension: back to basics.

Saleem MA, Leach OA, Miller TD, Sellar RJ.

BMJ Case Rep. 2010 Dec 29;2010. pii: bcr0920103336. doi: 10.1136/bcr.09.2010.3336.


The use of CT angiography in acute subarachnoid haemorrhage in Eastern Scotland.

White P, Macpherson R, Sellar R.

Scott Med J. 2009 Nov;54(4):20-3.


The presentation and clinical course of intracranial developmental venous anomalies in adults: a systematic review and prospective, population-based study.

Hon JM, Bhattacharya JJ, Counsell CE, Papanastassiou V, Ritchie V, Roberts RC, Sellar RJ, Warlow CP, Al-Shahi Salman R; SIVMS Collaborators.

Stroke. 2009 Jun;40(6):1980-5. doi: 10.1161/STROKEAHA.108.533034. Epub 2009 Apr 23.


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