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Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.

Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ.

Neuron. 2018 Oct 10;100(1):75-90.e5. doi: 10.1016/j.neuron.2018.09.014.


Light at the End of the Amyloid TunnelPublished as part of the Biochemistry series "Biochemistry to Bedside".

Selkoe DJ.

Biochemistry. 2018 Oct 1. doi: 10.1021/acs.biochem.8b00985. [Epub ahead of print] No abstract available.


Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.

Zhao J, Li A, Rajsombath M, Dang Y, Selkoe DJ, Li S.

iScience. 2018 Aug 31;6:138-150. doi: 10.1016/j.isci.2018.07.018. Epub 2018 Jul 24.


Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.

Xu H, Rajsombath MM, Weikop P, Selkoe DJ.

EMBO Mol Med. 2018 Sep;10(9). pii: e8931. doi: 10.15252/emmm.201808931.


An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM.

Nat Commun. 2018 Jul 11;9(1):2676. doi: 10.1038/s41467-018-05068-w.


MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.

El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM.

Acta Neuropathol. 2018 Oct;136(4):537-555. doi: 10.1007/s00401-018-1880-5. Epub 2018 Jul 7.


Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM.

Int J Mol Sci. 2018 Feb 27;19(3). pii: E663. doi: 10.3390/ijms19030663.


Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL.

Stem Cell Reports. 2017 Dec 12;9(6):1868-1884. doi: 10.1016/j.stemcr.2017.10.015. Epub 2017 Nov 16.


β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR.

Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934.


Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory.

Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY.

Cell Rep. 2017 Aug 8;20(6):1335-1347. doi: 10.1016/j.celrep.2017.07.030.


A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.

Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, Frasier M, Taylor P; Investigating Synuclein Consortium of the Michael J. Fox Foundation for Parkinson's Research.

Mov Disord. 2017 Aug;32(8):1117-1130. doi: 10.1002/mds.27090. Epub 2017 Jul 22. Review.


Showing transmitters the door: synucleins accelerate vesicle release.

Selkoe DJ.

Nat Neurosci. 2017 Apr 25;20(5):629-631. doi: 10.1038/nn.4551. No abstract available.


Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex.

Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL.

Dev Biol. 2017 Apr 15;424(2):138-146. doi: 10.1016/j.ydbio.2017.03.007. Epub 2017 Mar 8.


Enzymatic Assays for Studying Intramembrane Proteolysis.

Bolduc DM, Selkoe DJ, Wolfe MS.

Methods Enzymol. 2017;584:295-308. doi: 10.1016/bs.mie.2016.10.026. Epub 2016 Dec 24.


Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.

Yang T, Li S, Xu H, Walsh DM, Selkoe DJ.

J Neurosci. 2017 Jan 4;37(1):152-163. doi: 10.1523/JNEUROSCI.1698-16.2016.


The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.

Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ.

Elife. 2016 Aug 31;5. pii: e17578. doi: 10.7554/eLife.17578.


Caspase-1 clipping causes complications for α-synuclein.

Nuber S, Selkoe DJ.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9958-60. doi: 10.1073/pnas.1610993113. Epub 2016 Aug 22. No abstract available.


Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones.

Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2138-41. doi: 10.1016/j.bmcl.2016.03.077. Epub 2016 Mar 23.


Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B.

Science. 2016 May 6;352(6286):712-716. doi: 10.1126/science.aad8373. Epub 2016 Mar 31.


The amyloid hypothesis of Alzheimer's disease at 25 years.

Selkoe DJ, Hardy J.

EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252/emmm.201606210. Print 2016 Jun. Review.


Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols.

Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2133-7. doi: 10.1016/j.bmcl.2016.03.042. Epub 2016 Mar 15.


Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.

Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2129-32. doi: 10.1016/j.bmcl.2016.03.040. Epub 2016 Mar 12.


A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

Walsh DM, Selkoe DJ.

Nat Rev Neurosci. 2016 Apr;17(4):251-60. doi: 10.1038/nrn.2016.13. Review.


Editorial overview: Neurobiology of disease.

Selkoe DJ, Weinberger DR.

Curr Opin Neurobiol. 2016 Feb;36:v-vii. doi: 10.1016/j.conb.2016.01.001. Epub 2016 Jan 18. No abstract available.


Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E509-18. doi: 10.1073/pnas.1512952113. Epub 2015 Dec 22.


Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.

Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ.

J Cell Biol. 2015 Dec 21;211(6):1157-76. doi: 10.1083/jcb.201502001.


Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells.

Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J.

ACS Chem Neurosci. 2016 Jan 20;7(1):40-5. doi: 10.1021/acschemneuro.5b00283. Epub 2015 Nov 18.


Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.

Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S.

Neurobiol Dis. 2016 Jan;85:111-121. doi: 10.1016/j.nbd.2015.10.019. Epub 2015 Oct 22.


Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.

Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL.

Cell Rep. 2015 Sep 1;12(9):1414-29. doi: 10.1016/j.celrep.2015.07.061. Epub 2015 Aug 20.


Massachusetts Alzheimer's Disease Research Center: progress and challenges.

Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR Jr, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, Selkoe DJ, Sperling RA, St George-Hyslop P, Tanzi RE, Yap L, Young AB, Phelps CH, McCaffrey PG.

Alzheimers Dement. 2015 Oct;11(10):1241-5. doi: 10.1016/j.jalz.2015.06.1887. Epub 2015 Aug 19. No abstract available.


C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.

Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM.

J Neurosci. 2015 Jul 29;35(30):10851-65. doi: 10.1523/JNEUROSCI.0387-15.2015.


Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, Selkoe DJ, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman BT, Growdon JH, Sudarsky LR, Schlossmacher MG, Ravina B, Scherzer CR.

Brain. 2015 Sep;138(Pt 9):2659-71. doi: 10.1093/brain/awv202. Epub 2015 Jul 28.


Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol.

Jin M, Selkoe DJ.

Neurobiol Dis. 2015 Oct;82:152-163. doi: 10.1016/j.nbd.2015.05.020. Epub 2015 Jun 6.


A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ.

Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y. eCollection 2015.


Purification of α-synuclein from human brain reveals an instability of endogenous multimers as the protein approaches purity.

Luth ES, Bartels T, Dettmer U, Kim NC, Selkoe DJ.

Biochemistry. 2015 Jan 20;54(2):279-92. doi: 10.1021/bi501188a. Epub 2014 Dec 23.


N-alpha-acetylation of α-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation.

Bartels T, Kim NC, Luth ES, Selkoe DJ.

PLoS One. 2014 Jul 30;9(7):e103727. doi: 10.1371/journal.pone.0103727. eCollection 2014.


Genetic deletion of the GATA1-regulated protein α-synuclein reduces oxidative stress and nitric oxide synthase levels in mature erythrocytes.

Renella R, Schlehe JS, Selkoe DJ, Williams DA, LaVoie MJ.

Am J Hematol. 2014 Oct;89(10):974-7. doi: 10.1002/ajh.23796. Epub 2014 Jul 21.


γ-Secretase: a horseshoe structure brings good luck.

Wolfe MS, Selkoe DJ.

Cell. 2014 Jul 17;158(2):247-249. doi: 10.1016/j.cell.2014.06.043.


Soluble, prefibrillar α-synuclein oligomers promote complex I-dependent, Ca2+-induced mitochondrial dysfunction.

Luth ES, Stavrovskaya IG, Bartels T, Kristal BS, Selkoe DJ.

J Biol Chem. 2014 Aug 1;289(31):21490-507. doi: 10.1074/jbc.M113.545749. Epub 2014 Jun 18.


Pen-2 is essential for γ-secretase complex stability and trafficking but partially dispensable for endoproteolysis.

Holmes O, Paturi S, Selkoe DJ, Wolfe MS.

Biochemistry. 2014 Jul 15;53(27):4393-406. doi: 10.1021/bi500489j. Epub 2014 Jun 30.


Functional analysis and purification of a Pen-2 fusion protein for γ-secretase structural studies.

Holmes O, Paturi S, Wolfe MS, Selkoe DJ.

J Neurochem. 2014 Oct;131(1):94-100. doi: 10.1111/jnc.12772. Epub 2014 Jun 18.


Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ.

Biochemistry. 2014 Jun 24;53(24):3908-21.


Soluble Aβ oligomers are rapidly sequestered from brain ISF in vivo and bind GM1 ganglioside on cellular membranes.

Hong S, Ostaszewski BL, Yang T, O'Malley TT, Jin M, Yanagisawa K, Li S, Bartels T, Selkoe DJ.

Neuron. 2014 Apr 16;82(2):308-19. doi: 10.1016/j.neuron.2014.02.027. Epub 2014 Mar 27.


The familial Alzheimer's disease APPV717I mutation alters APP processing and Tau expression in iPSC-derived neurons.

Muratore CR, Rice HC, Srikanth P, Callahan DG, Shin T, Benjamin LN, Walsh DM, Selkoe DJ, Young-Pearse TL.

Hum Mol Genet. 2014 Jul 1;23(13):3523-36. doi: 10.1093/hmg/ddu064. Epub 2014 Feb 12.


Unrecognized vitamin D3 deficiency is common in Parkinson disease: Harvard Biomarker Study.

Ding H, Dhima K, Lockhart KC, Locascio JJ, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Hayes MT, Sohur US, Wills AM, Mollenhauer B, Flaherty AW, Hung AY, Mejia N, Khurana V, Gomperts SN, Selkoe DJ, Schwarzschild MA, Schlossmacher MG, Hyman BT, Sudarsky LR, Growdon JH, Scherzer CR.

Neurology. 2013 Oct 22;81(17):1531-7. doi: 10.1212/WNL.0b013e3182a95818. Epub 2013 Sep 25.


The therapeutics of Alzheimer's disease: where we stand and where we are heading.

Selkoe DJ.

Ann Neurol. 2013 Sep;74(3):328-36. doi: 10.1002/ana.24001. Review.


SnapShot: pathobiology of Alzheimer's disease.

Selkoe DJ.

Cell. 2013 Jul 18;154(2):468-468.e1. doi: 10.1016/j.cell.2013.07.003. No abstract available.


Systematic evaluation of candidate ligands regulating ectodomain shedding of amyloid precursor protein.

Rice HC, Young-Pearse TL, Selkoe DJ.

Biochemistry. 2013 May 14;52(19):3264-77. doi: 10.1021/bi400165f. Epub 2013 May 2.


Impaired glutamate recycling and GluN2B-mediated neuronal calcium overload in mice lacking TGF-β1 in the CNS.

Koeglsperger T, Li S, Brenneis C, Saulnier JL, Mayo L, Carrier Y, Selkoe DJ, Weiner HL.

Glia. 2013 Jun;61(6):985-1002. doi: 10.1002/glia.22490. Epub 2013 Mar 28.


Environmental novelty activates β2-adrenergic signaling to prevent the impairment of hippocampal LTP by Aβ oligomers.

Li S, Jin M, Zhang D, Yang T, Koeglsperger T, Fu H, Selkoe DJ.

Neuron. 2013 Mar 6;77(5):929-41. doi: 10.1016/j.neuron.2012.12.040.

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