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Items: 1 to 50 of 450

1.

Multiple BACE1 inhibitors abnormally increase the BACE1 protein level in neurons by prolonging its half-life.

Liu L, Lauro BM, Ding L, Rovere M, Wolfe MS, Selkoe DJ.

Alzheimers Dement. 2019 Aug 12. pii: S1552-5260(19)34083-X. doi: 10.1016/j.jalz.2019.06.3918. [Epub ahead of print]

PMID:
31416794
2.

Early network dysfunction in Alzheimer's disease.

Selkoe DJ.

Science. 2019 Aug 9;365(6453):540-541. doi: 10.1126/science.aay5188. No abstract available.

PMID:
31395769
3.

Verubecestat for Prodromal Alzheimer's Disease.

Li S, Liu L, Selkoe D.

N Engl J Med. 2019 Jul 25;381(4):388. doi: 10.1056/NEJMc1906679. No abstract available.

PMID:
31340105
4.

β-secretase inhibitors for Alzheimer's disease: heading in the wrong direction?

Selkoe D.

Lancet Neurol. 2019 Jul;18(7):624-626. doi: 10.1016/S1474-4422(19)30202-9. No abstract available.

PMID:
31202466
5.

Target engagement in an alzheimer trial: Crenezumab lowers amyloid β oligomers in cerebrospinal fluid.

Yang T, Dang Y, Ostaszewski B, Mengel D, Steffen V, Rabe C, Bittner T, Walsh DM, Selkoe DJ.

Ann Neurol. 2019 Aug;86(2):215-224. doi: 10.1002/ana.25513. Epub 2019 Jun 22.

PMID:
31168802
6.

Alzheimer disease and aducanumab: adjusting our approach.

Selkoe DJ.

Nat Rev Neurol. 2019 Jul;15(7):365-366. doi: 10.1038/s41582-019-0205-1. No abstract available.

PMID:
31138932
7.

Identification of neurotoxic cross-linked amyloid-β dimers in the Alzheimer's brain.

Brinkmalm G, Hong W, Wang Z, Liu W, O'Malley TT, Sun X, Frosch MP, Selkoe DJ, Portelius E, Zetterberg H, Blennow K, Walsh DM.

Brain. 2019 May 1;142(5):1441-1457. doi: 10.1093/brain/awz066.

PMID:
31032851
8.

A cellular complex of BACE1 and γ-secretase sequentially generates Aβ from its full-length precursor.

Liu L, Ding L, Rovere M, Wolfe MS, Selkoe DJ.

J Cell Biol. 2019 Feb 4;218(2):644-663. doi: 10.1083/jcb.201806205. Epub 2019 Jan 9.

9.

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D.

Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4.

PMID:
30527540
10.

Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease.

Chen Z, Mengel D, Keshavan A, Rissman RA, Billinton A, Perkinton M, Percival-Alwyn J, Schultz A, Properzi M, Johnson K, Selkoe DJ, Sperling RA, Patel P, Zetterberg H, Galasko D, Schott JM, Walsh DM.

Alzheimers Dement. 2019 Mar;15(3):487-496. doi: 10.1016/j.jalz.2018.09.010. Epub 2018 Nov 9.

11.

Decoding the synaptic dysfunction of bioactive human AD brain soluble Aβ to inspire novel therapeutic avenues for Alzheimer's disease.

Li S, Jin M, Liu L, Dang Y, Ostaszewski BL, Selkoe DJ.

Acta Neuropathol Commun. 2018 Nov 8;6(1):121. doi: 10.1186/s40478-018-0626-x.

12.

Abrogating Native α-Synuclein Tetramers in Mice Causes a L-DOPA-Responsive Motor Syndrome Closely Resembling Parkinson's Disease.

Nuber S, Rajsombath M, Minakaki G, Winkler J, Müller CP, Ericsson M, Caldarone B, Dettmer U, Selkoe DJ.

Neuron. 2018 Oct 10;100(1):75-90.e5. doi: 10.1016/j.neuron.2018.09.014.

PMID:
30308173
13.

Light at the End of the Amyloid TunnelPublished as part of the Biochemistry series "Biochemistry to Bedside".

Selkoe DJ.

Biochemistry. 2018 Oct 16;57(41):5921-5922. doi: 10.1021/acs.biochem.8b00985. Epub 2018 Oct 1. No abstract available.

PMID:
30272957
14.

Soluble Aβ Oligomers Impair Dipolar Heterodendritic Plasticity by Activation of mGluR in the Hippocampal CA1 Region.

Zhao J, Li A, Rajsombath M, Dang Y, Selkoe DJ, Li S.

iScience. 2018 Aug 31;6:138-150. doi: 10.1016/j.isci.2018.07.018. Epub 2018 Jul 24.

15.

Enriched environment enhances β-adrenergic signaling to prevent microglia inflammation by amyloid-β.

Xu H, Rajsombath MM, Weikop P, Selkoe DJ.

EMBO Mol Med. 2018 Sep;10(9). pii: e8931. doi: 10.15252/emmm.201808931.

16.

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM.

Nat Commun. 2018 Jul 11;9(1):2676. doi: 10.1038/s41467-018-05068-w.

17.

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.

El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM.

Acta Neuropathol. 2018 Oct;136(4):537-555. doi: 10.1007/s00401-018-1880-5. Epub 2018 Jul 7.

18.

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM.

Int J Mol Sci. 2018 Feb 27;19(3). pii: E663. doi: 10.3390/ijms19030663.

19.

Cell-type Dependent Alzheimer's Disease Phenotypes: Probing the Biology of Selective Neuronal Vulnerability.

Muratore CR, Zhou C, Liao M, Fernandez MA, Taylor WM, Lagomarsino VN, Pearse RV 2nd, Rice HC, Negri JM, He A, Srikanth P, Callahan DG, Shin T, Zhou M, Bennett DA, Noggle S, Love JC, Selkoe DJ, Young-Pearse TL.

Stem Cell Reports. 2017 Dec 12;9(6):1868-1884. doi: 10.1016/j.stemcr.2017.10.015. Epub 2017 Nov 16.

20.

Loss of native α-synuclein multimerization by strategically mutating its amphipathic helix causes abnormal vesicle interactions in neuronal cells.

Dettmer U, Ramalingam N, von Saucken VE, Kim TE, Newman AJ, Terry-Kantor E, Nuber S, Ericsson M, Fanning S, Bartels T, Lindquist S, Levy OA, Selkoe D.

Hum Mol Genet. 2017 Sep 15;26(18):3466-3481. doi: 10.1093/hmg/ddx227.

21.

β2-Adrenoreceptor is a regulator of the α-synuclein gene driving risk of Parkinson's disease.

Mittal S, Bjørnevik K, Im DS, Flierl A, Dong X, Locascio JJ, Abo KM, Long E, Jin M, Xu B, Xiang YK, Rochet JC, Engeland A, Rizzu P, Heutink P, Bartels T, Selkoe DJ, Caldarone BJ, Glicksman MA, Khurana V, Schüle B, Park DS, Riise T, Scherzer CR.

Science. 2017 Sep 1;357(6354):891-898. doi: 10.1126/science.aaf3934.

22.

Crucial Roles for SIRT2 and AMPA Receptor Acetylation in Synaptic Plasticity and Memory.

Wang G, Li S, Gilbert J, Gritton HJ, Wang Z, Li Z, Han X, Selkoe DJ, Man HY.

Cell Rep. 2017 Aug 8;20(6):1335-1347. doi: 10.1016/j.celrep.2017.07.030.

23.

A user's guide for α-synuclein biomarker studies in biological fluids: Perianalytical considerations.

Mollenhauer B, Batrla R, El-Agnaf O, Galasko DR, Lashuel HA, Merchant KM, Shaw LM, Selkoe DJ, Umek R, Vanderstichele H, Zetterberg H, Zhang J, Caspell-Garcia C, Coffey C, Hutten SJ, Frasier M, Taylor P; Investigating Synuclein Consortium of the Michael J. Fox Foundation for Parkinson's Research.

Mov Disord. 2017 Aug;32(8):1117-1130. doi: 10.1002/mds.27090. Epub 2017 Jul 22. Review.

24.

Showing transmitters the door: synucleins accelerate vesicle release.

Selkoe DJ.

Nat Neurosci. 2017 Apr 25;20(5):629-631. doi: 10.1038/nn.4551. No abstract available.

PMID:
28440807
25.

Embryonic mosaic deletion of APP results in displaced Reelin-expressing cells in the cerebral cortex.

Callahan DG, Taylor WM, Tilearcio M, Cavanaugh T, Selkoe DJ, Young-Pearse TL.

Dev Biol. 2017 Apr 15;424(2):138-146. doi: 10.1016/j.ydbio.2017.03.007. Epub 2017 Mar 8.

26.

Enzymatic Assays for Studying Intramembrane Proteolysis.

Bolduc DM, Selkoe DJ, Wolfe MS.

Methods Enzymol. 2017;584:295-308. doi: 10.1016/bs.mie.2016.10.026. Epub 2016 Dec 24.

27.

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.

Yang T, Li S, Xu H, Walsh DM, Selkoe DJ.

J Neurosci. 2017 Jan 4;37(1):152-163. doi: 10.1523/JNEUROSCI.1698-16.2016.

28.

Environmental Enrichment Potently Prevents Microglia-Mediated Neuroinflammation by Human Amyloid β-Protein Oligomers.

Xu H, Gelyana E, Rajsombath M, Yang T, Li S, Selkoe D.

J Neurosci. 2016 Aug 31;36(35):9041-56. doi: 10.1523/JNEUROSCI.1023-16.2016.

29.

The amyloid-beta forming tripeptide cleavage mechanism of γ-secretase.

Bolduc DM, Montagna DR, Seghers MC, Wolfe MS, Selkoe DJ.

Elife. 2016 Aug 31;5. pii: e17578. doi: 10.7554/eLife.17578.

30.

Caspase-1 clipping causes complications for α-synuclein.

Nuber S, Selkoe DJ.

Proc Natl Acad Sci U S A. 2016 Sep 6;113(36):9958-60. doi: 10.1073/pnas.1610993113. Epub 2016 Aug 22. No abstract available.

31.

Part 3: Notch-sparing γ-secretase inhibitors: SAR studies of 2-substituted aminopyridopyrimidinones.

Zhang J, Lu D, Wei HX, Gu Y, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2138-41. doi: 10.1016/j.bmcl.2016.03.077. Epub 2016 Mar 23.

PMID:
27038496
32.

Complement and microglia mediate early synapse loss in Alzheimer mouse models.

Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B.

Science. 2016 May 6;352(6286):712-716. doi: 10.1126/science.aad8373. Epub 2016 Mar 31.

33.

The amyloid hypothesis of Alzheimer's disease at 25 years.

Selkoe DJ, Hardy J.

EMBO Mol Med. 2016 Jun 1;8(6):595-608. doi: 10.15252/emmm.201606210. Print 2016 Jun. Review.

34.

Part 2. Notch-sparing γ-secretase inhibitors: The study of novel γ-amino naphthyl alcohols.

Wei HX, Lu D, Sun V, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2133-7. doi: 10.1016/j.bmcl.2016.03.042. Epub 2016 Mar 15.

PMID:
27020305
35.

Part 1: Notch-sparing γ-secretase inhibitors: The identification of novel naphthyl and benzofuranyl amide analogs.

Lu D, Wei HX, Zhang J, Gu Y, Osenkowski P, Ye W, Selkoe DJ, Wolfe MS, Augelli-Szafran CE.

Bioorg Med Chem Lett. 2016 May 1;26(9):2129-32. doi: 10.1016/j.bmcl.2016.03.040. Epub 2016 Mar 12.

PMID:
27013392
36.

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

Walsh DM, Selkoe DJ.

Nat Rev Neurosci. 2016 Apr;17(4):251-60. doi: 10.1038/nrn.2016.13. Review.

PMID:
26988744
37.

Editorial overview: Neurobiology of disease.

Selkoe DJ, Weinberger DR.

Curr Opin Neurobiol. 2016 Feb;36:v-vii. doi: 10.1016/j.conb.2016.01.001. Epub 2016 Jan 18. No abstract available.

PMID:
26797413
38.

Nicastrin functions to sterically hinder γ-secretase-substrate interactions driven by substrate transmembrane domain.

Bolduc DM, Montagna DR, Gu Y, Selkoe DJ, Wolfe MS.

Proc Natl Acad Sci U S A. 2016 Feb 2;113(5):E509-18. doi: 10.1073/pnas.1512952113. Epub 2015 Dec 22.

39.

Physical and functional interaction between the α- and γ-secretases: A new model of regulated intramembrane proteolysis.

Chen AC, Kim S, Shepardson N, Patel S, Hong S, Selkoe DJ.

J Cell Biol. 2015 Dec 21;211(6):1157-76. doi: 10.1083/jcb.201502001.

40.

Fluorescent Analogue of Batimastat Enables Imaging of α-Secretase in Living Cells.

Leriche G, Chen AC, Kim S, Selkoe DJ, Yang J.

ACS Chem Neurosci. 2016 Jan 20;7(1):40-5. doi: 10.1021/acschemneuro.5b00283. Epub 2015 Nov 18.

41.

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.

Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S.

Neurobiol Dis. 2016 Jan;85:111-121. doi: 10.1016/j.nbd.2015.10.019. Epub 2015 Oct 22.

42.

Genomic DISC1 Disruption in hiPSCs Alters Wnt Signaling and Neural Cell Fate.

Srikanth P, Han K, Callahan DG, Makovkina E, Muratore CR, Lalli MA, Zhou H, Boyd JD, Kosik KS, Selkoe DJ, Young-Pearse TL.

Cell Rep. 2015 Sep 1;12(9):1414-29. doi: 10.1016/j.celrep.2015.07.061. Epub 2015 Aug 20.

43.

Massachusetts Alzheimer's Disease Research Center: progress and challenges.

Hyman BT, Growdon JH, Albers MW, Buckner RL, Chhatwal J, Gomez-Isla MT, Haass C, Hudry E, Jack CR Jr, Johnson KA, Khachaturian ZS, Kim DY, Martin JB, Nitsch RM, Rosen BR, Selkoe DJ, Sperling RA, St George-Hyslop P, Tanzi RE, Yap L, Young AB, Phelps CH, McCaffrey PG.

Alzheimers Dement. 2015 Oct;11(10):1241-5. doi: 10.1016/j.jalz.2015.06.1887. Epub 2015 Aug 19. No abstract available.

44.

New insights into cellular α-synuclein homeostasis in health and disease.

Dettmer U, Selkoe D, Bartels T.

Curr Opin Neurobiol. 2016 Feb;36:15-22. doi: 10.1016/j.conb.2015.07.007. Epub 2015 Aug 15. Review.

PMID:
26282834
45.

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.

Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM.

J Neurosci. 2015 Jul 29;35(30):10851-65. doi: 10.1523/JNEUROSCI.0387-15.2015.

46.

Corrigendum: Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D.

Nat Commun. 2015 Jul 30;6:8008. doi: 10.1038/ncomms9008. No abstract available.

47.

Association between α-synuclein blood transcripts and early, neuroimaging-supported Parkinson's disease.

Locascio JJ, Eberly S, Liao Z, Liu G, Hoesing AN, Duong K, Trisini-Lipsanopoulos A, Dhima K, Hung AY, Flaherty AW, Schwarzschild MA, Hayes MT, Wills AM, Shivraj Sohur U, Mejia NI, Selkoe DJ, Oakes D, Shoulson I, Dong X, Marek K, Zheng B, Ivinson A, Hyman BT, Growdon JH, Sudarsky LR, Schlossmacher MG, Ravina B, Scherzer CR.

Brain. 2015 Sep;138(Pt 9):2659-71. doi: 10.1093/brain/awv202. Epub 2015 Jul 28.

48.

KTKEGV repeat motifs are key mediators of normal α-synuclein tetramerization: Their mutation causes excess monomers and neurotoxicity.

Dettmer U, Newman AJ, von Saucken VE, Bartels T, Selkoe D.

Proc Natl Acad Sci U S A. 2015 Aug 4;112(31):9596-601. doi: 10.1073/pnas.1505953112. Epub 2015 Jul 7.

49.

Parkinson-causing α-synuclein missense mutations shift native tetramers to monomers as a mechanism for disease initiation.

Dettmer U, Newman AJ, Soldner F, Luth ES, Kim NC, von Saucken VE, Sanderson JB, Jaenisch R, Bartels T, Selkoe D.

Nat Commun. 2015 Jun 16;6:7314. doi: 10.1038/ncomms8314. Erratum in: Nat Commun. 2015;6:8008.

50.

Systematic analysis of time-dependent neural effects of soluble amyloid β oligomers in culture and in vivo: Prevention by scyllo-inositol.

Jin M, Selkoe DJ.

Neurobiol Dis. 2015 Oct;82:152-163. doi: 10.1016/j.nbd.2015.05.020. Epub 2015 Jun 6.

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