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Items: 1 to 50 of 239

1.

The reduced form of coagulation factor XI is associated with illness severity and coagulopathy in critically-ill septic patients.

Mor-Cohen R, Zucker M, Grissom C, Brown SM, Seligsohn U, Campbell RA, Blair AM, Rondina MT.

J Thromb Thrombolysis. 2019 Feb;47(2):186-191. doi: 10.1007/s11239-018-1797-9.

PMID:
30600428
2.

Low Concentrations of Recombinant Factor VIIa May Improve the Impaired Thrombin Generation of Glanzmann Thrombasthenia Patients.

Levy-Mendelovich S, Levy T, Budnik I, Barg AA, Rosenberg N, Seligsohn U, Kenet G, Livnat T.

Thromb Haemost. 2019 Jan;119(1):117-127. doi: 10.1055/s-0038-1676348. Epub 2018 Dec 31.

PMID:
30597506
3.

Platelet factor XI: intracellular localization and mRNA splicing following platelet activation.

Zucker M, Hauschner H, Seligsohn U, Rosenberg N.

Blood Cells Mol Dis. 2018 Mar;69:30-37. doi: 10.1016/j.bcmd.2017.04.006. Epub 2017 Apr 21.

PMID:
28760385
4.

An allosteric disulfide bond is involved in enhanced activation of factor XI by protein disulfide isomerase.

Zucker M, Seligsohn U, Yeheskel A, Mor-Cohen R.

J Thromb Haemost. 2016 Nov;14(11):2202-2211. doi: 10.1111/jth.13488. Epub 2016 Oct 20.

5.

Thromboembolic events in patients with severe inherited fibrinogen deficiency.

Rottenstreich A, Lask A, Schliamser L, Zivelin A, Seligsohn U, Kalish Y.

J Thromb Thrombolysis. 2016 Aug;42(2):261-6. doi: 10.1007/s11239-015-1325-0.

PMID:
26712130
6.

The role of protein disulfide isomerase in the post-ligation phase of β3 integrin-dependent cell adhesion.

Leader A, Mor-Cohen R, Ram R, Sheptovitsky V, Seligsohn U, Rosenberg N, Lahav J.

Thromb Res. 2015 Dec;136(6):1259-65. doi: 10.1016/j.thromres.2015.10.030. Epub 2015 Oct 17.

PMID:
26514956
7.

Persistent neonatal thrombocytopenia can be caused by IgA antiplatelet antibodies in breast milk of immune thrombocytopenic mothers.

Hauschner H, Rosenberg N, Seligsohn U, Mendelsohn R, Simmonds A, Shiff Y, Schachter Y, Aviner S, Sharon N.

Blood. 2015 Jul 30;126(5):661-4. doi: 10.1182/blood-2014-12-614446. Epub 2015 Jun 15.

PMID:
26077397
8.

Abnormal cytoplasmic extensions associated with active αIIbβ3 are probably the cause for macrothrombocytopenia in Glanzmann thrombasthenia-like syndrome.

Hauschner H, Mor-Cohen R, Messineo S, Mansour W, Seligsohn U, Savoia A, Rosenberg N.

Blood Coagul Fibrinolysis. 2015 Apr;26(3):302-8. doi: 10.1097/MBC.0000000000000241.

PMID:
25806962
9.

Natural and artificial mutations in αIIb integrin lead to a structural deformation of a calcium-binding site.

Mansour W, Hauschner H, Seligsohn U, Rosenberg N, Einav Y.

Protein J. 2014 Oct;33(5):474-83. doi: 10.1007/s10930-014-9579-5.

PMID:
25216802
10.

Abnormal plasma clot structure and stability distinguish bleeding risk in patients with severe factor XI deficiency.

Zucker M, Seligsohn U, Salomon O, Wolberg AS.

J Thromb Haemost. 2014 Jul;12(7):1121-30. doi: 10.1111/jth.12600. Epub 2014 Jun 19.

11.

Disulfide bond exchanges in integrins αIIbβ3 and αvβ3 are required for activation and post-ligation signaling during clot retraction.

Mor-Cohen R, Rosenberg N, Averbukh Y, Seligsohn U, Lahav J.

Thromb Res. 2014 May;133(5):826-36. doi: 10.1016/j.thromres.2014.02.001. Epub 2014 Feb 7.

PMID:
24560420
12.

Type I mutation in the F11 gene is a third ancestral mutation which causes factor XI deficiency in Ashkenazi Jews.

Peretz H, Salomon O, Mor-Cohen R, Usher S, Zucker M, Zivelin A, Seligsohn U.

J Thromb Haemost. 2013 Apr;11(4):724-30. doi: 10.1111/jth.12137.

13.

Clinical utility gene card for: Glanzmann thrombasthenia.

Fiore M, Nurden AT, Nurden P, Seligsohn U.

Eur J Hum Genet. 2012 Oct;20(10). doi: 10.1038/ejhg.2012.151. Epub 2012 Jul 11. No abstract available. Erratum in: Eur J Hum Genet. 2012 Oct;20(10):1102.

14.

Treatment of inherited platelet disorders.

Seligsohn U.

Haemophilia. 2012 Jul;18 Suppl 4:161-5. doi: 10.1111/j.1365-2516.2012.02842.x. Review.

PMID:
22726101
15.

Inherited platelet disorders.

Nurden AT, Freson K, Seligsohn U.

Haemophilia. 2012 Jul;18 Suppl 4:154-60. doi: 10.1111/j.1365-2516.2012.02856.x. Review.

PMID:
22726100
16.

Unique disulfide bonds in epidermal growth factor (EGF) domains of β3 affect structure and function of αIIbβ3 and αvβ3 integrins in different manner.

Mor-Cohen R, Rosenberg N, Einav Y, Zelzion E, Landau M, Mansour W, Averbukh Y, Seligsohn U.

J Biol Chem. 2012 Mar 16;287(12):8879-91. doi: 10.1074/jbc.M111.311043. Epub 2012 Feb 3.

17.

A mutation in the β3 cytoplasmic tail causes variant Glanzmann thrombasthenia by abrogating transition of αIIb β3 to an active state.

Hauschner H, Mor-Cohen R, Seligsohn U, Rosenberg N.

J Thromb Haemost. 2012 Feb;10(2):289-97. doi: 10.1111/j.1538-7836.2011.04577.x.

18.

Point mutations regarded as missense mutations cause splicing defects in the factor XI gene.

Zucker M, Rosenberg N, Peretz H, Green D, Bauduer F, Zivelin A, Seligsohn U.

J Thromb Haemost. 2011 Oct;9(10):1977-84. doi: 10.1111/j.1538-7836.2011.04426.x.

19.

Patients with severe factor XI deficiency have a reduced incidence of deep-vein thrombosis.

Salomon O, Steinberg DM, Zucker M, Varon D, Zivelin A, Seligsohn U.

Thromb Haemost. 2011 Feb;105(2):269-73. doi: 10.1160/TH10-05-0307. Epub 2010 Nov 5.

PMID:
21057700
20.

An αIIb mutation in patients with Glanzmann thrombasthenia located in the N-terminus of blade 1 of the β-propeller (Asn2Asp) disrupts a calcium binding site in blade 6.

Mansour W, Einav Y, Hauschner H, Koren A, Seligsohn U, Rosenberg N.

J Thromb Haemost. 2011 Jan;9(1):192-200. doi: 10.1111/j.1538-7836.2010.04087.x.

21.

[Inherited bleeding disorders common in Jews].

Seligsohn U.

Harefuah. 2010 May;149(5):298-303, 335. Review. Hebrew.

PMID:
20929069
22.

The association of factor V leiden and prothrombin gene mutation and placenta-mediated pregnancy complications: a systematic review and meta-analysis of prospective cohort studies.

Rodger MA, Betancourt MT, Clark P, Lindqvist PG, Dizon-Townson D, Said J, Seligsohn U, Carrier M, Salomon O, Greer IA.

PLoS Med. 2010 Jun 15;7(6):e1000292. doi: 10.1371/journal.pmed.1000292. Review.

23.

A unique interaction between alphaIIb and beta3 in the head region is essential for outside-in signaling-related functions of alphaIIbbeta3 integrin.

Hauschner H, Landau M, Seligsohn U, Rosenberg N.

Blood. 2010 Jun 3;115(22):4542-50. doi: 10.1182/blood-2009-10-251066. Epub 2010 Mar 22.

PMID:
20308600
24.

Variable effects of alpha v suppression on VEGFR-2 expression in endothelial cells of different vascular beds.

Dardik R, Livnat T, Seligsohn U.

Thromb Haemost. 2009 Nov;102(5):975-82. doi: 10.1160/TH08-10-0687.

PMID:
19888537
25.

Risk factors for failure of heparin thromboprophylaxis in patients with acute traumatic spinal cord injury.

Rubin-Asher D, Zeilig G, Ratner A, Asher I, Zivelin A, Seligsohn U, Lubetsky A.

Thromb Res. 2010 Jun;125(6):501-4. doi: 10.1016/j.thromres.2009.09.012. Epub 2009 Oct 23.

PMID:
19853891
26.

Cataract extraction without prophylactic treatment in patients with severe factor XI deficiency.

Fabian ID, Sachs D, Moisseiev J, Alhalel A, Grinbaum A, Seligsohn U, Salomon O.

Am J Ophthalmol. 2009 Dec;148(6):920-4.e1. doi: 10.1016/j.ajo.2009.07.013. Epub 2009 Sep 5.

PMID:
19733832
27.

Recombinant activated factor VII and tranexamic acid are haemostatically effective during major surgery in factor XI-deficient patients with inhibitor antibodies.

Livnat T, Tamarin I, Mor Y, Winckler H, Horowitz Z, Korianski Y, Bar-Zakay B, Seligsohn U, Salomon O.

Thromb Haemost. 2009 Sep;102(3):487-92. doi: 10.1160/TH09-03-0172.

PMID:
19718468
28.

Factor XI deficiency in humans.

Seligsohn U.

J Thromb Haemost. 2009 Jul;7 Suppl 1:84-7. doi: 10.1111/j.1538-7836.2009.03395.x. Review.

29.

Three residues at the interface of factor XI (FXI) monomers augment covalent dimerization of FXI.

Zucker M, Zivelin A, Landau M, Rosenberg N, Seligsohn U.

J Thromb Haemost. 2009 Jun;7(6):970-5. doi: 10.1111/j.1538-7836.2009.03353.x.

30.

False-positive tests for heparin-induced thrombocytopenia in patients with antiphospholipid syndrome and systemic lupus erythematosus.

Pauzner R, Greinacher A, Selleng K, Althaus K, Shenkman B, Seligsohn U.

J Thromb Haemost. 2009 Jul;7(7):1070-4. doi: 10.1111/j.1538-7836.2009.03335.x. Epub 2009 Mar 5.

31.

Plasma levels of microparticles at 24 weeks of gestation do not predict subsequent pregnancy complications.

Salomon O, Katz BZ, Dardik R, Livnat T, Steinberg DM, Achiron R, Seligsohn U.

Fertil Steril. 2009 Aug;92(2):682-7. doi: 10.1016/j.fertnstert.2008.06.015. Epub 2008 Aug 9.

PMID:
18692836
32.

Specific cysteines in beta3 are involved in disulfide bond exchange-dependent and -independent activation of alphaIIbbeta3.

Mor-Cohen R, Rosenberg N, Landau M, Lahav J, Seligsohn U.

J Biol Chem. 2008 Jul 11;283(28):19235-44. doi: 10.1074/jbc.M802399200. Epub 2008 May 5.

33.

Genotype-phenotype correlation in combined deficiency of factor V and factor VIII.

Zhang B, Spreafico M, Zheng C, Yang A, Platzer P, Callaghan MU, Avci Z, Ozbek N, Mahlangu J, Haw T, Kaufman RJ, Marchant K, Tuddenham EG, Seligsohn U, Peyvandi F, Ginsburg D.

Blood. 2008 Jun 15;111(12):5592-600. doi: 10.1182/blood-2007-10-113951. Epub 2008 Apr 7.

34.

Simultaneous genotyping of coagulation factor XI type II and type III mutations by multiplex real-time polymerase chain reaction to determine their prevalence in healthy and factor XI-deficient Italians.

Zadra G, Asselta R, Tenchini ML, Castaman G, Seligsohn U, Mannucci PM, Duga S.

Haematologica. 2008 May;93(5):715-21. doi: 10.3324/haematol.12180. Epub 2008 Apr 2.

35.

Effects of factor VIII inhibitor bypassing activity (FEIBA), recombinant factor VIIa or both on thrombin generation in normal and haemophilia A plasma.

Livnat T, Martinowitz U, Zivelin A, Seligsohn U.

Haemophilia. 2008 Jul;14(4):782-6. doi: 10.1111/j.1365-2516.2008.01688.x. Epub 2008 Mar 21.

PMID:
18371162
36.

Reduced incidence of ischemic stroke in patients with severe factor XI deficiency.

Salomon O, Steinberg DM, Koren-Morag N, Tanne D, Seligsohn U.

Blood. 2008 Apr 15;111(8):4113-7. doi: 10.1182/blood-2007-10-120139. Epub 2008 Feb 11.

PMID:
18268095
37.

Discerning the ancestry of European Americans in genetic association studies.

Price AL, Butler J, Patterson N, Capelli C, Pascali VL, Scarnicci F, Ruiz-Linares A, Groop L, Saetta AA, Korkolopoulou P, Seligsohn U, Waliszewska A, Schirmer C, Ardlie K, Ramos A, Nemesh J, Arbeitman L, Goldstein DB, Reich D, Hirschhorn JN.

PLoS Genet. 2008 Jan;4(1):e236. doi: 10.1371/journal.pgen.0030236. Epub 2007 Nov 19.

38.
39.

Induction of an inhibitor antibody to factor XI in a patient with severe inherited factor XI deficiency by Rh immune globulin.

Zucker M, Zivelin A, Teitel J, Seligsohn U.

Blood. 2008 Feb 1;111(3):1306-8. Epub 2007 Nov 20.

PMID:
18029554
40.

Characterization of seven novel mutations causing factor XI deficiency.

Zucker M, Zivelin A, Landau M, Salomon O, Kenet G, Bauduer F, Samama M, Conard J, Denninger MH, Hani AS, Berruyer M, Feinstein D, Seligsohn U.

Haematologica. 2007 Oct;92(10):1375-80.

41.

Factor XI in haemostasis and thrombosis: past, present and future.

Seligsohn U.

Thromb Haemost. 2007 Jul;98(1):84-9. Review. No abstract available.

PMID:
17597996
42.

Age estimates of ancestral mutations causing factor VII deficiency and Dubin-Johnson syndrome in Iranian and Moroccan Jews are consistent with ancient Jewish migrations.

Mor-Cohen R, Zivelin A, Fromovich-Amit Y, Kovalski V, Rosenberg N, Seligsohn U.

Blood Coagul Fibrinolysis. 2007 Mar;18(2):139-44.

PMID:
17287630
43.

The interval between prothrombin time tests and the quality of oral anticoagulants treatment in patients with chronic atrial fibrillation.

Shalev V, Rogowski O, Shimron O, Sheinberg B, Shapira I, Seligsohn U, Berliner S, Misgav M.

Thromb Res. 2007;120(2):201-6. Epub 2006 Nov 21.

PMID:
17118431
44.
45.

ADAMTS-13 regulates platelet adhesion under flow. A new method for differentiation between inherited and acquired thrombotic thrombocytopenic purpura.

Shenkman B, Budde U, Angerhaus D, Lubetsky A, Savion N, Seligsohn U, Varon D.

Thromb Haemost. 2006 Aug;96(2):160-6.

PMID:
16894459
46.

Diversity of Glanzmann thrombasthenia in southern India: 10 novel mutations identified among 15 unrelated patients.

Nelson EJ, Nair SC, Peretz H, Coller BS, Seligsohn U, Chandy M, Srivastava A.

J Thromb Haemost. 2006 Aug;4(8):1730-7.

47.

ADP-coupled integrin regulation by the extracellular redox system.

Lahav J, Hess O, Calo D, Kehrel B, Jurk K, Seligsohn U, Mor-Cohen R, Rosenberg N.

Pathophysiol Haemost Thromb. 2006;35(1-2):36. No abstract available.

PMID:
16855344
48.

Deciphering the mystery of combined factor V and factor VIII deficiency.

Seligsohn U, Ginsburg D.

J Thromb Haemost. 2006 May;4(5):927-31. No abstract available.

49.

Rare bleeding disorders.

Peyvandi F, Kaufman RJ, Seligsohn U, Salomon O, Bolton-Maggs PH, Spreafico M, Menegatti M, Palla R, Siboni S, Mannucci PM.

Haemophilia. 2006 Jul;12 Suppl 3:137-42. Review.

50.

Prothrombin 20210G>A is an ancestral prothrombotic mutation that occurred in whites approximately 24,000 years ago.

Zivelin A, Mor-Cohen R, Kovalsky V, Kornbrot N, Conard J, Peyvandi F, Kyrle PA, Bertina R, Peyvandi F, Emmerich J, Seligsohn U.

Blood. 2006 Jun 15;107(12):4666-8. Epub 2006 Feb 21.

PMID:
16493002

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