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Association Between Folate Metabolites and the Development of Food Allergy in Children.

McGowan EC, Hong X, Selhub J, Paul L, Wood RA, Matsui EC, Keet CA, Wang X.

J Allergy Clin Immunol Pract. 2020 Jan;8(1):132-140.e5. doi: 10.1016/j.jaip.2019.06.017. Epub 2019 Jun 25.


Plasma B-vitamins and one-carbon metabolites and the risk of breast cancer in younger women.

Houghton SC, Eliassen AH, Zhang SM, Selhub J, Rosner BA, Willett WC, Hankinson SE.

Breast Cancer Res Treat. 2019 Jul;176(1):191-203. doi: 10.1007/s10549-019-05223-x. Epub 2019 Apr 6.


Presence of circulating folic acid in plasma and its relation with dietary intake, vitamin B complex concentrations and genetic variants.

Steluti J, Reginaldo C, Selhub J, Paul L, Fisberg RM, Marchioni DM.

Eur J Nutr. 2019 Dec;58(8):3069-3077. doi: 10.1007/s00394-018-1852-5. Epub 2018 Nov 2.


Plasma B-vitamin and one-carbon metabolites and risk of breast cancer before and after folic acid fortification in the United States.

Houghton SC, Eliassen AH, Zhang SM, Selhub J, Rosner BA, Willett WC, Hankinson SE.

Int J Cancer. 2019 Apr 15;144(8):1929-1940. doi: 10.1002/ijc.31934. Epub 2019 Jan 3.


Prenatal folic acid use associated with decreased risk of myelomeningocele: A case-control study offers further support for folic acid fortification in Bangladesh.

Kancherla V, Ibne Hasan MOS, Hamid R, Paul L, Selhub J, Oakley G, Quamruzzaman Q, Mazumdar M.

PLoS One. 2017 Nov 30;12(11):e0188726. doi: 10.1371/journal.pone.0188726. eCollection 2017.


B-Vitamin Therapy for Kidney Transplant Recipients Lowers Homocysteine and Improves Selective Cognitive Outcomes in the Randomized FAVORIT Ancillary Cognitive Trial.

Scott TM, Rogers G, Weiner DE, Livingston K, Selhub J, Jacques PF, Rosenberg IH, Troen AM.

J Prev Alzheimers Dis. 2017;4(3):174-182. doi: 10.14283/jpad.2017.15.


Low vitamin B12 increases risk of gastric cancer: A prospective study of one-carbon metabolism nutrients and risk of upper gastrointestinal tract cancer.

Miranti EH, Stolzenberg-Solomon R, Weinstein SJ, Selhub J, Männistö S, Taylor PR, Freedman ND, Albanes D, Abnet CC, Murphy G.

Int J Cancer. 2017 Sep 15;141(6):1120-1129. doi: 10.1002/ijc.30809. Epub 2017 Jun 21.


An overview of folate status in a population-based study from São Paulo, Brazil and the potential impact of 10 years of national folic acid fortification policy.

Steluti J, Selhub J, Paul L, Reginaldo C, Fisberg RM, Marchioni DML.

Eur J Clin Nutr. 2017 Oct;71(10):1173-1178. doi: 10.1038/ejcn.2017.60. Epub 2017 May 10.


Redox homeostasis in stomach medium by foods: The Postprandial Oxidative Stress Index (POSI) for balancing nutrition and human health.

Kanner J, Selhub J, Shpaizer A, Rabkin B, Shacham I, Tirosh O.

Redox Biol. 2017 Aug;12:929-936. doi: 10.1016/j.redox.2017.04.029. Epub 2017 Apr 24.


Associations between post translational histone modifications, myelomeningocele risk, environmental arsenic exposure, and folate deficiency among participants in a case control study in Bangladesh.

Tauheed J, Sanchez-Guerra M, Lee JJ, Paul L, Ibne Hasan MOS, Quamruzzaman Q, Selhub J, Wright RO, Christiani DC, Coull BA, Baccarelli AA, Mazumdar M.

Epigenetics. 2017 Jun 3;12(6):484-491. doi: 10.1080/15592294.2017.1312238. Epub 2017 Apr 7.


Investigating methotrexate toxicity within a randomized double-blinded, placebo-controlled trial: Rationale and design of the Cardiovascular Inflammation Reduction Trial-Adverse Events (CIRT-AE) Study.

Sparks JA, Barbhaiya M, Karlson EW, Ritter SY, Raychaudhuri S, Corrigan CC, Lu F, Selhub J, Chasman DI, Paynter NP, Ridker PM, Solomon DH.

Semin Arthritis Rheum. 2017 Aug;47(1):133-142. doi: 10.1016/j.semarthrit.2017.02.003. Epub 2017 Feb 10.


Interaction between excess folate and low vitamin B12 status.

Paul L, Selhub J.

Mol Aspects Med. 2017 Feb;53:43-47. doi: 10.1016/j.mam.2016.11.004. Epub 2016 Nov 20. Review.


Prospective study of serum B vitamins levels and oesophageal and gastric cancers in China.

Ren J, Murphy G, Fan J, Dawsey SM, Taylor PR, Selhub J, Qiao Y, Abnet CC.

Sci Rep. 2016 Oct 17;6:35281. doi: 10.1038/srep35281.


Transcobalamin 776C→G polymorphism is associated with peripheral neuropathy in elderly individuals with high folate intake.

Sawaengsri H, Bergethon PR, Qiu WQ, Scott TM, Jacques PF, Selhub J, Paul L.

Am J Clin Nutr. 2016 Dec;104(6):1665-1670. Epub 2016 Oct 12.


Prospective study of serum cysteine and cysteinylglycine and cancer of the head and neck, esophagus, and stomach in a cohort of male smokers.

Miranti EH, Freedman ND, Weinstein SJ, Abnet CC, Selhub J, Murphy G, Diaw L, Männistö S, Taylor PR, Albanes D, Stolzenberg-Solomon RZ.

Am J Clin Nutr. 2016 Sep;104(3):686-93. doi: 10.3945/ajcn.115.125799. Epub 2016 Aug 17.


Bacterial Folates Provide an Exogenous Signal for C. elegans Germline Stem Cell Proliferation.

Chaudhari SN, Mukherjee M, Vagasi AS, Bi G, Rahman MM, Nguyen CQ, Paul L, Selhub J, Kipreos ET.

Dev Cell. 2016 Jul 11;38(1):33-46. doi: 10.1016/j.devcel.2016.06.013.


Excessive folic acid intake and relation to adverse health outcome.

Selhub J, Rosenberg IH.

Biochimie. 2016 Jul;126:71-8. doi: 10.1016/j.biochi.2016.04.010. Epub 2016 Apr 27. Review.


High folic acid intake reduces natural killer cell cytotoxicity in aged mice.

Sawaengsri H, Wang J, Reginaldo C, Steluti J, Wu D, Meydani SN, Selhub J, Paul L.

J Nutr Biochem. 2016 Apr;30:102-7. doi: 10.1016/j.jnutbio.2015.12.006. Epub 2016 Jan 6.


Decision on folic acid fortification in Europe must consider both risks and benefits.

Smith AD, Refsum H, Selhub J, Rosenberg IH.

BMJ. 2016 Feb 16;352:i734. doi: 10.1136/bmj.i734. No abstract available.


Evidence from a Randomized Trial That Exposure to Supplemental Folic Acid at Recommended Levels during Pregnancy Does Not Lead to Increased Unmetabolized Folic Acid Concentrations in Maternal or Cord Blood.

Pentieva K, Selhub J, Paul L, Molloy AM, McNulty B, Ward M, Marshall B, Dornan J, Reilly R, Parle-McDermott A, Bradbury I, Ozaki M, Scott JM, McNulty H.

J Nutr. 2016 Mar;146(3):494-500. doi: 10.3945/jn.115.223644. Epub 2016 Jan 27.


Sulfur amino acids and atherosclerosis: a role for excess dietary methionine.

Selhub J, Troen AM.

Ann N Y Acad Sci. 2016 Jan;1363:18-25. doi: 10.1111/nyas.12962. Epub 2015 Dec 8.


Unmetabolized Folic Acid in Prediagnostic Plasma and the Risk of Colorectal Cancer.

Cho E, Zhang X, Townsend MK, Selhub J, Paul L, Rosner B, Fuchs CS, Willett WC, Giovannucci EL.

J Natl Cancer Inst. 2015 Sep 15;107(12):djv260. doi: 10.1093/jnci/djv260. Print 2015 Dec.


Dihydrofolate reductase 19-bp deletion polymorphism modifies the association of folate status with memory in a cross-sectional multi-ethnic study of adults.

Philip D, Buch A, Moorthy D, Scott TM, Parnell LD, Lai CQ, Ordovás JM, Selhub J, Rosenberg IH, Tucker KL, Troen AM.

Am J Clin Nutr. 2015 Nov;102(5):1279-88. doi: 10.3945/ajcn.115.111054. Epub 2015 Sep 9.


Diet- and Genetically-Induced Obesity Differentially Affect the Fecal Microbiome and Metabolome in Apc1638N Mice.

Pfalzer AC, Nesbeth PD, Parnell LD, Iyer LK, Liu Z, Kane AV, Chen CY, Tai AK, Bowman TA, Obin MS, Mason JB, Greenberg AS, Choi SW, Selhub J, Paul L, Crott JW.

PLoS One. 2015 Aug 18;10(8):e0135758. doi: 10.1371/journal.pone.0135758. eCollection 2015.


Polymorphisms in maternal folate pathway genes interact with arsenic in drinking water to influence risk of myelomeningocele.

Mazumdar M, Valeri L, Rodrigues EG, Ibne Hasan MO, Hamid R, Paul L, Selhub J, Silva F, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC.

Birth Defects Res A Clin Mol Teratol. 2015 Sep;103(9):754-62. doi: 10.1002/bdra.23399. Epub 2015 Aug 6.


Arsenic is associated with reduced effect of folic acid in myelomeningocele prevention: a case control study in Bangladesh.

Mazumdar M, Ibne Hasan MO, Hamid R, Valeri L, Paul L, Selhub J, Rodrigues EG, Silva F, Mia S, Mostofa MG, Quamruzzaman Q, Rahman M, Christiani DC.

Environ Health. 2015 Apr 10;14:34. doi: 10.1186/s12940-015-0020-0.


The association between vitamin B12, albuminuria and reduced kidney function: an observational cohort study.

McMahon GM, Hwang SJ, Tanner RM, Jacques PF, Selhub J, Muntner P, Fox CS.

BMC Nephrol. 2015 Feb 2;16:7. doi: 10.1186/1471-2369-16-7.


High plasma folate is negatively associated with leukocyte telomere length in Framingham Offspring cohort.

Paul L, Jacques PF, Aviv A, Vasan RS, D'Agostino RB, Levy D, Selhub J.

Eur J Nutr. 2015 Mar;54(2):235-41. doi: 10.1007/s00394-014-0704-1. Epub 2014 May 3.


Genome-wide meta-analysis of homocysteine and methionine metabolism identifies five one carbon metabolism loci and a novel association of ALDH1L1 with ischemic stroke.

Williams SR, Yang Q, Chen F, Liu X, Keene KL, Jacques P, Chen WM, Weinstein G, Hsu FC, Beiser A, Wang L, Bookman E, Doheny KF, Wolf PA, Zilka M, Selhub J, Nelson S, Gogarten SM, Worrall BB, Seshadri S, Sale MM; Genomics and Randomized Trials Network; Framingham Heart Study.

PLoS Genet. 2014 Mar 20;10(3):e1004214. doi: 10.1371/journal.pgen.1004214. eCollection 2014 Mar.


Dietary vitamin B6 intake modulates colonic inflammation in the IL10-/- model of inflammatory bowel disease.

Selhub J, Byun A, Liu Z, Mason JB, Bronson RT, Crott JW.

J Nutr Biochem. 2013 Dec;24(12):2138-43. doi: 10.1016/j.jnutbio.2013.08.005. Epub 2013 Oct 2.


Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.

van Meurs JB, Pare G, Schwartz SM, Hazra A, Tanaka T, Vermeulen SH, Cotlarciuc I, Yuan X, Mälarstig A, Bandinelli S, Bis JC, Blom H, Brown MJ, Chen C, Chen YD, Clarke RJ, Dehghan A, Erdmann J, Ferrucci L, Hamsten A, Hofman A, Hunter DJ, Goel A, Johnson AD, Kathiresan S, Kampman E, Kiel DP, Kiemeney LA, Chambers JC, Kraft P, Lindemans J, McKnight B, Nelson CP, O'Donnell CJ, Psaty BM, Ridker PM, Rivadeneira F, Rose LM, Seedorf U, Siscovick DS, Schunkert H, Selhub J, Ueland PM, Vollenweider P, Waeber G, Waterworth DM, Watkins H, Witteman JC, den Heijer M, Jacques P, Uitterlinden AG, Kooner JS, Rader DJ, Reilly MP, Mooser V, Chasman DI, Samani NJ, Ahmadi KR.

Am J Clin Nutr. 2013 Sep;98(3):668-76. doi: 10.3945/ajcn.112.044545. Epub 2013 Jul 3.


Pre-diagnostic leukocyte genomic DNA methylation and the risk of colorectal cancer in women.

Nan H, Giovannucci EL, Wu K, Selhub J, Paul L, Rosner B, Fuchs CS, Cho E.

PLoS One. 2013;8(4):e59455. doi: 10.1371/journal.pone.0059455. Epub 2013 Apr 1.


Mechanistic perspective on the relationship between pyridoxal 5'-phosphate and inflammation.

Paul L, Ueland PM, Selhub J.

Nutr Rev. 2013 Apr;71(4):239-44. doi: 10.1111/nure.12014. Epub 2013 Mar 8. Review.


Prediagnostic plasma vitamin B6 (pyridoxal 5'-phosphate) and survival in patients with colorectal cancer.

Je Y, Lee JE, Ma J, Zhang X, Cho E, Rosner B, Selhub J, Fuchs CS, Meyerhardt J, Giovannucci E.

Cancer Causes Control. 2013 Apr;24(4):719-29. doi: 10.1007/s10552-013-0152-x. Epub 2013 Jan 23.


Moderately high intake of folic acid has a negative impact on mouse embryonic development.

Mikael LG, Deng L, Paul L, Selhub J, Rozen R.

Birth Defects Res A Clin Mol Teratol. 2013 Jan;97(1):47-52. doi: 10.1002/bdra.23092. Epub 2012 Nov 2.


Effect of combined folic acid, vitamin B(6), and vitamin B(12) on colorectal adenoma.

Song Y, Manson JE, Lee IM, Cook NR, Paul L, Selhub J, Giovannucci E, Zhang SM.

J Natl Cancer Inst. 2012 Oct 17;104(20):1562-75. doi: 10.1093/jnci/djs370. Epub 2012 Oct 12.


Prevalence of MTHFR C677T and MS A2756G polymorphisms in major depressive disorder, and their impact on response to fluoxetine treatment.

Mischoulon D, Lamon-Fava S, Selhub J, Katz J, Papakostas GI, Iosifescu DV, Yeung AS, Dording CM, Farabaugh AH, Clain AJ, Baer L, Alpert JE, Nierenberg AA, Fava M.

CNS Spectr. 2012 Jun;17(2):76-86. doi: 10.1017/S1092852912000430.


Vitamin B-12 and folate status in relation to decline in scores on the mini-mental state examination in the framingham heart study.

Morris MS, Selhub J, Jacques PF.

J Am Geriatr Soc. 2012 Aug;60(8):1457-64. doi: 10.1111/j.1532-5415.2012.04076.x. Epub 2012 Jul 12.


Methotrexate Increases Skeletal Muscle GLUT4 Expression and Improves Metabolic Control in Experimental Diabetes.

Russo GT, Minutoli L, Bitto A, Altavilla D, Alessi E, Giandalia A, Romeo EL, Stagno MF, Squadrito F, Cucinotta D, Selhub J.

J Nutr Metab. 2012;2012:132056. doi: 10.1155/2012/132056. Epub 2012 Jun 13.


Status of vitamins B-12 and B-6 but not of folate, homocysteine, and the methylenetetrahydrofolate reductase C677T polymorphism are associated with impaired cognition and depression in adults.

Moorthy D, Peter I, Scott TM, Parnell LD, Lai CQ, Crott JW, Ordovás JM, Selhub J, Griffith J, Rosenberg IH, Tucker KL, Troen AM.

J Nutr. 2012 Aug;142(8):1554-60. doi: 10.3945/jn.112.161828. Epub 2012 Jun 27.


Risk of retinoblastoma is associated with a maternal polymorphism in dihydrofolatereductase (DHFR) and prenatal folic acid intake.

Orjuela MA, Cabrera-Muñoz L, Paul L, Ramirez-Ortiz MA, Liu X, Chen J, Mejia-Rodriguez F, Medina-Sanson A, Diaz-Carreño S, Suen IH, Selhub J, Ponce-Castañeda MV.

Cancer. 2012 Dec 1;118(23):5912-9. doi: 10.1002/cncr.27621. Epub 2012 May 30.


Plasma pyridoxal-5-phosphate is inversely associated with systemic markers of inflammation in a population of U.S. adults.

Sakakeeny L, Roubenoff R, Obin M, Fontes JD, Benjamin EJ, Bujanover Y, Jacques PF, Selhub J.

J Nutr. 2012 Jul;142(7):1280-5. doi: 10.3945/jn.111.153056. Epub 2012 May 23.


Multiple biomarkers and risk of clinical and subclinical vascular brain injury: the Framingham Offspring Study.

Pikula A, Beiser AS, DeCarli C, Himali JJ, Debette S, Au R, Selhub J, Toffler GH, Wang TJ, Meigs JB, Kelly-Hayes M, Kase CS, Wolf PA, Vasan RS, Seshadri S.

Circulation. 2012 May 1;125(17):2100-7. doi: 10.1161/CIRCULATIONAHA.110.989145. Epub 2012 Mar 28.


Plasma folate, methylenetetrahydrofolate reductase (MTHFR), and colorectal cancer risk in three large nested case-control studies.

Lee JE, Wei EK, Fuchs CS, Hunter DJ, Lee IM, Selhub J, Stampfer MJ, Willett WC, Ma J, Giovannucci E.

Cancer Causes Control. 2012 Apr;23(4):537-45. doi: 10.1007/s10552-012-9911-3. Epub 2012 Feb 26.


Associations between genes in the one-carbon metabolism pathway and advanced colorectal adenoma risk in individuals with low folate intake.

Han SS, Sue LY, Berndt SI, Selhub J, Burdette LA, Rosenberg PS, Ziegler RG.

Cancer Epidemiol Biomarkers Prev. 2012 Mar;21(3):417-27. doi: 10.1158/1055-9965.EPI-11-0782. Epub 2012 Jan 17.


Cognitive dysfunction and depression in adult kidney transplant recipients: baseline findings from the FAVORIT Ancillary Cognitive Trial (FACT).

Troen AM, Scott TM, D'Anci KE, Moorthy D, Dobson B, Rogers G, Weiner DE, Levey AS, Dallal GE, Jacques PF, Selhub J, Rosenberg IH; FACT Study Investigators.

J Ren Nutr. 2012 Mar;22(2):268-76.e1-3. doi: 10.1053/j.jrn.2011.07.009. Epub 2011 Dec 6.


Folic acid fortification: why not vitamin B12 also?

Selhub J, Paul L.

Biofactors. 2011 Jul-Aug;37(4):269-71. doi: 10.1002/biof.173. Epub 2011 Jun 14. Review.


Biomarkers of vitamin B-12 status in NHANES: a roundtable summary.

Yetley EA, Pfeiffer CM, Phinney KW, Bailey RL, Blackmore S, Bock JL, Brody LC, Carmel R, Curtin LR, Durazo-Arvizu RA, Eckfeldt JH, Green R, Gregory JF 3rd, Hoofnagle AN, Jacobsen DW, Jacques PF, Lacher DA, Molloy AM, Massaro J, Mills JL, Nexo E, Rader JI, Selhub J, Sempos C, Shane B, Stabler S, Stover P, Tamura T, Tedstone A, Thorpe SJ, Coates PM, Johnson CL, Picciano MF.

Am J Clin Nutr. 2011 Jul;94(1):313S-321S. doi: 10.3945/ajcn.111.013243. Epub 2011 May 18. Review.


Biomarkers of folate status in NHANES: a roundtable summary.

Yetley EA, Pfeiffer CM, Phinney KW, Fazili Z, Lacher DA, Bailey RL, Blackmore S, Bock JL, Brody LC, Carmel R, Curtin LR, Durazo-Arvizu RA, Eckfeldt JH, Green R, Gregory JF 3rd, Hoofnagle AN, Jacobsen DW, Jacques PF, Molloy AM, Massaro J, Mills JL, Nexo E, Rader JI, Selhub J, Sempos C, Shane B, Stabler S, Stover P, Tamura T, Tedstone A, Thorpe SJ, Coates PM, Johnson CL, Picciano MF.

Am J Clin Nutr. 2011 Jul;94(1):303S-312S. doi: 10.3945/ajcn.111.013011. Epub 2011 May 18. Review.


Determination of unmetabolized folic acid in human plasma using affinity HPLC.

Kalmbach R, Paul L, Selhub J.

Am J Clin Nutr. 2011 Jul;94(1):343S-347S. doi: 10.3945/ajcn.111.013433. Epub 2011 May 18. Review.

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