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Items: 32

1.

Direct stimulation of NADP+ synthesis through Akt-mediated phosphorylation of NAD kinase.

Hoxhaj G, Ben-Sahra I, Lockwood SE, Timson RC, Byles V, Henning GT, Gao P, Selfors LM, Asara JM, Manning BD.

Science. 2019 Mar 8;363(6431):1088-1092. doi: 10.1126/science.aau3903.

PMID:
30846598
2.

Deubiquitinases Maintain Protein Homeostasis and Survival of Cancer Cells upon Glutathione Depletion.

Harris IS, Endress JE, Coloff JL, Selfors LM, McBrayer SK, Rosenbluth JM, Takahashi N, Dhakal S, Koduri V, Oser MG, Schauer NJ, Doherty LM, Hong AL, Kang YP, Younger ST, Doench JG, Hahn WC, Buhrlage SJ, DeNicola GM, Kaelin WG Jr, Brugge JS.

Cell Metab. 2019 May 7;29(5):1166-1181.e6. doi: 10.1016/j.cmet.2019.01.020. Epub 2019 Feb 21.

PMID:
30799286
3.

Combined MEK and BCL-2/XL Inhibition Is Effective in High-Grade Serous Ovarian Cancer Patient-Derived Xenograft Models and BIM Levels Are Predictive of Responsiveness.

Iavarone C, Zervantonakis IK, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis UA, Hallberg D, Velculescu VE, Leverson JD, Sampath D, Mills GB, Brugge JS.

Mol Cancer Ther. 2019 Mar;18(3):642-655. doi: 10.1158/1535-7163.MCT-18-0413. Epub 2019 Jan 24.

PMID:
30679390
4.

CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.

Walker SJ, Selfors LM, Margolis BL, Brugge JS.

PLoS One. 2018 Nov 15;13(11):e0207470. doi: 10.1371/journal.pone.0207470. eCollection 2018.

5.

Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance.

Takahashi N, Chen HY, Harris IS, Stover DG, Selfors LM, Bronson RT, Deraedt T, Cichowski K, Welm AL, Mori Y, Mills GB, Brugge JS.

Cancer Cell. 2018 Jun 11;33(6):985-1003.e7. doi: 10.1016/j.ccell.2018.05.001. Epub 2018 May 24.

6.

Identification of cancer genes that are independent of dominant proliferation and lineage programs.

Selfors LM, Stover DG, Harris IS, Brugge JS, Coloff JL.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):E11276-E11284. doi: 10.1073/pnas.1714877115. Epub 2017 Dec 11.

7.

Erratum: Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS.

NPJ Breast Cancer. 2017 Sep 22;3:38. doi: 10.1038/s41523-017-0031-9. eCollection 2017.

8.

Systems analysis of apoptotic priming in ovarian cancer identifies vulnerabilities and predictors of drug response.

Zervantonakis IK, Iavarone C, Chen HY, Selfors LM, Palakurthi S, Liu JF, Drapkin R, Matulonis U, Leverson JD, Sampath D, Mills GB, Brugge JS.

Nat Commun. 2017 Aug 28;8(1):365. doi: 10.1038/s41467-017-00263-7.

9.

Niche-localized tumor cells are protected from HER2-targeted therapy via upregulation of an anti-apoptotic program in vivo.

Zoeller JJ, Bronson RT, Selfors LM, Mills GB, Brugge JS.

NPJ Breast Cancer. 2017 May 1;3:18. doi: 10.1038/s41523-017-0020-z. eCollection 2017. Erratum in: NPJ Breast Cancer. 2017 Sep 22;3:38.

10.

ERK and p38 MAPK Activities Determine Sensitivity to PI3K/mTOR Inhibition via Regulation of MYC and YAP.

Muranen T, Selfors LM, Hwang J, Gallegos LL, Coloff JL, Thoreen CC, Kang SA, Sabatini DM, Mills GB, Brugge JS.

Cancer Res. 2016 Dec 15;76(24):7168-7180. Epub 2016 Oct 20.

11.

Establishment of Patient-Derived Tumor Xenograft Models of Epithelial Ovarian Cancer for Preclinical Evaluation of Novel Therapeutics.

Liu JF, Palakurthi S, Zeng Q, Zhou S, Ivanova E, Huang W, Zervantonakis IK, Selfors LM, Shen Y, Pritchard CC, Zheng M, Adleff V, Papp E, Piao H, Novak M, Fotheringham S, Wulf GM, English J, Kirschmeier PT, Velculescu VE, Paweletz C, Mills GB, Livingston DM, Brugge JS, Matulonis UA, Drapkin R.

Clin Cancer Res. 2017 Mar 1;23(5):1263-1273. doi: 10.1158/1078-0432.CCR-16-1237. Epub 2016 Aug 29.

12.

The Role of Proliferation in Determining Response to Neoadjuvant Chemotherapy in Breast Cancer: A Gene Expression-Based Meta-Analysis.

Stover DG, Coloff JL, Barry WT, Brugge JS, Winer EP, Selfors LM.

Clin Cancer Res. 2016 Dec 15;22(24):6039-6050. Epub 2016 Jun 21.

13.

A protein interaction map for cell-cell adhesion regulators identifies DUSP23 as a novel phosphatase for β-catenin.

Gallegos LL, Ng MR, Sowa ME, Selfors LM, White A, Zervantonakis IK, Singh P, Dhakal S, Harper JW, Brugge JS.

Sci Rep. 2016 Jun 3;6:27114. doi: 10.1038/srep27114.

14.

Differential Glutamate Metabolism in Proliferating and Quiescent Mammary Epithelial Cells.

Coloff JL, Murphy JP, Braun CR, Harris IS, Shelton LM, Kami K, Gygi SP, Selfors LM, Brugge JS.

Cell Metab. 2016 May 10;23(5):867-80. doi: 10.1016/j.cmet.2016.03.016. Epub 2016 Apr 28.

15.

Cytokinesis involves a nontranscriptional function of the Hippo pathway effector YAP.

Bui DA, Lee W, White AE, Harper JW, Schackmann RC, Overholtzer M, Selfors LM, Brugge JS.

Sci Signal. 2016 Mar 1;9(417):ra23. doi: 10.1126/scisignal.aaa9227.

16.

Characterization of twenty-five ovarian tumour cell lines that phenocopy primary tumours.

Ince TA, Sousa AD, Jones MA, Harrell JC, Agoston ES, Krohn M, Selfors LM, Liu W, Chen K, Yong M, Buchwald P, Wang B, Hale KS, Cohick E, Sergent P, Witt A, Kozhekbaeva Z, Gao S, Agoston AT, Merritt MA, Foster R, Rueda BR, Crum CP, Brugge JS, Mills GB.

Nat Commun. 2015 Jun 17;6:7419. doi: 10.1038/ncomms8419.

17.

Mesenchymal gene program-expressing ovarian cancer spheroids exhibit enhanced mesothelial clearance.

Davidowitz RA, Selfors LM, Iwanicki MP, Elias KM, Karst A, Piao H, Ince TA, Drage MG, Dering J, Konecny GE, Matulonis U, Mills GB, Slamon DJ, Drapkin R, Brugge JS.

J Clin Invest. 2014 Jun;124(6):2611-25. doi: 10.1172/JCI69815. Epub 2014 Apr 24.

18.

Evidence for a multipotent mammary progenitor with pregnancy-specific activity.

Kaanta AS, Virtanen C, Selfors LM, Brugge JS, Neel BG.

Breast Cancer Res. 2013;15(4):R65.

19.

PDEF promotes luminal differentiation and acts as a survival factor for ER-positive breast cancer cells.

Buchwalter G, Hickey MM, Cromer A, Selfors LM, Gunawardane RN, Frishman J, Jeselsohn R, Lim E, Chi D, Fu X, Schiff R, Brown M, Brugge JS.

Cancer Cell. 2013 Jun 10;23(6):753-67. doi: 10.1016/j.ccr.2013.04.026.

20.

Differential remodeling of actin cytoskeleton architecture by profilin isoforms leads to distinct effects on cell migration and invasion.

Mouneimne G, Hansen SD, Selfors LM, Petrak L, Hickey MM, Gallegos LL, Simpson KJ, Lim J, Gertler FB, Hartwig JH, Mullins RD, Brugge JS.

Cancer Cell. 2012 Nov 13;22(5):615-30. doi: 10.1016/j.ccr.2012.09.027.

21.

Inhibition of PI3K/mTOR leads to adaptive resistance in matrix-attached cancer cells.

Muranen T, Selfors LM, Worster DT, Iwanicki MP, Song L, Morales FC, Gao S, Mills GB, Brugge JS.

Cancer Cell. 2012 Feb 14;21(2):227-39. doi: 10.1016/j.ccr.2011.12.024.

22.

Profiling Y561-dependent and -independent substrates of CSF-1R in epithelial cells.

Knowlton ML, Selfors LM, Wrobel CN, Gu TL, Ballif BA, Gygi SP, Polakiewicz R, Brugge JS.

PLoS One. 2010 Oct 26;5(10):e13587. doi: 10.1371/journal.pone.0013587.

23.

PTK6 regulates IGF-1-induced anchorage-independent survival.

Irie HY, Shrestha Y, Selfors LM, Frye F, Iida N, Wang Z, Zou L, Yao J, Lu Y, Epstein CB, Natesan S, Richardson AL, Polyak K, Mills GB, Hahn WC, Brugge JS.

PLoS One. 2010 Jul 23;5(7):e11729. doi: 10.1371/journal.pone.0011729.

24.

Screensaver: an open source lab information management system (LIMS) for high throughput screening facilities.

Tolopko AN, Sullivan JP, Erickson SD, Wrobel D, Chiang SL, Rudnicki K, Rudnicki S, Nale J, Selfors LM, Greenhouse D, Muhlich JL, Shamu CE.

BMC Bioinformatics. 2010 May 18;11:260. doi: 10.1186/1471-2105-11-260.

25.

Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells.

Mazzone M, Selfors LM, Albeck J, Overholtzer M, Sale S, Carroll DL, Pandya D, Lu Y, Mills GB, Aster JC, Artavanis-Tsakonas S, Brugge JS.

Proc Natl Acad Sci U S A. 2010 Mar 16;107(11):5012-7. doi: 10.1073/pnas.1000896107. Epub 2010 Mar 1.

26.

Statistical methods for analysis of high-throughput RNA interference screens.

Birmingham A, Selfors LM, Forster T, Wrobel D, Kennedy CJ, Shanks E, Santoyo-Lopez J, Dunican DJ, Long A, Kelleher D, Smith Q, Beijersbergen RL, Ghazal P, Shamu CE.

Nat Methods. 2009 Aug;6(8):569-75. doi: 10.1038/nmeth.1351. Review.

27.

Fibroblast growth factor receptor 1-transformed mammary epithelial cells are dependent on RSK activity for growth and survival.

Xian W, Pappas L, Pandya D, Selfors LM, Derksen PW, de Bruin M, Gray NS, Jonkers J, Rosen JM, Brugge JS.

Cancer Res. 2009 Mar 15;69(6):2244-51. doi: 10.1158/0008-5472.CAN-08-3398. Epub 2009 Mar 3. Erratum in: Cancer Res. 2009 Aug 1;69(15):6366.

28.

Identification of genes that regulate epithelial cell migration using an siRNA screening approach.

Simpson KJ, Selfors LM, Bui J, Reynolds A, Leake D, Khvorova A, Brugge JS.

Nat Cell Biol. 2008 Sep;10(9):1027-38. doi: 10.1038/ncb1762.

PMID:
19160483
29.

Vav family proteins couple to diverse cell surface receptors.

Moores SL, Selfors LM, Fredericks J, Breit T, Fujikawa K, Alt FW, Brugge JS, Swat W.

Mol Cell Biol. 2000 Sep;20(17):6364-73.

30.

soc-2 encodes a leucine-rich repeat protein implicated in fibroblast growth factor receptor signaling.

Selfors LM, Schutzman JL, Borland CZ, Stern MJ.

Proc Natl Acad Sci U S A. 1998 Jun 9;95(12):6903-8.

31.

Identification of the cellular source of laminin beta2 in adult and developing vertebrate retinae.

Libby RT, Xu Y, Selfors LM, Brunken WJ, Hunter DD.

J Comp Neurol. 1997 Dec 29;389(4):655-67.

PMID:
9421145
32.

MAP kinase function in C. elegans.

Selfors LM, Stern MJ.

Bioessays. 1994 May;16(5):301-4. Review. No abstract available.

PMID:
8024537

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