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Photolysis of Staphyloxanthin in Methicillin-Resistant Staphylococcus aureus Potentiates Killing by Reactive Oxygen Species.

Dong PT, Mohammad H, Hui J, Leanse LG, Li J, Liang L, Dai T, Seleem MN, Cheng JX.

Adv Sci (Weinh). 2019 Mar 30;6(11):1900030. doi: 10.1002/advs.201900030. eCollection 2019 Jun 5.


Lipophilic efficient phenylthiazoles with potent undecaprenyl pyrophosphatase inhibitory activity.

Elsebaei MM, Mohammad H, Samir A, Abutaleb NS, Norvil AB, Michie AR, Moustafa MM, Samy H, Gowher H, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2019 Aug 1;175:49-62. doi: 10.1016/j.ejmech.2019.04.063. Epub 2019 Apr 27.


An aryl isonitrile compound with an improved physicochemical profile that is effective in two mouse models of multidrug-resistant Staphylococcus aureus infection.

Mohammad H, Kyei-Baffour K, Abutaleb NS, Dai M, Seleem MN.

J Glob Antimicrob Resist. 2019 Apr 30. pii: S2213-7165(19)30105-5. doi: 10.1016/j.jgar.2019.04.016. [Epub ahead of print]


Second-generation aryl isonitrile compounds targeting multidrug-resistant Staphylococcus aureus.

Kyei-Baffour K, Mohammad H, Seleem MN, Dai M.

Bioorg Med Chem. 2019 May 1;27(9):1845-1854. doi: 10.1016/j.bmc.2019.03.034. Epub 2019 Mar 19.


Discovery of Lipophilic Bisphosphonates That Target Bacterial Cell Wall and Quinone Biosynthesis.

Malwal SR, Chen L, Hicks H, Qu F, Liu W, Shillo A, Law WX, Zhang J, Chandnani N, Han X, Zheng Y, Chen CC, Guo RT, AbdelKhalek A, Seleem MN, Oldfield E.

J Med Chem. 2019 Mar 14;62(5):2564-2581. doi: 10.1021/acs.jmedchem.8b01878. Epub 2019 Feb 21.


Antibacterial and antivirulence activities of auranofin against Clostridium difficile.

AbdelKhalek A, Abutaleb NS, Mohammad H, Seleem MN.

Int J Antimicrob Agents. 2019 Jan;53(1):54-62. doi: 10.1016/j.ijantimicag.2018.09.018. Epub 2018 Sep 28.


Correction to "Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide".

Brezden A, Mohamed MF, Nepal M, Harwood JS, Kuriakose J, Seleem MN, Chmielewski J.

J Am Chem Soc. 2018 Oct 10;140(40):13125-13126. doi: 10.1021/jacs.8b09906. Epub 2018 Sep 28. No abstract available.


Naphthylthiazoles: Targeting Multidrug-Resistant and Intracellular Staphylococcus aureus with Biofilm Disruption Activity.

Hagras M, Abutaleb NS, Ali AO, Abdel-Aleem JA, Elsebaei MM, Seleem MN, Mayhoub AS.

ACS Infect Dis. 2018 Dec 14;4(12):1679-1691. doi: 10.1021/acsinfecdis.8b00172. Epub 2018 Oct 8.


Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX.

Morales-de-Echegaray AV, Maltais TR, Lin L, Younis W, Kadasala NR, Seleem MN, Wei A.

ACS Infect Dis. 2018 Nov 9;4(11):1564-1573. doi: 10.1021/acsinfecdis.8b00125. Epub 2018 Sep 13.


Synergistic interactions of sulfamethoxazole and azole antifungal drugs against emerging multidrug-resistant Candida auris.

Eldesouky HE, Li X, Abutaleb NS, Mohammad H, Seleem MN.

Int J Antimicrob Agents. 2018 Dec;52(6):754-761. doi: 10.1016/j.ijantimicag.2018.08.016. Epub 2018 Aug 24.


A Library Approach to Cationic Amphiphilic Polyproline Helices that Target Intracellular Pathogenic Bacteria.

Nepal M, Mohamed MF, Blade R, Eldesouky HE, N Anderson T, Seleem MN, Chmielewski J.

ACS Infect Dis. 2018 Sep 14;4(9):1300-1305. doi: 10.1021/acsinfecdis.8b00124. Epub 2018 Jul 13.


N-(1,3,4-oxadiazol-2-yl)benzamide analogs, bacteriostatic agents against methicillin- and vancomycin-resistant bacteria.

Opoku-Temeng C, Naclerio GA, Mohammad H, Dayal N, Abutaleb NS, Seleem MN, Sintim HO.

Eur J Med Chem. 2018 Jul 15;155:797-805. doi: 10.1016/j.ejmech.2018.06.023. Epub 2018 Jun 15.


Repurposing ebselen for decolonization of vancomycin-resistant enterococci (VRE).

AbdelKhalek A, Abutaleb NS, Mohammad H, Seleem MN.

PLoS One. 2018 Jun 28;13(6):e0199710. doi: 10.1371/journal.pone.0199710. eCollection 2018.


Repurposing auranofin as an intestinal decolonizing agent for vancomycin-resistant enterococci.

AbdelKhalek A, Abutaleb NS, Elmagarmid KA, Seleem MN.

Sci Rep. 2018 May 29;8(1):8353. doi: 10.1038/s41598-018-26674-0.


Alkoxyphenylthiazoles with broad-spectrum activity against multidrug-resistant gram-positive bacterial pathogens.

ElAwamy M, Mohammad H, Hussien A, Abutaleb NS, Hagras M, Serya RAT, Taher AT, Abouzid KA, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 May 25;152:318-328. doi: 10.1016/j.ejmech.2018.04.049. Epub 2018 Apr 25.


Phenylthiazoles with tert-Butyl side chain: Metabolically stable with anti-biofilm activity.

Kotb A, Abutaleb NS, Seleem MA, Hagras M, Mohammad H, Bayoumi A, Ghiaty A, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 May 10;151:110-120. doi: 10.1016/j.ejmech.2018.03.044. Epub 2018 Mar 19.


Antibacterial activity and safety of commercial veterinary cationic steroid antibiotics and neutral superoxidized water.

Bergstrom BE, Abdelkhalek A, Younis W, Hammac GK, Townsend WM, Seleem MN.

PLoS One. 2018 Mar 7;13(3):e0193217. doi: 10.1371/journal.pone.0193217. eCollection 2018.


Antibiotic Susceptibility Determination within One Cell Cycle at Single-Bacterium Level by Stimulated Raman Metabolic Imaging.

Hong W, Karanja CW, Abutaleb NS, Younis W, Zhang X, Seleem MN, Cheng JX.

Anal Chem. 2018 Mar 20;90(6):3737-3743. doi: 10.1021/acs.analchem.7b03382. Epub 2018 Feb 27.


Alkynyl-containing phenylthiazoles: Systemically active antibacterial agents effective against methicillin-resistant Staphylococcus aureus (MRSA).

Elsebaei MM, Mohammad H, Abouf M, Abutaleb NS, Hegazy YA, Ghiaty A, Chen L, Zhang J, Malwal SR, Oldfield E, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 Mar 25;148:195-209. doi: 10.1016/j.ejmech.2018.02.031. Epub 2018 Feb 12.


Repurposing niclosamide for intestinal decolonization of vancomycin-resistant enterococci.

Mohammad H, AbdelKhalek A, Abutaleb NS, Seleem MN.

Int J Antimicrob Agents. 2018 Jun;51(6):897-904. doi: 10.1016/j.ijantimicag.2018.02.003. Epub 2018 Feb 9.


Discovery of a Novel Dibromoquinoline Compound Exhibiting Potent Antifungal and Antivirulence Activity That Targets Metal Ion Homeostasis.

Mohammad H, Elghazawy NH, Eldesouky HE, Hegazy YA, Younis W, Avrimova L, Hazbun T, Arafa RK, Seleem MN.

ACS Infect Dis. 2018 Mar 9;4(3):403-414. doi: 10.1021/acsinfecdis.7b00215. Epub 2018 Feb 2.


Reversal of Azole Resistance in Candida albicans by Sulfa Antibacterial Drugs.

Eldesouky HE, Mayhoub A, Hazbun TR, Seleem MN.

Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e00701-17. doi: 10.1128/AAC.00701-17. Print 2018 Mar.


Biphenylthiazole antibiotics with an oxadiazole linker: An approach to improve physicochemical properties and oral bioavailability.

Hagras M, Hegazy YA, Elkabbany AH, Mohammad H, Ghiaty A, Abdelghany TM, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2018 Jan 1;143:1448-1456. doi: 10.1016/j.ejmech.2017.10.048. Epub 2017 Oct 19.


Arylthiazole antibiotics targeting intracellular methicillin-resistant Staphylococcus aureus (MRSA) that interfere with bacterial cell wall synthesis.

Eid I, Elsebaei MM, Mohammad H, Hagras M, Peters CE, Hegazy YA, Cooper B, Pogliano J, Pogliano K, Abulkhair HS, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2017 Oct 20;139:665-673. doi: 10.1016/j.ejmech.2017.08.039. Epub 2017 Aug 18.


Virulence and transcriptome profile of multidrug-resistant Escherichia coli from chicken.

Hussain HI, Iqbal Z, Seleem MN, Huang D, Sattar A, Hao H, Yuan Z.

Sci Rep. 2017 Aug 21;7(1):8335. doi: 10.1038/s41598-017-07798-1.


Stimulated Raman Imaging Reveals Aberrant Lipogenesis as a Metabolic Marker for Azole-Resistant Candida albicans.

Karanja CW, Hong W, Younis W, Eldesouky HE, Seleem MN, Cheng JX.

Anal Chem. 2017 Sep 19;89(18):9822-9829. doi: 10.1021/acs.analchem.7b01798. Epub 2017 Aug 30.


Particle engineering for intracellular delivery of vancomycin to methicillin-resistant Staphylococcus aureus (MRSA)-infected macrophages.

Pei Y, Mohamed MF, Seleem MN, Yeo Y.

J Control Release. 2017 Dec 10;267:133-143. doi: 10.1016/j.jconrel.2017.08.007. Epub 2017 Aug 7.


Bacteriological profiling of diphenylureas as a novel class of antibiotics against methicillin-resistant Staphylococcus aureus.

Mohammad H, Younis W, Ezzat HG, Peters CE, AbdelKhalek A, Cooper B, Pogliano K, Pogliano J, Mayhoub AS, Seleem MN.

PLoS One. 2017 Aug 10;12(8):e0182821. doi: 10.1371/journal.pone.0182821. eCollection 2017.


A short D-enantiomeric antimicrobial peptide with potent immunomodulatory and antibiofilm activity against multidrug-resistant Pseudomonas aeruginosa and Acinetobacter baumannii.

Mohamed MF, Brezden A, Mohammad H, Chmielewski J, Seleem MN.

Sci Rep. 2017 Jul 31;7(1):6953. doi: 10.1038/s41598-017-07440-0.


Rapid synthesis of bicyclic lactones via palladium-catalyzed aminocarbonylative lactonizations.

Yin X, Mohammad H, Eldesouky HE, Abdelkhalek A, Seleem MN, Dai M.

Chem Commun (Camb). 2017 Jun 29;53(53):7238-7241. doi: 10.1039/c7cc02494k.


Investigating the Antibacterial Activity of Biphenylthiazoles against Methicillin- and Vancomycin-Resistant Staphylococcus aureus (MRSA and VRSA).

Hagras M, Mohammad H, Mandour MS, Hegazy YA, Ghiaty A, Seleem MN, Mayhoub AS.

J Med Chem. 2017 May 11;60(9):4074-4085. doi: 10.1021/acs.jmedchem.7b00392. Epub 2017 May 1.


Investigation of aryl isonitrile compounds with potent, broad-spectrum antifungal activity.

Mohammad H, Kyei-Baffour K, Younis W, Davis DC, Eldesouky H, Seleem MN, Dai M.

Bioorg Med Chem. 2017 Jun 1;25(11):2926-2931. doi: 10.1016/j.bmc.2017.03.035. Epub 2017 Mar 27.


Diphenylurea derivatives for combating methicillin- and vancomycin-resistant Staphylococcus aureus.

Eissa IH, Mohammad H, Qassem OA, Younis W, Abdelghany TM, Elshafeey A, Abd Rabo Moustafa MM, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2017 Apr 21;130:73-85. doi: 10.1016/j.ejmech.2017.02.044. Epub 2017 Feb 21.


Phenylthiazole Antibacterial Agents Targeting Cell Wall Synthesis Exhibit Potent Activity in Vitro and in Vivo against Vancomycin-Resistant Enterococci.

Mohammad H, Younis W, Chen L, Peters CE, Pogliano J, Pogliano K, Cooper B, Zhang J, Mayhoub A, Oldfield E, Cushman M, Seleem MN.

J Med Chem. 2017 Mar 23;60(6):2425-2438. doi: 10.1021/acs.jmedchem.6b01780. Epub 2017 Mar 15.


Aryl-alkyl-lysines: Membrane-Active Fungicides That Act against Biofilms of Candida albicans.

Ghosh C, Yadav V, Younis W, Mohammad H, Hegazy YA, Seleem MN, Sanyal K, Haldar J.

ACS Infect Dis. 2017 Apr 14;3(4):293-301. doi: 10.1021/acsinfecdis.6b00192. Epub 2017 Mar 14.


In Vitro Screening of an FDA-Approved Library Against ESKAPE Pathogens.

Younis W, AbdelKhalek A, Mayhoub AS, Seleem MN.

Curr Pharm Des. 2017;23(14):2147-2157. doi: 10.2174/1381612823666170209154745.


Repurposing Approach Identifies Auranofin with Broad Spectrum Antifungal Activity That Targets Mia40-Erv1 Pathway.

Thangamani S, Maland M, Mohammad H, Pascuzzi PE, Avramova L, Koehler CM, Hazbun TR, Seleem MN.

Front Cell Infect Microbiol. 2017 Jan 18;7:4. doi: 10.3389/fcimb.2017.00004. eCollection 2017.


Targeting biofilms and persisters of ESKAPE pathogens with P14KanS, a kanamycin peptide conjugate.

Mohamed MF, Brezden A, Mohammad H, Chmielewski J, Seleem MN.

Biochim Biophys Acta Gen Subj. 2017 Apr;1861(4):848-859. doi: 10.1016/j.bbagen.2017.01.029. Epub 2017 Jan 27.


Phenylthiazole antibiotics: A metabolism-guided approach to overcome short duration of action.

Yahia E, Mohammad H, Abdelghany TM, Fayed E, Seleem MN, Mayhoub AS.

Eur J Med Chem. 2017 Jan 27;126:604-613. doi: 10.1016/j.ejmech.2016.11.042. Epub 2016 Nov 22.


Ebselen exerts antifungal activity by regulating glutathione (GSH) and reactive oxygen species (ROS) production in fungal cells.

Thangamani S, Eldesouky HE, Mohammad H, Pascuzzi PE, Avramova L, Hazbun TR, Seleem MN.

Biochim Biophys Acta Gen Subj. 2017 Jan;1861(1 Pt A):3002-3010. doi: 10.1016/j.bbagen.2016.09.029. Epub 2016 Oct 3.


Comparative virulence studies and transcriptome analysis of Staphylococcus aureus strains isolated from animals.

Iqbal Z, Seleem MN, Hussain HI, Huang L, Hao H, Yuan Z.

Sci Rep. 2016 Oct 14;6:35442. doi: 10.1038/srep35442.


In Vitro Antibacterial Activity of Rhodanine Derivatives against Pathogenic Clinical Isolates.

AbdelKhalek A, Ashby CR Jr, Patel BA, Talele TT, Seleem MN.

PLoS One. 2016 Oct 6;11(10):e0164227. doi: 10.1371/journal.pone.0164227. eCollection 2016.


Dual Targeting of Intracellular Pathogenic Bacteria with a Cleavable Conjugate of Kanamycin and an Antibacterial Cell-Penetrating Peptide.

Brezden A, Mohamed MF, Nepal M, Harwood JS, Kuriakose J, Seleem MN, Chmielewski J.

J Am Chem Soc. 2016 Aug 31;138(34):10945-9. doi: 10.1021/jacs.6b04831. Epub 2016 Aug 17. Erratum in: J Am Chem Soc. 2018 Oct 10;140(40):13125-13126.


Targeting Multidrug-resistant Staphylococci with an anti-rpoA Peptide Nucleic Acid Conjugated to the HIV-1 TAT Cell Penetrating Peptide.

Abushahba MF, Mohammad H, Seleem MN.

Mol Ther Nucleic Acids. 2016 Jul 19;5(7):e339. doi: 10.1038/mtna.2016.53.


Evaluation of short synthetic antimicrobial peptides for treatment of drug-resistant and intracellular Staphylococcus aureus.

Mohamed MF, Abdelkhalek A, Seleem MN.

Sci Rep. 2016 Jul 11;6:29707. doi: 10.1038/srep29707.


Label-Free Detection and Discrimination of Bacterial Pathogens Based on Hemin Recognition.

Maltais TR, Adak AK, Younis W, Seleem MN, Wei A.

Bioconjug Chem. 2016 Jul 20;27(7):1713-22. doi: 10.1021/acs.bioconjchem.6b00236. Epub 2016 Jul 1.


Second-Generation Phenylthiazole Antibiotics with Enhanced Pharmacokinetic Properties.

Seleem MA, Disouky AM, Mohammad H, Abdelghany TM, Mancy AS, Bayoumi SA, Elshafeey A, El-Morsy A, Seleem MN, Mayhoub AS.

J Med Chem. 2016 May 26;59(10):4900-12. doi: 10.1021/acs.jmedchem.6b00233. Epub 2016 May 17.


Antibacterial activity and mechanism of action of auranofin against multi-drug resistant bacterial pathogens.

Thangamani S, Mohammad H, Abushahba MF, Sobreira TJ, Hedrick VE, Paul LN, Seleem MN.

Sci Rep. 2016 Mar 3;6:22571. doi: 10.1038/srep22571.


Repurposing auranofin for the treatment of cutaneous staphylococcal infections.

Thangamani S, Mohammad H, Abushahba MF, Sobreira TJ, Seleem MN.

Int J Antimicrob Agents. 2016 Mar;47(3):195-201. doi: 10.1016/j.ijantimicag.2015.12.016. Epub 2016 Jan 23.


Impact of different cell penetrating peptides on the efficacy of antisense therapeutics for targeting intracellular pathogens.

Abushahba MF, Mohammad H, Thangamani S, Hussein AA, Seleem MN.

Sci Rep. 2016 Feb 10;6:20832. doi: 10.1038/srep20832.

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