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Items: 31

1.

Single-step synthesis and in vitro anti-mycobacterial activity of novel nitrofurantoin analogues.

Zuma NH, Smit FJ, Seldon R, Aucamp J, Jordaan A, Warner DF, N'Da DD.

Bioorg Chem. 2020 Mar;96:103587. doi: 10.1016/j.bioorg.2020.103587. Epub 2020 Jan 16.

PMID:
32044516
2.

Synthesis and biological evaluation of bis-N2,N2'-(4-hydroxycoumarin-3-yl)ethylidene]-2,3-dihydroxysuccinodihydrazides.

Manyeruke MH, Tshiwawa T, Hoppe HC, Isaacs M, Seldon R, Warner DF, Krause RWM, Kaye PT.

Bioorg Med Chem Lett. 2020 Mar 1;30(5):126911. doi: 10.1016/j.bmcl.2019.126911. Epub 2019 Dec 19.

PMID:
31952962
3.

In Vitro Efficacies, ADME, and Pharmacokinetic Properties of Phenoxazine Derivatives Active against Mycobacterium tuberculosis.

Tanner L, Evans JC, Seldon R, Jordaan A, Warner DF, Haynes RK, Parkinson CJ, Wiesner L.

Antimicrob Agents Chemother. 2019 Oct 22;63(11). pii: e01010-19. doi: 10.1128/AAC.01010-19. Print 2019 Nov.

PMID:
31427302
4.

Semisynthetic Antimycobacterial C-3 Silicate and C-3/C-21 Ester Derivatives of Fusidic Acid: Pharmacological Evaluation and Stability Studies in Liver Microsomes, Rat Plasma, and Mycobacterium tuberculosis culture.

Njoroge M, Kaur G, Espinoza-Moraga M, Wasuna A, Dziwornu GA, Seldon R, Taylor D, Okombo J, Warner DF, Chibale K.

ACS Infect Dis. 2019 Sep 13;5(9):1634-1644. doi: 10.1021/acsinfecdis.9b00208. Epub 2019 Jul 29.

PMID:
31309823
5.

Bioisosteric ferrocenyl aminoquinoline-benzimidazole hybrids: Antimicrobial evaluation and mechanistic insights.

Baartzes N, Stringer T, Seldon R, Warner DF, Taylor D, Wittlin S, Chibale K, Smith GS.

Eur J Med Chem. 2019 Oct 15;180:121-133. doi: 10.1016/j.ejmech.2019.06.069. Epub 2019 Jun 26.

PMID:
31301563
6.

Azaaurones as Potent Antimycobacterial Agents Active against MDR- and XDR-TB.

Campaniço A, Carrasco MP, Njoroge M, Seldon R, Chibale K, Perdigão J, Portugal I, Warner DF, Moreira R, Lopes F.

ChemMedChem. 2019 Aug 20;14(16):1537-1546. doi: 10.1002/cmdc.201900289. Epub 2019 Jul 25.

PMID:
31294529
7.

Synthesis and biological evaluation of 2-chloro-3-[(thiazol-2-yl)amino]-1,4-naphthoquinones.

Olawode EO, Tandlich R, Prinsloo E, Isaacs M, Hoppe H, Seldon R, Warner DF, Steenkamp V, Kaye PT.

Bioorg Med Chem Lett. 2019 Jul 1;29(13):1572-1575. doi: 10.1016/j.bmcl.2019.05.001. Epub 2019 May 3.

PMID:
31080006
8.

New Quinolone-Based Thiosemicarbazones Showing Activity Against Plasmodium falciparum and Mycobacterium tuberculosis.

Beteck RM, Seldon R, Jordaan A, Warner DF, Hoppe HC, Laming D, Khanye SD.

Molecules. 2019 May 4;24(9). pii: E1740. doi: 10.3390/molecules24091740.

9.

Design, synthesis, and antimycobacterial activity of novel ciprofloxacin derivatives.

Cilliers P, Seldon R, Smit FJ, Aucamp J, Jordaan A, Warner DF, N'Da DD.

Chem Biol Drug Des. 2019 Aug;94(2):1518-1536. doi: 10.1111/cbdd.13534. Epub 2019 Jun 17.

PMID:
31033220
10.

Quinolone-isoniazid hybrids: synthesis and preliminary in vitro cytotoxicity and anti-tuberculosis evaluation.

Beteck RM, Seldon R, Jordaan A, Warner DF, Hoppe HC, Laming D, Legoabe LJ, Khanye SD.

Medchemcomm. 2019 Jan 11;10(2):326-331. doi: 10.1039/c8md00480c. eCollection 2019 Feb 1.

11.

Cinnamoyl-Oxaborole Amides: Synthesis and Their in Vitro Biological Activity.

Gumbo M, Beteck RM, Mandizvo T, Seldon R, Warner DF, Hoppe HC, Isaacs M, Laming D, Tam CC, Cheng LW, Liu N, Land KM, Khanye SD.

Molecules. 2018 Aug 15;23(8). pii: E2038. doi: 10.3390/molecules23082038.

12.

Novel Antitubercular 6-Dialkylaminopyrimidine Carboxamides from Phenotypic Whole-Cell High Throughput Screening of a SoftFocus Library: Structure-Activity Relationship and Target Identification Studies.

Wilson CR, Gessner RK, Moosa A, Seldon R, Warner DF, Mizrahi V, Soares de Melo C, Simelane SB, Nchinda A, Abay E, Taylor D, Njoroge M, Brunschwig C, Lawrence N, Boshoff HIM, Barry CE 3rd, Sirgel FA, van Helden P, Harris CJ, Gordon R, Ghidelli-Disse S, Pflaumer H, Boesche M, Drewes G, Sanz O, Santos G, Rebollo-Lopez MJ, Urones B, Selenski C, Lafuente-Monasterio MJ, Axtman M, Lelièvre J, Ballell L, Mueller R, Street LJ, Ghorpade SR, Chibale K.

J Med Chem. 2017 Dec 28;60(24):10118-10134. doi: 10.1021/acs.jmedchem.7b01347. Epub 2017 Dec 7.

13.

Antimicrobial activity of organometallic isonicotinyl and pyrazinyl ferrocenyl-derived complexes.

Stringer T, Seldon R, Liu N, Warner DF, Tam C, Cheng LW, Land KM, Smith PJ, Chibale K, Smith GS.

Dalton Trans. 2017 Aug 14;46(30):9875-9885. doi: 10.1039/c7dt01952a. Epub 2017 Jul 17.

PMID:
28713884
14.

The Influence of HIV on the Evolution of Mycobacterium tuberculosis.

Koch AS, Brites D, Stucki D, Evans JC, Seldon R, Heekes A, Mulder N, Nicol M, Oni T, Mizrahi V, Warner DF, Parkhill J, Gagneux S, Martin DP, Wilkinson RJ.

Mol Biol Evol. 2017 Jul 1;34(7):1654-1668. doi: 10.1093/molbev/msx107.

15.

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration.

van der Westhuyzen R, Winks S, Wilson CR, Boyle GA, Gessner RK, Soares de Melo C, Taylor D, de Kock C, Njoroge M, Brunschwig C, Lawrence N, Rao SP, Sirgel F, van Helden P, Seldon R, Moosa A, Warner DF, Arista L, Manjunatha UH, Smith PW, Street LJ, Chibale K.

J Med Chem. 2015 Dec 10;58(23):9371-81. doi: 10.1021/acs.jmedchem.5b01542. Epub 2015 Nov 20.

PMID:
26551248
16.

Cytotoxic mediators in paradoxical HIV-tuberculosis immune reconstitution inflammatory syndrome.

Wilkinson KA, Walker NF, Meintjes G, Deffur A, Nicol MP, Skolimowska KH, Matthews K, Tadokera R, Seldon R, Maartens G, Rangaka MX, Besra GS, Wilkinson RJ.

J Immunol. 2015 Feb 15;194(4):1748-54. doi: 10.4049/jimmunol.1402105. Epub 2015 Jan 14.

17.

Impairment of IFN-gamma response to synthetic peptides of Mycobacterium tuberculosis in a 7-day whole blood assay.

Gideon HP, Hamilton MS, Wood K, Pepper D, Oni T, Seldon R, Banwell C, Langford PR, Wilkinson RJ, Wilkinson KA.

PLoS One. 2013 Aug 8;8(8):e71351. doi: 10.1371/journal.pone.0071351. eCollection 2013.

18.

Role of the interleukin 10 family of cytokines in patients with immune reconstitution inflammatory syndrome associated with HIV infection and tuberculosis.

Tadokera R, Wilkinson KA, Meintjes GA, Skolimowska KH, Matthews K, Seldon R, Rangaka MX, Maartens G, Wilkinson RJ.

J Infect Dis. 2013 Apr;207(7):1148-56. doi: 10.1093/infdis/jit002. Epub 2013 Jan 9.

19.

Altered ratio of IFN-γ/IL-10 in patients with drug resistant Mycobacterium tuberculosis and HIV- Tuberculosis Immune Reconstitution Inflammatory Syndrome.

Skolimowska KH, Rangaka MX, Meintjes G, Pepper DJ, Seldon R, Matthews K, Wilkinson RJ, Wilkinson KA.

PLoS One. 2012;7(10):e46481. doi: 10.1371/journal.pone.0046481. Epub 2012 Oct 10.

20.

Smoking, BCG and employment and the risk of tuberculosis infection in HIV-infected persons in South Africa.

Oni T, Gideon HP, Bangani N, Tsekela R, Seldon R, Wood K, Wilkinson KA, Goliath RT, Ottenhoff TH, Wilkinson RJ.

PLoS One. 2012;7(10):e47072. doi: 10.1371/journal.pone.0047072. Epub 2012 Oct 9.

21.

Risk factors associated with indeterminate gamma interferon responses in the assessment of latent tuberculosis infection in a high-incidence environment.

Oni T, Gideon HP, Bangani N, Tsekela R, Seldon R, Wood K, Wilkinson KA, Goliath RT, Ottenhoff TH, Wilkinson RJ.

Clin Vaccine Immunol. 2012 Aug;19(8):1243-7. doi: 10.1128/CVI.00166-12. Epub 2012 Jun 20.

22.

Corticosteroid-modulated immune activation in the tuberculosis immune reconstitution inflammatory syndrome.

Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Tadokera R, Conesa-Botella A, Seldon R, Rangaka MX, Rebe K, Pepper DJ, Morroni C, Colebunders R, Maartens G, Wilkinson RJ.

Am J Respir Crit Care Med. 2012 Aug 15;186(4):369-77. doi: 10.1164/rccm.201201-0094OC. Epub 2012 Jun 14.

23.

Immunological characterisation of an unmasking TB-IRIS case.

Wilkinson KA, Meintjes G, Seldon R, Goliath R, Wilkinson RJ.

S Afr Med J. 2012 Mar 2;102(6):512-7.

PMID:
22668952
24.

High prevalence of subclinical tuberculosis in HIV-1-infected persons without advanced immunodeficiency: implications for TB screening.

Oni T, Burke R, Tsekela R, Bangani N, Seldon R, Gideon HP, Wood K, Wilkinson KA, Ottenhoff TH, Wilkinson RJ.

Thorax. 2011 Aug;66(8):669-73. doi: 10.1136/thx.2011.160168. Epub 2011 May 31.

25.

Hypercytokinaemia accompanies HIV-tuberculosis immune reconstitution inflammatory syndrome.

Tadokera R, Meintjes G, Skolimowska KH, Wilkinson KA, Matthews K, Seldon R, Chegou NN, Maartens G, Rangaka MX, Rebe K, Walzl G, Wilkinson RJ.

Eur Respir J. 2011 May;37(5):1248-59. doi: 10.1183/09031936.00091010. Epub 2010 Sep 3.

26.

Enhanced diagnosis of HIV-1-associated tuberculosis by relating T-SPOT.TB and CD4 counts.

Oni T, Patel J, Gideon HP, Seldon R, Wood K, Hlombe Y, Wilkinson KA, Rangaka MX, Mendelson M, Wilkinson RJ.

Eur Respir J. 2010 Sep;36(3):594-600. doi: 10.1183/09031936.00171509. Epub 2010 Jan 14.

27.

Dissection of regenerating T-Cell responses against tuberculosis in HIV-infected adults sensitized by Mycobacterium tuberculosis.

Wilkinson KA, Seldon R, Meintjes G, Rangaka MX, Hanekom WA, Maartens G, Wilkinson RJ.

Am J Respir Crit Care Med. 2009 Oct 1;180(7):674-83. doi: 10.1164/rccm.200904-0568OC. Epub 2009 Jul 23.

28.

Type 1 helper T cells and FoxP3-positive T cells in HIV-tuberculosis-associated immune reconstitution inflammatory syndrome.

Meintjes G, Wilkinson KA, Rangaka MX, Skolimowska K, van Veen K, Abrahams M, Seldon R, Pepper DJ, Rebe K, Mouton P, van Cutsem G, Nicol MP, Maartens G, Wilkinson RJ.

Am J Respir Crit Care Med. 2008 Nov 15;178(10):1083-9. doi: 10.1164/rccm.200806-858OC. Epub 2008 Aug 28.

29.

Enhanced ex vivo stimulation of Mycobacterium tuberculosis-specific T cells in human immunodeficiency virus-infected persons via antigen delivery by the Bordetella pertussis adenylate cyclase vector.

Connell TG, Shey MS, Seldon R, Rangaka MX, van Cutsem G, Simsova M, Marcekova Z, Sebo P, Curtis N, Diwakar L, Meintjes GA, Leclerc C, Wilkinson RJ, Wilkinson KA.

Clin Vaccine Immunol. 2007 Jul;14(7):847-54. Epub 2007 May 23.

30.

Clinical, immunological, and epidemiological importance of antituberculosis T cell responses in HIV-infected Africans.

Rangaka MX, Diwakar L, Seldon R, van Cutsem G, Meintjes GA, Morroni C, Mouton P, Shey MS, Maartens G, Wilkinson KA, Wilkinson RJ.

Clin Infect Dis. 2007 Jun 15;44(12):1639-46. Epub 2007 May 10.

PMID:
17516410
31.

Effect of HIV-1 infection on T-Cell-based and skin test detection of tuberculosis infection.

Rangaka MX, Wilkinson KA, Seldon R, Van Cutsem G, Meintjes GA, Morroni C, Mouton P, Diwakar L, Connell TG, Maartens G, Wilkinson RJ.

Am J Respir Crit Care Med. 2007 Mar 1;175(5):514-20. Epub 2006 Dec 7.

PMID:
17158278

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