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ZnR/GPR39 upregulation of K+/Cl--cotransporter 3 in tamoxifen resistant breast cancer cells.

Mero M, Asraf H, Sekler I, Taylor KM, Hershfinkel M.

Cell Calcium. 2019 May 22;81:12-20. doi: 10.1016/j.ceca.2019.05.005. [Epub ahead of print]


LRRK2 deficiency induced mitochondrial Ca2+ efflux inhibition can be rescued by Na+/Ca2+/Li+ exchanger upregulation.

Ludtmann MHR, Kostic M, Horne A, Gandhi S, Sekler I, Abramov AY.

Cell Death Dis. 2019 Mar 19;10(4):265. doi: 10.1038/s41419-019-1469-5.


Zinc transporter 10 (ZnT10)-dependent extrusion of cellular Mn2+ is driven by an active Ca2+-coupled exchange.

Levy M, Elkoshi N, Barber-Zucker S, Hoch E, Zarivach R, Hershfinkel M, Sekler I.

J Biol Chem. 2019 Apr 12;294(15):5879-5889. doi: 10.1074/jbc.RA118.006816. Epub 2019 Feb 12.


Functional properties and mode of regulation of the mitochondrial Na+/Ca2+ exchanger, NCLX.

Kostic M, Sekler I.

Semin Cell Dev Biol. 2019 Jan 29. pii: S1084-9521(18)30273-8. doi: 10.1016/j.semcdb.2019.01.009. [Epub ahead of print] Review.


Allosteric Regulation of NCLX by Mitochondrial Membrane Potential Links the Metabolic State and Ca2+ Signaling in Mitochondria.

Kostic M, Katoshevski T, Sekler I.

Cell Rep. 2018 Dec 18;25(12):3465-3475.e4. doi: 10.1016/j.celrep.2018.11.084.


Enhanced ZnR/GPR39 Activity in Breast Cancer, an Alternative Trigger of Signaling Leading to Cell Growth.

Ventura-Bixenshpaner H, Asraf H, Chakraborty M, Elkabets M, Sekler I, Taylor KM, Hershfinkel M.

Sci Rep. 2018 May 25;8(1):8119. doi: 10.1038/s41598-018-26459-5.


Crosslink between calcium and sodium signalling.

Verkhratsky A, Trebak M, Perocchi F, Khananshvili D, Sekler I.

Exp Physiol. 2018 Feb 1;103(2):157-169. doi: 10.1113/EP086534. Epub 2018 Jan 16. Review.


Parallel in vivo and in vitro transcriptomics analysis reveals calcium and zinc signalling in the brain as sensitive targets of HBCD neurotoxicity.

Reffatto V, Rasinger JD, Carroll TS, Ganay T, Lundebye AK, Sekler I, Hershfinkel M, Hogstrand C.

Arch Toxicol. 2018 Mar;92(3):1189-1203. doi: 10.1007/s00204-017-2119-2. Epub 2017 Nov 25.


Mitochondrial Calcium Dysregulation Contributes to Dendrite Degeneration Mediated by PD/LBD-Associated LRRK2 Mutants.

Verma M, Callio J, Otero PA, Sekler I, Wills ZP, Chu CT.

J Neurosci. 2017 Nov 15;37(46):11151-11165. doi: 10.1523/JNEUROSCI.3791-16.2017. Epub 2017 Oct 16.


Optogenetic control of mitochondrial metabolism and Ca2+ signaling by mitochondria-targeted opsins.

Tkatch T, Greotti E, Baranauskas G, Pendin D, Roy S, Nita LI, Wettmarshausen J, Prigge M, Yizhar O, Shirihai OS, Fishman D, Hershfinkel M, Fleidervish IA, Perocchi F, Pozzan T, Sekler I.

Proc Natl Acad Sci U S A. 2017 Jun 27;114(26):E5167-E5176. doi: 10.1073/pnas.1703623114. Epub 2017 Jun 13.


Mitochondria control store-operated Ca2+ entry through Na+ and redox signals.

Ben-Kasus Nissim T, Zhang X, Elazar A, Roy S, Stolwijk JA, Zhou Y, Motiani RK, Gueguinou M, Hempel N, Hershfinkel M, Gill DL, Trebak M, Sekler I.

EMBO J. 2017 Mar 15;36(6):797-815. doi: 10.15252/embj.201592481. Epub 2017 Feb 20.


The NCLX-type Na+/Ca2+ Exchanger NCX-9 Is Required for Patterning of Neural Circuits in Caenorhabditis elegans.

Sharma V, Roy S, Sekler I, O'Halloran DM.

J Biol Chem. 2017 Mar 31;292(13):5364-5377. doi: 10.1074/jbc.M116.758953. Epub 2017 Feb 14.


Identification of residues that control Li+ versus Na+ dependent Ca2+ exchange at the transport site of the mitochondrial NCLX.

Roy S, Dey K, Hershfinkel M, Ohana E, Sekler I.

Biochim Biophys Acta Mol Cell Res. 2017 Jun;1864(6):997-1008. doi: 10.1016/j.bbamcr.2017.01.011. Epub 2017 Jan 24.


The Zn2+-sensing receptor, ZnR/GPR39, upregulates colonocytic Cl- absorption, via basolateral KCC1, and reduces fluid loss.

Sunuwar L, Asraf H, Donowitz M, Sekler I, Hershfinkel M.

Biochim Biophys Acta Mol Basis Dis. 2017 Apr;1863(4):947-960. doi: 10.1016/j.bbadis.2017.01.009. Epub 2017 Jan 16.


Privileged crosstalk between TRPV1 channels and mitochondrial calcium shuttling machinery controls nociception.

Nita II, Caspi Y, Gudes S, Fishman D, Lev S, Hersfinkel M, Sekler I, Binshtok AM.

Biochim Biophys Acta. 2016 Dec;1863(12):2868-2880. doi: 10.1016/j.bbamcr.2016.09.009. Epub 2016 Sep 11.


Correction to 'The zinc sensing receptor, ZnR/GPR39, triggers metabotropic calcium signalling in colonocytes and regulates occludin recovery in experimental colitis'.

Sunuwar L, Medini M, Cohen L, Sekler I, Hershfinkel M.

Philos Trans R Soc Lond B Biol Sci. 2016 Sep 19;371(1703). pii: 20160331. doi: 10.1098/rstb.2016.0331. No abstract available.


Amyloid β attenuates metabotropic zinc sensing receptor, mZnR/GPR39, dependent Ca2+ , ERK1/2 and Clusterin signaling in neurons.

Abramovitch-Dahan C, Asraf H, Bogdanovic M, Sekler I, Bush AI, Hershfinkel M.

J Neurochem. 2016 Oct;139(2):221-233. doi: 10.1111/jnc.13760. Epub 2016 Sep 15.


The PP-motif in luminal loop 2 of ZnT transporters plays a pivotal role in TNAP activation.

Fujimoto S, Tsuji T, Fujiwara T, Takeda TA, Merriman C, Fukunaka A, Nishito Y, Fu D, Hoch E, Sekler I, Fukue K, Miyamae Y, Masuda S, Nagao M, Kambe T.

Biochem J. 2016 Sep 1;473(17):2611-21. doi: 10.1042/BCJ20160324. Epub 2016 Jun 14.


Plasmalemmal and mitochondrial Na(+) -Ca(2+) exchange in neuroglia.

Parpura V, Sekler I, Fern R.

Glia. 2016 Oct;64(10):1646-54. doi: 10.1002/glia.22975. Epub 2016 May 3.


PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons.

Kostic M, Ludtmann MH, Bading H, Hershfinkel M, Steer E, Chu CT, Abramov AY, Sekler I.

Cell Rep. 2015 Oct 13;13(2):376-86. doi: 10.1016/j.celrep.2015.08.079. Epub 2015 Oct 1.


Regulation of neuronal pH by the metabotropic Zn(2+)-sensing Gq-coupled receptor, mZnR/GPR39.

Ganay T, Asraf H, Aizenman E, Bogdanovic M, Sekler I, Hershfinkel M.

J Neurochem. 2015 Dec;135(5):897-907. doi: 10.1111/jnc.13367. Epub 2015 Oct 22.


Standing of giants shoulders the story of the mitochondrial Na(+)Ca(2+) exchanger.

Sekler I.

Biochem Biophys Res Commun. 2015 Apr 24;460(1):50-2. doi: 10.1016/j.bbrc.2015.02.170. Review.


Life after the birth of the mitochondrial Na+/Ca2+ exchanger, NCLX.

Nita LI, Hershfinkel M, Sekler I.

Sci China Life Sci. 2015 Jan;58(1):59-65. doi: 10.1007/s11427-014-4789-9. Epub 2015 Jan 10. Review.


A crosstalk between Na⁺ channels, Na⁺/K⁺ pump and mitochondrial Na⁺ transporters controls glucose-dependent cytosolic and mitochondrial Na⁺ signals.

Nita II, Hershfinkel M, Lewis EC, Sekler I.

Cell Calcium. 2015 Feb;57(2):69-75. doi: 10.1016/j.ceca.2014.12.007. Epub 2014 Dec 18.


Homeostatic regulation of KCC2 activity by the zinc receptor mZnR/GPR39 during seizures.

Gilad D, Shorer S, Ketzef M, Friedman A, Sekler I, Aizenman E, Hershfinkel M.

Neurobiol Dis. 2015 Sep;81:4-13. doi: 10.1016/j.nbd.2014.12.020. Epub 2015 Jan 3.


NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state.

De Marchi U, Santo-Domingo J, Castelbou C, Sekler I, Wiederkehr A, Demaurex N.

J Biol Chem. 2014 Jul 18;289(29):20377-85. doi: 10.1074/jbc.M113.540898. Epub 2014 Jun 4.


Pancreatic β-cell Na+ channels control global Ca2+ signaling and oxidative metabolism by inducing Na+ and Ca2+ responses that are propagated into mitochondria.

Nita II, Hershfinkel M, Kantor C, Rutter GA, Lewis EC, Sekler I.

FASEB J. 2014 Aug;28(8):3301-12. doi: 10.1096/fj.13-248161. Epub 2014 Apr 9.


Extreme population differences in the human zinc transporter ZIP4 (SLC39A4) are explained by positive selection in Sub-Saharan Africa.

Engelken J, Carnero-Montoro E, Pybus M, Andrews GK, Lalueza-Fox C, Comas D, Sekler I, de la Rasilla M, Rosas A, Stoneking M, Valverde MA, Vicente R, Bosch E.

PLoS Genet. 2014 Feb 20;10(2):e1004128. doi: 10.1371/journal.pgen.1004128. eCollection 2014 Feb.


The ZnR/GPR39 interacts with the CaSR to enhance signaling in prostate and salivary epithelia.

Asraf H, Salomon S, Nevo A, Sekler I, Mayer D, Hershfinkel M.

J Cell Physiol. 2014 Jul;229(7):868-77. doi: 10.1002/jcp.24514.


Mitochondrial exchanger NCLX plays a major role in the intracellular Ca2+ signaling, gliotransmission, and proliferation of astrocytes.

Parnis J, Montana V, Delgado-Martinez I, Matyash V, Parpura V, Kettenmann H, Sekler I, Nolte C.

J Neurosci. 2013 Apr 24;33(17):7206-19. doi: 10.1523/JNEUROSCI.5721-12.2013.


NCLX: the mitochondrial sodium calcium exchanger.

Boyman L, Williams GS, Khananshvili D, Sekler I, Lederer WJ.

J Mol Cell Cardiol. 2013 Jun;59:205-13. doi: 10.1016/j.yjmcc.2013.03.012. Epub 2013 Mar 26.


Effects of long-term treatment with pioglitazone on cognition and glucose metabolism of PS1-KI, 3xTg-AD, and wild-type mice.

Masciopinto F, Di Pietro N, Corona C, Bomba M, Pipino C, Curcio M, Di Castelnuovo A, Ciavardelli D, Silvestri E, Canzoniero LM, Sekler I, Pandolfi A, Sensi SL.

Cell Death Dis. 2012 Dec 20;3:e448. doi: 10.1038/cddis.2012.189.


The mitochondrial Na+/Ca2+ exchanger upregulates glucose dependent Ca2+ signalling linked to insulin secretion.

Nita II, Hershfinkel M, Fishman D, Ozeri E, Rutter GA, Sensi SL, Khananshvili D, Lewis EC, Sekler I.

PLoS One. 2012;7(10):e46649. doi: 10.1371/journal.pone.0046649. Epub 2012 Oct 8.


Extracellular pH regulates zinc signaling via an Asp residue of the zinc-sensing receptor (ZnR/GPR39).

Cohen L, Asraf H, Sekler I, Hershfinkel M.

J Biol Chem. 2012 Sep 28;287(40):33339-50. Epub 2012 Aug 9.


The mitochondrial Ca2+ uniporter MCU is essential for glucose-induced ATP increases in pancreatic β-cells.

Tarasov AI, Semplici F, Ravier MA, Bellomo EA, Pullen TJ, Gilon P, Sekler I, Rizzuto R, Rutter GA.

PLoS One. 2012;7(7):e39722. doi: 10.1371/journal.pone.0039722. Epub 2012 Jul 19.


Molecular identity and functional properties of the mitochondrial Na+/Ca2+ exchanger.

Palty R, Hershfinkel M, Sekler I.

J Biol Chem. 2012 Sep 14;287(38):31650-7. doi: 10.1074/jbc.R112.355867. Epub 2012 Jul 20. Review.


Zinc sensing receptor signaling, mediated by GPR39, reduces butyrate-induced cell death in HT29 colonocytes via upregulation of clusterin.

Cohen L, Azriel-Tamir H, Arotsker N, Sekler I, Hershfinkel M.

PLoS One. 2012;7(4):e35482. doi: 10.1371/journal.pone.0035482. Epub 2012 Apr 24.


Histidine pairing at the metal transport site of mammalian ZnT transporters controls Zn2+ over Cd2+ selectivity.

Hoch E, Lin W, Chai J, Hershfinkel M, Fu D, Sekler I.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7202-7. doi: 10.1073/pnas.1200362109. Epub 2012 Apr 23.


The mitochondrial Na(+)/Ca(2+) exchanger.

Palty R, Sekler I.

Cell Calcium. 2012 Jul;52(1):9-15. doi: 10.1016/j.ceca.2012.02.010. Epub 2012 Mar 18. Review.


Zinc homeostasis and signaling in glia.

Sekler I, Silverman WF.

Glia. 2012 May;60(6):843-50. doi: 10.1002/glia.22286. Epub 2012 Feb 10. Review.


Upregulation of KCC2 activity by zinc-mediated neurotransmission via the mZnR/GPR39 receptor.

Chorin E, Vinograd O, Fleidervish I, Gilad D, Herrmann S, Sekler I, Aizenman E, Hershfinkel M.

J Neurosci. 2011 Sep 7;31(36):12916-26. doi: 10.1523/JNEUROSCI.2205-11.2011.


Tissue nonspecific alkaline phosphatase is activated via a two-step mechanism by zinc transport complexes in the early secretory pathway.

Fukunaka A, Kurokawa Y, Teranishi F, Sekler I, Oda K, Ackland ML, Faundez V, Hiromura M, Masuda S, Nagao M, Enomoto S, Kambe T.

J Biol Chem. 2011 May 6;286(18):16363-73. doi: 10.1074/jbc.M111.227173. Epub 2011 Mar 14.


Zinc bells rang in Jerusalem!

Hershfinkel M, Aizenman E, Andrews G, Sekler I.

Sci Signal. 2010 Jul 6;3(129):mr2. doi: 10.1126/scisignal.3129mr2.


Coupling of mitochondria to store-operated Ca(2+)-signaling sustains constitutive activation of protein kinase B/Akt and augments survival of malignant melanoma cells.

Feldman B, Fedida-Metula S, Nita J, Sekler I, Fishman D.

Cell Calcium. 2010 Jun;47(6):525-37. doi: 10.1016/j.ceca.2010.05.002. Epub 2010 Jun 1.


Zinc released from injured cells is acting via the Zn2+-sensing receptor, ZnR, to trigger signaling leading to epithelial repair.

Sharir H, Zinger A, Nevo A, Sekler I, Hershfinkel M.

J Biol Chem. 2010 Aug 20;285(34):26097-106. doi: 10.1074/jbc.M110.107490. Epub 2010 Jun 3.


Zinc homeostatic proteins in the CNS are regulated by crosstalk between extracellular and intracellular zinc.

Karol N, Brodski C, Bibi Y, Kaisman T, Forberg M, Hershfinkel M, Sekler I, Silverman WF.

J Cell Physiol. 2010 Sep;224(3):567-74. doi: 10.1002/jcp.22168.


NCLX is an essential component of mitochondrial Na+/Ca2+ exchange.

Palty R, Silverman WF, Hershfinkel M, Caporale T, Sensi SL, Parnis J, Nolte C, Fishman D, Shoshan-Barmatz V, Herrmann S, Khananshvili D, Sekler I.

Proc Natl Acad Sci U S A. 2010 Jan 5;107(1):436-41. doi: 10.1073/pnas.0908099107. Epub 2009 Dec 15.


Zinc in the physiology and pathology of the CNS.

Sensi SL, Paoletti P, Bush AI, Sekler I.

Nat Rev Neurosci. 2009 Nov;10(11):780-91. doi: 10.1038/nrn2734. Epub 2009 Oct 14. Review.


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