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Items: 1 to 50 of 517

1.

Feasibility and utility of a panel testing for 114 cancer-associated genes in a clinical setting: A hospital-based study.

Sunami K, Ichikawa H, Kubo T, Kato M, Fujiwara Y, Shimomura A, Koyama T, Kakishima H, Kitami M, Matsushita H, Furukawa E, Narushima D, Nagai M, Taniguchi H, Motoi N, Sekine S, Maeshima A, Mori T, Watanabe R, Yoshida M, Yoshida A, Yoshida H, Satomi K, Sukeda A, Hashimoto T, Shimizu T, Iwasa S, Yonemori K, Kato K, Morizane C, Ogawa C, Tanabe N, Sugano K, Hiraoka N, Tamura K, Yoshida T, Fujiwara Y, Ochiai A, Yamamoto N, Kohno T.

Cancer Sci. 2019 Feb 11. doi: 10.1111/cas.13969. [Epub ahead of print]

2.

Structural insight into nucleosome transcription by RNA polymerase II with elongation factors.

Ehara H, Kujirai T, Fujino Y, Shirouzu M, Kurumizaka H, Sekine SI.

Science. 2019 Feb 15;363(6428):744-747. doi: 10.1126/science.aav8912. Epub 2019 Feb 7.

PMID:
30733384
3.

Reciprocal Roles of Tom7 and OMA1 during Mitochondrial Import and Activation of PINK1.

Sekine S, Wang C, Sideris DP, Bunker E, Zhang Z, Youle RJ.

Mol Cell. 2019 Jan 23. pii: S1097-2765(19)30002-4. doi: 10.1016/j.molcel.2019.01.002. [Epub ahead of print]

PMID:
30733118
4.

SLC20A2 variants cause dysfunctional phosphate transport activity in endothelial cells induced from Idiopathic Basal Ganglia Calcification patients-derived iPSCs.

Sekine SI, Nishii K, Masaka T, Kurita H, Inden M, Hozumi I.

Biochem Biophys Res Commun. 2019 Mar 5;510(2):303-308. doi: 10.1016/j.bbrc.2019.01.096. Epub 2019 Jan 28.

PMID:
30704756
5.

Frequent mutations of genes encoding vacuolar H+ -ATPase components in granular cell tumors.

Sekimizu M, Yoshida A, Mitani S, Asano N, Hirata M, Kubo T, Yamazaki F, Sakamoto H, Kato M, Makise N, Mori T, Yamazaki N, Sekine S, Oda I, Watanabe SI, Hiraga H, Yonemoto T, Kawamoto T, Naka N, Funauchi Y, Nishida Y, Honoki K, Kawano H, Tsuchiya H, Kunisada T, Matsuda K, Inagaki K, Kawai A, Ichikawa H.

Genes Chromosomes Cancer. 2018 Dec 30. doi: 10.1002/gcc.22727. [Epub ahead of print]

PMID:
30597645
6.

Author Correction: The selective tRNA aminoacylation mechanism based on a single G•U pair.

Naganuma M, Sekine SI, Chong YE, Guo M, Yang XL, Gamper H, Hou YM, Schimmel P, Yokoyama S.

Nature. 2018 Dec;564(7736):E37. doi: 10.1038/s41586-018-0760-4.

PMID:
30459470
7.

RHOA mutations and CLDN18-ARHGAP fusions in intestinal-type adenocarcinoma with anastomosing glands of the stomach.

Hashimoto T, Ogawa R, Tang TY, Yoshida H, Taniguchi H, Katai H, Oda I, Sekine S.

Mod Pathol. 2018 Nov 13. doi: 10.1038/s41379-018-0181-9. [Epub ahead of print]

PMID:
30425335
8.

Mediastinoscopic salvage esophagectomy for recurrent esophageal squamous cell carcinoma after definitive chemoradiotherapy in a previously pneumonectomized patient.

Okumura T, Seto Y, Aikou S, Moriyama M, Sekine S, Hashimoto I, Shibuya K, Hojo S, Yoshioka I, Nagata T, Fujii T.

Asian J Endosc Surg. 2018 Nov 8. doi: 10.1111/ases.12658. [Epub ahead of print]

PMID:
30411514
9.

Synthesis of novel benzbromarone derivatives designed to avoid metabolic activation.

Ohe T, Umezawa R, Kitagawara Y, Yasuda D, Takahashi K, Nakamura S, Abe A, Sekine S, Ito K, Okunushi K, Morio H, Furihata T, Anzai N, Mashino T.

Bioorg Med Chem Lett. 2018 Dec 15;28(23-24):3708-3711. doi: 10.1016/j.bmcl.2018.10.023. Epub 2018 Oct 15.

PMID:
30389287
10.

Structural basis of the nucleosome transition during RNA polymerase II passage.

Kujirai T, Ehara H, Fujino Y, Shirouzu M, Sekine SI, Kurumizaka H.

Science. 2018 Nov 2;362(6414):595-598. doi: 10.1126/science.aau9904. Epub 2018 Oct 4.

PMID:
30287617
11.

Acquisition of WNT Pathway Gene Alterations Coincides With the Transition From Precursor Polyps to Traditional Serrated Adenomas.

Hashimoto T, Ogawa R, Yoshida H, Taniguchi H, Kojima M, Saito Y, Sekine S.

Am J Surg Pathol. 2019 Jan;43(1):132-139. doi: 10.1097/PAS.0000000000001149.

PMID:
30179900
12.

Divergent Routes toward Wnt and R-spondin Niche Independency during Human Gastric Carcinogenesis.

Nanki K, Toshimitsu K, Takano A, Fujii M, Shimokawa M, Ohta Y, Matano M, Seino T, Nishikori S, Ishikawa K, Kawasaki K, Togasaki K, Takahashi S, Sukawa Y, Ishida H, Sugimoto S, Kawakubo H, Kim J, Kitagawa Y, Sekine S, Koo BK, Kanai T, Sato T.

Cell. 2018 Aug 9;174(4):856-869.e17. doi: 10.1016/j.cell.2018.07.027.

PMID:
30096312
13.

Distinct ways of G:U recognition by conserved tRNA binding motifs.

Chong YE, Guo M, Yang XL, Kuhle B, Naganuma M, Sekine SI, Yokoyama S, Schimmel P.

Proc Natl Acad Sci U S A. 2018 Jul 17;115(29):7527-7532. doi: 10.1073/pnas.1807109115. Epub 2018 Jul 2.

14.

The stress response gene ATF3 is a direct target of the Wnt/β-catenin pathway and inhibits the invasion and migration of HCT116 human colorectal cancer cells.

Inoue M, Uchida Y, Edagawa M, Hirata M, Mitamura J, Miyamoto D, Taketani K, Sekine S, Kawauchi J, Kitajima S.

PLoS One. 2018 Jul 2;13(7):e0194160. doi: 10.1371/journal.pone.0194160. eCollection 2018.

15.

Reappraisal of the genetic heterogeneity of sessile serrated adenoma/polyp.

Cho H, Hashimoto T, Yoshida H, Taniguchi H, Ogawa R, Mori T, Hiraoka N, Saito Y, Sekine S.

Histopathology. 2018 Oct;73(4):672-680. doi: 10.1111/his.13688. Epub 2018 Aug 2.

PMID:
29920740
16.

Slow luminescence kinetics of semi-synthetic aequorin: expression, purification and structure determination of cf3-aequorin.

Inouye S, Tomabechi Y, Hosoya T, Sekine SI, Shirouzu M.

J Biochem. 2018 Sep 1;164(3):247-255. doi: 10.1093/jb/mvy049.

PMID:
29796619
17.

Superficially serrated adenoma: a proposal for a novel subtype of colorectal serrated lesion.

Hashimoto T, Tanaka Y, Ogawa R, Mori T, Yoshida H, Taniguchi H, Hiraoka N, Kojima M, Oono Y, Saito Y, Sekine S.

Mod Pathol. 2018 Oct;31(10):1588-1598. doi: 10.1038/s41379-018-0069-8. Epub 2018 May 22.

PMID:
29789649
18.

Increased susceptibility to troglitazone-induced mitochondrial permeability transition in type 2 diabetes mellitus model rat.

Segawa M, Sekine S, Sato T, Ito K.

J Toxicol Sci. 2018;43(5):339-351. doi: 10.2131/jts.43.339.

19.

Relationship between the burden of major periodontal bacteria and serum lipid profile in a cross-sectional Japanese study.

Choi YH, Kosaka T, Ojima M, Sekine S, Kokubo Y, Watanabe M, Miyamoto Y, Ono T, Amano A.

BMC Oral Health. 2018 May 4;18(1):77. doi: 10.1186/s12903-018-0536-0.

20.

Pilot study on probe-based confocal laser endomicroscopy for colorectal neoplasms: an initial experience in Japan.

Abe S, Saito Y, Oono Y, Tanaka Y, Sakamoto T, Yamada M, Nakajima T, Matsuda T, Ikematsu H, Yano T, Sekine S, Kojima M, Yamagishi H, Kato H.

Int J Colorectal Dis. 2018 Aug;33(8):1071-1078. doi: 10.1007/s00384-018-3059-x. Epub 2018 Apr 26.

PMID:
29700599
21.

Inorganic phosphorus (Pi) in CSF is a biomarker for SLC20A2-associated idiopathic basal ganglia calcification (IBGC1).

Hozumi I, Kurita H, Ozawa K, Furuta N, Inden M, Sekine SI, Yamada M, Hayashi Y, Kimura A, Inuzuka T, Seishima M.

J Neurol Sci. 2018 May 15;388:150-154. doi: 10.1016/j.jns.2018.03.014. Epub 2018 Mar 8.

PMID:
29627011
22.

Architecture of the RNA polymerase II elongation complex: new insights into Spt4/5 and Elf1.

Ehara H, Sekine SI.

Transcription. 2018;9(5):286-291. doi: 10.1080/21541264.2018.1454817. Epub 2018 May 7. Review.

23.

Structural Basis of Heterochromatin Formation by Human HP1.

Machida S, Takizawa Y, Ishimaru M, Sugita Y, Sekine S, Nakayama JI, Wolf M, Kurumizaka H.

Mol Cell. 2018 Feb 1;69(3):385-397.e8. doi: 10.1016/j.molcel.2017.12.011. Epub 2018 Jan 11.

24.

PINK1 import regulation; a fine system to convey mitochondrial stress to the cytosol.

Sekine S, Youle RJ.

BMC Biol. 2018 Jan 10;16(1):2. doi: 10.1186/s12915-017-0470-7. Review.

25.

Predictive relevance of lymphovascular invasion in T1 colorectal cancer before endoscopic treatment.

Inoki K, Sakamoto T, Takamaru H, Sekiguchi M, Yamada M, Nakajima T, Matsuda T, Taniguchi H, Sekine S, Kanemitsu Y, Ohe Y, Saito Y.

Endosc Int Open. 2017 Dec;5(12):E1278-E1283. doi: 10.1055/s-0043-117952. Epub 2017 Dec 6.

26.

Automated histological classification of whole slide images of colorectal biopsy specimens.

Yoshida H, Yamashita Y, Shimazu T, Cosatto E, Kiyuna T, Taniguchi H, Sekine S, Ochiai A.

Oncotarget. 2017 Oct 12;8(53):90719-90729. doi: 10.18632/oncotarget.21819. eCollection 2017 Oct 31.

27.

Feasibility of endoscopic resection using bipolar snare for nonampullary duodenal tumours in familial adenomatous polyposis patients.

Inoki K, Nakajima T, Nonaka S, Abe S, Suzuki H, Yoshinaga S, Oda I, Yamada M, Takatsu M, Yoshida H, Taniguchi H, Sekine S, Ohe Y, Saito Y.

Fam Cancer. 2018 Oct;17(4):517-524. doi: 10.1007/s10689-017-0063-1.

PMID:
29189961
28.

A Thermus phage protein inhibits host RNA polymerase by preventing template DNA strand loading during open promoter complex formation.

Ooi WY, Murayama Y, Mekler V, Minakhin L, Severinov K, Yokoyama S, Sekine SI.

Nucleic Acids Res. 2018 Jan 9;46(1):431-441. doi: 10.1093/nar/gkx1162.

29.

Disentangling the prognostic heterogeneity of stage III colorectal cancer through histologic stromal categorization.

Ueno H, Sekine S, Oshiro T, Kanemitsu Y, Hamaguchi T, Shida D, Takashima A, Ishiguro M, Ito E, Hashiguchi Y, Kondo F, Shimazaki H, Mochizuki S, Kajiwara Y, Shinto E, Yamamoto J, Shimada Y.

Surgery. 2018 Apr;163(4):777-783. doi: 10.1016/j.surg.2017.09.007. Epub 2017 Nov 20.

PMID:
29162344
30.

Evaluation of immune-mediated idiosyncratic drug toxicity using chimeric HLA transgenic mice.

Susukida T, Aoki S, Kogo K, Fujimori S, Song B, Liu C, Sekine S, Ito K.

Arch Toxicol. 2018 Mar;92(3):1177-1188. doi: 10.1007/s00204-017-2112-9. Epub 2017 Nov 17.

PMID:
29150704
31.

[I. Key Points of the Guidelines for Clinical Practice of Hereditary Colorectal Cancer].

Ishida H, Yamaguchi T, Tanakaya K, Akagi K, Sekine S, Shimodaira H, Tomita N, Sugihara K, Watanabe T.

Gan To Kagaku Ryoho. 2017 Nov;44(11):986-989. Japanese. No abstract available.

PMID:
29138373
32.

Quantitative Detection of Ethanol/Acetone in Complex Solutions Using Raman Spectroscopy Based on Headspace Gas Analysis.

Zhao Y, Yamaguchi Y, Liu C, Sekine S, Dou X.

Appl Spectrosc. 2018 Feb;72(2):280-287. doi: 10.1177/0003702817738010. Epub 2017 Oct 30.

PMID:
29082758
33.

SOX10 Expression as Well as BRAF and GNAQ/11 Mutations Distinguish Pigmented Ciliary Epithelium Neoplasms From Uveal Melanomas.

Mori T, Sukeda A, Sekine S, Shibata S, Ryo E, Okano H, Suzuki S, Hiraoka N.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5445-5451. doi: 10.1167/iovs.17-22362.

PMID:
29059311
34.

Induced pluripotent stem cells derived from a patient with familial idiopathic basal ganglia calcification (IBGC) caused by a mutation in SLC20A2 gene.

Sekine SI, Kondo T, Murakami N, Imamura K, Enami T, Shibukawa R, Tsukita K, Funayama M, Inden M, Kurita H, Hozumi I, Inoue H.

Stem Cell Res. 2017 Oct;24:40-43. doi: 10.1016/j.scr.2017.07.028. Epub 2017 Jul 29.

35.

Regulation of TG accumulation and lipid droplet morphology by the novel TLDP1 in Aurantiochytrium limacinum F26-b.

Watanabe T, Sakiyama R, Iimi Y, Sekine S, Abe E, Nomura KH, Nomura K, Ishibashi Y, Okino N, Hayashi M, Ito M.

J Lipid Res. 2017 Dec;58(12):2334-2347. doi: 10.1194/jlr.M079897. Epub 2017 Oct 12.

36.

Tumor location is a risk factor for lymph node metastasis in superficial Barrett's adenocarcinoma.

Yamada M, Oda I, Tanaka H, Abe S, Nonaka S, Suzuki H, Yoshinaga S, Kuchiba A, Koyanagi K, Igaki H, Taniguchi H, Sekine S, Saito Y, Tachimori Y.

Endosc Int Open. 2017 Sep;5(9):E868-E874. doi: 10.1055/s-0043-115388. Epub 2017 Sep 12.

37.

In situ synthesis of Au-shelled Ag nanoparticles on PDMS for flexible, long-life, and broad spectrum-sensitive SERS substrates.

Fortuni B, Inose T, Uezono S, Toyouchi S, Umemoto K, Sekine S, Fujita Y, Ricci M, Lu G, Masuhara A, Hutchison JA, Latterini L, Uji-I H.

Chem Commun (Camb). 2017 Oct 12;53(82):11298-11301. doi: 10.1039/c7cc05420c.

PMID:
28920592
38.

Mitochondrial fission facilitates the selective mitophagy of protein aggregates.

Burman JL, Pickles S, Wang C, Sekine S, Vargas JNS, Zhang Z, Youle AM, Nezich CL, Wu X, Hammer JA, Youle RJ.

J Cell Biol. 2017 Oct 2;216(10):3231-3247. doi: 10.1083/jcb.201612106. Epub 2017 Sep 11.

39.

Desmoplastic Pattern at the Tumor Front Defines Poor-prognosis Subtypes of Colorectal Cancer.

Ueno H, Kanemitsu Y, Sekine S, Ishiguro M, Ito E, Hashiguchi Y, Kondo F, Shimazaki H, Mochizuki S, Kajiwara Y, Shinto E, Yamamoto J.

Am J Surg Pathol. 2017 Nov;41(11):1506-1512. doi: 10.1097/PAS.0000000000000946.

PMID:
28877064
40.

Improved split fluorescent proteins for endogenous protein labeling.

Feng S, Sekine S, Pessino V, Li H, Leonetti MD, Huang B.

Nat Commun. 2017 Aug 29;8(1):370. doi: 10.1038/s41467-017-00494-8.

41.

Adenocarcinoma of the colon presenting as a submucosal tumor.

Cho H, Sekine S, Sekiguchi M.

Dig Endosc. 2018 Jan;30(1):114-115. doi: 10.1111/den.12949. Epub 2017 Sep 18. No abstract available.

PMID:
28816375
42.

Structure of the complete elongation complex of RNA polymerase II with basal factors.

Ehara H, Yokoyama T, Shigematsu H, Yokoyama S, Shirouzu M, Sekine SI.

Science. 2017 Sep 1;357(6354):921-924. doi: 10.1126/science.aan8552. Epub 2017 Aug 3.

PMID:
28775211
43.

Neuroprotective effect of 5-aminolevulinic acid against low inorganic phosphate in neuroblastoma SH-SY5Y cells.

Takase N, Inden M, Sekine SI, Ishii Y, Yonemitsu H, Iwashita W, Kurita H, Taketani Y, Hozumi I.

Sci Rep. 2017 Jul 18;7(1):5768. doi: 10.1038/s41598-017-06406-6.

44.

Intramucosal colorectal carcinoma with invasion of the lamina propria: a study by the Japanese Society for Cancer of the Colon and Rectum.

Kojima M, Shimazaki H, Iwaya K, Nakamura T, Kawachi H, Ichikawa K, Sekine S, Ishiguro S, Shimoda T, Kushima R, Yao T, Fujimori T, Hase K, Watanabe T, Sugihara K, Lauwers GY, Ochiai A.

Hum Pathol. 2017 Aug;66:230-237. doi: 10.1016/j.humpath.2017.04.031. Epub 2017 Jul 13.

PMID:
28711649
45.

Isoform switch of CD44 induces different chemotactic and tumorigenic ability in gallbladder cancer.

Miwa T, Nagata T, Kojima H, Sekine S, Okumura T.

Int J Oncol. 2017 Sep;51(3):771-780. doi: 10.3892/ijo.2017.4063. Epub 2017 Jul 3.

46.

Parallel homodimer structures of the extracellular domains of the voltage-gated sodium channel β4 subunit explain its role in cell-cell adhesion.

Shimizu H, Tosaki A, Ohsawa N, Ishizuka-Katsura Y, Shoji S, Miyazaki H, Oyama F, Terada T, Shirouzu M, Sekine SI, Nukina N, Yokoyama S.

J Biol Chem. 2017 Aug 11;292(32):13428-13440. doi: 10.1074/jbc.M117.786509. Epub 2017 Jun 27.

47.

Structures of PGAM5 Provide Insight into Active Site Plasticity and Multimeric Assembly.

Chaikuad A, Filippakopoulos P, Marcsisin SR, Picaud S, Schröder M, Sekine S, Ichijo H, Engen JR, Takeda K, Knapp S.

Structure. 2017 Jul 5;25(7):1089-1099.e3. doi: 10.1016/j.str.2017.05.020. Epub 2017 Jun 22.

48.

Dendritic Eph organizes dendrodendritic segregation in discrete olfactory map formation in Drosophila.

Anzo M, Sekine S, Makihara S, Chao K, Miura M, Chihara T.

Genes Dev. 2017 May 15;31(10):1054-1065. doi: 10.1101/gad.297424.117.

49.

Mitochondrial proteolysis and its roles in stress responses.

Sekine S.

Nihon Yakurigaku Zasshi. 2017;149(6):264-268. doi: 10.1254/fpj.149.264. Japanese. No abstract available.

PMID:
28626118
50.

WNT Pathway Gene Mutations Are Associated With the Presence of Dysplasia in Colorectal Sessile Serrated Adenoma/Polyps.

Hashimoto T, Yamashita S, Yoshida H, Taniguchi H, Ushijima T, Yamada T, Saito Y, Ochiai A, Sekine S, Hiraoka N.

Am J Surg Pathol. 2017 Sep;41(9):1188-1197. doi: 10.1097/PAS.0000000000000877.

PMID:
28614199

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