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Items: 1 to 50 of 198

1.

Insights into product release dynamics through structural analyses of thymidylate kinase.

Chaudhary SK, Iyyappan Y, Elayappan M, Jeyakanthan J, Sekar K.

Int J Biol Macromol. 2018 Nov 14;123:637-647. doi: 10.1016/j.ijbiomac.2018.11.025. [Epub ahead of print]

PMID:
30447376
2.

Spectral Content of Electroencephalographic Burst-Suppression Patterns May Reflect Neuronal Recovery in Comatose Post-cardiac Arrest Patients.

Sekar K, Schiff ND, Labar D, Forgacs PB.

J Clin Neurophysiol. 2018 Nov 12. doi: 10.1097/WNP.0000000000000536. [Epub ahead of print]

PMID:
30422916
3.

Synthesis and degradation of FtsZ quantitatively predict the first cell division in starved bacteria.

Sekar K, Rusconi R, Sauls JT, Fuhrer T, Noor E, Nguyen J, Fernandez VI, Buffing MF, Berney M, Jun S, Stocker R, Sauer U.

Mol Syst Biol. 2018 Nov 5;14(11):e8623. doi: 10.15252/msb.20188623.

4.

Children's Reactions to Flood Disaster in Kashmir.

Hassan FU, Singh G, Sekar K.

Indian J Psychol Med. 2018 Sep-Oct;40(5):414-419. doi: 10.4103/IJPSYM.IJPSYM_571_17.

5.

CDK1-mediated BCL9 phosphorylation inhibits clathrin to promote mitotic Wnt signalling.

Chen J, Rajasekaran M, Xia H, Kong SN, Deivasigamani A, Sekar K, Gao H, Swa HL, Gunaratne J, Ooi LL, Xie T, Hong W, Hui KM.

EMBO J. 2018 Oct 15;37(20). pii: e99395. doi: 10.15252/embj.201899395. Epub 2018 Sep 14.

PMID:
30217955
6.

Predictive Analysis on Behavioural Risk Factor Surveillance System through Ensemble Classifiers and Clusters.

Sekar KR, Easwar M, Manikandan R, Ravichandran KS.

J Natl Med Assoc. 2018 Aug 2. pii: S0027-9684(18)30069-5. doi: 10.1016/j.jnma.2018.07.001. [Epub ahead of print]

PMID:
30078757
7.

Insights into the etiology-associated gene regulatory networks in hepatocellular carcinoma from The Cancer Genome Atlas.

Seshachalam VP, Sekar K, Hui KM.

J Gastroenterol Hepatol. 2018 Dec;33(12):2037-2047. doi: 10.1111/jgh.14262. Epub 2018 May 24.

PMID:
29672926
8.

Glaucoma Pred: Glaucoma prediction based on Myocilin genotype and phenotype information.

Rangachari K, Bankoti N, Shyamala N, Michael D, Sameer Ahmed Z, Chandrasekaran P, Sekar K.

Genomics. 2018 Apr 14. pii: S0888-7543(18)30087-9. doi: 10.1016/j.ygeno.2018.04.006. [Epub ahead of print]

PMID:
29665417
9.

Structural and functional roles of dynamically correlated residues in thymidylate kinase.

Chaudhary SK, Jeyakanthan J, Sekar K.

Acta Crystallogr D Struct Biol. 2018 Apr 1;74(Pt 4):341-354. doi: 10.1107/S2059798318002267. Epub 2018 Apr 6.

PMID:
29652261
10.

Cystinuria in a 13-month-old Girl with Absence of Mutations in the SLC3A1 and SLC7A9 Genes.

Krishnamurthy S, Pavani C, Kurup PM, Palanisamy S, Jagadeesh A, Sekar K, Mahadevan S, Bisceglia L.

Indian J Nephrol. 2018 Jan-Feb;28(1):84-85. doi: 10.4103/ijn.IJN_20_17. No abstract available.

11.

First 2 Years of Experience of "Residential Care" at "Sakalawara Rehabilitation Services," National Institute of Mental Health and Neurosciences, Bengaluru, India.

Manjunatha N, Agarwal PP, Shashidhara HN, Palakode M, Raj EA, Mary Kapanee AR, Nattala P, Kumar CN, Sudhir P, Thirthalli J, Bharath S, Sekar K, Varghese M.

Indian J Psychol Med. 2017 Nov-Dec;39(6):750-755. doi: 10.4103/IJPSYM.IJPSYM_40_17.

12.

Molecular docking and molecular dynamics simulations of fumarate hydratase and its mutant H235N complexed with pyromellitic acid and citrate.

Subasri S, Chaudhary SK, Sekar K, Kesherwani M, Velmurugan D.

J Bioinform Comput Biol. 2017 Dec;15(6):1750026. doi: 10.1142/S0219720017500263. Epub 2017 Nov 13.

PMID:
29226743
13.

Simultaneous silencing of ACSL4 and induction of GADD45B in hepatocellular carcinoma cells amplifies the synergistic therapeutic effect of aspirin and sorafenib.

Xia H, Lee KW, Chen J, Kong SN, Sekar K, Deivasigamani A, Seshachalam VP, Goh BKP, Ooi LL, Hui KM.

Cell Death Discov. 2017 Sep 11;3:17058. doi: 10.1038/cddiscovery.2017.58. eCollection 2017.

14.

Opioid Receptor Modulators with a Cinnamyl Group.

Ravilla L, Venkata Subba Naidu N, Dogra S, Umrao D, Yadav PN, Biswas A, Michael D, Sekar K, Nagarajan K.

J Med Chem. 2017 Aug 10;60(15):6733-6750. doi: 10.1021/acs.jmedchem.7b00643. Epub 2017 Aug 1.

PMID:
28726402
15.

Structural studies of a hyperthermophilic thymidylate kinase enzyme reveal conformational substates along the reaction coordinate.

Biswas A, Shukla A, Chaudhary SK, Santhosh R, Jeyakanthan J, Sekar K.

FEBS J. 2017 Aug;284(15):2527-2544. doi: 10.1111/febs.14140. Epub 2017 Jul 13.

16.

Comparison of Amikacin Pharmacokinetics in Neonates Following Implementation of a New Dosage Protocol.

Hughes KM, Johnson PN, Anderson MP, Sekar KC, Welliver RC, Miller JL.

J Pediatr Pharmacol Ther. 2017 Jan-Feb;22(1):33-40. doi: 10.5863/1551-6776-22.1.33.

17.

Rhodamine Diaminomaleonitrile Conjugate as a Novel Colorimetric Fluorescent Sensor for Recognition of Cd2+ Ion.

Sakthivel P, Sekar K, Sivaraman G, Singaravadivel S.

J Fluoresc. 2017 May;27(3):1109-1115. doi: 10.1007/s10895-017-2046-x. Epub 2017 Feb 21.

PMID:
28220278
18.

Structure determination of contaminant proteins using the MarathonMR procedure.

Hatti K, Biswas A, Chaudhary S, Dadireddy V, Sekar K, Srinivasan N, Murthy MRN.

J Struct Biol. 2017 Mar;197(3):372-378. doi: 10.1016/j.jsb.2017.01.005. Epub 2017 Feb 3.

PMID:
28167161
19.

New biochemical insight of conserved water molecules at catalytic and structural Zn2+ ions in human matrix metalloproteinase-I: a study by MD-simulation.

Chakrabarti B, Bairagya HR, Mukhopadhyay BP, Sekar K.

J Mol Model. 2017 Feb;23(2):57. doi: 10.1007/s00894-017-3210-6. Epub 2017 Feb 4.

PMID:
28161785
20.

Frontiers of high-throughput metabolomics.

Zampieri M, Sekar K, Zamboni N, Sauer U.

Curr Opin Chem Biol. 2017 Feb;36:15-23. doi: 10.1016/j.cbpa.2016.12.006. Epub 2017 Jan 5. Review.

PMID:
28064089
21.

Crystal structures of an archaeal thymidylate kinase from Sulfolobus tokodaii provide insights into the role of a conserved active site Arginine residue.

Biswas A, Shukla A, Vijayan RSK, Jeyakanthan J, Sekar K.

J Struct Biol. 2017 Mar;197(3):236-249. doi: 10.1016/j.jsb.2016.12.001. Epub 2016 Dec 9.

PMID:
27940092
22.

PanGeT: Pan-genomics tool.

Yuvaraj I, Sridhar J, Michael D, Sekar K.

Gene. 2017 Feb 5;600:77-84. doi: 10.1016/j.gene.2016.11.025. Epub 2016 Nov 13.

PMID:
27851981
23.

MELK is an oncogenic kinase essential for early hepatocellular carcinoma recurrence.

Xia H, Kong SN, Chen J, Shi M, Sekar K, Seshachalam VP, Rajasekaran M, Goh BKP, Ooi LL, Hui KM.

Cancer Lett. 2016 Dec 1;383(1):85-93. doi: 10.1016/j.canlet.2016.09.017. Epub 2016 Sep 28.

24.

Role of sequence evolution and conformational dynamics in the substrate specificity and oligomerization mode of thymidylate kinases.

Biswas A, Jasti S, Jeyakanthan J, Sekar K.

J Biomol Struct Dyn. 2017 Aug;35(10):2136-2154. doi: 10.1080/07391102.2016.1207563. Epub 2016 Jul 27.

PMID:
27376462
25.

Ebolavirus Database: Gene and Protein Information Resource for Ebolaviruses.

Swetha RG, Ramaiah S, Anbarasu A, Sekar K.

Adv Bioinformatics. 2016;2016:1673284. doi: 10.1155/2016/1673284. Epub 2016 Apr 14.

26.

The microtubule-associated protein PRC1 promotes early recurrence of hepatocellular carcinoma in association with the Wnt/β-catenin signalling pathway.

Chen J, Rajasekaran M, Xia H, Zhang X, Kong SN, Sekar K, Seshachalam VP, Deivasigamani A, Goh BK, Ooi LL, Hong W, Hui KM.

Gut. 2016 Sep;65(9):1522-34. doi: 10.1136/gutjnl-2015-310625. Epub 2016 Mar 3.

27.

N-Terminal-Based Targeted, Inducible Protein Degradation in Escherichia coli.

Sekar K, Gentile AM, Bostick JW, Tyo KE.

PLoS One. 2016 Feb 22;11(2):e0149746. doi: 10.1371/journal.pone.0149746. eCollection 2016.

28.

The putative role of some conserved water molecules in the structure and function of human transthyretin.

Banerjee A, Dasgupta S, Mukhopadhyay BP, Sekar K.

Acta Crystallogr D Biol Crystallogr. 2015 Nov;71(Pt 11):2248-66. doi: 10.1107/S1399004715016004. Epub 2015 Oct 31.

PMID:
26527142
29.

Catalytic pathway, substrate binding and stability in SAICAR synthetase: A structure and molecular dynamics study.

Manjunath K, Jeyakanthan J, Sekar K.

J Struct Biol. 2015 Jul;191(1):22-31. doi: 10.1016/j.jsb.2015.06.006. Epub 2015 Jun 10.

PMID:
26072057
30.

EDIL3 is a novel regulator of epithelial-mesenchymal transition controlling early recurrence of hepatocellular carcinoma.

Xia H, Chen J, Shi M, Gao H, Sekar K, Seshachalam VP, Ooi LL, Hui KM.

J Hepatol. 2015 Oct;63(4):863-73. doi: 10.1016/j.jhep.2015.05.005. Epub 2015 May 14.

PMID:
25980764
31.

Regulatory effects on central carbon metabolism from poly-3-hydroxybutryate synthesis.

Sekar K, Tyo KEJ.

Metab Eng. 2015 Mar;28:180-189. doi: 10.1016/j.ymben.2015.01.003. Epub 2015 Jan 15.

PMID:
25598516
32.

Haemophilus influenzae Genome Database (HIGDB): a single point web resource for Haemophilus influenzae.

Swetha RG, Kala Sekar DK, Ramaiah S, Anbarasu A, Sekar K.

Comput Biol Med. 2014 Dec;55:86-91. doi: 10.1016/j.compbiomed.2014.10.001. Epub 2014 Oct 14.

PMID:
25450223
33.

Anthrapyrazolone analogues intercept inflammatory JNK signals to moderate endotoxin induced septic shock.

Prasad KD, Trinath J, Biswas A, Sekar K, Balaji KN, Guru Row TN.

Sci Rep. 2014 Nov 27;4:7214. doi: 10.1038/srep07214.

34.

Streptococcus pneumoniae Genome Database (SPGDB): a database for strain specific comparative analysis of Streptococcus pneumoniae genes and proteins.

Swetha RG, Sekar DK, Devi ED, Ahmed ZZ, Ramaiah S, Anbarasu A, Sekar K.

Genomics. 2014 Dec;104(6 Pt B):582-6. doi: 10.1016/j.ygeno.2014.09.012. Epub 2014 Sep 28.

35.

Adverse cardiac events after orthotopic liver transplantation: a cross-sectional study in 389 consecutive patients.

Nicolau-Raducu R, Gitman M, Ganier D, Loss GE, Cohen AJ, Patel H, Girgrah N, Sekar K, Nossaman B.

Liver Transpl. 2015 Jan;21(1):13-21. doi: 10.1002/lt.23997.

36.

Catecholamine-resistant hypotension and myocardial performance following patent ductus arteriosus ligation.

Noori S, McNamara P, Jain A, Lavoie PM, Wickremasinghe A, Merritt TA, Solomon T, Sekar K, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, Poindexter BB, Brook M, Auchus RJ, Clyman RI; PDA Ligation/Hypotension Trial Investigators.

J Perinatol. 2015 Feb;35(2):123-7. doi: 10.1038/jp.2014.151. Epub 2014 Aug 14.

37.

Do we see what we should see? Describing non-covalent interactions in protein structures including precision.

Gurusaran M, Shankar M, Nagarajan R, Helliwell JR, Sekar K.

IUCrJ. 2013 Dec 5;1(Pt 1):74-81. doi: 10.1107/S2052252513031485. eCollection 2014 Jan 1.

38.

Alkyl chain substituted 1,9-pyrazoloanthrones exhibit prominent inhibitory effect on c-Jun N-terminal kinase (JNK).

Prasad KD, Trinath J, Biswas A, Sekar K, Balaji KN, Guru Row TN.

Org Biomol Chem. 2014 Jul 14;12(26):4656-62. doi: 10.1039/c4ob00548a.

PMID:
24853961
39.

Hypotension following patent ductus arteriosus ligation: the role of adrenal hormones.

Clyman RI, Wickremasinghe A, Merritt TA, Solomon T, McNamara P, Jain A, Singh J, Chu A, Noori S, Sekar K, Lavoie PM, Attridge JT, Swanson JR, Gillam-Krakauer M, Reese J, DeMauro S, Poindexter B, Aucott S, Satpute M, Fernandez E, Auchus RJ; Patent Ductus Arteriosus Ligation/Hypotension Trial Investigators.

J Pediatr. 2014 Jun;164(6):1449-55.e1. doi: 10.1016/j.jpeds.2014.01.058. Epub 2014 Mar 15.

40.

PPS: A computing engine to find Palindromes in all Protein sequences.

Ahmed Z, Gurusaran M, Narayana P, Kumar KS, Mohanapriya J, Vaishnavi MK, Sekar K.

Bioinformation. 2014 Jan 29;10(1):48-51. doi: 10.6026/97320630010048. eCollection 2014.

41.

Late preterm infant - Nature's unfinished master piece.

Nandyal R, Sekar K.

Zhongguo Dang Dai Er Ke Za Zhi. 2013 Dec;15(12):1037-44.

42.

A blood-based three-gene signature for the non-invasive detection of early human hepatocellular carcinoma.

Shi M, Chen MS, Sekar K, Tan CK, Ooi LL, Hui KM.

Eur J Cancer. 2014 Mar;50(5):928-36. doi: 10.1016/j.ejca.2013.11.026. Epub 2013 Dec 11.

PMID:
24332572
43.

Reactivity of Cyclanols Towards Quinaldinium Fluorochromate Oxidation.

Sekar KG, Sakthivel RV.

J Solution Chem. 2013;42:1748-1756. Epub 2013 Sep 29.

44.

Molecular dynamics perspective on the protein thermal stability: a case study using SAICAR synthetase.

Manjunath K, Sekar K.

J Chem Inf Model. 2013 Sep 23;53(9):2448-61. doi: 10.1021/ci400306m. Epub 2013 Sep 6.

PMID:
23962324
45.

RepEx: repeat extractor for biological sequences.

Gurusaran M, Ravella D, Sekar K.

Genomics. 2013 Oct;102(4):403-8. doi: 10.1016/j.ygeno.2013.07.005. Epub 2013 Jul 21.

46.

Conserved water-mediated recognition and dynamics of NAD+ (carboxamide group) to hIMPDH enzyme: water mimic approach toward the design of isoform-selective inhibitor.

Bairagya HR, Mishra DK, Mukhopadhyay BP, Sekar K.

J Biomol Struct Dyn. 2014;32(8):1248-62. doi: 10.1080/07391102.2013.812982. Epub 2013 Jul 8.

PMID:
23829371
47.

Antibiofilm and quorum sensing inhibitory activity of Achyranthes aspera on cariogenic Streptococcus mutans: an in vitro and in silico study.

Murugan K, Sekar K, Sangeetha S, Ranjitha S, Sohaibani SA.

Pharm Biol. 2013 Jun;51(6):728-36. doi: 10.3109/13880209.2013.764330. Epub 2013 Apr 11.

PMID:
23577802
48.

A method to find palindromes in nucleic acid sequences.

Anjana R, Shankar M, Vaishnavi MK, Sekar K.

Bioinformation. 2013;9(5):255-8. doi: 10.6026/97320630009255. Epub 2013 Mar 2.

49.

Cortical response tracking the conscious experience of threshold duration visual stimuli indicates visual perception is all or none.

Sekar K, Findley WM, Poeppel D, Llinás RR.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5642-7. doi: 10.1073/pnas.1302229110. Epub 2013 Mar 18.

50.

In response to "Detection of body packing by magnetic resonance imaging: a new diagnostic tool?".

Connors NJ, Sekar K, Howland MA, Hoffman RS, Nelson LS.

Abdom Imaging. 2013 Aug;38(4):879. doi: 10.1007/s00261-013-9994-7. No abstract available.

PMID:
23494715

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