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Items: 49


Accelerated evolution and diversifying selection drove the adaptation of cetacean bone microstructure.

Sun D, Zhou X, Yu Z, Xu S, Seim I, Yang G.

BMC Evol Biol. 2019 Oct 24;19(1):194. doi: 10.1186/s12862-019-1509-x.


The long non-coding RNA GHSROS facilitates breast cancer cell migration and orthotopic xenograft tumour growth.

Thomas PB, Seim I, Jeffery PL, Gahete MD, Maugham M, Crisp GJ, Stacey A, Shah ET, Walpole C, Whiteside EJ, Nelson CC, Herington AC, Luque RM, Veedu RN, Chopin LK.

Int J Oncol. 2019 Dec;55(6):1223-1236. doi: 10.3892/ijo.2019.4891. Epub 2019 Oct 4.


Distinct evolution of toll-like receptor signaling pathway genes in cetaceans.

Tian R, Seim I, Zhang Z, Yang Y, Ren W, Xu S, Yang G.

Genes Genomics. 2019 Dec;41(12):1417-1430. doi: 10.1007/s13258-019-00861-3. Epub 2019 Sep 18.


MUC13 promotes the development of colitis-associated colorectal tumors via β-catenin activity.

Sheng YH, Wong KY, Seim I, Wang R, He Y, Wu A, Patrick M, Lourie R, Schreiber V, Giri R, Ng CP, Popat A, Hooper J, Kijanka G, Florin TH, Begun J, Radford KJ, Hasnain S, McGuckin MA.

Oncogene. 2019 Aug 19. doi: 10.1038/s41388-019-0951-y. [Epub ahead of print]


Constraints to counting bioluminescence producing cells by a commonly used transgene promoter and its implications for experimental design.

Mosaad EO, Futrega K, Seim I, Gloss B, Chambers KF, Clements JA, Doran MR.

Sci Rep. 2019 Aug 5;9(1):11334. doi: 10.1038/s41598-019-46916-z.


Contraction of the ROS Scavenging Enzyme Glutathione S-Transferase Gene Family in Cetaceans.

Tian R, Seim I, Ren W, Xu S, Yang G.

G3 (Bethesda). 2019 Jul 9;9(7):2303-2315. doi: 10.1534/g3.119.400224.


A chromosome-level genome of black rockfish, Sebastes schlegelii, provides insights into the evolution of live birth.

He Y, Chang Y, Bao L, Yu M, Li R, Niu J, Fan G, Song W, Seim I, Qin Y, Li X, Liu J, Kong X, Peng M, Sun M, Wang M, Qu J, Wang X, Liu X, Wu X, Zhao X, Wang X, Zhang Y, Guo J, Liu Y, Liu K, Wang Y, Zhang H, Liu L, Wang M, Yu H, Wang X, Cheng J, Wang Z, Xu X, Wang J, Yang H, Lee SM, Liu X, Zhang Q, Qi J.

Mol Ecol Resour. 2019 Sep;19(5):1309-1321. doi: 10.1111/1755-0998.13034. Epub 2019 Jul 9.


Mucus accumulation in the lungs precedes structural changes and infection in children with cystic fibrosis.

Esther CR Jr, Muhlebach MS, Ehre C, Hill DB, Wolfgang MC, Kesimer M, Ramsey KA, Markovetz MR, Garbarine IC, Forest MG, Seim I, Zorn B, Morrison CB, Delion MF, Thelin WR, Villalon D, Sabater JR, Turkovic L, Ranganathan S, Stick SM, Boucher RC.

Sci Transl Med. 2019 Apr 3;11(486). pii: eaav3488. doi: 10.1126/scitranslmed.aav3488.


No effect of unacylated ghrelin administration on subcutaneous PC3 xenograft growth or metabolic parameters in a Rag1-/- mouse model of metabolic dysfunction.

Maugham ML, Seim I, Thomas PB, Crisp GJ, Shah ET, Herington AC, Brown KA, Gregory LS, Nelson CC, Jeffery PL, Chopin LK.

PLoS One. 2018 Nov 20;13(11):e0198495. doi: 10.1371/journal.pone.0198495. eCollection 2018.


Limited short-term effects on human prostate cancer xenograft growth and epidermal growth factor receptor gene expression by the ghrelin receptor antagonist [D-Lys3]-GHRP-6.

Maugham ML, Seim I, Thomas PB, Crisp GJ, Shah ET, Herington AC, Gregory LS, Nelson CC, Jeffery PL, Chopin LK.

Endocrine. 2019 May;64(2):393-405. doi: 10.1007/s12020-018-1796-9. Epub 2018 Nov 2.


RadAA: A Command-line Tool for Identification of Radical Amino Acid Changes in Multiple Sequence Alignments.

Seim I, Baker AM, Chopin LK.

Mol Inform. 2019 Jan;38(1-2):e1800057. doi: 10.1002/minf.201800057. Epub 2018 Jul 17.


Transparency on scientific instruments.

Bergenholtz C, MacAulay SC, Kolympiris C, Seim I.

EMBO Rep. 2018 Jun;19(6). pii: e45853. doi: 10.15252/embr.201845853. Epub 2018 May 22. No abstract available.


Population genomics of finless porpoises reveal an incipient cetacean species adapted to freshwater.

Zhou X, Guang X, Sun D, Xu S, Li M, Seim I, Jie W, Yang L, Zhu Q, Xu J, Gao Q, Kaya A, Dou Q, Chen B, Ren W, Li S, Zhou K, Gladyshev VN, Nielsen R, Fang X, Yang G.

Nat Commun. 2018 Apr 10;9(1):1276. doi: 10.1038/s41467-018-03722-x.


Adaptive Evolution of Energy Metabolism-Related Genes in Hypoxia-Tolerant Mammals.

Tian R, Yin D, Liu Y, Seim I, Xu S, Yang G.

Front Genet. 2017 Dec 7;8:205. doi: 10.3389/fgene.2017.00205. eCollection 2017.


Technological strategies to estimate and control diffusive passage times through the mucus barrier in mucosal drug delivery.

Newby JM, Seim I, Lysy M, Ling Y, Huckaby J, Lai SK, Forest MG.

Adv Drug Deliv Rev. 2018 Jan 15;124:64-81. doi: 10.1016/j.addr.2017.12.002. Epub 2017 Dec 12. Review.


Gene expression signatures of human cell and tissue longevity.

Seim I, Ma S, Gladyshev VN.

NPJ Aging Mech Dis. 2016 Jul 7;2:16014. doi: 10.1038/npjamd.2016.14. eCollection 2016.


Whole-Genome Sequence of the Metastatic PC3 and LNCaP Human Prostate Cancer Cell Lines.

Seim I, Jeffery PL, Thomas PB, Nelson CC, Chopin LK.

G3 (Bethesda). 2017 Jun 7;7(6):1731-1741. doi: 10.1534/g3.117.039909.


Insights from engraftable immunodeficient mouse models of hyperinsulinaemia.

Maugham ML, Thomas PB, Crisp GJ, Philp LK, Shah ET, Herington AC, Chen C, Gregory LS, Nelson CC, Seim I, Jeffery PL, Chopin LK.

Sci Rep. 2017 Mar 28;7(1):491. doi: 10.1038/s41598-017-00443-x.


MUC13 overexpression in renal cell carcinoma plays a central role in tumor progression and drug resistance.

Sheng Y, Ng CP, Lourie R, Shah ET, He Y, Wong KY, Seim I, Oancea I, Morais C, Jeffery PL, Hooper J, Gobe GC, McGuckin MA.

Int J Cancer. 2017 May 15;140(10):2351-2363. doi: 10.1002/ijc.30651. Epub 2017 Feb 28.


Erratum to: Fusion transcript loci share many genomic features with non-fusion loci.

Lai J, An J, Seim I, Walpole C, Hoffman A, Moya L, Srinivasan S, Perry-Keene JL; Australian Prostate Cancer Bioresource, Wang C, Lehman ML, Nelson CC, Clements JA, Batra J.

BMC Genomics. 2016 Jun 3;17(1):424. No abstract available.


Multi-species sequence comparison reveals conservation of ghrelin gene-derived splice variants encoding a truncated ghrelin peptide.

Seim I, Jeffery PL, Thomas PB, Walpole CM, Maugham M, Fung JN, Yap PY, O'Keeffe AJ, Lai J, Whiteside EJ, Herington AC, Chopin LK.

Endocrine. 2016 Jun;52(3):609-17. doi: 10.1007/s12020-015-0848-7. Epub 2016 Jan 20.


Fusion transcript loci share many genomic features with non-fusion loci.

Lai J, An J, Seim I, Walpole C, Hoffman A, Moya L, Srinivasan S, Perry-Keene JL; Australian Prostate Cancer Bioresource, Wang C, Lehman ML, Nelson CC, Clements JA, Batra J.

BMC Genomics. 2015 Dec 1;16:1021. doi: 10.1186/s12864-015-2235-4. Erratum in: BMC Genomics. 2016;17:424.


Convergent evolution of marine mammals is associated with distinct substitutions in common genes.

Zhou X, Seim I, Gladyshev VN.

Sci Rep. 2015 Nov 9;5:16550. doi: 10.1038/srep16550.


Adaptive aneuploidy protects against thiol peroxidase deficiency by increasing respiration via key mitochondrial proteins.

Kaya A, Gerashchenko MV, Seim I, Labarre J, Toledano MB, Gladyshev VN.

Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):10685-90. doi: 10.1073/pnas.1505315112. Epub 2015 Aug 10.


Comparative analysis of genome maintenance genes in naked mole rat, mouse, and human.

MacRae SL, Zhang Q, Lemetre C, Seim I, Calder RB, Hoeijmakers J, Suh Y, Gladyshev VN, Seluanov A, Gorbunova V, Vijg J, Zhang ZD.

Aging Cell. 2015 Apr;14(2):288-91. doi: 10.1111/acel.12314. Epub 2015 Jan 28.


Comparative analysis reveals loss of the appetite-regulating peptide hormone ghrelin in falcons.

Seim I, Jeffery PL, Herington AC, Chopin LK.

Gen Comp Endocrinol. 2015 May 15;216:98-102. doi: 10.1016/j.ygcen.2014.11.016. Epub 2014 Dec 8.


The transcriptome of the bowhead whale Balaena mysticetus reveals adaptations of the longest-lived mammal.

Seim I, Ma S, Zhou X, Gerashchenko MV, Lee SG, Suydam R, George JC, Bickham JW, Gladyshev VN.

Aging (Albany NY). 2014 Oct;6(10):879-99.


Associations between ghrelin and ghrelin receptor polymorphisms and cancer in Caucasian populations: a meta-analysis.

Pabalan NA, Seim I, Jarjanazi H, Chopin LK.

BMC Genet. 2014 Nov 7;15:118. doi: 10.1186/s12863-014-0118-3.


Cloning and tissue distribution of novel splice variants of the ovine ghrelin gene.

Menzies M, Seim I, Josh P, Nagaraj SH, Lees M, Walpole C, Chopin LK, Colgrave M, Ingham A.

BMC Vet Res. 2014 Sep 6;10:211. doi: 10.1186/s12917-014-0211-x.


Adaptations to a subterranean environment and longevity revealed by the analysis of mole rat genomes.

Fang X, Seim I, Huang Z, Gerashchenko MV, Xiong Z, Turanov AA, Zhu Y, Lobanov AV, Fan D, Yim SH, Yao X, Ma S, Yang L, Lee SG, Kim EB, Bronson RT, Šumbera R, Buffenstein R, Zhou X, Krogh A, Park TJ, Zhang G, Wang J, Gladyshev VN.

Cell Rep. 2014 Sep 11;8(5):1354-64. doi: 10.1016/j.celrep.2014.07.030. Epub 2014 Aug 28.


Turtle ghrelin.

Seim I, Jeffery PL, Herington AC, Chopin LK.

Nat Genet. 2014 Jun;46(6):525-6. doi: 10.1038/ng.2964. No abstract available.


Genome analysis reveals insights into physiology and longevity of the Brandt's bat Myotis brandtii.

Seim I, Fang X, Xiong Z, Lobanov AV, Huang Z, Ma S, Feng Y, Turanov AA, Zhu Y, Lenz TL, Gerashchenko MV, Fan D, Hee Yim S, Yao X, Jordan D, Xiong Y, Ma Y, Lyapunov AN, Chen G, Kulakova OI, Sun Y, Lee SG, Bronson RT, Moskalev AA, Sunyaev SR, Zhang G, Krogh A, Wang J, Gladyshev VN.

Nat Commun. 2013;4:2212. doi: 10.1038/ncomms3212.


Ghrelin O-acyltransferase (GOAT) is expressed in prostate cancer tissues and cell lines and expression is differentially regulated in vitro by ghrelin.

Seim I, Jeffery PL, de Amorim L, Walpole CM, Fung J, Whiteside EJ, Lourie R, Herington AC, Chopin LK.

Reprod Biol Endocrinol. 2013 Jul 23;11:70. doi: 10.1186/1477-7827-11-70.


Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo.

Fung JN, Jeffery PL, Lee JD, Seim I, Roche D, Obermair A, Chopin LK, Chen C.

Am J Physiol Endocrinol Metab. 2013 Jul 15;305(2):E305-13. doi: 10.1152/ajpendo.00156.2013. Epub 2013 Jun 4.


Identification of a long non-coding RNA gene, growth hormone secretagogue receptor opposite strand, which stimulates cell migration in non-small cell lung cancer cell lines.

Whiteside EJ, Seim I, Pauli JP, O'Keeffe AJ, Thomas PB, Carter SL, Walpole CM, Fung JN, Josh P, Herington AC, Chopin LK.

Int J Oncol. 2013 Aug;43(2):566-74. doi: 10.3892/ijo.2013.1969. Epub 2013 May 30.


Cloning of a novel insulin-regulated ghrelin transcript in prostate cancer.

Seim I, Lubik AA, Lehman ML, Tomlinson N, Whiteside EJ, Herington AC, Nelson CC, Chopin LK.

J Mol Endocrinol. 2013 Feb 15;50(2):179-91. doi: 10.1530/JME-12-0150. Print 2013 Apr.


The ghrelin axis--does it have an appetite for cancer progression?

Chopin LK, Seim I, Walpole CM, Herington AC.

Endocr Rev. 2012 Dec;33(6):849-91. doi: 10.1210/er.2011-1007. Epub 2012 Jul 23. Review.


Irritable bowel syndrome: the role of gut neuroendocrine peptides.

El-Salhy M, Seim I, Chopin L, Gundersen D, Hatlebakk JG, Hausken T.

Front Biosci (Elite Ed). 2012 Jun 1;4:2783-800. Review.


Ghrelin and the brain-gut axis as a pharmacological target for appetite control.

Seim I, El-Salhy M, Hausken T, Gundersen D, Chopin L.

Curr Pharm Des. 2012;18(6):768-75. Review.


Expression and in vitro functions of the ghrelin axis in endometrial cancer.

Fung JN, Seim I, Wang D, Obermair A, Chopin LK, Chen C.

Horm Cancer. 2010 Oct;1(5):245-55. doi: 10.1007/s12672-010-0047-1.


Ghrelin axis genes, peptides and receptors: recent findings and future challenges.

Seim I, Josh P, Cunningham P, Herington A, Chopin L.

Mol Cell Endocrinol. 2011 Jun 20;340(1):3-9. doi: 10.1016/j.mce.2011.05.002. Epub 2011 May 25. Review.


Ghrelin and cancer.

Chopin L, Walpole C, Seim I, Cunningham P, Murray R, Whiteside E, Josh P, Herington A.

Mol Cell Endocrinol. 2011 Jun 20;340(1):65-9. doi: 10.1016/j.mce.2011.04.013. Epub 2011 May 25. Review.


The expanding roles of the ghrelin-gene derived peptide obestatin in health and disease.

Seim I, Walpole C, Amorim L, Josh P, Herington A, Chopin L.

Mol Cell Endocrinol. 2011 Jun 20;340(1):111-7. doi: 10.1016/j.mce.2011.03.018. Epub 2011 Apr 1. Review.


A variant of the KLK4 gene is expressed as a cis sense-antisense chimeric transcript in prostate cancer cells.

Lai J, Lehman ML, Dinger ME, Hendy SC, Mercer TR, Seim I, Lawrence MG, Mattick JS, Clements JA, Nelson CC.

RNA. 2010 Jun;16(6):1156-66. doi: 10.1261/rna.2019810. Epub 2010 Apr 20.


New insights into the molecular complexity of the ghrelin gene locus.

Seim I, Herington AC, Chopin LK.

Cytokine Growth Factor Rev. 2009 Aug;20(4):297-304. doi: 10.1016/j.cytogfr.2009.07.006. Epub 2009 Aug 8. Review.


Ghrelin gene-related peptides: multifunctional endocrine / autocrine modulators in health and disease.

Seim I, Amorim L, Walpole C, Carter S, Chopin LK, Herington AC.

Clin Exp Pharmacol Physiol. 2010 Jan;37(1):125-31. doi: 10.1111/j.1440-1681.2009.05241.x. Epub 2009 Jun 29.


The proximal first exon architecture of the murine ghrelin gene is highly similar to its human orthologue.

Seim I, Carter SL, Herington AC, Chopin LK.

BMC Res Notes. 2009 May 9;2:85. doi: 10.1186/1756-0500-2-85.


Complex organisation and structure of the ghrelin antisense strand gene GHRLOS, a candidate non-coding RNA gene.

Seim I, Carter SL, Herington AC, Chopin LK.

BMC Mol Biol. 2008 Oct 28;9:95. doi: 10.1186/1471-2199-9-95.

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