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Altering the Neisseria gonorrhoeae pilE Guanine Quadruplex Loop Bases Affects Pilin Antigenic Variation.

Prister LL, Yin S, Cahoon LA, Seifert HS.

Biochemistry. 2020 Mar 17;59(10):1104-1112. doi: 10.1021/acs.biochem.9b01038. Epub 2020 Feb 27.



Unemo M, Seifert HS, Hook EW 3rd, Hawkes S, Ndowa F, Dillon JR.

Nat Rev Dis Primers. 2019 Nov 21;5(1):79. doi: 10.1038/s41572-019-0128-6. Review.


PacBio Amplicon Sequencing Method To Measure Pilin Antigenic Variation Frequencies of Neisseria gonorrhoeae.

Ozer EA, Prister LL, Yin S, Ward BH, Ivanov S, Seifert HS.

mSphere. 2019 Oct 2;4(5). pii: e00562-19. doi: 10.1128/mSphere.00562-19.


Transcriptional initiation of a small RNA, not R-loop stability, dictates the frequency of pilin antigenic variation in Neisseria gonorrhoeae.

Prister LL, Ozer EA, Cahoon LA, Seifert HS.

Mol Microbiol. 2019 Oct;112(4):1219-1234. doi: 10.1111/mmi.14356. Epub 2019 Aug 8.


Anti-psychotic drugs block meningococcal virulence.

Seifert HS.

Nat Microbiol. 2019 Jun;4(6):906-907. doi: 10.1038/s41564-019-0467-9. No abstract available.


A Double-Strand Break Does Not Promote Neisseria gonorrhoeae Pilin Antigenic Variation.

Prister LL, Xu J, Seifert HS.

J Bacteriol. 2019 Jun 10;201(13). pii: e00256-19. doi: 10.1128/JB.00256-19. Print 2019 Jul 1.


Location, Location, Location-Commensalism, Damage and Evolution of the Pathogenic Neisseria.

Seifert HS.

J Mol Biol. 2019 Jul 26;431(16):3010-3014. doi: 10.1016/j.jmb.2019.04.007. Epub 2019 Apr 12. Review.


R-loops modulate Trypanosome antigenic variation.

Prister LL, Seifert HS.

PLoS Genet. 2018 Dec 13;14(12):e1007809. doi: 10.1371/journal.pgen.1007809. eCollection 2018 Dec. No abstract available.


Neisseria gonorrhoeae Exposed to Sublethal Levels of Hydrogen Peroxide Mounts a Complex Transcriptional Response.

Quillin SJ, Hockenberry AJ, Jewett MC, Seifert HS.

mSystems. 2018 Oct 2;3(5). pii: e00156-18. doi: 10.1128/mSystems.00156-18. eCollection 2018 Sep-Oct.


Analysis of Pilin Antigenic Variation in Neisseria meningitidis by Next-Generation Sequencing.

Xu J, Seifert HS.

J Bacteriol. 2018 Oct 23;200(22). pii: e00465-18. doi: 10.1128/JB.00465-18. Print 2018 Nov 15.


Above and Beyond Watson and Crick: Guanine Quadruplex Structures and Microbes.

Seifert HS.

Annu Rev Microbiol. 2018 Sep 8;72:49-69. doi: 10.1146/annurev-micro-090817-062629. Epub 2018 May 31. Review.


The low-molecular-mass, penicillin-binding proteins DacB and DacC combine to modify peptidoglycan cross-linking and allow stable Type IV pilus expression in Neisseria gonorrhoeae.

Obergfell KP, Schaub RE, Priniski LL, Dillard JP, Seifert HS.

Mol Microbiol. 2018 Mar 24. doi: 10.1111/mmi.13955. [Epub ahead of print]


Neisseria gonorrhoeae host adaptation and pathogenesis.

Quillin SJ, Seifert HS.

Nat Rev Microbiol. 2018 Apr;16(4):226-240. doi: 10.1038/nrmicro.2017.169. Epub 2018 Feb 12. Review.


Haemophilus spills its guts to make a biofilm.

Seifert HS.

Proc Natl Acad Sci U S A. 2017 Aug 8;114(32):8444-8446. doi: 10.1073/pnas.1711077114. Epub 2017 Jul 26. No abstract available.


Analyzing Neisseria gonorrhoeae Pilin Antigenic Variation Using 454 Sequencing Technology.

Rotman E, Webber DM, Seifert HS.

J Bacteriol. 2016 Aug 25;198(18):2470-82. doi: 10.1128/JB.00330-16. Print 2016 Sep 15.


Seminal Plasma Promotes Neisseria gonorrhoeae Aggregation and Biofilm Formation.

Anderson MT, Byerly L, Apicella MA, Seifert HS.

J Bacteriol. 2016 Jul 28;198(16):2228-35. doi: 10.1128/JB.00165-16. Print 2016 Aug 15.


The Pilin N-terminal Domain Maintains Neisseria gonorrhoeae Transformation Competence during Pilus Phase Variation.

Obergfell KP, Seifert HS.

PLoS Genet. 2016 May 23;12(5):e1006069. doi: 10.1371/journal.pgen.1006069. eCollection 2016 May.


Antigenic Variation in Bacterial Pathogens.

Palmer GH, Bankhead T, Seifert HS.

Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.VMBF-0005-2015.


Amidase Activity of AmiC Controls Cell Separation and Stem Peptide Release and Is Enhanced by NlpD in Neisseria gonorrhoeae.

Lenz JD, Stohl EA, Robertson RM, Hackett KT, Fisher K, Xiong K, Lee M, Hesek D, Mobashery S, Seifert HS, Davies C, Dillard JP.

J Biol Chem. 2016 May 13;291(20):10916-33. doi: 10.1074/jbc.M116.715573. Epub 2016 Mar 16.


The Gonococcal NlpD Protein Facilitates Cell Separation by Activating Peptidoglycan Cleavage by AmiC.

Stohl EA, Lenz JD, Dillard JP, Seifert HS.

J Bacteriol. 2015 Nov 16;198(4):615-22. doi: 10.1128/JB.00540-15.


Neisseria meningitidis Lacking the Major Porins PorA and PorB Is Viable and Modulates Apoptosis and the Oxidative Burst of Neutrophils.

Peak IR, Chen A, Jen FE, Jennings C, Schulz BL, Saunders NJ, Khan A, Seifert HS, Jennings MP.

J Proteome Res. 2016 Aug 5;15(8):2356-65. doi: 10.1021/acs.jproteome.5b00938. Epub 2016 Jul 21.


DNase H Activity of Neisseria meningitidis Cas9.

Zhang Y, Rajan R, Seifert HS, Mondragón A, Sontheimer EJ.

Mol Cell. 2015 Oct 15;60(2):242-55. doi: 10.1016/j.molcel.2015.09.020.


Neisseria gonorrhoeae survives within and modulates apoptosis and inflammatory cytokine production of human macrophages.

Château A, Seifert HS.

Cell Microbiol. 2016 Apr;18(4):546-60. doi: 10.1111/cmi.12529. Epub 2015 Oct 26.


Neisseria meningitidis Type IV Pili Composed of Sequence Invariable Pilins Are Masked by Multisite Glycosylation.

Gault J, Ferber M, Machata S, Imhaus AF, Malosse C, Charles-Orszag A, Millien C, Bouvier G, Bardiaux B, Péhau-Arnaudet G, Klinge K, Podglajen I, Ploy MC, Seifert HS, Nilges M, Chamot-Rooke J, Duménil G.

PLoS Pathog. 2015 Sep 14;11(9):e1005162. doi: 10.1371/journal.ppat.1005162. eCollection 2015 Sep.


Mobile DNA in the Pathogenic Neisseria.

Obergfell KP, Seifert HS.

Microbiol Spectr. 2015 Feb;3(1):MDNA3-0015-2014. doi: 10.1128/microbiolspec.MDNA3-0015-2014. Review.


Mobile DNA in the pathogenic Neisseria.

Obergfell KP, Seifert HS.

Microbiol Spectr. 2015 Feb;3(3). pii: MDNA3-0015-2014.


Neisseria gonorrhoeae MutS affects pilin antigenic variation through mismatch correction and not by pilE guanine quartet binding.

Rotman E, Seifert HS.

J Bacteriol. 2015 May;197(10):1828-38. doi: 10.1128/JB.02594-14. Epub 2015 Mar 16.


Neisseria gonorrhoeae elicits extracellular traps in primary neutrophil culture while suppressing the oxidative burst.

Gunderson CW, Seifert HS.

mBio. 2015 Feb 10;6(1). pii: e02452-14. doi: 10.1128/mBio.02452-14.


The genetics of Neisseria species.

Rotman E, Seifert HS.

Annu Rev Genet. 2014;48:405-31. doi: 10.1146/annurev-genet-120213-092007. Epub 2014 Sep 10. Review.


Seminal plasma initiates a Neisseria gonorrhoeae transmission state.

Anderson MT, Dewenter L, Maier B, Seifert HS.

mBio. 2014 Mar 4;5(2):e01004-13. doi: 10.1128/mBio.01004-13.


Saturating mutagenesis of an essential gene: a majority of the Neisseria gonorrhoeae major outer membrane porin (PorB) is mutable.

Chen A, Seifert HS.

J Bacteriol. 2014 Feb;196(3):540-7. doi: 10.1128/JB.01073-13. Epub 2013 Nov 15.


Structure-function studies of the Neisseria gonorrhoeae major outer membrane porin.

Chen A, Seifert HS.

Infect Immun. 2013 Dec;81(12):4383-91. doi: 10.1128/IAI.00367-13. Epub 2013 Sep 16.


Phase variation leads to the misidentification of a Neisseria gonorrhoeae virulence gene.

Anderson MT, Seifert HS.

PLoS One. 2013 Aug 16;8(8):e72183. doi: 10.1371/journal.pone.0072183. eCollection 2013.


Processing-independent CRISPR RNAs limit natural transformation in Neisseria meningitidis.

Zhang Y, Heidrich N, Ampattu BJ, Gunderson CW, Seifert HS, Schoen C, Vogel J, Sontheimer EJ.

Mol Cell. 2013 May 23;50(4):488-503. doi: 10.1016/j.molcel.2013.05.001.


Neisseria gonorrhoeae RecQ helicase HRDC domains are essential for efficient binding and unwinding of the pilE guanine quartet structure required for pilin antigenic variation.

Cahoon LA, Manthei KA, Rotman E, Keck JL, Seifert HS.

J Bacteriol. 2013 May;195(10):2255-61. doi: 10.1128/JB.02217-12. Epub 2013 Mar 8.


Transcription of a cis-acting, noncoding, small RNA is required for pilin antigenic variation in Neisseria gonorrhoeae.

Cahoon LA, Seifert HS.

PLoS Pathog. 2013 Jan;9(1):e1003074. doi: 10.1371/journal.ppat.1003074. Epub 2013 Jan 17.


RecA-binding pilE G4 sequence essential for pilin antigenic variation forms monomeric and 5' end-stacked dimeric parallel G-quadruplexes.

Kuryavyi V, Cahoon LA, Seifert HS, Patel DJ.

Structure. 2012 Dec 5;20(12):2090-102. doi: 10.1016/j.str.2012.09.013. Epub 2012 Oct 18.


Genetic transformation of Neisseria gonorrhoeae shows a strand preference.

Duffin PM, Seifert HS.

FEMS Microbiol Lett. 2012 Sep;334(1):44-8. doi: 10.1111/j.1574-6968.2012.02612.x. Epub 2012 Jul 3.


Neisseria gonorrhoeae virulence factor NG1686 is a bifunctional M23B family metallopeptidase that influences resistance to hydrogen peroxide and colony morphology.

Stohl EA, Chan YA, Hackett KT, Kohler PL, Dillard JP, Seifert HS.

J Biol Chem. 2012 Mar 30;287(14):11222-33. doi: 10.1074/jbc.M111.338830. Epub 2012 Feb 13.


A bacterial siren song: intimate interactions between Neisseria and neutrophils.

Criss AK, Seifert HS.

Nat Rev Microbiol. 2012 Jan 31;10(3):178-90. doi: 10.1038/nrmicro2713. Review.


Microbial antigenic variation mediated by homologous DNA recombination.

Vink C, Rudenko G, Seifert HS.

FEMS Microbiol Rev. 2012 Sep;36(5):917-48. doi: 10.1111/j.1574-6976.2011.00321.x. Epub 2012 Jan 17. Review.


Neisseria gonorrhoeae and humans perform an evolutionary LINE dance.

Anderson MT, Seifert HS.

Mob Genet Elements. 2011 May;1(1):85-87.


Neisseria gonorrhoeae-mediated inhibition of apoptotic signalling in polymorphonuclear leukocytes.

Chen A, Seifert HS.

Infect Immun. 2011 Nov;79(11):4447-58. doi: 10.1128/IAI.01267-10. Epub 2011 Aug 15.


Interactions with Host Cells Causes Neisseria meningitidis Pili to Become Unglued.

Chen A, Seifert HS.

Front Microbiol. 2011 Apr 4;2:66. doi: 10.3389/fmicb.2011.00066. eCollection 2011. No abstract available.


Focusing homologous recombination: pilin antigenic variation in the pathogenic Neisseria.

Cahoon LA, Seifert HS.

Mol Microbiol. 2011 Sep;81(5):1136-43. doi: 10.1111/j.1365-2958.2011.07773.x. Epub 2011 Aug 4. Review.


Purification and characterization of the RecA protein from Neisseria gonorrhoeae.

Stohl EA, Gruenig MC, Cox MM, Seifert HS.

PLoS One. 2011 Feb 17;6(2):e17101. doi: 10.1371/journal.pone.0017101.


Opportunity and means: horizontal gene transfer from the human host to a bacterial pathogen.

Anderson MT, Seifert HS.

mBio. 2011 Feb 15;2(1):e00005-11. doi: 10.1128/mBio.00005-11. Print 2011.


The DNA-binding activity of the Neisseria gonorrhoeae LexA orthologue NG1427 is modulated by oxidation.

Schook PO, Stohl EA, Criss AK, Seifert HS.

Mol Microbiol. 2011 Feb;79(4):846-60. doi: 10.1111/j.1365-2958.2010.07491.x. Epub 2010 Dec 22.


The Neisseria gonorrhoeae photolyase orthologue phrB is required for proper DNA supercoiling but does not function in photo-reactivation.

Cahoon LA, Stohl EA, Seifert HS.

Mol Microbiol. 2011 Feb;79(3):729-42. doi: 10.1111/j.1365-2958.2010.07481.x. Epub 2010 Dec 13.

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