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Items: 38

1.

The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2'-α-chloro-2'-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors.

Alexandre FR, Badaroux E, Bilello JP, Bot S, Bouisset T, Brandt G, Cappelle S, Chapron C, Chaves D, Convard T, Counor C, Da Costa D, Dukhan D, Gay M, Gosselin G, Griffon JF, Gupta K, Hernandez-Santiago B, La Colla M, Lioure MP, Milhau J, Paparin JL, Peyronnet J, Parsy C, Pierra Rouvière C, Rahali H, Rahali R, Salanson A, Seifer M, Serra I, Standring D, Surleraux D, Dousson CB.

Bioorg Med Chem Lett. 2017 Sep 15;27(18):4323-4330. doi: 10.1016/j.bmcl.2017.08.029. Epub 2017 Aug 16.

PMID:
28835346
2.

Discovery of benzophosphadiazine drug candidate IDX375: A novel hepatitis C allosteric NS5B RdRp inhibitor.

Paparin JL, Amador A, Badaroux E, Bot S, Caillet C, Convard T, Da Costa D, Dukhan D, Griffe L, Griffon JF, LaColla M, Leroy F, Liuzzi M, Giulia Loi A, McCarville J, Mascia V, Milhau J, Onidi L, Pierra C, Rahali R, Rosinosky E, Sais E, Seifer M, Surleraux D, Standring D, Dousson CB.

Bioorg Med Chem Lett. 2017 Jun 1;27(11):2634-2640. doi: 10.1016/j.bmcl.2017.01.017. Epub 2017 Jan 13.

PMID:
28416131
3.

Synthesis of potent and broad genotypically active NS5B HCV non-nucleoside inhibitors binding to the thumb domain allosteric site 2 of the viral polymerase.

Pierra Rouvière C, Amador A, Badaroux E, Convard T, Da Costa D, Dukhan D, Griffe L, Griffon JF, LaColla M, Leroy F, Liuzzi M, Loi AG, McCarville J, Mascia V, Milhau J, Onidi L, Paparin JL, Rahali R, Sais E, Seifer M, Surleraux D, Standring D, Dousson C.

Bioorg Med Chem Lett. 2016 Sep 15;26(18):4536-4541. doi: 10.1016/j.bmcl.2016.01.042. Epub 2016 Jan 22.

PMID:
27520942
4.

Discovery of the Aryl-phospho-indole IDX899, a Highly Potent Anti-HIV Non-nucleoside Reverse Transcriptase Inhibitor.

Dousson C, Alexandre FR, Amador A, Bonaric S, Bot S, Caillet C, Convard T, da Costa D, Lioure MP, Roland A, Rosinovsky E, Maldonado S, Parsy C, Trochet C, Storer R, Stewart A, Wang J, Mayes BA, Musiu C, Poddesu B, Vargiu L, Liuzzi M, Moussa A, Jakubik J, Hubbard L, Seifer M, Standring D.

J Med Chem. 2016 Mar 10;59(5):1891-8. doi: 10.1021/acs.jmedchem.5b01430. Epub 2016 Feb 3.

PMID:
26804933
5.

Design, synthesis and antiviral evaluation of 2'-C-methyl branched guanosine pronucleotides: the discovery of IDX184, a potent liver-targeted HCV polymerase inhibitor.

Sizun G, Pierra C, Peyronnet J, Badaroux E, Rabeson C, Benzaria-Prad S, Surleraux D, Loi AG, Musiu C, Liuzzi M, Seifer M, Standring D, Sommadossi JP, Gosselin G.

Future Med Chem. 2015;7(13):1675-700. doi: 10.4155/fmc.15.96. Epub 2015 Oct 1.

PMID:
26424162
6.

Discovery and structural diversity of the hepatitis C virus NS3/4A serine protease inhibitor series leading to clinical candidate IDX320.

Parsy CC, Alexandre FR, Bidau V, Bonnaterre F, Brandt G, Caillet C, Cappelle S, Chaves D, Convard T, Derock M, Gloux D, Griffon Y, Lallos LB, Leroy F, Liuzzi M, Loi AG, Moulat L, Chiara M, Rahali H, Roques V, Rosinovsky E, Savin S, Seifer M, Standring D, Surleraux D.

Bioorg Med Chem Lett. 2015 Nov 15;25(22):5427-36. doi: 10.1016/j.bmcl.2015.09.009. Epub 2015 Sep 5.

PMID:
26410074
7.

Synthesis and antiviral evaluation of a novel series of homoserine-based inhibitors of the hepatitis C virus NS3/4A serine protease.

Alexandre FR, Brandt G, Caillet C, Chaves D, Convard T, Derock M, Gloux D, Griffon Y, Lallos L, Leroy F, Liuzzi M, Loi AG, Moulat L, Musiu C, Parsy C, Rahali H, Roques V, Seifer M, Standring D, Surleraux D.

Bioorg Med Chem Lett. 2015 Sep 15;25(18):3984-91. doi: 10.1016/j.bmcl.2015.07.020. Epub 2015 Jul 14.

PMID:
26231161
8.

Structure-based design of a novel series of azetidine inhibitors of the hepatitis C virus NS3/4A serine protease.

Parsy C, Alexandre FR, Brandt G, Caillet C, Cappelle S, Chaves D, Convard T, Derock M, Gloux D, Griffon Y, Lallos L, Leroy F, Liuzzi M, Loi AG, Moulat L, Musiu C, Rahali H, Roques V, Seifer M, Standring D, Surleraux D.

Bioorg Med Chem Lett. 2014 Sep 15;24(18):4444-4449. doi: 10.1016/j.bmcl.2014.08.002. Epub 2014 Aug 9.

PMID:
25155387
9.

In vitro activity and resistance profile of samatasvir, a novel NS5A replication inhibitor of hepatitis C virus.

Bilello JP, Lallos LB, McCarville JF, La Colla M, Serra I, Chapron C, Gillum JM, Pierra C, Standring DN, Seifer M.

Antimicrob Agents Chemother. 2014 Aug;58(8):4431-42. doi: 10.1128/AAC.02777-13. Epub 2014 May 27.

10.

Synthesis of 2'-O,4'-C-alkylene-bridged ribonucleosides and their evaluation as inhibitors of HCV NS5B polymerase.

Chapron C, Glen R, La Colla M, Mayes BA, McCarville JF, Moore S, Moussa A, Sarkar R, Seifer M, Serra I, Stewart A.

Bioorg Med Chem Lett. 2014 Jun 15;24(12):2699-702. doi: 10.1016/j.bmcl.2014.04.050. Epub 2014 Apr 19.

PMID:
24815510
11.

Synthesis and biological evaluation of aryl-phospho-indole as novel HIV-1 non-nucleoside reverse transcriptase inhibitors.

Alexandre FR, Amador A, Bot S, Caillet C, Convard T, Jakubik J, Musiu C, Poddesu B, Vargiu L, Liuzzi M, Roland A, Seifer M, Standring D, Storer R, Dousson CB.

J Med Chem. 2011 Jan 13;54(1):392-5. doi: 10.1021/jm101142k. Epub 2010 Dec 13.

PMID:
21142105
12.

Telbivudine, a nucleoside analog inhibitor of HBV polymerase, has a different in vitro cross-resistance profile than the nucleotide analog inhibitors adefovir and tenofovir.

Seifer M, Patty A, Serra I, Li B, Standring DN.

Antiviral Res. 2009 Feb;81(2):147-55. doi: 10.1016/j.antiviral.2008.10.008. Epub 2008 Nov 24.

PMID:
19028525
13.

2'-C-Methyl branched pyrimidine ribonucleoside analogues: potent inhibitors of RNA virus replication.

Benzaria S, Bardiot D, Bouisset T, Counor C, Rabeson C, Pierra C, Storer R, Loi AG, Cadeddu A, Mura M, Musiu C, Liuzzi M, Loddo R, Bergelson S, Bichko V, Bridges E, Cretton-Scott E, Mao J, Sommadossi JP, Seifer M, Standring D, Tausek M, Gosselin G, La Colla P.

Antivir Chem Chemother. 2007;18(4):225-42.

PMID:
17907380
14.

Diagnosis of an intraoperative aortic dissection by transesophageal echocardiography during routine coronary artery bypass grafting surgery.

Cottrell DJ, Cornett ES, Seifer MS, Kincaid EH, Zvara DA.

Anesth Analg. 2003 Nov;97(5):1254-6.

PMID:
14570632
15.

Optimised conditions for the production of hepatitis B virus from cell culture.

Glebe D, Berting A, Broehl S, Naumann H, Schuster R, Fiedler N, Tolle TK, Nitsche S, Seifer M, Gerlich WH, Schaefer S.

Intervirology. 2001;44(6):370-8.

PMID:
11805445
16.

Antiviral efficacy of lobucavir (BMS-180194), a cyclobutyl-guanosine nucleoside analogue, in the woodchuck (Marmota monax) model of chronic hepatitis B virus (HBV) infection.

Genovesi EV, Lamb L, Medina I, Taylor D, Seifer M, Innaimo S, Colonno RJ, Clark JM.

Antiviral Res. 2000 Dec;48(3):197-203.

PMID:
11164506
17.

Efficacy of the carbocyclic 2'-deoxyguanosine nucleoside BMS-200475 in the woodchuck model of hepatitis B virus infection.

Genovesi EV, Lamb L, Medina I, Taylor D, Seifer M, Innaimo S, Colonno RJ, Standring DN, Clark JM.

Antimicrob Agents Chemother. 1998 Dec;42(12):3209-17. Erratum in: Antimicrob Agents Chemother 1999 Mar;43(3):726.

18.

In vitro inhibition of hepadnavirus polymerases by the triphosphates of BMS-200475 and lobucavir.

Seifer M, Hamatake RK, Colonno RJ, Standring DN.

Antimicrob Agents Chemother. 1998 Dec;42(12):3200-8.

19.

Properties of tumour suppressor p53 in murine hepatocyte lines transformed by hepatitis B virus X protein.

Schaefer S, Seifer M, Grimmsmann T, Fink L, Wenderhold S, Höhne MW, Gerlich WH.

J Gen Virol. 1998 Apr;79 ( Pt 4):767-77.

PMID:
9568972
20.

Generation of replication-competent hepatitis B virus nucleocapsids in insect cells.

Seifer M, Hamatake R, Bifano M, Standring DN.

J Virol. 1998 Apr;72(4):2765-76.

21.

Identification of BMS-200475 as a potent and selective inhibitor of hepatitis B virus.

Innaimo SF, Seifer M, Bisacchi GS, Standring DN, Zahler R, Colonno RJ.

Antimicrob Agents Chemother. 1997 Jul;41(7):1444-8.

22.

Ribonucleoprotein complex formation by the human hepatitis B virus polymerase.

Seifer M, Standring DN.

Intervirology. 1995;38(5):295-303.

PMID:
8724861
23.

Assembly and antigenicity of hepatitis B virus core particles.

Seifer M, Standring DN.

Intervirology. 1995;38(1-2):47-62. Review.

PMID:
8666524
28.
29.

In vitro tumorigenicity of hepatitis B virus DNA and HBx protein.

Seifer M, Höhne M, Schaefer S, Gerlich WH.

J Hepatol. 1991;13 Suppl 4:S61-5.

PMID:
1822516
30.

Replication of hepatitis B virus in transfected nonhepatic cells.

Seifer M, Heermann KH, Gerlich WH.

Virology. 1990 Nov;179(1):300-11.

PMID:
2219725
31.

Expression pattern of the hepatitis B virus genome in transfected mouse fibroblasts.

Seifer M, Heermann KH, Gerlich WH.

Virology. 1990 Nov;179(1):287-99.

PMID:
2219724
32.

Interaction between hepatitis B surface proteins and monomeric human serum albumin.

Krone B, Lenz A, Heermann KH, Seifer M, Lu XY, Gerlich WH.

Hepatology. 1990 Jun;11(6):1050-6.

PMID:
2163967
33.

Malignant transformation of immortalized transgenic hepatocytes after transfection with hepatitis B virus DNA.

Höhne M, Schaefer S, Seifer M, Feitelson MA, Paul D, Gerlich WH.

EMBO J. 1990 Apr;9(4):1137-45.

34.

Protective potential of hepatitis B virus antigens other than the S gene protein.

Gerlich WH, Deepen R, Heermann KH, Krone B, Lu XY, Seifer M, Thomssen R.

Vaccine. 1990 Mar;8 Suppl:S63-8; discussion S79-80. Review.

PMID:
1691567
35.

Alexithymia and the split brain: VII. Evidence from graphologic signs.

TenHouten WD, Seifer MJ, Siegel PC.

Psychiatr Clin North Am. 1988 Sep;11(3):331-8.

PMID:
3226965
36.

Cell type specific expression of pre S 1 antigen and secretion of hepatitis B virus surface antigen. Brief Report.

Marquardt O, Heermann KH, Seifer M, Gerlich WH.

Arch Virol. 1987;96(3-4):249-56.

PMID:
3662826
37.

Cell-type dependent expression and secretion of hepatitis B virus pre-S1 surface antigen.

Marquardt O, Heermann KH, Seifer M, Gerlich WH.

Postgrad Med J. 1987;63 Suppl 2:41-50.

PMID:
3317359
38.

Immunogenicity of the gene S and Pre-S domains in hepatitis B virions and HBsAg filaments.

Heermann KH, Kruse F, Seifer M, Gerlich WH.

Intervirology. 1987;28(1):14-25.

PMID:
2448264

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