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Items: 1 to 50 of 117


Defective postreplication repair of UV photoproducts in melanoma: a mutator phenotype.

Brash DE, Seidman MM.

Mol Oncol. 2020 Jan;14(1):5-7. doi: 10.1002/1878-0261.12612. Epub 2019 Dec 31.


Replisome structure suggests mechanism for continuous fork progression and post-replication repair.

Yang W, Seidman MM, Rupp WD, Gao Y.

DNA Repair (Amst). 2019 Sep;81:102658. doi: 10.1016/j.dnarep.2019.102658. Epub 2019 Jul 8. Review.


EXD2 Protects Stressed Replication Forks and Is Required for Cell Viability in the Absence of BRCA1/2.

Nieminuszczy J, Broderick R, Bellani MA, Smethurst E, Schwab RA, Cherdyntseva V, Evmorfopoulou T, Lin YL, Minczuk M, Pasero P, Gagos S, Seidman MM, Niedzwiedz W.

Mol Cell. 2019 Aug 8;75(3):605-619.e6. doi: 10.1016/j.molcel.2019.05.026. Epub 2019 Jun 26.


Loss of ARID1A in Tumor Cells Renders Selective Vulnerability to Combined Ionizing Radiation and PARP Inhibitor Therapy.

Park Y, Chui MH, Suryo Rahmanto Y, Yu ZC, Shamanna RA, Bellani MA, Gaillard S, Ayhan A, Viswanathan A, Seidman MM, Franco S, Leung AKL, Bohr VA, Shih IM, Wang TL.

Clin Cancer Res. 2019 Sep 15;25(18):5584-5594. doi: 10.1158/1078-0432.CCR-18-4222. Epub 2019 Jun 13.


Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2.

Huang J, Zhang J, Bellani MA, Pokharel D, Gichimu J, James RC, Gali H, Ling C, Yan Z, Xu D, Chen J, Meetei AR, Li L, Wang W, Seidman MM.

Cell Rep. 2019 May 7;27(6):1794-1808.e5. doi: 10.1016/j.celrep.2019.04.032.


Imaging cellular responses to antigen tagged DNA damage.

Bellani MA, Huang J, Paramasivam M, Pokharel D, Gichimu J, Zhang J, Seidman MM.

DNA Repair (Amst). 2018 Nov;71:183-189. doi: 10.1016/j.dnarep.2018.08.023. Epub 2018 Aug 23. Review.


R-loops cause genomic instability in T helper lymphocytes from patients with Wiskott-Aldrich syndrome.

Sarkar K, Han SS, Wen KK, Ochs HD, Dupré L, Seidman MM, Vyas YM.

J Allergy Clin Immunol. 2018 Jul;142(1):219-234. doi: 10.1016/j.jaci.2017.11.023. Epub 2017 Dec 15.


Mechanistic insights into how CMG helicase facilitates replication past DNA roadblocks.

Trakselis MA, Seidman MM, Brosh RM Jr.

DNA Repair (Amst). 2017 Jul;55:76-82. doi: 10.1016/j.dnarep.2017.05.005. Epub 2017 May 20. Review.


Arsenite Binds to the RING Finger Domain of FANCL E3 Ubiquitin Ligase and Inhibits DNA Interstrand Crosslink Repair.

Jiang J, Bellani M, Li L, Wang P, Seidman MM, Wang Y.

ACS Chem Biol. 2017 Jul 21;12(7):1858-1866. doi: 10.1021/acschembio.6b01135. Epub 2017 Jun 1.


CHD4 Has Oncogenic Functions in Initiating and Maintaining Epigenetic Suppression of Multiple Tumor Suppressor Genes.

Xia L, Huang W, Bellani M, Seidman MM, Wu K, Fan D, Nie Y, Cai Y, Zhang YW, Yu LR, Li H, Zahnow CA, Xie W, Chiu Yen RW, Rassool FV, Baylin SB.

Cancer Cell. 2017 May 8;31(5):653-668.e7. doi: 10.1016/j.ccell.2017.04.005.


Single Molecule Analysis of Laser Localized Psoralen Adducts.

Huang J, Gali H, Gichimu J, Bellani MA, Pokharel D, Paramasivam M, Seidman MM.

J Vis Exp. 2017 Apr 20;(122). doi: 10.3791/55541.


Enhancing the Cytotoxic Effects of PARP Inhibitors with DNA Demethylating Agents - A Potential Therapy for Cancer.

Muvarak NE, Chowdhury K, Xia L, Robert C, Choi EY, Cai Y, Bellani M, Zou Y, Singh ZN, Duong VH, Rutherford T, Nagaria P, Bentzen SM, Seidman MM, Baer MR, Lapidus RG, Baylin SB, Rassool FV.

Cancer Cell. 2016 Oct 10;30(4):637-650. doi: 10.1016/j.ccell.2016.09.002.


Single Molecule Analysis of Laser Localized Interstrand Crosslinks.

Huang J, Gali H, Paramasivam M, Muniandy P, Gichimu J, Bellani MA, Seidman MM.

Front Genet. 2016 May 9;7:84. doi: 10.3389/fgene.2016.00084. eCollection 2016.


Fanconi Anemia: A DNA repair disorder characterized by accelerated decline of the hematopoietic stem cell compartment and other features of aging.

Brosh RM Jr, Bellani M, Liu Y, Seidman MM.

Ageing Res Rev. 2017 Jan;33:67-75. doi: 10.1016/j.arr.2016.05.005. Epub 2016 May 17. Review.


Fan1 deficiency results in DNA interstrand cross-link repair defects, enhanced tissue karyomegaly, and organ dysfunction.

Thongthip S, Bellani M, Gregg SQ, Sridhar S, Conti BA, Chen Y, Seidman MM, Smogorzewska A.

Genes Dev. 2016 Mar 15;30(6):645-59. doi: 10.1101/gad.276261.115.


Catalytic strand separation by RECQ1 is required for RPA-mediated response to replication stress.

Banerjee T, Sommers JA, Huang J, Seidman MM, Brosh RM Jr.

Curr Biol. 2015 Nov 2;25(21):2830-2838. doi: 10.1016/j.cub.2015.09.026. Epub 2015 Oct 8.


MERIT40 cooperates with BRCA2 to resolve DNA interstrand cross-links.

Jiang Q, Paramasivam M, Aressy B, Wu J, Bellani M, Tong W, Seidman MM, Greenberg RA.

Genes Dev. 2015 Sep 15;29(18):1955-68. doi: 10.1101/gad.264192.115. Epub 2015 Sep 3.


UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold.

Tian Y, Paramasivam M, Ghosal G, Chen D, Shen X, Huang Y, Akhter S, Legerski R, Chen J, Seidman MM, Qin J, Li L.

Cell Rep. 2015 Mar 31;10(12):1957-66. doi: 10.1016/j.celrep.2015.03.038. Epub 2015 Mar 26.


CSB interacts with SNM1A and promotes DNA interstrand crosslink processing.

Iyama T, Lee SY, Berquist BR, Gileadi O, Bohr VA, Seidman MM, McHugh PJ, Wilson DM 3rd.

Nucleic Acids Res. 2015 Jan;43(1):247-58. doi: 10.1093/nar/gku1279. Epub 2014 Dec 10.


Arsenite binds to the RING finger domains of RNF20-RNF40 histone E3 ubiquitin ligase and inhibits DNA double-strand break repair.

Zhang F, Paramasivam M, Cai Q, Dai X, Wang P, Lin K, Song J, Seidman MM, Wang Y.

J Am Chem Soc. 2014 Sep 17;136(37):12884-7. doi: 10.1021/ja507863d. Epub 2014 Sep 9.


Preparation and application of triple helix forming oligonucleotides and single strand oligonucleotide donors for gene correction.

Alam R, Thazhathveetil AK, Li H, Seidman MM.

Methods Mol Biol. 2014;1114:103-13. doi: 10.1007/978-1-62703-761-7_7.


The DNA translocase FANCM/MHF promotes replication traverse of DNA interstrand crosslinks.

Huang J, Liu S, Bellani MA, Thazhathveetil AK, Ling C, de Winter JP, Wang Y, Wang W, Seidman MM.

Mol Cell. 2013 Nov 7;52(3):434-46. doi: 10.1016/j.molcel.2013.09.021. Epub 2013 Oct 24.


The RecQ helicase RECQL5 participates in psoralen-induced interstrand cross-link repair.

Ramamoorthy M, May A, Tadokoro T, Popuri V, Seidman MM, Croteau DL, Bohr VA.

Carcinogenesis. 2013 Oct;34(10):2218-30. doi: 10.1093/carcin/bgt183. Epub 2013 May 28.


ATR-dependent phosphorylation of FANCM at serine 1045 is essential for FANCM functions.

Singh TR, Ali AM, Paramasivam M, Pradhan A, Wahengbam K, Seidman MM, Meetei AR.

Cancer Res. 2013 Jul 15;73(14):4300-10. doi: 10.1158/0008-5472.CAN-12-3976. Epub 2013 May 22.


Fanconi anemia group J helicase and MRE11 nuclease interact to facilitate the DNA damage response.

Suhasini AN, Sommers JA, Muniandy PA, Coulombe Y, Cantor SB, Masson JY, Seidman MM, Brosh RM Jr.

Mol Cell Biol. 2013 Jun;33(11):2212-27. doi: 10.1128/MCB.01256-12. Epub 2013 Mar 25.


NEIL1 responds and binds to psoralen-induced DNA interstrand crosslinks.

McNeill DR, Paramasivam M, Baldwin J, Huang J, Vyjayanti VN, Seidman MM, Wilson DM 3rd.

J Biol Chem. 2013 May 3;288(18):12426-36. doi: 10.1074/jbc.M113.456087. Epub 2013 Mar 18.


Age-related disease association of endogenous γ-H2AX foci in mononuclear cells derived from leukapheresis.

Schurman SH, Dunn CA, Greaves R, Yu B, Ferrucci L, Croteau DL, Seidman MM, Bohr VA.

PLoS One. 2012;7(9):e45728. doi: 10.1371/journal.pone.0045728. Epub 2012 Sep 21.


A ubiquitin-binding protein, FAAP20, links RNF8-mediated ubiquitination to the Fanconi anemia DNA repair network.

Yan Z, Guo R, Paramasivam M, Shen W, Ling C, Fox D 3rd, Wang Y, Oostra AB, Kuehl J, Lee DY, Takata M, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Li L, Seidman MM, Wang W.

Mol Cell. 2012 Jul 13;47(1):61-75. doi: 10.1016/j.molcel.2012.05.026. Epub 2012 Jun 14.


Targeting of an interrupted polypurine:polypyrimidine sequence in mammalian cells by a triplex-forming oligonucleotide containing a novel base analogue.

Semenyuk A, Darian E, Liu J, Majumdar A, Cuenoud B, Miller PS, Mackerell AD Jr, Seidman MM.

Biochemistry. 2010 Sep 14;49(36):7867-78. doi: 10.1021/bi100797z.


Sequence conversion by single strand oligonucleotide donors via non-homologous end joining in mammalian cells.

Liu J, Majumdar A, Liu J, Thompson LH, Seidman MM.

J Biol Chem. 2010 Jul 23;285(30):23198-207. doi: 10.1074/jbc.M110.123844. Epub 2010 May 19.


A histone-fold complex and FANCM form a conserved DNA-remodeling complex to maintain genome stability.

Yan Z, Delannoy M, Ling C, Daee D, Osman F, Muniandy PA, Shen X, Oostra AB, Du H, Steltenpool J, Lin T, Schuster B, Décaillet C, Stasiak A, Stasiak AZ, Stone S, Hoatlin ME, Schindler D, Woodcock CL, Joenje H, Sen R, de Winter JP, Li L, Seidman MM, Whitby MC, Myung K, Constantinou A, Wang W.

Mol Cell. 2010 Mar 26;37(6):865-78. doi: 10.1016/j.molcel.2010.01.039.


A novel link to base excision repair?

Wilson DM 3rd, Seidman MM.

Trends Biochem Sci. 2010 May;35(5):247-52. doi: 10.1016/j.tibs.2010.01.003. Epub 2010 Feb 19.


DNA interstrand crosslink repair in mammalian cells: step by step.

Muniandy PA, Liu J, Majumdar A, Liu ST, Seidman MM.

Crit Rev Biochem Mol Biol. 2010 Feb;45(1):23-49. doi: 10.3109/10409230903501819. Review.


Repair of laser-localized DNA interstrand cross-links in G1 phase mammalian cells.

Muniandy PA, Thapa D, Thazhathveetil AK, Liu ST, Seidman MM.

J Biol Chem. 2009 Oct 9;284(41):27908-17. doi: 10.1074/jbc.M109.029025. Epub 2009 Aug 14.


Correction of a splice-site mutation in the beta-globin gene stimulated by triplex-forming peptide nucleic acids.

Chin JY, Kuan JY, Lonkar PS, Krause DS, Seidman MM, Peterson KR, Nielsen PE, Kole R, Glazer PM.

Proc Natl Acad Sci U S A. 2008 Sep 9;105(36):13514-9. doi: 10.1073/pnas.0711793105. Epub 2008 Aug 29.


Interstrand cross-link formation in duplex and triplex DNA by modified pyrimidines.

Peng X, Hong IS, Li H, Seidman MM, Greenberg MM.

J Am Chem Soc. 2008 Aug 6;130(31):10299-306. doi: 10.1021/ja802177u. Epub 2008 Jul 12.


Human replication protein A melts a DNA triple helix structure in a potent and specific manner.

Wu Y, Rawtani N, Thazhathveetil AK, Kenny MK, Seidman MM, Brosh RM Jr.

Biochemistry. 2008 May 6;47(18):5068-77. doi: 10.1021/bi702102d. Epub 2008 Apr 15.


Targeted gene knock in and sequence modulation mediated by a psoralen-linked triplex-forming oligonucleotide.

Majumdar A, Muniandy PA, Liu J, Liu JL, Liu ST, Cuenoud B, Seidman MM.

J Biol Chem. 2008 Apr 25;283(17):11244-52. doi: 10.1074/jbc.M800607200. Epub 2008 Feb 25.


Twenty-fifth anniversary meeting of the International Tinnitus Forum, September 15, 2007, Washington, DC.

Shulman A, Goldstein B, Claussen CF, Seidman MM.

Int Tinnitus J. 2007;13(2):77-80. No abstract available.


Extensive sugar modification improves triple helix forming oligonucleotide activity in vitro but reduces activity in vivo.

Alam MR, Majumdar A, Thazhathveetil AK, Liu ST, Liu JL, Puri N, Cuenoud B, Sasaki S, Miller PS, Seidman MM.

Biochemistry. 2007 Sep 4;46(35):10222-33. Epub 2007 Aug 11.


A human neuronal tissue culture model for Lesch-Nyhan disease.

Shirley TL, Lewers JC, Egami K, Majumdar A, Kelly M, Ceballos-Picot I, Seidman MM, Jinnah HA.

J Neurochem. 2007 May;101(3):841-53.


Psoralen conjugates for visualization of genomic interstrand cross-links localized by laser photoactivation.

Thazhathveetil AK, Liu ST, Indig FE, Seidman MM.

Bioconjug Chem. 2007 Mar-Apr;18(2):431-7.


Targeted cross-linking of the human beta-globin gene in living cells mediated by a triple helix forming oligonucleotide.

Shahid KA, Majumdar A, Alam R, Liu ST, Kuan JY, Sui X, Cuenoud B, Glazer PM, Miller PS, Seidman MM.

Biochemistry. 2006 Feb 14;45(6):1970-8.


The development of bioactive triple helix-forming oligonucleotides.

Seidman MM, Puri N, Majumdar A, Cuenoud B, Miller PS, Alam R.

Ann N Y Acad Sci. 2005 Nov;1058:119-27. Review.


Triplex targeted genomic crosslinks enter separable deletion and base substitution pathways.

Richards S, Liu ST, Majumdar A, Liu JL, Nairn RS, Bernier M, Maher V, Seidman MM.

Nucleic Acids Res. 2005 Sep 25;33(17):5382-93. Print 2005.


Triplex-induced recombination and repair in the pyrimidine motif.

Kalish JM, Seidman MM, Weeks DL, Glazer PM.

Nucleic Acids Res. 2005 Jun 16;33(11):3492-502. Print 2005.


Oligonucleotide mediated gene targeting in mammalian cells.

Seidman MM.

Curr Pharm Biotechnol. 2004 Oct;5(5):421-30. Review.


Setting standards in gene repair.

Seidman MM, Glazer PM.

Oligonucleotides. 2004;14(2):79. No abstract available.


Werner syndrome protein 1367 variants and disposition towards coronary artery disease in Caucasian patients.

Bohr VA, Metter EJ, Harrigan JA, von Kobbe C, Liu JL, Gray MD, Majumdar A, Wilson DM 3rd, Seidman MM.

Mech Ageing Dev. 2004 Jul;125(7):491-6.


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