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Items: 26

1.

Lgr6 is a stem cell marker in mouse skin squamous cell carcinoma.

Huang PY, Kandyba E, Jabouille A, Sjolund J, Kumar A, Halliwill K, McCreery M, DelRosario R, Kang HC, Wong CE, Seibler J, Beuger V, Pellegrino M, Sciambi A, Eastburn DJ, Balmain A.

Nat Genet. 2017 Nov;49(11):1624-1632. doi: 10.1038/ng.3957. Epub 2017 Sep 25.

2.

Generation and utility of genetically humanized mouse models.

Scheer N, Snaith M, Wolf CR, Seibler J.

Drug Discov Today. 2013 Dec;18(23-24):1200-11. doi: 10.1016/j.drudis.2013.07.007. Epub 2013 Jul 18. Review.

PMID:
23872278
3.

A high-throughput functional complementation assay for classification of BRCA1 missense variants.

Bouwman P, van der Gulden H, van der Heijden I, Drost R, Klijn CN, Prasetyanti P, Pieterse M, Wientjens E, Seibler J, Hogervorst FB, Jonkers J.

Cancer Discov. 2013 Oct;3(10):1142-55. doi: 10.1158/2159-8290.CD-13-0094. Epub 2013 Jul 18.

4.

Polycomb group gene Ezh2 regulates mammary gland morphogenesis and maintains the luminal progenitor pool.

Michalak EM, Nacerddine K, Pietersen A, Beuger V, Pawlitzky I, Cornelissen-Steijger P, Wientjens E, Tanger E, Seibler J, van Lohuizen M, Jonkers J.

Stem Cells. 2013 Sep;31(9):1910-20. doi: 10.1002/stem.1437.

5.

Focal segmental glomerulosclerosis is induced by microRNA-193a and its downregulation of WT1.

Gebeshuber CA, Kornauth C, Dong L, Sierig R, Seibler J, Reiss M, Tauber S, Bilban M, Wang S, Kain R, Böhmig GA, Moeller MJ, Gröne HJ, Englert C, Martinez J, Kerjaschki D.

Nat Med. 2013 Apr;19(4):481-7. doi: 10.1038/nm.3142. Epub 2013 Mar 17.

PMID:
23502960
6.

Obesity-induced overexpression of miR-802 impairs glucose metabolism through silencing of Hnf1b.

Kornfeld JW, Baitzel C, Könner AC, Nicholls HT, Vogt MC, Herrmanns K, Scheja L, Haumaitre C, Wolf AM, Knippschild U, Seibler J, Cereghini S, Heeren J, Stoffel M, Brüning JC.

Nature. 2013 Feb 7;494(7435):111-5. doi: 10.1038/nature11793.

PMID:
23389544
7.

Meiotic functions of RAD18.

Inagaki A, Sleddens-Linkels E, Wassenaar E, Ooms M, van Cappellen WA, Hoeijmakers JH, Seibler J, Vogt TF, Shin MK, Grootegoed JA, Baarends WM.

J Cell Sci. 2011 Aug 15;124(Pt 16):2837-50. doi: 10.1242/jcs.081968.

8.

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells.

Raab M, Kappel S, Krämer A, Sanhaji M, Matthess Y, Kurunci-Csacsko E, Calzada-Wack J, Rathkolb B, Rozman J, Adler T, Busch DH, Esposito I, Fuchs H, Gailus-Durner V, Klingenspor M, Wolf E, Sänger N, Prinz F, Angelis MH, Seibler J, Yuan J, Bergmann M, Knecht R, Kreft B, Strebhardt K.

Nat Commun. 2011 Jul 19;2:395. doi: 10.1038/ncomms1395.

9.

Quantitative prediction of human pregnane X receptor and cytochrome P450 3A4 mediated drug-drug interaction in a novel multiple humanized mouse line.

Hasegawa M, Kapelyukh Y, Tahara H, Seibler J, Rode A, Krueger S, Lee DN, Wolf CR, Scheer N.

Mol Pharmacol. 2011 Sep;80(3):518-28. doi: 10.1124/mol.111.071845. Epub 2011 May 31.

PMID:
21628639
10.

Obesity-induced overexpression of miRNA-143 inhibits insulin-stimulated AKT activation and impairs glucose metabolism.

Jordan SD, Krüger M, Willmes DM, Redemann N, Wunderlich FT, Brönneke HS, Merkwirth C, Kashkar H, Olkkonen VM, Böttger T, Braun T, Seibler J, Brüning JC.

Nat Cell Biol. 2011 Apr;13(4):434-46. doi: 10.1038/ncb2211. Epub 2011 Mar 27.

PMID:
21441927
11.

Transgenic RNAi applications in the mouse.

Seibler J, Schwenk F.

Methods Enzymol. 2010;477:367-86. doi: 10.1016/S0076-6879(10)77019-1.

PMID:
20699151
12.

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis.

Glaser S, Lubitz S, Loveland KL, Ohbo K, Robb L, Schwenk F, Seibler J, Roellig D, Kranz A, Anastassiadis K, Stewart AF.

Epigenetics Chromatin. 2009 Apr 6;2(1):5. doi: 10.1186/1756-8935-2-5.

13.

Inducible transgenic rat model for diabetes mellitus based on shRNA-mediated gene knockdown.

Kotnik K, Popova E, Todiras M, Mori MA, Alenina N, Seibler J, Bader M.

PLoS One. 2009;4(4):e5124. doi: 10.1371/journal.pone.0005124. Epub 2009 Apr 2.

14.

Inducible and reversible gene silencing by stable integration of an shRNA-encoding lentivirus in transgenic rats.

Herold MJ, van den Brandt J, Seibler J, Reichardt HM.

Proc Natl Acad Sci U S A. 2008 Nov 25;105(47):18507-12. doi: 10.1073/pnas.0806213105. Epub 2008 Nov 18.

15.

Central insulin action regulates peripheral glucose and fat metabolism in mice.

Koch L, Wunderlich FT, Seibler J, Könner AC, Hampel B, Irlenbusch S, Brabant G, Kahn CR, Schwenk F, Brüning JC.

J Clin Invest. 2008 Jun;118(6):2132-47. doi: 10.1172/JCI31073.

16.

Investigation of TRPV1 loss-of-function phenotypes in transgenic shRNA expressing and knockout mice.

Christoph T, Bahrenberg G, De Vry J, Englberger W, Erdmann VA, Frech M, Kögel B, Röhl T, Schiene K, Schröder W, Seibler J, Kurreck J.

Mol Cell Neurosci. 2008 Mar;37(3):579-89. doi: 10.1016/j.mcn.2007.12.006. Epub 2007 Dec 15.

PMID:
18249134
17.

Reversible gene knockdown in mice using a tight, inducible shRNA expression system.

Seibler J, Kleinridders A, Küter-Luks B, Niehaves S, Brüning JC, Schwenk F.

Nucleic Acids Res. 2007;35(7):e54. Epub 2007 Mar 21.

18.

Enhanced PIP3 signaling in POMC neurons causes KATP channel activation and leads to diet-sensitive obesity.

Plum L, Ma X, Hampel B, Balthasar N, Coppari R, Münzberg H, Shanabrough M, Burdakov D, Rother E, Janoschek R, Alber J, Belgardt BF, Koch L, Seibler J, Schwenk F, Fekete C, Suzuki A, Mak TW, Krone W, Horvath TL, Ashcroft FM, Brüning JC.

J Clin Invest. 2006 Jul;116(7):1886-901. Epub 2006 Jun 22.

19.

Single copy shRNA configuration for ubiquitous gene knockdown in mice.

Seibler J, Küter-Luks B, Kern H, Streu S, Plum L, Mauer J, Kühn R, Brüning JC, Schwenk F.

Nucleic Acids Res. 2005 Apr 14;33(7):e67.

20.

Performance of genomic bordering elements at predefined genomic loci.

Goetze S, Baer A, Winkelmann S, Nehlsen K, Seibler J, Maass K, Bode J.

Mol Cell Biol. 2005 Mar;25(6):2260-72.

21.

Elk-1 knock-out mice engineered by Flp recombinase-mediated cassette exchange.

Cesari F, Rennekampff V, Vintersten K, Vuong LG, Seibler J, Bode J, Wiebel FF, Nordheim A.

Genesis. 2004 Feb;38(2):87-92.

PMID:
14994271
22.

Rapid generation of inducible mouse mutants.

Seibler J, Zevnik B, Küter-Luks B, Andreas S, Kern H, Hennek T, Rode A, Heimann C, Faust N, Kauselmann G, Schoor M, Jaenisch R, Rajewsky K, Kühn R, Schwenk F.

Nucleic Acids Res. 2003 Feb 15;31(4):e12.

23.

The transgeneticist's toolbox: novel methods for the targeted modification of eukaryotic genomes.

Bode J, Schlake T, Iber M, Schübeler D, Seibler J, Snezhkov E, Nikolaev L.

Biol Chem. 2000 Sep-Oct;381(9-10):801-13. Review.

PMID:
11076013
24.

Site-specific chromosomal integration in mammalian cells: highly efficient CRE recombinase-mediated cassette exchange.

Feng YQ, Seibler J, Alami R, Eisen A, Westerman KA, Leboulch P, Fiering S, Bouhassira EE.

J Mol Biol. 1999 Oct 1;292(4):779-85.

PMID:
10525404
25.
26.

Double-reciprocal crossover mediated by FLP-recombinase: a concept and an assay.

Seibler J, Bode J.

Biochemistry. 1997 Feb 18;36(7):1740-7.

PMID:
9048557

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