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Phase-variable bacterial loci: how bacteria gamble to maximise fitness in changing environments.

Phillips ZN, Tram G, Seib KL, Atack JM.

Biochem Soc Trans. 2019 Jul 24. pii: BST20180633. doi: 10.1042/BST20180633. [Epub ahead of print] Review.


Glycointeractome of Neisseria gonorrhoeae: Identification of Host Glycans Targeted by the Gonococcus To Facilitate Adherence to Cervical and Urethral Epithelial Cells.

Semchenko EA, Everest-Dass AV, Jen FE, Mubaiwa TD, Day CJ, Seib KL.

MBio. 2019 Jul 9;10(4). pii: e01339-19. doi: 10.1128/mBio.01339-19.


Antimicrobial susceptibility and impact of macrolide antibiotics on Moraxella catarrhalis in the upper and lower airways of children with chronic endobronchial suppuration.

Hare KM, Seib KL, Chang AB, Harris TM, Spargo JC, Smith-Vaughan HC.

J Med Microbiol. 2019 Aug;68(8):1140-1147. doi: 10.1099/jmm.0.001033. Epub 2019 Jul 5.


Phasevarions of bacterial pathogens - phase-variable epigenetic regulators evolving from restriction-modification systems.

Phillips ZN, Husna AU, Jennings MP, Seib KL, Atack JM.

Microbiology. 2019 Apr 17. doi: 10.1099/mic.0.000805. [Epub ahead of print]


Lectin activity of Pseudomonas aeruginosa vaccine candidates PSE17-1, PSE41-5 and PSE54.

Day CJ, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Jennings MP.

Biochem Biophys Res Commun. 2019 May 21;513(1):287-290. doi: 10.1016/j.bbrc.2019.03.092. Epub 2019 Apr 3.


Investigation of Whole Cell Meningococcal Glycan Interactions Using High Throughput Glycobiology Techniques: Glycan Array and Surface Plasmon Resonance.

Mubaiwa TD, Hartley-Tassell LE, Semchenko EA, Day CJ, Jennings MP, Seib KL.

Methods Mol Biol. 2019;1969:113-121. doi: 10.1007/978-1-4939-9202-7_8.


Screening DNA Repeat Tracts of Phase Variable Genes by Fragment Analysis.

Jen FE, Seib KL, Tan A.

Methods Mol Biol. 2019;1969:93-104. doi: 10.1007/978-1-4939-9202-7_6.


Analysis of Invasive Nontypeable Haemophilus influenzae Isolates Reveals Selection for the Expression State of Particular Phase-Variable Lipooligosaccharide Biosynthetic Genes.

Phillips ZN, Brizuela C, Jennison AV, Staples M, Grimwood K, Seib KL, Jennings MP, Atack JM.

Infect Immun. 2019 Apr 23;87(5). pii: e00093-19. doi: 10.1128/IAI.00093-19. Print 2019 Mar.


Moraxella catarrhalis NucM is an entry nuclease involved in extracellular DNA and RNA degradation, cell competence and biofilm scaffolding.

Tan A, Li WS, Verderosa AD, Blakeway LV, D Mubaiwa T, Totsika M, Seib KL.

Sci Rep. 2019 Feb 22;9(1):2579. doi: 10.1038/s41598-019-39374-0.


The Neisseria gonorrhoeae Methionine Sulfoxide Reductase (MsrA/B) Is a Surface Exposed, Immunogenic, Vaccine Candidate.

Jen FE, Semchenko EA, Day CJ, Seib KL, Jennings MP.

Front Immunol. 2019 Feb 6;10:137. doi: 10.3389/fimmu.2019.00137. eCollection 2019.


Modelling the in-host dynamics of Neisseria gonorrhoeae infection.

Jayasundara P, Regan DG, Seib KL, Jayasundara D, Wood JG.

Pathog Dis. 2019 Feb 1;77(1). pii: ftz008. doi: 10.1093/femspd/ftz008.


Nasal swab bacteriology by PCR during the first 24-months of life: A prospective birth cohort study.

Palmu AA, Ware RS, Lambert SB, Sarna M, Bialasiewicz S, Seib KL, Atack JM, Nissen MD, Grimwood K.

Pediatr Pulmonol. 2019 Mar;54(3):289-296. doi: 10.1002/ppul.24231. Epub 2019 Jan 4.


The serogroup B meningococcal vaccine Bexsero elicits antibodies to Neisseria gonorrhoeae.

Semchenko EA, Tan A, Borrow R, Seib KL.

Clin Infect Dis. 2018 Dec 14. doi: 10.1093/cid/ciy1061. [Epub ahead of print]


Closed Complete Genome Sequences of Two Nontypeable Haemophilus influenzae Strains Containing Novel modA Alleles from the Sputum of Patients with Chronic Obstructive Pulmonary Disease.

Atack JM, Murphy TF, Bakaletz LO, Seib KL, Jennings MP.

Microbiol Resour Announc. 2018 Jul 19;7(2). pii: e00821-18. doi: 10.1128/MRA.00821-18. eCollection 2018 Jul.


Lectin Activity of the TcdA and TcdB Toxins of Clostridium difficile.

Hartley-Tassell LE, Awad MM, Seib KL, Scarselli M, Savino S, Tiralongo J, Lyras D, Day CJ, Jennings MP.

Infect Immun. 2019 Feb 21;87(3). pii: e00676-18. doi: 10.1128/IAI.00676-18. Print 2019 Mar.


Moraxella catarrhalis Restriction-Modification Systems Are Associated with Phylogenetic Lineage and Disease.

Blakeway LV, Tan A, Lappan R, Ariff A, Pickering JL, Peacock CS, Blyth CC, Kahler CM, Chang BJ, Lehmann D, Kirkham LS, Murphy TF, Jennings MP, Bakaletz LO, Atack JM, Peak IR, Seib KL.

Genome Biol Evol. 2018 Nov 1;10(11):2932-2946. doi: 10.1093/gbe/evy226.


Self-derived structure-disrupting peptides targeting methionine aminopeptidase in pathogenic bacteria: a new strategy to generate antimicrobial peptides.

Zhan J, Jia H, Semchenko EA, Bian Y, Zhou AM, Li Z, Yang Y, Wang J, Sarkar S, Totsika M, Blanchard H, Jen FE, Ye Q, Haselhorst T, Jennings MP, Seib KL, Zhou Y.

FASEB J. 2019 Feb;33(2):2095-2104. doi: 10.1096/fj.201700613RR. Epub 2018 Sep 27.


The Bexsero Neisseria meningitidis serogroup B vaccine antigen NHBA is a high-affinity chondroitin sulfate binding protein.

Mubaiwa TD, Hartley-Tassell LE, Semchenko EA, Day CJ, Jennings MP, Seib KL.

Sci Rep. 2018 Apr 25;8(1):6512. doi: 10.1038/s41598-018-24639-x.


Neisseria gonorrhoeae vaccine development: hope on the horizon?

Edwards JL, Jennings MP, Seib KL.

Curr Opin Infect Dis. 2018 Jun;31(3):246-250. doi: 10.1097/QCO.0000000000000450. Review.


A survey of Type III restriction-modification systems reveals numerous, novel epigenetic regulators controlling phase-variable regulons; phasevarions.

Atack JM, Yang Y, Seib KL, Zhou Y, Jennings MP.

Nucleic Acids Res. 2018 Apr 20;46(7):3532-3542. doi: 10.1093/nar/gky192.


Phasevarions of Bacterial Pathogens: Methylomics Sheds New Light on Old Enemies.

Atack JM, Tan A, Bakaletz LO, Jennings MP, Seib KL.

Trends Microbiol. 2018 Aug;26(8):715-726. doi: 10.1016/j.tim.2018.01.008. Epub 2018 Feb 13. Review.


Characterizing the meningococcal glycointeractome: what is new?

Seib KL, Jennings MP, Day CJ.

Future Microbiol. 2018 Mar;13:279-282. doi: 10.2217/fmb-2017-0222. Epub 2018 Feb 14. No abstract available.


Lectin activity of the pneumococcal pilin proteins.

Day CJ, Paton AW, Harvey RM, Hartley-Tassell LE, Seib KL, Tiralongo J, Bovin N, Savino S, Masignani V, Paton JC, Jennings MP.

Sci Rep. 2017 Dec 19;7(1):17784. doi: 10.1038/s41598-017-17850-9.


Virulence determinants of Moraxella catarrhalis: distribution and considerations for vaccine development.

Blakeway LV, Tan A, Peak IRA, Seib KL.

Microbiology. 2017 Oct;163(10):1371-1384. doi: 10.1099/mic.0.000523. Epub 2017 Sep 12. Review.


Phase variation of DNA methyltransferases and the regulation of virulence and immune evasion in the pathogenic Neisseria.

Seib KL, Jen FE, Scott AL, Tan A, Jennings MP.

Pathog Dis. 2017 Aug 31;75(6). doi: 10.1093/femspd/ftx080.


The glycointeractome of serogroup B Neisseria meningitidis strain MC58.

Mubaiwa TD, Hartley-Tassell LE, Semchenko EA, Jen FE, Srikhanta YN, Day CJ, Jennings MP, Seib KL.

Sci Rep. 2017 Jul 18;7(1):5693. doi: 10.1038/s41598-017-05894-w.


Gonorrhoea vaccines: a step in the right direction.

Seib KL.

Lancet. 2017 Sep 30;390(10102):1567-1569. doi: 10.1016/S0140-6736(17)31605-7. Epub 2017 Jul 10. No abstract available.


The sweet side of the pathogenic Neisseria: the role of glycan interactions in colonisation and disease.

Mubaiwa TD, Semchenko EA, Hartley-Tassell LE, Day CJ, Jennings MP, Seib KL.

Pathog Dis. 2017 Jul 31;75(5). doi: 10.1093/femspd/ftx063. Review.


Complete Genome Sequence of Moraxella catarrhalis Strain CCRI-195ME, Isolated from the Middle Ear.

Tan A, Blakeway LV, Bakaletz LO, Boitano M, Clark TA, Korlach J, Jennings MP, Peak IR, Seib KL.

Genome Announc. 2017 May 25;5(21). pii: e00384-17. doi: 10.1128/genomeA.00384-17.


The Capricious Nature of Bacterial Pathogens: Phasevarions and Vaccine Development.

Tan A, Atack JM, Jennings MP, Seib KL.

Front Immunol. 2016 Dec 12;7:586. doi: 10.3389/fimmu.2016.00586. eCollection 2016. Review.


MetQ of Neisseria gonorrhoeae Is a Surface-Expressed Antigen That Elicits Bactericidal and Functional Blocking Antibodies.

Semchenko EA, Day CJ, Seib KL.

Infect Immun. 2017 Jan 26;85(2). pii: e00898-16. doi: 10.1128/IAI.00898-16. Print 2017 Feb.


Neisserial Heparin Binding Antigen (NHBA) Contributes to the Adhesion of Neisseria meningitidis to Human Epithelial Cells.

Vacca I, Del Tordello E, Gasperini G, Pezzicoli A, Di Fede M, Rossi Paccani S, Marchi S, Mubaiwa TD, Hartley-Tassell LE, Jennings MP, Seib KL, Masignani V, Pizza M, Serruto D, Aricò B, Delany I.

PLoS One. 2016 Oct 25;11(10):e0162878. doi: 10.1371/journal.pone.0162878. eCollection 2016.


Intractable problems require novel solutions: it's time to get serious about developing a gonorrhoea vaccine.

Semchenko EA, Seib KL.

Sex Transm Infect. 2016 Dec;92(8):561-562. doi: 10.1136/sextrans-2015-052378. Epub 2016 Apr 1. No abstract available.


Distribution of the type III DNA methyltransferases modA, modB and modD among Neisseria meningitidis genotypes: implications for gene regulation and virulence.

Tan A, Hill DM, Harrison OB, Srikhanta YN, Jennings MP, Maiden MC, Seib KL.

Sci Rep. 2016 Feb 12;6:21015. doi: 10.1038/srep21015.


Is gonococcal disease preventable? The importance of understanding immunity and pathogenesis in vaccine development.

Edwards JL, Jennings MP, Apicella MA, Seib KL.

Crit Rev Microbiol. 2016 Nov;42(6):928-41. doi: 10.3109/1040841X.2015.1105782. Epub 2016 Jan 23. Review.


The potential impact of vaccination on the prevalence of gonorrhea.

Craig AP, Gray RT, Edwards JL, Apicella MA, Jennings MP, Wilson DP, Seib KL.

Vaccine. 2015 Aug 26;33(36):4520-4525. doi: 10.1016/j.vaccine.2015.07.015. Epub 2015 Jul 17.


Specificity of the ModA11, ModA12 and ModD1 epigenetic regulator N(6)-adenine DNA methyltransferases of Neisseria meningitidis.

Seib KL, Jen FE, Tan A, Scott AL, Kumar R, Power PM, Chen LT, Wu HJ, Wang AH, Hill DM, Luyten YA, Morgan RD, Roberts RJ, Maiden MC, Boitano M, Clark TA, Korlach J, Rao DN, Jennings MP.

Nucleic Acids Res. 2015 Apr 30;43(8):4150-62. doi: 10.1093/nar/gkv219. Epub 2015 Apr 6.


Neisseria meningitidis factor H-binding protein fHbp: a key virulence factor and vaccine antigen.

Seib KL, Scarselli M, Comanducci M, Toneatto D, Masignani V.

Expert Rev Vaccines. 2015 Jun;14(6):841-59. doi: 10.1586/14760584.2015.1016915. Epub 2015 Feb 23. Review.


ModM DNA methyltransferase methylome analysis reveals a potential role for Moraxella catarrhalis phasevarions in otitis media.

Blakeway LV, Power PM, Jen FE, Worboys SR, Boitano M, Clark TA, Korlach J, Bakaletz LO, Jennings MP, Peak IR, Seib KL.

FASEB J. 2014 Dec;28(12):5197-207. doi: 10.1096/fj.14-256578. Epub 2014 Sep 2.


SslE elicits functional antibodies that impair in vitro mucinase activity and in vivo colonization by both intestinal and extraintestinal Escherichia coli strains.

Nesta B, Valeri M, Spagnuolo A, Rosini R, Mora M, Donato P, Alteri CJ, Del Vecchio M, Buccato S, Pezzicoli A, Bertoldi I, Buzzigoli L, Tuscano G, Falduto M, Rippa V, Ashhab Y, Bensi G, Fontana MR, Seib KL, Mobley HL, Pizza M, Soriani M, Serino L.

PLoS Pathog. 2014 May 8;10(5):e1004124. doi: 10.1371/journal.ppat.1004124. eCollection 2014 May. Erratum in: PLoS Pathog. 2015 Mar;11(3):e1004773.


Phasevarions mediate epigenetic regulation of antimicrobial susceptibility in Neisseria meningitidis.

Jen FE, Seib KL, Jennings MP.

Antimicrob Agents Chemother. 2014 Jul;58(7):4219-21. doi: 10.1128/AAC.00004-14. Epub 2014 Apr 28.


Vaccines, reverse vaccinology, and bacterial pathogenesis.

Delany I, Rappuoli R, Seib KL.

Cold Spring Harb Perspect Med. 2013 May 1;3(5):a012476. doi: 10.1101/cshperspect.a012476.


The factor H binding protein of Neisseria meningitidis interacts with xenosiderophores in vitro.

Veggi D, Gentile MA, Cantini F, Lo Surdo P, Nardi-Dei V, Seib KL, Pizza M, Rappuoli R, Banci L, Savino S, Scarselli M.

Biochemistry. 2012 Nov 20;51(46):9384-93. doi: 10.1021/bi301161w. Epub 2012 Nov 12.


Developing vaccines in the era of genomics: a decade of reverse vaccinology.

Seib KL, Zhao X, Rappuoli R.

Clin Microbiol Infect. 2012 Oct;18 Suppl 5:109-16. doi: 10.1111/j.1469-0691.2012.03939.x. Epub 2012 Aug 6. Review.


Escherichia coli: great diversity around a common core.

Moriel DG, Rosini R, Seib KL, Serino L, Pizza M, Rappuoli R.

MBio. 2012 Jun 5;3(3). pii: e00118-12. doi: 10.1128/mBio.00118-12. Print 2012.


A novel epigenetic regulator associated with the hypervirulent Neisseria meningitidis clonal complex 41/44.

Seib KL, Pigozzi E, Muzzi A, Gawthorne JA, Delany I, Jennings MP, Rappuoli R.

FASEB J. 2011 Oct;25(10):3622-33. doi: 10.1096/fj.11-183590. Epub 2011 Jun 16.


Transcriptome analysis of Neisseria meningitidis in human whole blood and mutagenesis studies identify virulence factors involved in blood survival.

Echenique-Rivera H, Muzzi A, Del Tordello E, Seib KL, Francois P, Rappuoli R, Pizza M, Serruto D.

PLoS Pathog. 2011 May;7(5):e1002027. doi: 10.1371/journal.ppat.1002027. Epub 2011 May 5.


Neisseria meningitidis is structured in clades associated with restriction modification systems that modulate homologous recombination.

Budroni S, Siena E, Dunning Hotopp JC, Seib KL, Serruto D, Nofroni C, Comanducci M, Riley DR, Daugherty SC, Angiuoli SV, Covacci A, Pizza M, Rappuoli R, Moxon ER, Tettelin H, Medini D.

Proc Natl Acad Sci U S A. 2011 Mar 15;108(11):4494-9. doi: 10.1073/pnas.1019751108. Epub 2011 Feb 28.


Characterization of diverse subvariants of the meningococcal factor H (fH) binding protein for their ability to bind fH, to mediate serum resistance, and to induce bactericidal antibodies.

Seib KL, Brunelli B, Brogioni B, Palumbo E, Bambini S, Muzzi A, DiMarcello F, Marchi S, van der Ende A, Aricó B, Savino S, Scarselli M, Comanducci M, Rappuoli R, Giuliani MM, Pizza M.

Infect Immun. 2011 Feb;79(2):970-81. doi: 10.1128/IAI.00891-10. Epub 2010 Dec 13.

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