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Items: 1 to 50 of 62

1.

Liver-specific induction of Abcg5 and Abcg8 stimulates reverse cholesterol transport in response to ezetimibe treatment.

Altemus JB, Patel SB, Sehayek E.

Metabolism. 2014 Oct;63(10):1334-41. doi: 10.1016/j.metabol.2014.06.014. Epub 2014 Jun 22.

PMID:
25060694
2.

Maternal nutrition induces pervasive gene expression changes but no detectable DNA methylation differences in the liver of adult offspring.

Cannon MV, Buchner DA, Hester J, Miller H, Sehayek E, Nadeau JH, Serre D.

PLoS One. 2014 Mar 3;9(3):e90335. doi: 10.1371/journal.pone.0090335. eCollection 2014.

3.

Targeting of Acyl-CoA synthetase 5 decreases jejunal fatty acid activation with no effect on dietary long-chain fatty acid absorption.

Meller N, Morgan ME, Wong WP, Altemus JB, Sehayek E.

Lipids Health Dis. 2013 Jun 14;12:88. doi: 10.1186/1476-511X-12-88.

4.

Cathepsin B is a novel gender-dependent determinant of cholesterol absorption from the intestine.

Wong WP, Altemus JB, Hester JF, Chan ER, Côté JF, Serre D, Sehayek E.

J Lipid Res. 2013 Mar;54(3):816-22. doi: 10.1194/jlr.M034579. Epub 2012 Dec 17.

5.

Dysregulation of cholesterol homeostasis in human prostate cancer through loss of ABCA1.

Lee BH, Taylor MG, Robinet P, Smith JD, Schweitzer J, Sehayek E, Falzarano SM, Magi-Galluzzi C, Klein EA, Ting AH.

Cancer Res. 2013 Feb 1;73(3):1211-8. doi: 10.1158/0008-5472.CAN-12-3128. Epub 2012 Dec 11.

6.

Systematic haplotype analysis resolves a complex plasma plant sterol locus on the Micronesian Island of Kosrae.

Kenny EE, Gusev A, Riegel K, Lütjohann D, Lowe JK, Salit J, Maller JB, Stoffel M, Daly MJ, Altshuler DM, Friedman JM, Breslow JL, Pe'er I, Sehayek E.

Proc Natl Acad Sci U S A. 2009 Aug 18;106(33):13886-91. doi: 10.1073/pnas.0907336106. Epub 2009 Aug 10.

7.

Moderately decreased cholesterol absorption rates are associated with a large atheroprotective effect.

Greenberg ME, Smith JD, Sehayek E.

Arterioscler Thromb Vasc Biol. 2009 Nov;29(11):1745-50. doi: 10.1161/ATVBAHA.109.194605. Epub 2009 Aug 6.

8.

Cholesterol absorption from the intestine is a major determinant of reverse cholesterol transport from peripheral tissue macrophages.

Sehayek E, Hazen SL.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1296-7. doi: 10.1161/ATVBAHA.108.165803. Epub 2008 Apr 17.

9.

Bioinformatics tools enabling u-statistics for microarrays.

Wittkowski KM, Haider A, Sehayek E, Suárez-Fariñas M, Pellegrino M, Peshansky A, Coffran C, Coker S.

Conf Proc IEEE Eng Med Biol Soc. 2006;1:3464-9.

10.

Effect of aerobic exercise on paraoxonase activity in a cardiac rehabilitation setting.

Sehayek E.

J Cardiopulm Rehabil Prev. 2007 May-Jun;27(3):155-6. No abstract available.

PMID:
17558197
11.

Identification of quantitative trait loci affecting body composition in a mouse intercross.

Vitarius JA, Sehayek E, Breslow JL.

Proc Natl Acad Sci U S A. 2006 Dec 26;103(52):19860-5. Epub 2006 Dec 18.

12.

A complex plasma plant sterol locus on mouse chromosome 14 has at least two genes regulating intestinal sterol absorption.

Sehayek E, Fung YY, Yu HJ, Lembcke J, Ceglarek U, Teupser D, Thiery J, Lutjohann D, von Bergmann K, Breslow JL.

J Lipid Res. 2006 Oct;47(10):2291-6. Epub 2006 Jul 13.

13.

Two loci on chromosome 9 control bile acid composition: evidence that a strong candidate gene, Cyp8b1, is not the culprit.

Sehayek E, Hagey LR, Fung YY, Duncan EM, Yu HJ, Eggertsen G, Björkhem I, Hofmann AF, Breslow JL.

J Lipid Res. 2006 Sep;47(9):2020-7. Epub 2006 Jun 8.

14.

Plasma plant sterol levels: another coronary heart disease risk factor?

Sehayek E, Breslow JL.

Arterioscler Thromb Vasc Biol. 2005 Jan;25(1):5-6. Review. No abstract available.

PMID:
15626765
15.

Phytosterolemia on the island of Kosrae: founder effect for a novel ABCG8 mutation results in high carrier rate and increased plasma plant sterol levels.

Sehayek E, Yu HJ, von Bergmann K, Lutjohann D, Stoffel M, Duncan EM, Garcia-Naveda L, Salit J, Blundell ML, Friedman JM, Breslow JL.

J Lipid Res. 2004 Sep;45(9):1608-13. Epub 2004 Jun 21.

16.

Cholesterol feeding of mice expressing cholesterol 7alpha-hydroxylase increases bile acid pool size despite decreased enzyme activity.

Tiemann M, Han Z, Soccio R, Bollineni J, Shefer S, Sehayek E, Breslow JL.

Proc Natl Acad Sci U S A. 2004 Feb 17;101(7):1846-51. Epub 2004 Feb 4.

17.

Effects of streptozotocin-induced diabetes in apolipoprotein AI deficient mice.

Goldberg IJ, Isaacs A, Sehayek E, Breslow JL, Huang LS.

Atherosclerosis. 2004 Jan;172(1):47-53.

PMID:
14709356
18.
19.

Novel putative SREBP and LXR target genes identified by microarray analysis in liver of cholesterol-fed mice.

Maxwell KN, Soccio RE, Duncan EM, Sehayek E, Breslow JL.

J Lipid Res. 2003 Nov;44(11):2109-19. Epub 2003 Aug 1.

20.

Loci controlling plasma non-HDL and HDL cholesterol levels in a C57BL /6J x CASA /Rk intercross.

Sehayek E, Duncan EM, Yu HJ, Petukhova L, Breslow JL.

J Lipid Res. 2003 Sep;44(9):1744-50. Epub 2003 Jun 16.

21.

Localization of the PE methylation pathway and SR-BI to the canalicular membrane: evidence for apical PC biosynthesis that may promote biliary excretion of phospholipid and cholesterol.

Sehayek E, Wang R, Ono JG, Zinchuk VS, Duncan EM, Shefer S, Vance DE, Ananthanarayanan M, Chait BT, Breslow JL.

J Lipid Res. 2003 Sep;44(9):1605-13. Epub 2003 Jun 16.

22.

Hypercholesterolemia and changes in lipid and bile acid metabolism in male and female cyp7A1-deficient mice.

Erickson SK, Lear SR, Deane S, Dubrac S, Huling SL, Nguyen L, Bollineni JS, Shefer S, Hyogo H, Cohen DE, Shneider B, Sehayek E, Ananthanarayanan M, Balasubramaniyan N, Suchy FJ, Batta AK, Salen G.

J Lipid Res. 2003 May;44(5):1001-9. Epub 2003 Feb 16.

23.

Liver receptor homologue-1 mediates species- and cell line-specific bile acid-dependent negative feedback regulation of the apical sodium-dependent bile acid transporter.

Chen F, Ma L, Dawson PA, Sinal CJ, Sehayek E, Gonzalez FJ, Breslow J, Ananthanarayanan M, Shneider BL.

J Biol Chem. 2003 May 30;278(22):19909-16. Epub 2002 Nov 26.

24.

Loci on chromosomes 14 and 2, distinct from ABCG5/ABCG8, regulate plasma plant sterol levels in a C57BL/6J x CASA/Rk intercross.

Sehayek E, Duncan EM, Lutjohann D, Von Bergmann K, Ono JG, Batta AK, Salen G, Breslow JL.

Proc Natl Acad Sci U S A. 2002 Dec 10;99(25):16215-9. Epub 2002 Nov 22.

25.

The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6.

Soccio RE, Adams RM, Romanowski MJ, Sehayek E, Burley SK, Breslow JL.

Proc Natl Acad Sci U S A. 2002 May 14;99(10):6943-8.

26.

Hyodeoxycholic acid efficiently suppresses atherosclerosis formation and plasma cholesterol levels in mice.

Sehayek E, Ono JG, Duncan EM, Batta AK, Salen G, Shefer S, Neguyen LB, Yang K, Lipkin M, Breslow JL.

J Lipid Res. 2001 Aug;42(8):1250-6.

27.

Hepatocyte nuclear factor-1alpha is an essential regulator of bile acid and plasma cholesterol metabolism.

Shih DQ, Bussen M, Sehayek E, Ananthanarayanan M, Shneider BL, Suchy FJ, Shefer S, Bollileni JS, Gonzalez FJ, Breslow JL, Stoffel M.

Nat Genet. 2001 Apr;27(4):375-82.

PMID:
11279518
28.

A synthetic heparin-mimicking polyanionic compound binds to the LDL receptor-related protein and inhibits vascular smooth muscle cell proliferation.

Benezra M, Vogel T, Ben-Sasson SA, Panet A, Sehayek E, Al-Haideiri M, Decklbaum RJ, Vlodavsky I.

J Cell Biochem. 2001;81(1):114-27.

PMID:
11180402
29.

Apolipoprotein E regulates dietary cholesterol absorption and biliary cholesterol excretion: studies in C57BL/6 apolipoprotein E knockout mice.

Sehayek E, Shefer S, Nguyen LB, Ono JG, Merkel M, Breslow JL.

Proc Natl Acad Sci U S A. 2000 Mar 28;97(7):3433-7.

30.

Role of the CDP-choline and the alternative pathway for phosphatidylcholine biosynthesis.

Sehayek E.

Hepatology. 2000 Feb;31(2):543-4. No abstract available.

PMID:
10691377
31.

Hepatic scavenger receptor BI promotes rapid clearance of high density lipoprotein free cholesterol and its transport into bile.

Ji Y, Wang N, Ramakrishnan R, Sehayek E, Huszar D, Breslow JL, Tall AR.

J Biol Chem. 1999 Nov 19;274(47):33398-402.

33.

Biliary cholesterol excretion: a novel mechanism that regulates dietary cholesterol absorption.

Sehayek E, Ono JG, Shefer S, Nguyen LB, Wang N, Batta AK, Salen G, Smith JD, Tall AR, Breslow JL.

Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):10194-9.

34.

Decreased HDL cholesterol levels but normal lipid absorption, growth, and feeding behavior in apolipoprotein A-IV knockout mice.

Weinstock PH, Bisgaier CL, Hayek T, Aalto-Setala K, Sehayek E, Wu L, Sheiffele P, Merkel M, Essenburg AD, Breslow JL.

J Lipid Res. 1997 Sep;38(9):1782-94.

35.

Cellular metabolism of triglyceride-rich lipoproteins: role of heparan sulfate, lipoprotein lipase and lipoprotein receptors.

Sehayek E, Eisenberg S.

Z Gastroenterol. 1996 Jun;34 Suppl 3:110-2. Review. No abstract available.

PMID:
8767482
36.

Heparan sulfate-dependent and low density lipoprotein receptor-related protein-dependent catabolic pathways for lipoprotein lipase in mouse embryonic fibroblasts.

Sehayek E, Wang XX, Vlodavsky I, Avner R, Levkovitz H, Olivecrona T, Olivecrona G, Willnow TE, Herz J, Eisenberg S.

Isr J Med Sci. 1996 Jun;32(6):449-54.

PMID:
8682650
37.
38.

Biochemical and cognitive studies of apolipoprotein-E-deficient mice.

Gordon I, Genis I, Grauer E, Sehayek E, Michaelson DM.

Mol Chem Neuropathol. 1996 May-Aug;28(1-3):97-103.

PMID:
8871947
39.

Derangement in stress response of apolipoprotein E-deficient mice.

Gordon I, Ben-Eliyahu S, Rosenne E, Sehayek E, Michaelson DM.

Neurosci Lett. 1996 Mar 15;206(2-3):212-4.

PMID:
8710189
40.

Phosphorylation of tau in apolipoprotein E-deficient mice.

Genis I, Gordon I, Sehayek E, Michaelson DM.

Neurosci Lett. 1995 Oct 13;199(1):5-8.

PMID:
8584225
41.

Memory deficits and cholinergic impairments in apolipoprotein E-deficient mice.

Gordon I, Grauer E, Genis I, Sehayek E, Michaelson DM.

Neurosci Lett. 1995 Oct 13;199(1):1-4.

PMID:
8584214
42.

Remnant particles and their metabolism.

Eisenberg S, Sehayek E.

Baillieres Clin Endocrinol Metab. 1995 Oct;9(4):739-53. Review.

PMID:
8593123
43.

[Screening and treatment of hyperlipidemias in Israel].

Sehayek E, Eisenberg S.

Harefuah. 1995 May 1;128(9):529-32, 600. Hebrew.

PMID:
7797148
44.

Binding to heparan sulfate is a major event during catabolism of lipoprotein lipase by HepG2 and other cell cultures.

Sehayek E, Olivecrona T, Bengtsson-Olivecrona G, Vlodavsky I, Levkovitz H, Avner R, Eisenberg S.

Atherosclerosis. 1995 Apr 7;114(1):1-8.

PMID:
7605368
45.

[Hypercalcemia following rhabdomyolysis-induced acute renal failure].

Izsak E, Eisenberg S, Shechter P, Sehayek E.

Harefuah. 1995 Feb 1;128(3):147-50, 199. Hebrew.

PMID:
7759004
46.

The role of native apolipoprotein B-containing lipoproteins in atherosclerosis: cellular mechanisms.

Sehayek E, Eisenberg S.

Curr Opin Lipidol. 1994 Oct;5(5):350-3. Review.

PMID:
7858909
47.

Efficacy and safety of a combination fluvastatin-bezafibrate treatment for familial hypercholesterolemia: comparative analysis with a fluvastatin-cholestyramine combination.

Leitersdorf E, Muratti EN, Eliav O, Meiner V, Eisenberg S, Dann EJ, Sehayek E, Peters TK, Stein Y.

Am J Med. 1994 May;96(5):401-7.

PMID:
8192170
48.

Enhanced cellular metabolism of very low density lipoprotein by simvastatin. A novel mechanism of action of HMG-CoA reductase inhibitors.

Sehayek E, Butbul E, Avner R, Levkovitz H, Eisenberg S.

Eur J Clin Invest. 1994 Mar;24(3):173-8.

PMID:
8033951
50.

Genetic determinants of responsiveness to the HMG-CoA reductase inhibitor fluvastatin in patients with molecularly defined heterozygous familial hypercholesterolemia.

Leitersdorf E, Eisenberg S, Eliav O, Friedlander Y, Berkman N, Dann EJ, Landsberger D, Sehayek E, Meiner V, Wurm M, et al.

Circulation. 1993 Apr;87(4 Suppl):III35-44.

PMID:
8462179

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