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Vitamin D deficiency is a potential risk factor for lipid Amphotericin B nephrotoxicity.

Ferreira D, de Bragança AC, Volpini RA, Shimizu MHM, Gois PHF, Girardi ACC, Seguro AC, Canale D.

PLoS Negl Trop Dis. 2019 Jul 11;13(7):e0007567. doi: 10.1371/journal.pntd.0007567. eCollection 2019 Jul.

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Atypical presentation of familial hypomagnesemia with hypercalciuria and nephrocalcinosis in a patient with a new claudin-16 gene mutation.

Vianna JGP, Simor TG, Senna P, De Bortoli MR, Costalonga EF, Seguro AC, Luchi WM.

Clin Nephrol Case Stud. 2019 May 16;7:27-34. doi: 10.5414/CNCS109595. eCollection 2019.


The role of urea-induced osmotic diuresis and hypernatremia in a critically ill patient: case report and literature review.

Distenhreft JIQ, Vianna JGP, Scopel GS, Ramos JM, Seguro AC, Luchi WM.

J Bras Nefrol. 2019 Apr 25. pii: S0101-28002019005015101. doi: 10.1590/2175-8239-JBN-2018-0226. [Epub ahead of print] English, Portuguese.


Effects of Brazilian green propolis on proteinuria and renal function in patients with chronic kidney disease: a randomized, double-blind, placebo-controlled trial.

Silveira MAD, Teles F, Berretta AA, Sanches TR, Rodrigues CE, Seguro AC, Andrade L.

BMC Nephrol. 2019 Apr 25;20(1):140. doi: 10.1186/s12882-019-1337-7.


Cardioprotection Conferred by Sitagliptin Is Associated with Reduced Cardiac Angiotensin II/Angiotensin-(1-7) Balance in Experimental Chronic Kidney Disease.

Beraldo JI, Benetti A, Borges-Júnior FA, Arruda-Junior DF, Martins FL, Jensen L, Dariolli R, Shimizu MH, Seguro AC, Luchi WM, Girardi ACC.

Int J Mol Sci. 2019 Apr 20;20(8). pii: E1940. doi: 10.3390/ijms20081940.


Chronic Hyponatremia Due to the Syndrome of Inappropriate Antidiuresis (SIAD) in an Adult Woman with Corpus Callosum Agenesis (CCA).

Silveira MAD, Seguro AC, da Silva JB, Arantes de Oliveira MF, Seabra VF, Reichert BV, Rodrigues CE, Andrade L.

Am J Case Rep. 2018 Nov 12;19:1345-1349. doi: 10.12659/AJCR.911810.


Vitamin D Deficiency Aggravates the Renal Features of Moderate Chronic Kidney Disease in 5/6 Nephrectomized Rats.

de Bragança AC, Canale D, Gonçalves JG, Shimizu MHM, Seguro AC, Volpini RA.

Front Med (Lausanne). 2018 Oct 10;5:282. doi: 10.3389/fmed.2018.00282. eCollection 2018.


Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies.

Franca Gois PH, Wolley M, Ranganathan D, Seguro AC.

Int J Environ Res Public Health. 2018 Aug 17;15(8). pii: E1773. doi: 10.3390/ijerph15081773. Review.


A physiology-based approach to a patient with hyperkalemic renal tubular acidosis.

Menegussi J, Tatagiba LS, Vianna JGP, Seguro AC, Luchi WM.

J Bras Nefrol. 2018 Oct-Dec;40(4):410-417. doi: 10.1590/2175-8239-JBN-3821. Epub 2018 Jul 23. English, Portuguese.


Previous Exercise Training Reduces Markers of Renal Oxidative Stress and Inflammation in Streptozotocin-Induced Diabetic Female Rats.

Amaral LSB, Souza CS, Volpini RA, Shimizu MHM, de Bragança AC, Canale D, Seguro AC, Coimbra TM, de Magalhães ACM, Soares TJ.

J Diabetes Res. 2018 Mar 29;2018:6170352. doi: 10.1155/2018/6170352. eCollection 2018.


Correction: Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage.

de Bragança AC, Moreau RLM, de Brito T, Shimizu MHM, Canale D, de Jesus DA, Silva AMG, Gois PH, Seguro AC, Magaldi AJ.

PLoS One. 2018 Feb 1;13(2):e0192535. doi: 10.1371/journal.pone.0192535. eCollection 2018.


Allopurinol attenuates acute kidney injury following Bothrops jararaca envenomation.

Gois PHF, Martines MS, Ferreira D, Volpini R, Canale D, Malaque C, Crajoinas R, Girardi ACC, Massola Shimizu MH, Seguro AC.

PLoS Negl Trop Dis. 2017 Nov 20;11(11):e0006024. doi: 10.1371/journal.pntd.0006024. eCollection 2017 Nov.


Ecstasy induces reactive oxygen species, kidney water absorption and rhabdomyolysis in normal rats. Effect of N-acetylcysteine and Allopurinol in oxidative stress and muscle fiber damage.

de Bragança AC, Moreau RLM, de Brito T, Shimizu MHM, Canale D, de Jesus DA, Silva AMG, Gois PH, Seguro AC, Magaldi AJ.

PLoS One. 2017 Jul 5;12(7):e0179199. doi: 10.1371/journal.pone.0179199. eCollection 2017. Erratum in: PLoS One. 2018 Feb 1;13(2):e0192535.


Vitamin D and Infectious Diseases: Simple Bystander or Contributing Factor?

Gois PHF, Ferreira D, Olenski S, Seguro AC.

Nutrients. 2017 Jun 24;9(7). pii: E651. doi: 10.3390/nu9070651. Review.


Attenuated diuresis and natriuresis in response to glucagon-like peptide-1 in hypertensive rats are associated with lower expression of the glucagon-like peptide-1 receptor in the renal vasculature.

Savignano FA, Crajoinas RO, Pacheco BPM, Campos LCG, Shimizu MHM, Seguro AC, Girardi ACC.

Eur J Pharmacol. 2017 Sep 15;811:38-47. doi: 10.1016/j.ejphar.2017.05.054. Epub 2017 May 30.


Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis.

Abreu PAE, Seguro AC, Canale D, Silva AMGD, Matos LDRB, Gotti TB, Monaris D, Jesus DA, Vasconcellos SA, de Brito T, B Magaldi AJ.

PLoS Negl Trop Dis. 2017 May 15;11(5):e0005615. doi: 10.1371/journal.pntd.0005615. eCollection 2017 May.


Triple A Syndrome: Preliminary Response to the Antioxidant N-Acetylcysteine Treatment in a Child.

Fragoso MCBV, Albuquerque EVA, Cardoso ALA, da Rosa PWL, de Paulo RB, Schimizu MHM, Seguro AC, Passarelli M, Koehler K, Huebner A, Almeida MQ, Latronico AC, Arnhold IJP, Mendonca BB.

Horm Res Paediatr. 2017;88(2):167-171. doi: 10.1159/000465520. Epub 2017 Apr 10.


N-acetylcysteine protects against star fruit-induced acute kidney injury.

Shimizu MH, Gois PH, Volpini RA, Canale D, Luchi WM, Froeder L, Heilberg IP, Seguro AC.

Ren Fail. 2017 Nov;39(1):193-202. doi: 10.1080/0886022X.2016.1256315. Epub 2016 Nov 15.


Allopurinol attenuates rhabdomyolysis-associated acute kidney injury: Renal and muscular protection.

Gois PHF, Canale D, Volpini RA, Ferreira D, Veras MM, Andrade-Oliveira V, Câmara NOS, Shimizu MHM, Seguro AC.

Free Radic Biol Med. 2016 Dec;101:176-189. doi: 10.1016/j.freeradbiomed.2016.10.012. Epub 2016 Oct 18.


Hemodiafiltration Decreases Serum Levels of Inflammatory Mediators in Severe Leptospirosis: A Prospective Study.

Cleto SA, Rodrigues CE, Malaque CM, Sztajnbok J, Seguro AC, Andrade L.

PLoS One. 2016 Aug 3;11(8):e0160010. doi: 10.1371/journal.pone.0160010. eCollection 2016.


Beneficial effects of previous exercise training on renal changes in streptozotocin-induced diabetic female rats.

Amaral LS, Silva FA, Correia VB, Andrade CE, Dutra BA, Oliveira MV, de Magalhães AC, Volpini RA, Seguro AC, Coimbra TM, Soares Tde J.

Exp Biol Med (Maywood). 2016 Feb;241(4):437-45. doi: 10.1177/1535370215609696. Epub 2015 Oct 20.


The role of dexamethasone in scorpion venom-induced deregulation of sodium and water transport in rat lungs.

Malaque CM, de Bragança AC, Sanches TR, Volpini RA, Shimizu MH, Hiyane MI, Câmara NO, Seguro AC, Andrade L.

Intensive Care Med Exp. 2015 Dec;3(1):28. doi: 10.1186/s40635-015-0063-0. Epub 2015 Sep 21.


Can creatine supplementation form carcinogenic heterocyclic amines in humans?

Pereira RT, Dörr FA, Pinto E, Solis MY, Artioli GG, Fernandes AL, Murai IH, Dantas WS, Seguro AC, Santinho MA, Roschel H, Carpentier A, Poortmans JR, Gualano B.

J Physiol. 2015 Sep 1;593(17):3959-71. doi: 10.1113/JP270861. Epub 2015 Jul 30.


Vitamin D deficiency is a potential risk factor for contrast-induced nephropathy.

Luchi WM, Shimizu MH, Canale D, Gois PH, de Bragança AC, Volpini RA, Girardi AC, Seguro AC.

Am J Physiol Regul Integr Comp Physiol. 2015 Aug 1;309(3):R215-22. doi: 10.1152/ajpregu.00526.2014. Epub 2015 Jun 3.


Vitamin D deficiency aggravates ischemic acute kidney injury in rats.

de Bragança AC, Volpini RA, Canale D, Gonçalves JG, Shimizu MH, Sanches TR, Seguro AC, Andrade L.

Physiol Rep. 2015 Mar;3(3). pii: e12331. doi: 10.14814/phy2.12331.


Endothelial glycocalyx damage is associated with leptospirosis acute kidney injury.

Libório AB, Braz MB, Seguro AC, Meneses GC, Neves FM, Pedrosa DC, Cavalcanti LP, Martins AM, Daher Ede F.

Am J Trop Med Hyg. 2015 Mar;92(3):611-6. doi: 10.4269/ajtmh.14-0232. Epub 2015 Jan 26.


Serum and Urinary Values of CA 19-9 and TGFß1 in a Rat Model of Partial or Complete Ureteral Obstruction.

Lopes RI, Dénes FT, Bartolamei MG, Reis S, Sanches TR, Leite KR, Srougi M, Seguro AC.

Eur J Pediatr Surg. 2015 Dec;25(6):513-9. doi: 10.1055/s-0034-1395263. Epub 2015 Jan 5.


Tenofovir during pregnancy in rats: a novel pathway for programmed hypertension in the offspring.

Gois PH, Canale D, Luchi WM, Volpini RA, Veras MM, Costa Nde S, Shimizu MH, Seguro AC.

J Antimicrob Chemother. 2015 Apr;70(4):1094-105. doi: 10.1093/jac/dku483. Epub 2014 Dec 9.


N-acetylcysteine prevents endoplasmic reticulum stress elicited in macrophages by serum albumin drawn from chronic kidney disease rats and selectively affects lipid transporters, ABCA-1 and ABCG-1.

Machado JT, Iborra RT, Fusco FB, Castilho G, Pinto RS, Machado-Lima A, Nakandakare ER, Seguro AC, Shimizu MH, Catanozi S, Passarelli M.

Atherosclerosis. 2014 Nov;237(1):343-52. doi: 10.1016/j.atherosclerosis.2014.09.020. Epub 2014 Sep 30.


Vitamin D deficiency aggravates chronic kidney disease progression after ischemic acute kidney injury.

Gonçalves JG, de Bragança AC, Canale D, Shimizu MH, Sanches TR, Moysés RM, Andrade L, Seguro AC, Volpini RA.

PLoS One. 2014 Sep 15;9(9):e107228. doi: 10.1371/journal.pone.0107228. eCollection 2014.


Vitamin D deficiency aggravates nephrotoxicity, hypertension and dyslipidemia caused by tenofovir: role of oxidative stress and renin-angiotensin system.

Canale D, de Bragança AC, Gonçalves JG, Shimizu MH, Sanches TR, Andrade L, Volpini RA, Seguro AC.

PLoS One. 2014 Jul 21;9(7):e103055. doi: 10.1371/journal.pone.0103055. eCollection 2014.


Apolipoprotein A-I mimetic peptide 4F attenuates kidney injury, heart injury, and endothelial dysfunction in sepsis.

Moreira RS, Irigoyen M, Sanches TR, Volpini RA, Camara NO, Malheiros DM, Shimizu MH, Seguro AC, Andrade L.

Am J Physiol Regul Integr Comp Physiol. 2014 Sep 1;307(5):R514-24. doi: 10.1152/ajpregu.00445.2013. Epub 2014 Jun 11.


Renal tubular dysfunction in sickle cell disease.

Silva Junior GB, Vieira AP, Couto Bem AX, Alves MP, Meneses GC, Martins AM, Sanches TR, Andrade LC, Seguro AC, Libório AB, Daher EF.

Kidney Blood Press Res. 2013;38(1):1-10. doi: 10.1159/000355748. Epub 2014 Jan 28.


N-acetyl-cysteine is associated to renal function improvement in patients with nephropathic cystinosis.

Pache de Faria Guimaraes L, Seguro AC, Shimizu MH, Lopes Neri LA, Sumita NM, de Bragança AC, Aparecido Volpini R, Cunha Sanches TR, Macaferri da Fonseca FA, Moreira Filho CA, Vaisbich MH.

Pediatr Nephrol. 2014 Jun;29(6):1097-102. doi: 10.1007/s00467-013-2705-3. Epub 2013 Dec 11.


Allopurinol on hypertension: insufficient evidence to recommend.

Gois PH, Luchi WM, Seguro AC.

J Clin Hypertens (Greenwich). 2013 Sep;15(9):700. doi: 10.1111/jch.12154. Epub 2013 Jun 25. No abstract available.


Human hemorrhagic pulmonary leptospirosis: pathological findings and pathophysiological correlations.

De Brito T, Aiello VD, da Silva LF, Gonçalves da Silva AM, Ferreira da Silva WL, Castelli JB, Seguro AC.

PLoS One. 2013 Aug 12;8(8):e71743. doi: 10.1371/journal.pone.0071743. eCollection 2013. Erratum in: PLoS One. 2013;8(9). doi:10.1371/annotation/af645b13-6dbb-4327-8e78-021ea552106a.


Pathophysiology of leptospirosis.

Seguro AC, Andrade L.

Shock. 2013 May;39 Suppl 1:17-23. doi: 10.1097/SHK.0b013e31828fae49.


N-acetylcysteine attenuates renal alterations induced by senescence in the rat.

Shimizu MH, Volpini RA, de Bragança AC, Campos R, Canale D, Sanches TR, Andrade L, Seguro AC.

Exp Gerontol. 2013 Feb;48(2):298-303. doi: 10.1016/j.exger.2012.11.006. Epub 2012 Nov 23. Erratum in: Exp Gerontol. 2013 Nov;48(11):1378.


N-acetylcysteine protects rats with chronic renal failure from gadolinium-chelate nephrotoxicity.

Pereira LV, Shimizu MH, Rodrigues LP, Leite CC, Andrade L, Seguro AC.

PLoS One. 2012;7(7):e39528. doi: 10.1371/journal.pone.0039528. Epub 2012 Jul 16.


Renal function evaluation in patients with American cutaneous leishmaniasis after specific treatment with pentavalent antimonial.

Oliveira RA, Lima CG, Mota RM, Martins AM, Sanches TR, Seguro AC, Andrade LC, Junior GB, Libório AB, Daher EF.

BMC Nephrol. 2012 Jun 20;13:44. doi: 10.1186/1471-2369-13-44.


Atorvastatin prevents the downregulation of aquaporin-2 receptor after bilateral ureteral obstruction and protects renal function in a rat model.

Danilovic A, Lopes RI, Sanches TR, Shimizu MH, Oshiro FM, Andrade L, Dénes FT, Seguro AC.

Urology. 2012 Aug;80(2):485.e15-20. doi: 10.1016/j.urology.2012.02.021. Epub 2012 Apr 13.


N-acetylcysteine prevents pulmonary edema and acute kidney injury in rats with sepsis submitted to mechanical ventilation.

Campos R, Shimizu MH, Volpini RA, de Bragança AC, Andrade L, Lopes FD, Olivo C, Canale D, Seguro AC.

Am J Physiol Lung Cell Mol Physiol. 2012 Apr 1;302(7):L640-50. doi: 10.1152/ajplung.00097.2011. Epub 2012 Jan 20.


Erythropoietin prevents sepsis-related acute kidney injury in rats by inhibiting NF-κB and upregulating endothelial nitric oxide synthase.

Souza AC, Volpini RA, Shimizu MH, Sanches TR, Camara NO, Semedo P, Rodrigues CE, Seguro AC, Andrade L.

Am J Physiol Renal Physiol. 2012 Apr 15;302(8):F1045-54. doi: 10.1152/ajprenal.00148.2011. Epub 2012 Jan 11.


Effects of continuous erythropoietin receptor activator in sepsis-induced acute kidney injury and multi-organ dysfunction.

Rodrigues CE, Sanches TR, Volpini RA, Shimizu MH, Kuriki PS, Camara NO, Seguro AC, Andrade L.

PLoS One. 2012;7(1):e29893. doi: 10.1371/journal.pone.0029893. Epub 2012 Jan 3.


High cholesterol feeding may induce tubular dysfunction resulting in hypomagnesemia.

Favaro VF, Oshiro-Monreal FM, de Bragança AC, Andrade L, Seguro AC, Helou CM.

Kidney Blood Press Res. 2012;35(3):137-46. doi: 10.1159/000332399. Epub 2011 Nov 19.


Sildenafil reduces polyuria in rats with lithium-induced NDI.

Sanches TR, Volpini RA, Massola Shimizu MH, Bragança AC, Oshiro-Monreal F, Seguro AC, Andrade L.

Am J Physiol Renal Physiol. 2012 Jan 1;302(1):F216-25. doi: 10.1152/ajprenal.00439.2010. Epub 2011 Oct 26.


Renal tubular dysfunction in patients with American cutaneous leishmaniasis.

Oliveira RA, Diniz LF, Teotônio LO, Lima CG, Mota RM, Martins A, Sanches TR, Seguro AC, Andrade L, Silva GB Jr, Libório AB, Daher EF.

Kidney Int. 2011 Nov;80(10):1099-106. doi: 10.1038/ki.2011.251. Epub 2011 Aug 3.


N-acetylcysteine (NAC) protects against acute kidney injury (AKI) following prolonged pneumoperitoneum in the rat.

Seguro AC, Poli de Figueiredo LF, Shimizu MH.

J Surg Res. 2012 Jun 15;175(2):312-5. doi: 10.1016/j.jss.2011.05.052. Epub 2011 Jun 23.


Protective effect of N-acetylcysteine on early outcomes of deceased renal transplantation.

Danilovic A, Lucon AM, Srougi M, Shimizu MH, Ianhez LE, Nahas WC, Seguro AC.

Transplant Proc. 2011 Jun;43(5):1443-9. doi: 10.1016/j.transproceed.2011.02.020.


N-Acetylcysteine protects the peritoneum from the injury induced by hypertonic dialysis solution.

Bui DS, Seguro AC, Shimitzu MH, Schliemann I, Martini D, Romão JE Jr, Pecoits Filho RF, Abensur H.

J Nephrol. 2012 Jan-Feb;25(1):90-5. doi: 10.5301/JN.2011.8404.


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