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Items: 48

1.

Inhibition of a G9a/DNMT network triggers immune-mediated bladder cancer regression.

Segovia C, San José-Enériz E, Munera-Maravilla E, Martínez-Fernández M, Garate L, Miranda E, Vilas-Zornoza A, Lodewijk I, Rubio C, Segrelles C, Valcárcel LV, Rabal O, Casares N, Bernardini A, Suarez-Cabrera C, López-Calderón FF, Fortes P, Casado JA, Dueñas M, Villacampa F, Lasarte JJ, Guerrero-Ramos F, de Velasco G, Oyarzabal J, Castellano D, Agirre X, Prósper F, Paramio JM.

Nat Med. 2019 Jul;25(7):1073-1081. doi: 10.1038/s41591-019-0499-y. Epub 2019 Jul 3.

PMID:
31270502
2.

Competitive Repopulation Assay of Long-Term Epidermal Stem Cell Regeneration Potential.

Segrelles C, Santos-de-Frutos K, Paramio JM, Lorz C.

Methods Mol Biol. 2019 May 14. doi: 10.1007/7651_2019_234. [Epub ahead of print]

PMID:
31087286
3.

The transcriptional co-activator YAP: A new player in head and neck cancer.

Segrelles C, Paramio JM, Lorz C.

Oral Oncol. 2018 Nov;86:25-32. doi: 10.1016/j.oraloncology.2018.08.020. Epub 2018 Sep 11. Review.

PMID:
30409308
4.

CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status.

Rubio C, Martínez-Fernández M, Segovia C, Lodewijk I, Suarez-Cabrera C, Segrelles C, López-Calderón F, Munera-Maravilla E, Santos M, Bernardini A, García-Escudero R, Lorz C, Gómez-Rodriguez MJ, de Velasco G, Otero I, Villacampa F, Guerrero-Ramos F, Ruiz S, de la Rosa F, Domínguez-Rodríguez S, Real FX, Malats N, Castellano D, Dueñas M, Paramio JM.

Clin Cancer Res. 2019 Jan 1;25(1):390-402. doi: 10.1158/1078-0432.CCR-18-0685. Epub 2018 Sep 21.

PMID:
30242024
5.

Bosutinib Inhibits EGFR Activation in Head and Neck Cancer.

Segrelles C, Contreras D, Navarro EM, Gutiérrez-Muñoz C, García-Escudero R, Paramio JM, Lorz C.

Int J Mol Sci. 2018 Jun 21;19(7). pii: E1824. doi: 10.3390/ijms19071824.

6.

Differential Role of the RasGEFs Sos1 and Sos2 in Mouse Skin Homeostasis and Carcinogenesis.

Liceras-Boillos P, Jimeno D, García-Navas R, Lorenzo-Martín LF, Menacho-Marquez M, Segrelles C, Gómez C, Calzada N, Fuentes-Mateos R, Paramio JM, Bustelo XR, Baltanás FC, Santos E.

Mol Cell Biol. 2018 Jul 30;38(16). pii: e00049-18. doi: 10.1128/MCB.00049-18. Print 2018 Aug 15.

7.

Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway.

García-Escudero R, Segrelles C, Dueñas M, Pombo M, Ballestín C, Alonso-Riaño M, Nenclares P, Álvarez-Rodríguez R, Sánchez-Aniceto G, Ruíz-Alonso A, López-Cedrún JL, Paramio JM, Lorz C.

Oral Oncol. 2018 Apr;79:55-63. doi: 10.1016/j.oraloncology.2018.02.014. Epub 2018 Mar 3.

PMID:
29598951
8.

Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells.

Alonso-Lecue P, de Pedro I, Coulon V, Molinuevo R, Lorz C, Segrelles C, Ceballos L, López-Aventín D, García-Valtuille A, Bernal JM, Mazorra F, Pujol RM, Paramio J, Ramón Sanz J, Freije A, Toll A, Gandarillas A.

Cell Death Dis. 2017 Jun 29;8(6):e2901. doi: 10.1038/cddis.2017.259.

9.

IKKβ-Mediated Resistance to Skin Cancer Development Is Ink4a/Arf-Dependent.

Page A, Bravo A, Suarez-Cabrera C, Alameda JP, Casanova ML, Lorz C, Segrelles C, Segovia JC, Paramio JM, Navarro M, Ramirez A.

Mol Cancer Res. 2017 Sep;15(9):1255-1264. doi: 10.1158/1541-7786.MCR-17-0157. Epub 2017 Jun 5.

10.

The downregulation of ΔNp63 in p53-deficient mouse epidermal tumors favors metastatic behavior.

Bornachea O, López-Calderón FF, Dueñas M, Segrelles C, Lorz C, Suárez-Cabrera C, Marañón M, Paradela-Dobarro B, Santos M, Paramio JM.

Oncotarget. 2015 Sep 15;6(27):24230-45.

11.

Akt signaling leads to stem cell activation and promotes tumor development in epidermis.

Segrelles C, García-Escudero R, Garín MI, Aranda JF, Hernández P, Ariza JM, Santos M, Paramio JM, Lorz C.

Stem Cells. 2014 Jul;32(7):1917-28. doi: 10.1002/stem.1669.

12.

p21 suppresses inflammation and tumorigenesis on pRB-deficient stratified epithelia.

Saiz-Ladera C, Lara MF, Garín M, Ruiz S, Santos M, Lorz C, García-Escudero R, Martínez-Fernández M, Bravo A, Fernández-Capetillo O, Segrelles C, Paramio JM.

Oncogene. 2014 Sep 11;33(37):4599-4612. doi: 10.1038/onc.2013.417. Epub 2013 Oct 14.

13.

A novel tumor suppressor network in squamous malignancies.

Costa C, Santos M, Segrelles C, Dueñas M, Lara MF, Agirre X, Prosper F, García-Escudero R, Paramio JM.

Sci Rep. 2012;2:828. doi: 10.1038/srep00828. Epub 2012 Nov 9.

14.

EMT and induction of miR-21 mediate metastasis development in Trp53-deficient tumours.

Bornachea O, Santos M, Martínez-Cruz AB, García-Escudero R, Dueñas M, Costa C, Segrelles C, Lorz C, Buitrago A, Saiz-Ladera C, Agirre X, Grande T, Paradela B, Maraver A, Ariza JM, Prosper F, Serrano M, Sánchez-Céspedes M, Paramio JM.

Sci Rep. 2012;2:434. doi: 10.1038/srep00434. Epub 2012 May 31.

15.

The thyroid hormone receptors modulate the skin response to retinoids.

García-Serrano L, Gomez-Ferrería MA, Contreras-Jurado C, Segrelles C, Paramio JM, Aranda A.

PLoS One. 2011;6(8):e23825. doi: 10.1371/journal.pone.0023825. Epub 2011 Aug 17.

16.

Establishment of a murine epidermal cell line suitable for in vitro and in vivo skin modelling.

Segrelles C, Holguín A, Hernández P, Ariza JM, Paramio JM, Lorz C.

BMC Dermatol. 2011 Apr 21;11:9. doi: 10.1186/1471-5945-11-9.

17.

Gene expression profiling of mouse p53-deficient epidermal carcinoma defines molecular determinants of human cancer malignancy.

García-Escudero R, Martínez-Cruz AB, Santos M, Lorz C, Segrelles C, Garaulet G, Saiz-Ladera C, Costa C, Buitrago-Pérez A, Dueñas M, Paramio JM.

Mol Cancer. 2010 Jul 14;9:193. doi: 10.1186/1476-4598-9-193.

18.

A functional role of RB-dependent pathway in the control of quiescence in adult epidermal stem cells revealed by genomic profiling.

Lorz C, García-Escudero R, Segrelles C, Garín MI, Ariza JM, Santos M, Ruiz S, Lara MF, Martínez-Cruz AB, Costa C, Buitrago-Pérez A, Saiz-Ladera C, Dueñas M, Paramio JM.

Stem Cell Rev Rep. 2010 Jun;6(2):162-77. doi: 10.1007/s12015-010-9139-0.

19.

Isolation of adult mouse stem keratinocytes using magnetic cell sorting (MACS).

Lorz C, Segrelles C, Garín M, Paramio JM.

Methods Mol Biol. 2010;585:1-11. doi: 10.1007/978-1-60761-380-0_1.

PMID:
19907992
20.

Transgenic mice expressing constitutively active Akt in oral epithelium validate KLFA as a potential biomarker of head and neck squamous cell carcinoma.

Moral M, Segrelles C, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Buitrago A, Costa C, Saiz C, Ariza JM, Dueñas M, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Digiovanni J, Paramio JM.

In Vivo. 2009 Sep-Oct;23(5):653-60.

21.

Spontaneous tumor formation in Trp53-deficient epidermis mediated by chromosomal instability and inflammation.

Martínez-Cruz AB, Santos M, García-Escudero R, Moral M, Segrelles C, Lorz C, Saiz C, Buitrago-Pérez A, Costa C, Paramio JM.

Anticancer Res. 2009 Aug;29(8):3035-42.

22.

On the origin of epidermal cancers.

Lorz C, Segrelles C, Paramio JM.

Curr Mol Med. 2009 Apr;9(3):353-64. Review.

PMID:
19355916
23.

Akt activation synergizes with Trp53 loss in oral epithelium to produce a novel mouse model for head and neck squamous cell carcinoma.

Moral M, Segrelles C, Lara MF, Martínez-Cruz AB, Lorz C, Santos M, García-Escudero R, Lu J, Kiguchi K, Buitrago A, Costa C, Saiz C, Rodriguez-Peralto JL, Martinez-Tello FJ, Rodriguez-Pinilla M, Sanchez-Cespedes M, Garín M, Grande T, Bravo A, DiGiovanni J, Paramio JM.

Cancer Res. 2009 Feb 1;69(3):1099-108. doi: 10.1158/0008-5472.CAN-08-3240. Epub 2009 Jan 27.

24.

Susceptibility of pRb-deficient epidermis to chemical skin carcinogenesis is dependent on the p107 allele dosage.

Santos M, Ruiz S, Lara MF, Segrelles C, Moral M, Martínez-Cruz AB, Ballestín C, Lorz C, García-Escudero R, Paramio JM.

Mol Carcinog. 2008 Nov;47(11):815-21. doi: 10.1002/mc.20426.

PMID:
18300254
25.

Spontaneous squamous cell carcinoma induced by the somatic inactivation of retinoblastoma and Trp53 tumor suppressors.

Martínez-Cruz AB, Santos M, Lara MF, Segrelles C, Ruiz S, Moral M, Lorz C, García-Escudero R, Paramio JM.

Cancer Res. 2008 Feb 1;68(3):683-92. doi: 10.1158/0008-5472.CAN-07-3049.

26.

Deregulated activity of Akt in epithelial basal cells induces spontaneous tumors and heightened sensitivity to skin carcinogenesis.

Segrelles C, Lu J, Hammann B, Santos M, Moral M, Cascallana JL, Lara MF, Rho O, Carbajal S, Traag J, Beltrán L, Martínez-Cruz AB, García-Escudero R, Lorz C, Ruiz S, Bravo A, Paramio JM, DiGiovanni J.

Cancer Res. 2007 Nov 15;67(22):10879-88.

27.

Constitutively active Akt induces ectodermal defects and impaired bone morphogenetic protein signaling.

Segrelles C, Moral M, Lorz C, Santos M, Lu J, Cascallana JL, Lara MF, Carbajal S, Martínez-Cruz AB, García-Escudero R, Beltran L, Segovia JC, Bravo A, DiGiovanni J, Paramio JM.

Mol Biol Cell. 2008 Jan;19(1):137-49. Epub 2007 Oct 24.

28.

Gene profiling approaches help to define the specific functions of retinoblastoma family in epidermis.

Lara MF, García-Escudero R, Ruiz S, Santos M, Moral M, Martínez-Cruz AB, Segrelles C, Lorz C, Paramio JM.

Mol Carcinog. 2008 Mar;47(3):209-21.

PMID:
17932948
29.

p107 acts as a tumor suppressor in pRb-deficient epidermis.

Lara MF, Santos M, Ruiz S, Segrelles C, Moral M, Martínez-Cruz AB, Hernández P, Martínez-Palacio J, Lorz C, García-Escudero R, Paramio JM.

Mol Carcinog. 2008 Feb;47(2):105-13.

PMID:
17932945
30.

Unexpected roles for pRb in mouse skin carcinogenesis.

Ruiz S, Santos M, Lara MF, Segrelles C, Ballestín C, Paramio JM.

Cancer Res. 2005 Nov 1;65(21):9678-86.

31.

Molecular determinants of Akt-induced keratinocyte transformation.

Segrelles C, Moral M, Lara MF, Ruiz S, Santos M, Leis H, García-Escudero R, Martínez-Cruz AB, Martínez-Palacio J, Hernández P, Ballestín C, Paramio JM.

Oncogene. 2006 Feb 23;25(8):1174-85.

PMID:
16247457
32.

Altered T cell differentiation and Notch signaling induced by the ectopic expression of keratin K10 in the epithelial cells of the thymus.

Santos M, Río P, Ruiz S, Martínez-Palacio J, Segrelles C, Lara MF, Segovia JC, Paramio JM.

J Cell Biochem. 2005 Jun 1;95(3):543-58.

PMID:
15786499
33.

Functional link between retinoblastoma family of proteins and the Wnt signaling pathway in mouse epidermis.

Ruiz S, Segrelles C, Santos M, Lara MF, Paramio JM.

Dev Dyn. 2004 Jul;230(3):410-8.

34.

Unique and overlapping functions of pRb and p107 in the control of proliferation and differentiation in epidermis.

Ruiz S, Santos M, Segrelles C, Leis H, Jorcano JL, Berns A, Paramio JM, Vooijs M.

Development. 2004 Jun;131(11):2737-48.

35.

Akt mediates an angiogenic switch in transformed keratinocytes.

Segrelles C, Ruiz S, Santos M, Martínez-Palacio J, Lara MF, Paramio JM.

Carcinogenesis. 2004 Jul;25(7):1137-47. Epub 2004 Mar 4.

PMID:
15001536
36.

Glucocorticoid Receptor Counteracts Tumorigenic Activity of Akt in Skin through Interference with the Phosphatidylinositol 3-Kinase Signaling Pathway.

Leis H, Page A, Ramírez A, Bravo A, Segrelles C, Paramio J, Barettino D, Jorcano JL, Pérez P.

Mol Endocrinol. 2004 Feb;18(2):303-11. Epub 2003 Nov 13.

PMID:
14615607
37.

Abnormal epidermal differentiation and impaired epithelial-mesenchymal tissue interactions in mice lacking the retinoblastoma relatives p107 and p130.

Ruiz S, Segrelles C, Bravo A, Santos M, Perez P, Leis H, Jorcano JL, Paramio JM.

Development. 2003 Jun;130(11):2341-53.

38.

Impaired NF-kappa B activation and increased production of tumor necrosis factor alpha in transgenic mice expressing keratin K10 in the basal layer of the epidermis.

Santos M, Perez P, Segrelles C, Ruiz S, Jorcano JL, Paramio JM.

J Biol Chem. 2003 Apr 11;278(15):13422-30. Epub 2003 Feb 1.

39.

Expression, localization, and activity of glycogen synthase kinase 3beta during mouse skin tumorigenesis.

Leis H, Segrelles C, Ruiz S, Santos M, Paramio JM.

Mol Carcinog. 2002 Dec;35(4):180-5.

PMID:
12489109
40.

Functional roles of Akt signaling in mouse skin tumorigenesis.

Segrelles C, Ruiz S, Perez P, Murga C, Santos M, Budunova IV, Martínez J, Larcher F, Slaga TJ, Gutkind JS, Jorcano JL, Paramio JM.

Oncogene. 2002 Jan 3;21(1):53-64.

41.

Inhibition of protein kinase B (PKB) and PKCzeta mediates keratin K10-induced cell cycle arrest.

Paramio JM, Segrelles C, Ruiz S, Jorcano JL.

Mol Cell Biol. 2001 Nov;21(21):7449-59.

42.

The ink4a/arf tumor suppressors cooperate with p21cip1/waf in the processes of mouse epidermal differentiation, senescence, and carcinogenesis.

Paramio JM, Segrelles C, Ruiz S, Martin-Caballero J, Page A, Martinez J, Serrano M, Jorcano JL.

J Biol Chem. 2001 Nov 23;276(47):44203-11. Epub 2001 Sep 10.

43.

p53 is phosphorylated at the carboxyl terminus and promotes the differentiation of human HaCaT keratinocytes.

Paramio JM, Segrelles C, Laín S, Gómez-Casero E, Lane DP, Lane EB, Jorcano JL.

Mol Carcinog. 2000 Dec;29(4):251-62.

PMID:
11170263
44.

Opposite functions for E2F1 and E2F4 in human epidermal keratinocyte differentiation.

Paramio JM, Segrelles C, Casanova ML, Jorcano JL.

J Biol Chem. 2000 Dec 29;275(52):41219-26.

45.

PTEN tumour suppressor is linked to the cell cycle control through the retinoblastoma protein.

Paramio JM, Navarro M, Segrelles C, Gómez-Casero E, Jorcano JL.

Oncogene. 1999 Dec 9;18(52):7462-8.

46.

Modulation of cell proliferation by cytokeratins K10 and K16.

Paramio JM, Casanova ML, Segrelles C, Mittnacht S, Lane EB, Jorcano JL.

Mol Cell Biol. 1999 Apr;19(4):3086-94.

47.
48.

Autolytic processing of a phosphorothioate diester bond.

Buzayan JM, Feldstein PA, Segrelles C, Bruening G.

Nucleic Acids Res. 1988 May 11;16(9):4009-23.

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