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Items: 26

1.

Reversible 26S proteasome disassembly upon mitochondrial stress.

Livnat-Levanon N, Kevei É, Kleifeld O, Krutauz D, Segref A, Rinaldi T, Erpapazoglou Z, Cohen M, Reis N, Hoppe T, Glickman MH.

Cell Rep. 2014 Jun 12;7(5):1371-1380. doi: 10.1016/j.celrep.2014.04.030. Epub 2014 May 22.

2.

Pathogenesis of human mitochondrial diseases is modulated by reduced activity of the ubiquitin/proteasome system.

Segref A, Kevei É, Pokrzywa W, Schmeisser K, Mansfeld J, Livnat-Levanon N, Ensenauer R, Glickman MH, Ristow M, Hoppe T.

Cell Metab. 2014 Apr 1;19(4):642-52. doi: 10.1016/j.cmet.2014.01.016.

3.

Role of sirtuins in lifespan regulation is linked to methylation of nicotinamide.

Schmeisser K, Mansfeld J, Kuhlow D, Weimer S, Priebe S, Heiland I, Birringer M, Groth M, Segref A, Kanfi Y, Price NL, Schmeisser S, Schuster S, Pfeiffer AF, Guthke R, Platzer M, Hoppe T, Cohen HY, Zarse K, Sinclair DA, Ristow M.

Nat Chem Biol. 2013 Nov;9(11):693-700. doi: 10.1038/nchembio.1352. Epub 2013 Sep 29.

4.

DNA damage in germ cells induces an innate immune response that triggers systemic stress resistance.

Ermolaeva MA, Segref A, Dakhovnik A, Ou HL, Schneider JI, Utermöhlen O, Hoppe T, Schumacher B.

Nature. 2013 Sep 19;501(7467):416-20. doi: 10.1038/nature12452. Epub 2013 Aug 25.

5.

A novel interaction between aging and ER overload in a protein conformational dementia.

Schipanski A, Lange S, Segref A, Gutschmidt A, Lomas DA, Miranda E, Schweizer M, Hoppe T, Glatzel M.

Genetics. 2013 Mar;193(3):865-76. doi: 10.1534/genetics.112.149088. Epub 2013 Jan 18.

6.

Deficiency for the ubiquitin ligase UBE3B in a blepharophimosis-ptosis-intellectual-disability syndrome.

Basel-Vanagaite L, Dallapiccola B, Ramirez-Solis R, Segref A, Thiele H, Edwards A, Arends MJ, Miró X, White JK, Désir J, Abramowicz M, Dentici ML, Lepri F, Hofmann K, Har-Zahav A, Ryder E, Karp NA, Estabel J, Gerdin AK, Podrini C, Ingham NJ, Altmüller J, Nürnberg G, Frommolt P, Abdelhak S, Pasmanik-Chor M, Konen O, Kelley RI, Shohat M, Nürnberg P, Flint J, Steel KP, Hoppe T, Kubisch C, Adams DJ, Borck G.

Am J Hum Genet. 2012 Dec 7;91(6):998-1010. doi: 10.1016/j.ajhg.2012.10.011. Epub 2012 Nov 29.

7.

Analysis of ubiquitin-dependent proteolysis in Caenorhabditis elegans.

Segref A, Hoppe T.

Methods Mol Biol. 2012;832:531-44. doi: 10.1007/978-1-61779-474-2_38.

PMID:
22350911
8.

The Machado-Joseph disease deubiquitylase ATX-3 couples longevity and proteostasis.

Kuhlbrodt K, Janiesch PC, Kevei É, Segref A, Barikbin R, Hoppe T.

Nat Cell Biol. 2011 Mar;13(3):273-81. doi: 10.1038/ncb2200. Epub 2011 Feb 13.

PMID:
21317884
9.

A screenable in vivo assay to study proteostasis networks in Caenorhabditis elegans.

Segref A, Torres S, Hoppe T.

Genetics. 2011 Apr;187(4):1235-40. doi: 10.1534/genetics.111.126797. Epub 2011 Feb 1.

10.

Fate specification and tissue-specific cell cycle control of the Caenorhabditis elegans intestine.

Segref A, Cabello J, Clucas C, Schnabel R, Johnstone IL.

Mol Biol Cell. 2010 Mar 1;21(5):725-38. doi: 10.1091/mbc.E09-04-0268. Epub 2010 Jan 6.

11.

Think locally: control of ubiquitin-dependent protein degradation in neurons.

Segref A, Hoppe T.

EMBO Rep. 2009 Jan;10(1):44-50. doi: 10.1038/embor.2008.229. Epub 2008 Dec 12. Review.

12.

A compartmentalized phosphorylation/dephosphorylation system that regulates U snRNA export from the nucleus.

Kitao S, Segref A, Kast J, Wilm M, Mattaj IW, Ohno M.

Mol Cell Biol. 2008 Jan;28(1):487-97. Epub 2007 Oct 29.

13.

Identification of 40LoVe, a Xenopus hnRNP D family protein involved in localizing a TGF-beta-related mRNA during oogenesis.

Czaplinski K, Köcher T, Schelder M, Segref A, Wilm M, Mattaj IW.

Dev Cell. 2005 Apr;8(4):505-15.

14.

Co-crystallization of the human nuclear cap-binding complex with a m7GpppG cap analogue using protein engineering.

Mazza C, Segref A, Mattaj IW, Cusack S.

Acta Crystallogr D Biol Crystallogr. 2002 Dec;58(Pt 12):2194-7. Epub 2002 Nov 23.

PMID:
12454499
15.
16.

Identity elements used in export of mRNAs.

Ohno M, Segref A, Kuersten S, Mattaj IW.

Mol Cell. 2002 Mar;9(3):659-71.

17.

Crystal structure of the human nuclear cap binding complex.

Mazza C, Ohno M, Segref A, Mattaj IW, Cusack S.

Mol Cell. 2001 Aug;8(2):383-96.

19.

PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylation.

Ohno M, Segref A, Bachi A, Wilm M, Mattaj IW.

Cell. 2000 Apr 14;101(2):187-98.

20.

Mex67p mediates nuclear export of a variety of RNA polymerase II transcripts.

Hurt E, Strässer K, Segref A, Bailer S, Schlaich N, Presutti C, Tollervey D, Jansen R.

J Biol Chem. 2000 Mar 24;275(12):8361-8.

21.

Generation of GTP-bound Ran by RCC1 is required for chromatin-induced mitotic spindle formation.

Carazo-Salas RE, Guarguaglini G, Gruss OJ, Segref A, Karsenti E, Mattaj IW.

Nature. 1999 Jul 8;400(6740):178-81.

PMID:
10408446
22.

Nuclear mRNA export requires complex formation between Mex67p and Mtr2p at the nuclear pores.

Santos-Rosa H, Moreno H, Simos G, Segref A, Fahrenkrog B, Panté N, Hurt E.

Mol Cell Biol. 1998 Nov;18(11):6826-38.

23.

Mex67p, a novel factor for nuclear mRNA export, binds to both poly(A)+ RNA and nuclear pores.

Segref A, Sharma K, Doye V, Hellwig A, Huber J, Lührmann R, Hurt E.

EMBO J. 1997 Jun 2;16(11):3256-71.

24.

The yeast protein Arc1p binds to tRNA and functions as a cofactor for the methionyl- and glutamyl-tRNA synthetases.

Simos G, Segref A, Fasiolo F, Hellmuth K, Shevchenko A, Mann M, Hurt EC.

EMBO J. 1996 Oct 1;15(19):5437-48.

25.

Nuclear pore proteins are involved in the biogenesis of functional tRNA.

Simos G, Tekotte H, Grosjean H, Segref A, Sharma K, Tollervey D, Hurt EC.

EMBO J. 1996 May 1;15(9):2270-84.

26.

A novel complex of nucleoporins, which includes Sec13p and a Sec13p homolog, is essential for normal nuclear pores.

Siniossoglou S, Wimmer C, Rieger M, Doye V, Tekotte H, Weise C, Emig S, Segref A, Hurt EC.

Cell. 1996 Jan 26;84(2):265-75.

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