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Anxiety symptoms are quantitatively and qualitatively different in dementia with Lewy bodies than in Alzheimer's disease in the years preceding clinical diagnosis.

Segers K, Benoit F, Meyts JM, Surquin M.

Psychogeriatrics. 2019 Nov 28. doi: 10.1111/psyg.12490. [Epub ahead of print]


Dementia, End of Life, and Euthanasia: A Survey Among Dementia Specialists Organized by the Belgian Dementia Council.

Picard G, Bier JC, Capron I, De Deyn PP, Deryck O, Engelborghs S, Hanseeuw B, Lemper JC, Mormont E, Petrovic M, Salmon E, Segers K, Sieben A, Thiery E, Ventura M, Versijpt J, Ivanoiu A.

J Alzheimers Dis. 2019;69(4):989-1001. doi: 10.3233/JAD-181277.


Assessing the suitability of capillary electrophoresis-mass spectrometry for biomarker discovery in plasma-based metabolomics.

Zhang W, Segers K, Mangelings D, Van Eeckhaut A, Hankemeier T, Vander Heyden Y, Ramautar R.

Electrophoresis. 2019 Sep;40(18-19):2309-2320. doi: 10.1002/elps.201900126. Epub 2019 May 2.


Validation of a brief Multicultural Cognitive Examination (MCE) for evaluation of dementia.

Nielsen TR, Segers K, Vanderaspoilden V, Beinhoff U, Minthon L, Pissiota A, Bekkhus-Wetterberg P, Bjørkløf GH, Tsolaki M, Gkioka M, Waldemar G.

Int J Geriatr Psychiatry. 2019 Jul;34(7):982-989. doi: 10.1002/gps.5099. Epub 2019 Apr 23.


[Hereditary diffuse gastric cancer : case serie of 8 patients from a single family and literature review].

Jadot V, Segers K, Bours V, Kohnen L, Honoré P, Martin M, De Flines J, Mutijima E, Leclercq P.

Rev Med Liege. 2019 Mar;74(3):134-138. Review. French.


Myocardial metaiodobenzylguanidine tomoscintigraphy for the diagnosis of Lewy body disease in patients with high clinical suspicion and non-diagnostic ioflupane single-photon emission computed tomography.

Le Moine M, Cytryn E, Hambye AS, Bizimungu A, Colson C, Surquin M, Segers K.

Psychogeriatrics. 2019 Nov;19(6):624-625. doi: 10.1111/psyg.12436. Epub 2019 Mar 18. No abstract available.


Assessing mixtures of supercharging agents to increase the abundance of a specific charge state of Neuromedin U.

Van Wanseele Y, Bongaerts J, Segers K, Viaene J, De Bundel D, Vander Heyden Y, Smolders I, Van Eeckhaut A.

Talanta. 2019 Jun 1;198:206-214. doi: 10.1016/j.talanta.2019.01.098. Epub 2019 Jan 29.


[How to avoid overmedicalization of the elderly patient ?]

Benoît F, Segers K, Sergeant C, Robberecht J, Meyts JM, Karmali R, Surquin M.

Rev Med Brux. 2018;39(4):394-398. French.


Validation of a European Cross-Cultural Neuropsychological Test Battery (CNTB) for evaluation of dementia.

Nielsen TR, Segers K, Vanderaspoilden V, Beinhoff U, Minthon L, Pissiota A, Bekkhus-Wetterberg P, Bjørkløf GH, Tsolaki M, Gkioka M, Waldemar G.

Int J Geriatr Psychiatry. 2019 Jan;34(1):144-152. doi: 10.1002/gps.5002. Epub 2018 Oct 17.


Validation of the Rowland Universal Dementia Assessment Scale (RUDAS) in a multicultural sample across five Western European countries: diagnostic accuracy and normative data.

Nielsen TR, Segers K, Vanderaspoilden V, Bekkhus-Wetterberg P, Bjørkløf GH, Beinhoff U, Minthon L, Pissiota A, Tsolaki M, Gkioka M, Waldemar G.

Int Psychogeriatr. 2019 Feb;31(2):287-296. doi: 10.1017/S1041610218000832. Epub 2018 Jul 18.


A Retrospective Belgian Multi-Center MRI Biomarker Study in Alzheimer's Disease (REMEMBER).

Niemantsverdriet E, Ribbens A, Bastin C, Benoit F, Bergmans B, Bier JC, Bladt R, Claes L, De Deyn PP, Deryck O, Hanseeuw B, Ivanoiu A, Lemper JC, Mormont E, Picard G, Salmon E, Segers K, Sieben A, Smeets D, Struyfs H, Thiery E, Tournoy J, Triau E, Vanbinst AM, Versijpt J, Bjerke M, Engelborghs S.

J Alzheimers Dis. 2018;63(4):1509-1522. doi: 10.3233/JAD-171140.


A dualistic model of primary anal canal adenocarcinoma with distinct cellular origins, etiologies, inflammatory microenvironments and mutational signatures: implications for personalised medicine.

Herfs M, Roncarati P, Koopmansch B, Peulen O, Bruyere D, Lebeau A, Hendrick E, Hubert P, Poncin A, Penny W, Piazzon N, Monnien F, Guenat D, Mougin C, Prétet JL, Vuitton L, Segers K, Lambert F, Bours V, de Leval L, Valmary-Degano S, Quick CM, Crum CP, Delvenne P.

Br J Cancer. 2018 May;118(10):1302-1312. doi: 10.1038/s41416-018-0049-2. Epub 2018 Apr 27.


Genetic assessment and folate receptor autoantibodies in infantile-onset cerebral folate deficiency (CFD) syndrome.

Ramaekers VT, Segers K, Sequeira JM, Koenig M, Van Maldergem L, Bours V, Kornak U, Quadros EV.

Mol Genet Metab. 2018 May;124(1):87-93. doi: 10.1016/j.ymgme.2018.03.001. Epub 2018 Mar 3.


Use of the Masquerade Flap in Ablepharon-Macrostomia Syndrome: A Case Report.

Hollanders K, Casteels I, Vandelanotte S, Reyniers R, Segers K, Nevens T, Mombaerts I.

Cornea. 2018 Jul;37(7):929-932. doi: 10.1097/ICO.0000000000001563. Review.


Innovative methodology for the identification of soluble biomarkers in fresh tissues.

Costanza B, Turtoi A, Bellahcène A, Hirano T, Peulen O, Blomme A, Hennequière V, Mutijima E, Boniver J, Meuwis MA, Josse C, Koopmansch B, Segers K, Yokobori T, Fahmy K, Thiry M, Coimbra C, Garbacki N, Colige A, Baiwir D, Bours V, Louis E, Detry O, Delvenne P, Nishiyama M, Castronovo V.

Oncotarget. 2018 Jan 31;9(12):10665-10680. doi: 10.18632/oncotarget.24366. eCollection 2018 Feb 13.


Diagnostic strategy in segmentation defect of the vertebrae: a retrospective study of 73 patients.

Lefebvre M, Dieux-Coeslier A, Baujat G, Schaefer E, Judith SO, Bazin A, Pinson L, Attie-Bitach T, Baumann C, Fradin M, Pierquin G, Julia S, Quélin C, Doray B, Berg S, Vincent-Delorme C, Lambert L, Bachmann N, Lacombe D, Isidor B, Laurent N, Joelle R, Blanchet P, Odent S, Kervran D, Leporrier N, Abel C, Segers K, Guiliano F, Ginglinger-Fabre E, Selicorni A, Goldenberg A, El Chehadeh S, Francannet C, Demeer B, Duffourd Y, Thauvin-Robinet C, Verloes A, Cormier-Daire V, Riviere JB, Faivre L, Thevenon J.

J Med Genet. 2018 Jun;55(6):422-429. doi: 10.1136/jmedgenet-2017-104939. Epub 2018 Feb 19.


In silico analysis of structural modifications in and around the integrin αIIb genu caused by ITGA2B variants in human platelets with emphasis on Glanzmann thrombasthenia.

Pillois X, Peters P, Segers K, Nurden AT.

Mol Genet Genomic Med. 2018 Mar;6(2):249-260. doi: 10.1002/mgg3.365. Epub 2018 Jan 31.


Performance of middle-aged and elderly European minority and majority populations on a Cross-Cultural Neuropsychological Test Battery (CNTB).

Nielsen TR, Segers K, Vanderaspoilden V, Bekkhus-Wetterberg P, Minthon L, Pissiota A, Bjørkløf GH, Beinhoff U, Tsolaki M, Gkioka M, Waldemar G.

Clin Neuropsychol. 2018 Nov;32(8):1411-1430. doi: 10.1080/13854046.2018.1430256. Epub 2018 Jan 24.


A next-generation newborn screening pilot study: NGS on dried blood spots detects causal mutations in patients with inherited metabolic diseases.

Boemer F, Fasquelle C, d'Otreppe S, Josse C, Dideberg V, Segers K, Guissard V, Capraro V, Debray FG, Bours V.

Sci Rep. 2017 Dec 15;7(1):17641. doi: 10.1038/s41598-017-18038-x.


Alzheimer's disease and driving: review of the literature and consensus guideline from Belgian dementia experts and the Belgian road safety institute endorsed by the Belgian Medical Association.

Versijpt J, Tant M, Beyer I, Bier JC, Cras P, De Deyn PP, De Wit P, Deryck O, Hanseeuw B, Lambert M, Lemper JC, Mormont E, Petrovic M, Picard G, Salmon E, Segers K, Sieben A, Thiery E, Tournoy J, Vandewoude M, Ventura M, Verschraegen J, Engelborghs S, Goffin T, Deneyer M, Ivanoiu A.

Acta Neurol Belg. 2017 Dec;117(4):811-819. doi: 10.1007/s13760-017-0840-5. Epub 2017 Oct 5. Review.


Successful forearm prosthesis fitting in a patient with epidermolysis bullosa dystrophica: Case report.

Verduyn C, Morren MA, Stas M, Sinnaeve F, Segers K, Kiekens C.

Prosthet Orthot Int. 2018 Jun;42(3):254-257. doi: 10.1177/0309364617718410. Epub 2017 Jul 20.


Antiplasmodial Activity, Cytotoxicity and Structure-Activity Relationship Study of Cyclopeptide Alkaloids.

Tuenter E, Segers K, Kang KB, Viaene J, Sung SH, Cos P, Maes L, Heyden YV, Pieters L.

Molecules. 2017 Feb 2;22(2). pii: E224. doi: 10.3390/molecules22020224.


Breast cancer in a male-to-female transsexual patient with a BRCA2 mutation.

Corman V, Potorac I, Manto F, Dassy S, Segers K, Thiry A, Bours V, Daly AF, Beckers A.

Endocr Relat Cancer. 2016 May;23(5):391-7. doi: 10.1530/ERC-16-0057. Epub 2016 Mar 21.


[The clinical use of the IWG diagnostic criteria for Alzheimer's disease: A retrospective study in a memory clinic].

Inthasot V, Segers K, Vanderaspoilden V, Guisset F, Dachy B.

Rev Med Brux. 2016;37(6):460-468. French.


Evaluation of BRCA1-related molecular features and microRNAs as prognostic factors for triple negative breast cancers.

Boukerroucha M, Josse C, ElGuendi S, Boujemla B, Frères P, Marée R, Wenric S, Segers K, Collignon J, Jerusalem G, Bours V.

BMC Cancer. 2015 Oct 21;15:755. doi: 10.1186/s12885-015-1740-9.



Dideberg V, Segers K, Koopmansch B, Lambert F, Bours V.

Rev Med Liege. 2015 May-Jun;70(5-6):251-6. French.


Cell-Free Expression of G Protein-Coupled Receptors.

Segers K, Masure S.

Curr Protoc Protein Sci. 2015 Aug 3;81:29.14.1-29.14.29. doi: 10.1002/0471140864.ps2914s81.


Identification of small-molecule inhibitors against SecA by structure-based virtual ligand screening.

De Waelheyns E, Segers K, Sardis MF, Anné J, Nicolaes GA, Economou A.

J Antibiot (Tokyo). 2015 Nov;68(11):666-73. doi: 10.1038/ja.2015.53. Epub 2015 May 20.


Dynamic reconstruction of complex abdominal wall defects with the pedicled innervated vastus lateralis and anterolateral thigh PIVA flap.

Vranckx JJ, Stoel AM, Segers K, Nanhekhan L.

J Plast Reconstr Aesthet Surg. 2015 Jun;68(6):837-45. doi: 10.1016/j.bjps.2015.03.009. Epub 2015 Mar 20.


BRCA1 germline mutation and glioblastoma development: report of cases.

Boukerroucha M, Josse C, Segers K, El-Guendi S, Frères P, Jerusalem G, Bours V.

BMC Cancer. 2015 Mar 26;15:181. doi: 10.1186/s12885-015-1205-1.


Characterization of human disease phenotypes associated with mutations in TREX1, RNASEH2A, RNASEH2B, RNASEH2C, SAMHD1, ADAR, and IFIH1.

Crow YJ, Chase DS, Lowenstein Schmidt J, Szynkiewicz M, Forte GM, Gornall HL, Oojageer A, Anderson B, Pizzino A, Helman G, Abdel-Hamid MS, Abdel-Salam GM, Ackroyd S, Aeby A, Agosta G, Albin C, Allon-Shalev S, Arellano M, Ariaudo G, Aswani V, Babul-Hirji R, Baildam EM, Bahi-Buisson N, Bailey KM, Barnerias C, Barth M, Battini R, Beresford MW, Bernard G, Bianchi M, Billette de Villemeur T, Blair EM, Bloom M, Burlina AB, Carpanelli ML, Carvalho DR, Castro-Gago M, Cavallini A, Cereda C, Chandler KE, Chitayat DA, Collins AE, Sierra Corcoles C, Cordeiro NJ, Crichiutti G, Dabydeen L, Dale RC, D'Arrigo S, De Goede CG, De Laet C, De Waele LM, Denzler I, Desguerre I, Devriendt K, Di Rocco M, Fahey MC, Fazzi E, Ferrie CD, Figueiredo A, Gener B, Goizet C, Gowrinathan NR, Gowrishankar K, Hanrahan D, Isidor B, Kara B, Khan N, King MD, Kirk EP, Kumar R, Lagae L, Landrieu P, Lauffer H, Laugel V, La Piana R, Lim MJ, Lin JP, Linnankivi T, Mackay MT, Marom DR, Marques Lourenço C, McKee SA, Moroni I, Morton JE, Moutard ML, Murray K, Nabbout R, Nampoothiri S, Nunez-Enamorado N, Oades PJ, Olivieri I, Ostergaard JR, Pérez-Dueñas B, Prendiville JS, Ramesh V, Rasmussen M, Régal L, Ricci F, Rio M, Rodriguez D, Roubertie A, Salvatici E, Segers KA, Sinha GP, Soler D, Spiegel R, Stödberg TI, Straussberg R, Swoboda KJ, Suri M, Tacke U, Tan TY, te Water Naude J, Wee Teik K, Thomas MM, Till M, Tonduti D, Valente EM, Van Coster RN, van der Knaap MS, Vassallo G, Vijzelaar R, Vogt J, Wallace GB, Wassmer E, Webb HJ, Whitehouse WP, Whitney RN, Zaki MS, Zuberi SM, Livingston JH, Rozenberg F, Lebon P, Vanderver A, Orcesi S, Rice GI.

Am J Med Genet A. 2015 Feb;167A(2):296-312. doi: 10.1002/ajmg.a.36887. Epub 2015 Jan 16.


Clinical utility and applicability of biomarker-based diagnostic criteria for Alzheimer's disease: a BeDeCo survey.

Bier JC, Verschraegen J, Vandenberghe R, Guillaume B, Picard G, Otte G, Mormont E, Gilles C, Segers K, Sieben A, Thiery E, Ventura M, De Deyn P, Deryck O, Versijpt J, Salmon E, Engelborghs S, Ivanoiu A.

Acta Neurol Belg. 2015 Dec;115(4):547-55. doi: 10.1007/s13760-014-0423-7. Epub 2015 Jan 10.


Involvement of peripheral and central nervous systems in a valosin-containing protein mutation.

Segers K, Glibert G, Callebaut J, Kevers L, Alcan I, Dachy B.

J Clin Neurol. 2014 Apr;10(2):166-70. doi: 10.3988/jcn.2014.10.2.166. Epub 2014 Apr 23.


[Screening of the risk of functional decline performed by an inpatient geriatric consultation team in a general hospital].

Benoît F, Bertiaux M, Schouterden R, Huard E, Segers K, Decorte L, Robberecht J, Simonetti C, Surquin M.

Rev Med Brux. 2013 Nov-Dec;34(6):462-8. French.


Subacute cognitive deterioration with high serum anti-thyroid peroxidase antibodies: two cases and a plea for pragmatism.

Segers K, Braconnier P, Corazza F, Divano L, Mabrouk A, Robberecht J, Surquin M.

Psychogeriatrics. 2013 Sep;13(3):175-9. doi: 10.1111/psyg.12018.


Pioneers in migration, pioneering in dementia: first generation immigrants in a European metropolitan memory clinic.

Segers K, Benoit F, Colson C, Kovac V, Nury D, Vanderaspoilden V.

Acta Neurol Belg. 2013 Dec;113(4):435-40. doi: 10.1007/s13760-013-0245-z. Epub 2013 Aug 23.


Rapid prenatal diagnosis of fetal Zellweger syndrome by biochemical tests, complementation studies, and molecular analyses.

Segers K, Pierquin G, Gaillez S, Delbecque K, Retz M, Tebache M, Waterham H, Wanders R, Ferdinandusse S, Debray FG.

Prenat Diagn. 2013 Feb;33(2):201-3. doi: 10.1002/pd.4038. Epub 2013 Jan 9. No abstract available.


Complex visual hallucinations in a Parkinson patient: don't blame James if it's Charles's fault.

Segers K.

Int Psychogeriatr. 2013 Mar;25(3):505-6. doi: 10.1017/S1041610212001913. Epub 2012 Nov 12.


The thing of which she could not speak: transient biopercular syndrome as a very late complication of unsuccessful chemical abortion.

Segers K, Mabiglia C, Bergmann P.

Acta Neurol Belg. 2013 Mar;113(1):85-6. doi: 10.1007/s13760-012-0127-9. Epub 2012 Sep 14. No abstract available.


Can mirtazapine counteract the weight loss associated with Alzheimer disease? A retrospective open-label study.

Segers K, Surquin M.

Alzheimer Dis Assoc Disord. 2014 Jul-Sep;28(3):291-3. doi: 10.1097/WAD.0b013e3182614f52.


Learning curve in tracheal allotransplantation.

Delaere PR, Vranckx JJ, Meulemans J, Vander Poorten V, Segers K, Van Raemdonck D, De Leyn P, Decaluwé H, Dooms C, Verleden G.

Am J Transplant. 2012 Sep;12(9):2538-45. doi: 10.1111/j.1600-6143.2012.04125.x. Epub 2012 Jun 8.


Do local meteorological conditions influence skin irritation caused by transdermal rivastigmine? A retroprospective, pilot study.

Segers K, Cytryn E, Surquin M.

J Clin Psychopharmacol. 2012 Jun;32(3):412-5. doi: 10.1097/JCP.0b013e3182524511.


Traffic jam at the bacterial sec translocase: targeting the SecA nanomotor by small-molecule inhibitors.

Segers K, Anné J.

Chem Biol. 2011 Jun 24;18(6):685-98. doi: 10.1016/j.chembiol.2011.04.007. Review.


Adult polyglucosan body disease masquerading as "ALS with dementia of the Alzheimer type": an exceptional phenotype in a rare pathology.

Segers K, Kadhim H, Colson C, Duttmann R, Glibert G.

Alzheimer Dis Assoc Disord. 2012 Jan-Mar;26(1):96-9. doi: 10.1097/WAD.0b013e31821cc65d.


3-years experience review of neonatal screening for hemoglobin disorders using tandem mass spectrometry.

Boemer F, Cornet Y, Libioulle C, Segers K, Bours V, Schoos R.

Clin Chim Acta. 2011 Jul 15;412(15-16):1476-9. doi: 10.1016/j.cca.2011.04.031. Epub 2011 May 4.


Development of a high-throughput screening assay for the discovery of small-molecule SecA inhibitors.

Segers K, Klaassen H, Economou A, Chaltin P, Anné J.

Anal Biochem. 2011 Jun 15;413(2):90-6. doi: 10.1016/j.ab.2011.02.012. Epub 2011 Feb 19.


Synthesis and antibacterial evaluation of a novel series of 2-(1,2-dihydro-3-oxo-3H-pyrazol-2-yl)benzothiazoles.

Stella A, Segers K, De Jonghe S, Vanderhoydonck B, Rozenski J, Anné J, Herdewijn P.

Chem Biodivers. 2011 Feb;8(2):253-65. doi: 10.1002/cbdv.201000241.


Synthesis of novel 5-amino-thiazolo[4,5-d]pyrimidines as E. coli and S. aureus SecA inhibitors.

Jang MY, De Jonghe S, Segers K, Anné J, Herdewijn P.

Bioorg Med Chem. 2011 Jan 1;19(1):702-14. doi: 10.1016/j.bmc.2010.10.027. Epub 2010 Oct 19.


Free sialic acid storage disease mimicking cerebral palsy and revealed by blood smear examination.

Debray FG, Lefebvre C, Colinet S, Segers K, Stevens R.

J Pediatr. 2011 Jan;158(1):165, 165.e1. doi: 10.1016/j.jpeds.2010.06.057. Epub 2010 Aug 21. No abstract available.


Inhibition of thrombin formation by active site mutated (S360A) activated protein C.

Nicolaes GA, Bock PE, Segers K, Wildhagen KC, Dahlbäck B, Rosing J.

J Biol Chem. 2010 Jul 23;285(30):22890-900. doi: 10.1074/jbc.M110.131029. Epub 2010 May 18.

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