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Items: 16


Serum- and Glucocorticoid-induced Kinase Sgk1 Directly Promotes the Differentiation of Colorectal Cancer Cells and Restrains Metastasis.

Lee LYW, Woolley C, Starkey T, Biswas S, Mirshahi T, Bardella C, Segditsas S, Irshad S, Tomlinson I.

Clin Cancer Res. 2019 Jan 15;25(2):629-640. doi: 10.1158/1078-0432.CCR-18-1033. Epub 2018 Oct 15.


Hereditary mixed polyposis syndrome is caused by a 40-kb upstream duplication that leads to increased and ectopic expression of the BMP antagonist GREM1.

Jaeger E, Leedham S, Lewis A, Segditsas S, Becker M, Cuadrado PR, Davis H, Kaur K, Heinimann K, Howarth K; HMPS Collaboration, East J, Taylor J, Thomas H, Tomlinson I.

Nat Genet. 2012 May 6;44(6):699-703. doi: 10.1038/ng.2263.


A basal gradient of Wnt and stem-cell number influences regional tumour distribution in human and mouse intestinal tracts.

Leedham SJ, Rodenas-Cuadrado P, Howarth K, Lewis A, Mallappa S, Segditsas S, Davis H, Jeffery R, Rodriguez-Justo M, Keshav S, Travis SP, Graham TA, East J, Clark S, Tomlinson IP.

Gut. 2013 Jan;62(1):83-93. doi: 10.1136/gutjnl-2011-301601. Epub 2012 Jan 27.


The C-terminus of Apc does not influence intestinal adenoma development or progression.

Lewis A, Davis H, Deheragoda M, Pollard P, Nye E, Jeffery R, Segditsas S, East P, Poulsom R, Stamp G, Wright N, Tomlinson I.

J Pathol. 2012 Jan;226(1):73-83. doi: 10.1002/path.2972. Epub 2011 Oct 18.


PHLDA1 expression marks the putative epithelial stem cells and contributes to intestinal tumorigenesis.

Sakthianandeswaren A, Christie M, D'Andreti C, Tsui C, Jorissen RN, Li S, Fleming NI, Gibbs P, Lipton L, Malaterre J, Ramsay RG, Phesse TJ, Ernst M, Jeffery RE, Poulsom R, Leedham SJ, Segditsas S, Tomlinson IP, Bernhard OK, Simpson RJ, Walker F, Faux MC, Church N, Catimel B, Flanagan DJ, Vincan E, Sieber OM.

Cancer Res. 2011 May 15;71(10):3709-19. doi: 10.1158/0008-5472.CAN-10-2342. Epub 2011 May 10.


Down-regulation of serum/glucocorticoid regulated kinase 1 in colorectal tumours is largely independent of promoter hypermethylation.

Lessi F, Beggs A, de Palo M, Anti M, Macarone Palmieri R, Francesconi S, Gomes V, Bevilacqua G, Tomlinson I, Segditsas S.

PLoS One. 2010 Nov 5;5(11):e13840. doi: 10.1371/journal.pone.0013840.


Severe polyposis in Apc(1322T) mice is associated with submaximal Wnt signalling and increased expression of the stem cell marker Lgr5.

Lewis A, Segditsas S, Deheragoda M, Pollard P, Jeffery R, Nye E, Lockstone H, Davis H, Clark S, Stamp G, Poulsom R, Wright N, Tomlinson I.

Gut. 2010 Dec;59(12):1680-6. doi: 10.1136/gut.2009.193680. Epub 2010 Oct 6.


The Apc 1322T mouse develops severe polyposis associated with submaximal nuclear beta-catenin expression.

Pollard P, Deheragoda M, Segditsas S, Lewis A, Rowan A, Howarth K, Willis L, Nye E, McCart A, Mandir N, Silver A, Goodlad R, Stamp G, Cockman M, East P, Spencer-Dene B, Poulsom R, Wright N, Tomlinson I.

Gastroenterology. 2009 Jun;136(7):2204-2213.e1-13. doi: 10.1053/j.gastro.2009.02.058. Epub 2009 Feb 25.


Promoter hypermethylation leads to decreased APC mRNA expression in familial polyposis and sporadic colorectal tumours, but does not substitute for truncating mutations.

Segditsas S, Sieber OM, Rowan A, Setien F, Neale K, Phillips RK, Ward R, Esteller M, Tomlinson IP.

Exp Mol Pathol. 2008 Dec;85(3):201-6. doi: 10.1016/j.yexmp.2008.09.006. Epub 2008 Oct 11.


APC and the three-hit hypothesis.

Segditsas S, Rowan AJ, Howarth K, Jones A, Leedham S, Wright NA, Gorman P, Chambers W, Domingo E, Roylance RR, Sawyer EJ, Sieber OM, Tomlinson IP.

Oncogene. 2009 Jan 8;28(1):146-55. doi: 10.1038/onc.2008.361. Epub 2008 Oct 6.


Putative direct and indirect Wnt targets identified through consistent gene expression changes in APC-mutant intestinal adenomas from humans and mice.

Segditsas S, Sieber O, Deheragoda M, East P, Rowan A, Jeffery R, Nye E, Clark S, Spencer-Dene B, Stamp G, Poulsom R, Suraweera N, Silver A, Ilyas M, Tomlinson I.

Hum Mol Genet. 2008 Dec 15;17(24):3864-75. doi: 10.1093/hmg/ddn286. Epub 2008 Sep 9.


Analysis of copy number changes suggests chromosomal instability in a minority of large colorectal adenomas.

Jones AM, Thirlwell C, Howarth KM, Graham T, Chambers W, Segditsas S, Page KM, Phillips RK, Thomas HJ, Sieber OM, Sawyer EJ, Tomlinson IP.

J Pathol. 2007 Nov;213(3):249-56.


Activation of AKT and nuclear accumulation of wild type TP53 and MDM2 in anal squamous cell carcinoma.

Patel H, Polanco-Echeverry G, Segditsas S, Volikos E, McCart A, Lai C, Guenther T, Zaitoun A, Sieber O, Ilyas M, Northover J, Silver A.

Int J Cancer. 2007 Dec 15;121(12):2668-73.


Investigation of pathogenic mechanisms in multiple colorectal adenoma patients without germline APC or MYH/MUTYH mutations.

Thirlwell C, Howarth KM, Segditsas S, Guerra G, Thomas HJ, Phillips RK, Talbot IC, Gorman M, Novelli MR, Sieber OM, Tomlinson IP.

Br J Cancer. 2007 Jun 4;96(11):1729-34. Epub 2007 May 15.


Colorectal cancer and genetic alterations in the Wnt pathway.

Segditsas S, Tomlinson I.

Oncogene. 2006 Dec 4;25(57):7531-7. Review.


Disease severity and genetic pathways in attenuated familial adenomatous polyposis vary greatly but depend on the site of the germline mutation.

Sieber OM, Segditsas S, Knudsen AL, Zhang J, Luz J, Rowan AJ, Spain SL, Thirlwell C, Howarth KM, Jaeger EE, Robinson J, Volikos E, Silver A, Kelly G, Aretz S, Frayling I, Hutter P, Dunlop M, Guenther T, Neale K, Phillips R, Heinimann K, Tomlinson IP.

Gut. 2006 Oct;55(10):1440-8. Epub 2006 Feb 4.

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