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Smad signaling in the rat model of monocrotaline pulmonary hypertension.
Ramos MF, Lamé MW, Segall HJ, Wilson DW.
Toxicol Pathol. 2008 Feb;36(2):311-20. doi: 10.1177/0192623307311402. Epub 2008 Mar 26.
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The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro.
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Monocrotaline pyrrole targets proteins with and without cysteine residues in the cytosol and membranes of human pulmonary artery endothelial cells.
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Characterization of cytosolic glutathione S-transferases in juvenile Chinook salmon (Oncorhynchus tshawytscha).
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Characterization of glutathione S-transferases in juvenile white sturgeon.
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Protein targets of 1,4-benzoquinone and 1,4-naphthoquinone in human bronchial epithelial cells.
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Effects of monocrotaline pyrrole and thrombin on pulmonary endothelial cell junction and matrix adhesion proteins.
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Long-term kinetic study of beta-carotene, using accelerator mass spectrometry in an adult volunteer.
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J Lipid Res. 2000 Nov;41(11):1790-800.
DNA damage cell checkpoint activities are altered in monocrotaline pyrrole-induced cell cycle arrest in human pulmonary artery endothelial cells.
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Protein targets of monocrotaline pyrrole in pulmonary artery endothelial cells.
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Manipulation of injury and repair of the alveolar epithelium using two pneumotoxicants: 3-methylindole and monocrotaline.
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Alteration in lung particle translocation, macrophage function, and microfilament arrangement in monocrotaline-treated rats.
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Toxicol Appl Pharmacol. 1998 Nov;153(1):28-38.
Monocrotaline pyrrole interacts with actin and increases thrombin-mediated permeability in pulmonary artery endothelial cells.
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Toxicol Appl Pharmacol. 1998 Sep;152(1):138-44.
Monocrotaline pyrrole induces apoptosis in pulmonary artery endothelial cells.
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Toxicol Appl Pharmacol. 1998 Aug;151(2):236-44.
Prolonged cell-cycle arrest associated with altered cdc2 kinase in monocrotaline pyrrole-treated pulmonary artery endothelial cells.
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Am J Respir Cell Mol Biol. 1998 Jul;19(1):129-42.
Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes.
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J Biochem Mol Toxicol. 1998;12(3):157-66.
Effect of monocrotaline metabolites on glutathione levels in human and bovine pulmonary artery endothelial cells.
Reid MJ, Dunston SK, Lamé MW, Wilson DW, Morin D, Segall HJ.
Res Commun Mol Pathol Pharmacol. 1998 Jan;99(1):53-68.
Association of dehydromonocrotaline with rat red blood cells.
Lamé MW, Jones AD, Morin D, Wilson DW, Segall HJ.
Chem Res Toxicol. 1997 Jun;10(6):694-701.
Monocrotaline metabolism and distribution in Fisher 344 and Sprague-Dawley rats.
Comp Biochem Physiol B Biochem Mol Biol. 1997 May;117(1):115-23.
Comparative cytotoxicity of monocrotaline and its metabolites in cultured pulmonary artery endothelial cells.
Taylor DW, Wilson DW, Lamé MW, Dunston SD, Jones AD, Segall HJ.
Toxicol Appl Pharmacol. 1997 Mar;143(1):196-204.
Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA.
Thomas HC, Lamé MW, Wilson DW, Segall HJ.
Toxicol Appl Pharmacol. 1996 Nov;141(1):319-29.
Biliary excretion of pyrrolic metabolites of [14C]monocrotaline in the rat.
Lamé MW, Jones AD, Morin D, Segall HJ, Wilson DW.
Drug Metab Dispos. 1995 Mar;23(3):422-9.
Hydrolysis rates of pyrrolizidine alkaloids derived from Senecio jacobaea.
Dueker SR, Lamé MW, Segall HJ.
Arch Toxicol. 1995;69(10):725-8.
Glutathione conjugation with the pyrrolizidine alkaloid, jacobine.
Dueker SR, Lamé MW, Jones AD, Morin D, Segall HJ.
Biochem Biophys Res Commun. 1994 Jan 28;198(2):516-22.
Strain differences in the response of Fischer 344 and Sprague-Dawley rats to monocrotaline induced pulmonary vascular disease.
Pan LC, Wilson DW, Segall HJ.
Toxicology. 1993 Mar 30;79(1):21-35.
In vivo metabolism of retrorsine and retrorsine-N-oxide.
Chu PS, Lamé MW, Segall HJ.
Arch Toxicol. 1993;67(1):39-43.
Analysis of mercapturic acid conjugates of xenobiotic compounds using negative ionization and tandem mass spectrometry.
Jones AD, Winter CK, Buonarati MH, Segall HJ.
Biol Mass Spectrom. 1993 Jan;22(1):68-76.
COR pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine.
Pan LC, Wilson DW, Lamé MW, Jones AD, Segall HJ.
Toxicol Appl Pharmacol. 1993 Jan;118(1):87-97.
Hydrolysis of pyrrolizidine alkaloids by guinea pig hepatic carboxylesterases.
Toxicol Appl Pharmacol. 1992 Nov;117(1):116-21.
Quantification of cytochrome P450 reductase gene expression in human tissues.
Shephard EA, Palmer CN, Segall HJ, Phillips IR.
Arch Biochem Biophys. 1992 Apr;294(1):168-72.
Guinea pig and rat hepatic microsomal metabolism of monocrotaline.
Dueker SR, Lamé MW, Morin D, Wilson DW, Segall HJ.
Drug Metab Dispos. 1992 Mar-Apr;20(2):275-80.
Mechanisms and pathology of monocrotaline pulmonary toxicity.
Wilson DW, Segall HJ, Pan LC, Lamé MW, Estep JE, Morin D.
Crit Rev Toxicol. 1992;22(5-6):307-25. Review.
DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships.
Hincks JR, Kim HY, Segall HJ, Molyneux RJ, Stermitz FR, Coulombe RA Jr.
Toxicol Appl Pharmacol. 1991 Oct;111(1):90-8.
Red blood cells augment transport of reactive metabolites of monocrotaline from liver to lung in isolated and tandem liver and lung preparations.
Pan LC, Lamé MW, Morin D, Wilson DW, Segall HJ.
Toxicol Appl Pharmacol. 1991 Sep 1;110(2):336-46.
Metabolism of [14C]monocrotaline by isolated perfused rat liver.
Lamé MW, Jones AD, Morin D, Segall HJ.
Drug Metab Dispos. 1991 Mar-Apr;19(2):516-24.
Species difference in the urinary excretion of isatinecic acid from the pyrrolizidine alkaloid retrorsine.
Chu PS, Segall HJ.
Comp Biochem Physiol C. 1991;100(3):683-6.
[14C]monocrotaline kinetics and metabolism in the rat.
Estep JE, Lamé MW, Morin D, Jones AD, Wilson DW, Segall HJ.
Drug Metab Dispos. 1991 Jan-Feb;19(1):135-9.
Excretion and blood radioactivity levels following [14C]senecionine administration in the rat.
Estep JE, Lamé MW, Segall HJ.
Toxicology. 1990 Nov;64(2):179-89.
N-acetylcysteine-conjugated pyrrole identified in rat urine following administration of two pyrrolizidine alkaloids, monocrotaline and senecionine.
Estep JE, Lamé MW, Jones AD, Segall HJ.
Toxicol Lett. 1990 Nov;54(1):61-9.
Changes in type II cell populations in monocrotaline pneumotoxicity.
Wilson DW, Segall HJ.
Am J Pathol. 1990 Jun;136(6):1293-9.
Isolation and identification of a pyrrolic glutathione conjugate metabolite of the pyrrolizidine alkaloid monocrotaline.
Lamé MW, Morin D, Jones AD, Segall HJ, Wilson DW.
Toxicol Lett. 1990 May;51(3):321-9.
Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats.
Wilson DW, Segall HJ, Pan LC, Dunston SK.
Microvasc Res. 1989 Jul;38(1):57-80.
Effects of the pyrrolizidine alkaloid senecionine and the alkenals trans-4-OH-hexenal and trans-2-hexenal on intracellular calcium compartmentation in isolated hepatocytes.
Griffin DS, Segall HJ.
Biochem Pharmacol. 1989 Feb 1;38(3):391-7.
Pyrrolizidine alkaloid-induced liver disease in horses: an early diagnosis.
Mendel VE, Witt MR, Gitchell BS, Gribble DN, Rogers QR, Segall HJ, Knight HD.
Am J Vet Res. 1988 Apr;49(4):572-8.
Determination of pyrrolizidine alkaloid metabolites from mouse liver microsomes using tandem mass spectrometry and gas chromatography/mass spectrometry.
Winter CK, Segall HJ, Jones AD.
Biomed Environ Mass Spectrom. 1988 Mar 1;15(5):265-73.
Species differences in the hepatic microsomal metabolism of the pyrrolizidine alkaloid senecionine.
Comp Biochem Physiol C. 1988;90(2):429-33.
Lipid peroxidation and cellular damage caused by the pyrrolizidine alkaloid senecionine, the alkenal trans-4-hydroxy-2-hexenal, and related alkenals.
Cell Biol Toxicol. 1987 Dec;3(4):379-90.
Distribution of trans-4-hydroxy-2-hexenal and tandem mass spectrometric detection of its urinary mercapturic acid in the rat.
Drug Metab Dispos. 1987 Sep-Oct;15(5):608-12.
In vitro effects of trans-4-hydroxy-2-alkenals on mouse liver cytochrome P-450.
Lame' MW, Segall HJ.
Chem Biol Interact. 1987;62(1):59-74.
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