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Items: 1 to 50 of 64

1.

Smad signaling in the rat model of monocrotaline pulmonary hypertension.

Ramos MF, Lamé MW, Segall HJ, Wilson DW.

Toxicol Pathol. 2008 Feb;36(2):311-20. doi: 10.1177/0192623307311402. Epub 2008 Mar 26.

PMID:
18367643
2.

Monocrotaline pyrrole induces Smad nuclear accumulation and altered signaling expression in human pulmonary arterial endothelial cells.

Ramos M, Lamé MW, Segall HJ, Wilson DW.

Vascul Pharmacol. 2007 Jun;46(6):439-48. Epub 2007 Feb 2.

3.

The BMP type II receptor is located in lipid rafts, including caveolae, of pulmonary endothelium in vivo and in vitro.

Ramos M, Lamé MW, Segall HJ, Wilson DW.

Vascul Pharmacol. 2006 Jan;44(1):50-9. Epub 2005 Nov 3.

PMID:
16271518
4.
5.

Characterization of cytosolic glutathione S-transferases in juvenile Chinook salmon (Oncorhynchus tshawytscha).

Donham RT, Morin D, Jewell WT, Lamé MW, Segall HJ, Tjeerdema RS.

Aquat Toxicol. 2005 Jul 1;73(3):221-9. Epub 2005 Apr 26.

PMID:
15935862
6.

Characterization of glutathione S-transferases in juvenile white sturgeon.

Donham RT, Morin D, Jewell WT, Burns SA, Mitchell AE, Lamé MW, Segall HJ, Tjeerdema RS.

Aquat Toxicol. 2005 Feb 10;71(3):203-14. Epub 2005 Jan 17.

PMID:
15670627
7.

Protein targets of 1,4-benzoquinone and 1,4-naphthoquinone in human bronchial epithelial cells.

Lamé MW, Jones AD, Wilson DW, Segall HJ.

Proteomics. 2003 Apr;3(4):479-95.

PMID:
12687615
8.

Effects of monocrotaline pyrrole and thrombin on pulmonary endothelial cell junction and matrix adhesion proteins.

Taylor DW, Lamé MW, Nakayama LS, Segall HJ, Wilson DW.

Toxicology. 2003 Mar 3;184(2-3):227-40.

PMID:
12499124
9.

Long-term kinetic study of beta-carotene, using accelerator mass spectrometry in an adult volunteer.

Dueker SR, Lin Y, Buchholz BA, Schneider PD, Lamé MW, Segall HJ, Vogel JS, Clifford AJ.

J Lipid Res. 2000 Nov;41(11):1790-800.

10.

DNA damage cell checkpoint activities are altered in monocrotaline pyrrole-induced cell cycle arrest in human pulmonary artery endothelial cells.

Wilson DW, Lamé MW, Dunston SK, Segall HJ.

Toxicol Appl Pharmacol. 2000 Jul 15;166(2):69-80.

PMID:
10896848
11.

Protein targets of monocrotaline pyrrole in pulmonary artery endothelial cells.

Lamé MW, Jones AD, Wilson DW, Dunston SK, Segall HJ.

J Biol Chem. 2000 Sep 15;275(37):29091-9.

12.
13.

Alteration in lung particle translocation, macrophage function, and microfilament arrangement in monocrotaline-treated rats.

Madl AK, Wilson DW, Segall HJ, Pinkerton KE.

Toxicol Appl Pharmacol. 1998 Nov;153(1):28-38.

PMID:
9875297
14.

Monocrotaline pyrrole interacts with actin and increases thrombin-mediated permeability in pulmonary artery endothelial cells.

Wilson DW, Lamé MW, Dunston SK, Taylor DW, Segall HJ.

Toxicol Appl Pharmacol. 1998 Sep;152(1):138-44.

PMID:
9772209
15.

Monocrotaline pyrrole induces apoptosis in pulmonary artery endothelial cells.

Thomas HC, Lamé MW, Dunston SK, Segall HJ, Wilson DW.

Toxicol Appl Pharmacol. 1998 Aug;151(2):236-44.

PMID:
9707500
16.

Prolonged cell-cycle arrest associated with altered cdc2 kinase in monocrotaline pyrrole-treated pulmonary artery endothelial cells.

Thomas HC, Lamé MW, Morin D, Wilson DW, Segall HJ.

Am J Respir Cell Mol Biol. 1998 Jul;19(1):129-42.

PMID:
9651189
17.

Involvement of cytochrome P450 3A in the metabolism and covalent binding of 14C-monocrotaline in rat liver microsomes.

Reid MJ, Lamé MW, Morin D, Wilson DW, Segall HJ.

J Biochem Mol Toxicol. 1998;12(3):157-66.

PMID:
9522275
18.

Effect of monocrotaline metabolites on glutathione levels in human and bovine pulmonary artery endothelial cells.

Reid MJ, Dunston SK, Lamé MW, Wilson DW, Morin D, Segall HJ.

Res Commun Mol Pathol Pharmacol. 1998 Jan;99(1):53-68.

PMID:
9523355
19.

Association of dehydromonocrotaline with rat red blood cells.

Lamé MW, Jones AD, Morin D, Wilson DW, Segall HJ.

Chem Res Toxicol. 1997 Jun;10(6):694-701.

PMID:
9208177
20.

Monocrotaline metabolism and distribution in Fisher 344 and Sprague-Dawley rats.

Reid MJ, Lamé MW, Morin D, Wilson DW, Segall HJ.

Comp Biochem Physiol B Biochem Mol Biol. 1997 May;117(1):115-23.

PMID:
9180020
21.

Comparative cytotoxicity of monocrotaline and its metabolites in cultured pulmonary artery endothelial cells.

Taylor DW, Wilson DW, Lamé MW, Dunston SD, Jones AD, Segall HJ.

Toxicol Appl Pharmacol. 1997 Mar;143(1):196-204.

PMID:
9073608
22.

Cell cycle alterations associated with covalent binding of monocrotaline pyrrole to pulmonary artery endothelial cell DNA.

Thomas HC, Lamé MW, Wilson DW, Segall HJ.

Toxicol Appl Pharmacol. 1996 Nov;141(1):319-29.

PMID:
8917705
23.

Biliary excretion of pyrrolic metabolites of [14C]monocrotaline in the rat.

Lamé MW, Jones AD, Morin D, Segall HJ, Wilson DW.

Drug Metab Dispos. 1995 Mar;23(3):422-9.

PMID:
7628310
24.

Hydrolysis rates of pyrrolizidine alkaloids derived from Senecio jacobaea.

Dueker SR, Lamé MW, Segall HJ.

Arch Toxicol. 1995;69(10):725-8.

PMID:
8572933
25.

Glutathione conjugation with the pyrrolizidine alkaloid, jacobine.

Dueker SR, Lamé MW, Jones AD, Morin D, Segall HJ.

Biochem Biophys Res Commun. 1994 Jan 28;198(2):516-22.

PMID:
8297362
26.
27.

In vivo metabolism of retrorsine and retrorsine-N-oxide.

Chu PS, Lamé MW, Segall HJ.

Arch Toxicol. 1993;67(1):39-43.

PMID:
8452478
28.

Analysis of mercapturic acid conjugates of xenobiotic compounds using negative ionization and tandem mass spectrometry.

Jones AD, Winter CK, Buonarati MH, Segall HJ.

Biol Mass Spectrom. 1993 Jan;22(1):68-76.

PMID:
8431504
29.

COR pulmonale is caused by monocrotaline and dehydromonocrotaline, but not by glutathione or cysteine conjugates of dihydropyrrolizine.

Pan LC, Wilson DW, Lamé MW, Jones AD, Segall HJ.

Toxicol Appl Pharmacol. 1993 Jan;118(1):87-97.

PMID:
8430429
30.

Hydrolysis of pyrrolizidine alkaloids by guinea pig hepatic carboxylesterases.

Dueker SR, Lamé MW, Segall HJ.

Toxicol Appl Pharmacol. 1992 Nov;117(1):116-21.

PMID:
1440605
31.

Quantification of cytochrome P450 reductase gene expression in human tissues.

Shephard EA, Palmer CN, Segall HJ, Phillips IR.

Arch Biochem Biophys. 1992 Apr;294(1):168-72.

PMID:
1550342
32.

Guinea pig and rat hepatic microsomal metabolism of monocrotaline.

Dueker SR, Lamé MW, Morin D, Wilson DW, Segall HJ.

Drug Metab Dispos. 1992 Mar-Apr;20(2):275-80.

PMID:
1352221
33.

Mechanisms and pathology of monocrotaline pulmonary toxicity.

Wilson DW, Segall HJ, Pan LC, Lamé MW, Estep JE, Morin D.

Crit Rev Toxicol. 1992;22(5-6):307-25. Review.

PMID:
1489509
34.

DNA cross-linking in mammalian cells by pyrrolizidine alkaloids: structure-activity relationships.

Hincks JR, Kim HY, Segall HJ, Molyneux RJ, Stermitz FR, Coulombe RA Jr.

Toxicol Appl Pharmacol. 1991 Oct;111(1):90-8.

PMID:
1949039
35.

Red blood cells augment transport of reactive metabolites of monocrotaline from liver to lung in isolated and tandem liver and lung preparations.

Pan LC, Lamé MW, Morin D, Wilson DW, Segall HJ.

Toxicol Appl Pharmacol. 1991 Sep 1;110(2):336-46.

PMID:
1909819
36.

Metabolism of [14C]monocrotaline by isolated perfused rat liver.

Lamé MW, Jones AD, Morin D, Segall HJ.

Drug Metab Dispos. 1991 Mar-Apr;19(2):516-24.

PMID:
1676664
37.
38.

[14C]monocrotaline kinetics and metabolism in the rat.

Estep JE, Lamé MW, Morin D, Jones AD, Wilson DW, Segall HJ.

Drug Metab Dispos. 1991 Jan-Feb;19(1):135-9.

PMID:
1673386
39.

Excretion and blood radioactivity levels following [14C]senecionine administration in the rat.

Estep JE, Lamé MW, Segall HJ.

Toxicology. 1990 Nov;64(2):179-89.

PMID:
2219139
40.
41.

Changes in type II cell populations in monocrotaline pneumotoxicity.

Wilson DW, Segall HJ.

Am J Pathol. 1990 Jun;136(6):1293-9.

42.

Isolation and identification of a pyrrolic glutathione conjugate metabolite of the pyrrolizidine alkaloid monocrotaline.

Lamé MW, Morin D, Jones AD, Segall HJ, Wilson DW.

Toxicol Lett. 1990 May;51(3):321-9.

PMID:
2111054
43.

Progressive inflammatory and structural changes in the pulmonary vasculature of monocrotaline-treated rats.

Wilson DW, Segall HJ, Pan LC, Dunston SK.

Microvasc Res. 1989 Jul;38(1):57-80.

PMID:
2503687
45.

Pyrrolizidine alkaloid-induced liver disease in horses: an early diagnosis.

Mendel VE, Witt MR, Gitchell BS, Gribble DN, Rogers QR, Segall HJ, Knight HD.

Am J Vet Res. 1988 Apr;49(4):572-8.

PMID:
3377320
46.
47.

Species differences in the hepatic microsomal metabolism of the pyrrolizidine alkaloid senecionine.

Winter CK, Segall HJ, Jones AD.

Comp Biochem Physiol C. 1988;90(2):429-33.

PMID:
2903002
49.
50.

In vitro effects of trans-4-hydroxy-2-alkenals on mouse liver cytochrome P-450.

Lame' MW, Segall HJ.

Chem Biol Interact. 1987;62(1):59-74.

PMID:
3581287

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