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Stronger together? Perspectives on phage-antibiotic synergy in clinical applications of phage therapy.

Segall AM, Roach DR, Strathdee SA.

Curr Opin Microbiol. 2019 Jun 18;51:46-50. doi: 10.1016/j.mib.2019.03.005. [Epub ahead of print] Review.


Erratum for Schooley et al., "Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection".

Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T.

Antimicrob Agents Chemother. 2018 Nov 26;62(12). pii: e02221-18. doi: 10.1128/AAC.02221-18. Print 2018 Dec. No abstract available.


Development and Use of Personalized Bacteriophage-Based Therapeutic Cocktails To Treat a Patient with a Disseminated Resistant Acinetobacter baumannii Infection.

Schooley RT, Biswas B, Gill JJ, Hernandez-Morales A, Lancaster J, Lessor L, Barr JJ, Reed SL, Rohwer F, Benler S, Segall AM, Taplitz R, Smith DM, Kerr K, Kumaraswamy M, Nizet V, Lin L, McCauley MD, Strathdee SA, Benson CA, Pope RK, Leroux BM, Picel AC, Mateczun AJ, Cilwa KE, Regeimbal JM, Estrella LA, Wolfe DM, Henry MS, Quinones J, Salka S, Bishop-Lilly KA, Young R, Hamilton T.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00954-17. doi: 10.1128/AAC.00954-17. Print 2017 Oct. Erratum in: Antimicrob Agents Chemother. 2018 Nov 26;62(12):.


Novel antimicrobial peptide prevents C. rodentium infection in C57BL/6 mice by enhancing acid-induced pathogen killing.

Lackraj T, Johnson-Henry K, Sherman PM, Goodman SD, Segall AM, Barnett Foster D.

Microbiology. 2016 Sep;162(9):1641-1650. doi: 10.1099/mic.0.000335. Epub 2016 Jul 13.


In retrospect: A century of phage lessons.

Rohwer F, Segall AM.

Nature. 2015 Dec 3;528(7580):46-8. doi: 10.1038/528046a. No abstract available.


Some of the most interesting CASP11 targets through the eyes of their authors.

Kryshtafovych A, Moult J, Baslé A, Burgin A, Craig TK, Edwards RA, Fass D, Hartmann MD, Korycinski M, Lewis RJ, Lorimer D, Lupas AN, Newman J, Peat TS, Piepenbrink KH, Prahlad J, van Raaij MJ, Rohwer F, Segall AM, Seguritan V, Sundberg EJ, Singh AK, Wilson MA, Schwede T.

Proteins. 2016 Sep;84 Suppl 1:34-50. doi: 10.1002/prot.24942. Epub 2015 Nov 16.


Phage Phenomics: Physiological Approaches to Characterize Novel Viral Proteins.

Sanchez SE, Cuevas DA, Rostron JE, Liang TY, Pivaroff CG, Haynes MR, Nulton J, Felts B, Bailey BA, Salamon P, Edwards RA, Burgin AB, Segall AM, Rohwer F.

J Vis Exp. 2015 Jun 11;(100):e52854. doi: 10.3791/52854.


Replication fork integrity and intra-S phase checkpoint suppress gene amplification.

Kondratova A, Watanabe T, Marotta M, Cannon M, Segall AM, Serre D, Tanaka H.

Nucleic Acids Res. 2015 Mar 11;43(5):2678-90. doi: 10.1093/nar/gkv084. Epub 2015 Feb 11.


Coxsackievirus B exits the host cell in shed microvesicles displaying autophagosomal markers.

Robinson SM, Tsueng G, Sin J, Mangale V, Rahawi S, McIntyre LL, Williams W, Kha N, Cruz C, Hancock BM, Nguyen DP, Sayen MR, Hilton BJ, Doran KS, Segall AM, Wolkowicz R, Cornell CT, Whitton JL, Gottlieb RA, Feuer R.

PLoS Pathog. 2014 Apr 10;10(4):e1004045. doi: 10.1371/journal.ppat.1004045. eCollection 2014 Apr.


Tumor cell death mediated by peptides that recognize branched intermediates of DNA replication and repair.

Dey M, Patra S, Su LY, Segall AM.

PLoS One. 2013 Nov 14;8(11):e78751. doi: 10.1371/journal.pone.0078751. eCollection 2013.


Structure and function of a cyanophage-encoded peptide deformylase.

Frank JA, Lorimer D, Youle M, Witte P, Craig T, Abendroth J, Rohwer F, Edwards RA, Segall AM, Burgin AB Jr.

ISME J. 2013 Jun;7(6):1150-60. doi: 10.1038/ismej.2013.4. Epub 2013 Feb 14.


wrwyrggrywrw is a single-chain functional analog of the Holliday junction-binding homodimer, (wrwycr)2.

Rideout MC, Naili I, Boldt JL, Flores-Fujimoto A, Patra S, Rostron JE, Segall AM.

Peptides. 2013 Feb;40:112-22. doi: 10.1016/j.peptides.2012.12.025. Epub 2013 Jan 3.


Similarities between exogenously- and endogenously-induced envelope stress: the effects of a new antibacterial molecule, TPI1609-10.

Yitzhaki S, Rostron JE, Xu Y, Rideout MC, Authement RN, Barlow SB, Segall AM.

PLoS One. 2012;7(10):e44896. doi: 10.1371/journal.pone.0044896. Epub 2012 Oct 11.


Artificial neural networks trained to detect viral and phage structural proteins.

Seguritan V, Alves N Jr, Arnoult M, Raymond A, Lorimer D, Burgin AB Jr, Salamon P, Segall AM.

PLoS Comput Biol. 2012;8(8):e1002657. doi: 10.1371/journal.pcbi.1002657. Epub 2012 Aug 23.


Potent antimicrobial small molecules screened as inhibitors of tyrosine recombinases and Holliday junction-resolving enzymes.

Rideout MC, Boldt JL, Vahi-Ferguson G, Salamon P, Nefzi A, Ostresh JM, Giulianotti M, Pinilla C, Segall AM.

Mol Divers. 2011 Nov;15(4):989-1005. doi: 10.1007/s11030-011-9333-2. Epub 2011 Sep 22.


A novel antimicrobial peptide significantly enhances acid-induced killing of Shiga toxin-producing Escherichia coli O157 and non-O157 serotypes.

Lino M, Kus JV, Tran SL, Naqvi Z, Binnington B, Goodman SD, Segall AM, Foster DB.

Microbiology. 2011 Jun;157(Pt 6):1768-75. doi: 10.1099/mic.0.047365-0. Epub 2011 Mar 31.


Small molecule functional analogs of peptides that inhibit lambda site-specific recombination and bind Holliday junctions.

Ranjit DK, Rideout MC, Nefzi A, Ostresh JM, Pinilla C, Segall AM.

Bioorg Med Chem Lett. 2010 Aug 1;20(15):4531-4. doi: 10.1016/j.bmcl.2010.06.029. Epub 2010 Jun 8.


An antimicrobial peptide that targets DNA repair intermediates in vitro inhibits Salmonella growth within murine macrophages.

Su LY, Willner DL, Segall AM.

Antimicrob Agents Chemother. 2010 May;54(5):1888-99. doi: 10.1128/AAC.01610-09. Epub 2010 Feb 22.


Control of directionality in the DNA strand-exchange reaction catalysed by the tyrosine recombinase TnpI.

Vanhooff V, Normand C, Galloy C, Segall AM, Hallet B.

Nucleic Acids Res. 2010 Apr;38(6):2044-56. doi: 10.1093/nar/gkp1187. Epub 2009 Dec 30.


Lysogeny and sporulation in Bacillus isolates from the Gulf of Mexico.

Mobberley J, Authement RN, Segall AM, Edwards RA, Slepecky RA, Paul JH.

Appl Environ Microbiol. 2010 Feb;76(3):829-42. doi: 10.1128/AEM.01710-09. Epub 2009 Dec 11.


Staphylococcus aureus SarA is a regulatory protein responsive to redox and pH that can support bacteriophage lambda integrase-mediated excision/recombination.

Fujimoto DF, Higginbotham RH, Sterba KM, Maleki SJ, Segall AM, Smeltzer MS, Hurlburt BK.

Mol Microbiol. 2009 Dec;74(6):1445-58. doi: 10.1111/j.1365-2958.2009.06942.x. Epub 2009 Nov 17.


Peptide wrwycr inhibits the excision of several prophages and traps holliday junctions inside bacteria.

Gunderson CW, Boldt JL, Authement RN, Segall AM.

J Bacteriol. 2009 Apr;191(7):2169-76. doi: 10.1128/JB.01559-08. Epub 2009 Jan 30.


Interactions between branched DNAs and peptide inhibitors of DNA repair.

Kepple KV, Patel N, Salamon P, Segall AM.

Nucleic Acids Res. 2008 Sep;36(16):5319-34. doi: 10.1093/nar/gkn512. Epub 2008 Aug 8.


The temperate marine phage PhiHAP-1 of Halomonas aquamarina possesses a linear plasmid-like prophage genome.

Mobberley JM, Authement RN, Segall AM, Paul JH.

J Virol. 2008 Jul;82(13):6618-30. doi: 10.1128/JVI.00140-08. Epub 2008 Apr 30.


Probing nucleoid structure in bacteria using phage lambda integrase-mediated chromosome rearrangements.

Garcia-Russell N, Orchard SS, Segall AM.

Methods Enzymol. 2007;421:209-26. Review.


Spermidine biases the resolution of Holliday junctions by phage lambda integrase.

Boldt JL, Kepple KV, Cassell GD, Segall AM.

Nucleic Acids Res. 2007;35(3):716-27. Epub 2006 Dec 19.


New peptide inhibitors of type IB topoisomerases: similarities and differences vis-a-vis inhibitors of tyrosine recombinases.

Fujimoto DF, Pinilla C, Segall AM.

J Mol Biol. 2006 Nov 10;363(5):891-907. Epub 2006 Aug 24.


New wrinkles and folds in site-specific recombination.

Segall AM, Craig NL.

Mol Cell. 2005 Aug 19;19(4):433-5. Review.


Complete genome sequence of phiHSIC, a pseudotemperate marine phage of Listonella pelagia.

Paul JH, Williamson SJ, Long A, Authement RN, John D, Segall AM, Rohwer FL, Androlewicz M, Patterson S.

Appl Environ Microbiol. 2005 Jun;71(6):3311-20.


Holliday junction-binding peptides inhibit distinct junction-processing enzymes.

Kepple KV, Boldt JL, Segall AM.

Proc Natl Acad Sci U S A. 2005 May 10;102(19):6867-72. Epub 2005 May 2.


Peptide trapping of the Holliday junction intermediate in Cre-loxP site-specific recombination.

Ghosh K, Lau CK, Guo F, Segall AM, Van Duyne GD.

J Biol Chem. 2005 Mar 4;280(9):8290-9. Epub 2004 Dec 8.


New views of the bacterial chromosome.

Lovett ST, Segall AM.

EMBO Rep. 2004 Sep;5(9):860-4. No abstract available.


Unequal access of chromosomal regions to each other in Salmonella: probing chromosome structure with phage lambda integrase-mediated long-range rearrangements.

Garcia-Russell N, Harmon TG, Le TQ, Amaladas NH, Mathewson RD, Segall AM.

Mol Microbiol. 2004 Apr;52(2):329-44. Erratum in: Mol Microbiol. 2004 Nov;54(3):850.


Genome sequences of two closely related Vibrio parahaemolyticus phages, VP16T and VP16C.

Seguritan V, Feng IW, Rohwer F, Swift M, Segall AM.

J Bacteriol. 2003 Nov;185(21):6434-47.


Mutations at residues 282, 286, and 293 of phage lambda integrase exert pathway-specific effects on synapsis and catalysis in recombination.

Bankhead TM, Etzel BJ, Wolven F, Bordenave S, Boldt JL, Larsen TA, Segall AM.

J Bacteriol. 2003 Apr;185(8):2653-66.


Novel antibiotics: macrocyclic peptides designed to trap Holliday junctions.

Bolla ML, Azevedo EV, Smith JM, Taylor RE, Ranjit DK, Segall AM, McAlpine SR.

Org Lett. 2003 Jan 23;5(2):109-12.


Marine phage genomics.

Paul JH, Sullivan MB, Segall AM, Rohwer F.

Comp Biochem Physiol B Biochem Mol Biol. 2002 Dec;133(4):463-76. Review.


Genomic analysis of uncultured marine viral communities.

Breitbart M, Salamon P, Andresen B, Mahaffy JM, Segall AM, Mead D, Azam F, Rohwer F.

Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14250-5. Epub 2002 Oct 16.


Production of shotgun libraries using random amplification.

Rohwer F, Seguritan V, Choi DH, Segall AM, Azam F.

Biotechniques. 2001 Jul;31(1):108-12, 114-6, 118.


Peptide inhibitors of DNA cleavage by tyrosine recombinases and topoisomerases.

Klemm M, Cheng C, Cassell G, Shuman S, Segall AM.

J Mol Biol. 2000 Jun 23;299(5):1203-16.


In vitro selection of integration host factor binding sites.

Goodman SD, Velten NJ, Gao Q, Robinson S, Segall AM.

J Bacteriol. 1999 May;181(10):3246-55.


Exclusive breast-feeding duration is associated with attitudinal, socioeconomic and biocultural determinants in three Latin American countries.

Pérez-Escamilla R, Lutter C, Segall AM, Rivera A, Treviño-Siller S, Sanghvi T.

J Nutr. 1995 Dec;125(12):2972-84.


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