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Advanced age protects resistance arteries of mouse skeletal muscle from oxidative stress through attenuating apoptosis induced by hydrogen peroxide.

Norton CE, Sinkler SY, Jacobsen NL, Segal SS.

J Physiol. 2019 Aug;597(15):3801-3816. doi: 10.1113/JP278255. Epub 2019 Jul 2.


Recovery of blood flow regulation in microvascular resistance networks during regeneration of mouse gluteus maximus muscle.

Fernando CA, Pangan AM, Cornelison D, Segal SS.

J Physiol. 2019 Mar;597(5):1401-1417. doi: 10.1113/JP277247. Epub 2019 Feb 3.


Microvascular mechanisms limiting skeletal muscle blood flow with advancing age.

Socha MJ, Segal SS.

J Appl Physiol (1985). 2018 Dec 1;125(6):1851-1859. doi: 10.1152/japplphysiol.00113.2018. Epub 2018 Nov 9.


Gene expression profiles of ion channels and receptors in mouse resistance arteries: Effects of cell type, vascular bed, and age.

Boerman EM, Sen S, Shaw RL, Joshi T, Segal SS.

Microcirculation. 2018 May;25(4):e12452. doi: 10.1111/micc.12452.


Calcitonin gene-related peptide hyperpolarizes mouse pulmonary artery endothelial tubes through KATP channel activation.

Norton CE, Segal SS.

Am J Physiol Lung Cell Mol Physiol. 2018 Aug 1;315(2):L212-L226. doi: 10.1152/ajplung.00044.2018. Epub 2018 Mar 15.


Biophysical properties of microvascular endothelium: Requirements for initiating and conducting electrical signals.

Kapela A, Behringer EJ, Segal SS, Tsoukias NM.

Microcirculation. 2018 Feb;25(2). doi: 10.1111/micc.12429.


Calcium and electrical dynamics in lymphatic endothelium.

Behringer EJ, Scallan JP, Jafarnejad M, Castorena-Gonzalez JA, Zawieja SD, Moore JE Jr, Davis MJ, Segal SS.

J Physiol. 2017 Dec 15;595(24):7347-7368. doi: 10.1113/JP274842. Epub 2017 Nov 9.


Impact of Aging on Calcium Signaling and Membrane Potential in Endothelium of Resistance Arteries: A Role for Mitochondria.

Behringer EJ, Segal SS.

J Gerontol A Biol Sci Med Sci. 2017 Nov 9;72(12):1627-1637. doi: 10.1093/gerona/glx079.


Increased amplitude of inward rectifier K+ currents with advanced age in smooth muscle cells of murine superior epigastric arteries.

Hayoz S, Pettis J, Bradley V, Segal SS, Jackson WF.

Am J Physiol Heart Circ Physiol. 2017 Jun 1;312(6):H1203-H1214. doi: 10.1152/ajpheart.00679.2016. Epub 2017 Apr 21.


Enhanced functional sympatholysis through endothelial signalling in healthy young men and women.

Segal SS.

J Physiol. 2016 Dec 15;594(24):7149-7150. doi: 10.1113/JP273454. No abstract available.


Differential α-adrenergic modulation of rapid onset vasodilatation along resistance networks of skeletal muscle in old versus young mice.

Sinkler SY, Fernando CA, Segal SS.

J Physiol. 2016 Dec 1;594(23):6987-7004. doi: 10.1113/JP272409. Epub 2016 Sep 23.


Attenuated rapid onset vasodilation with greater force production in skeletal muscle of caveolin-2-/- mice.

Fernando CA, Liu Y, Sowa G, Segal SS.

Am J Physiol Heart Circ Physiol. 2016 Aug 1;311(2):H415-25. doi: 10.1152/ajpheart.00082.2016. Epub 2016 Jun 17.


Advanced age decreases local calcium signaling in endothelium of mouse mesenteric arteries in vivo.

Boerman EM, Everhart JE, Segal SS.

Am J Physiol Heart Circ Physiol. 2016 May 1;310(9):H1091-6. doi: 10.1152/ajpheart.00038.2016. Epub 2016 Mar 4.


Membrane potential governs calcium influx into microvascular endothelium: integral role for muscarinic receptor activation.

Behringer EJ, Segal SS.

J Physiol. 2015 Oct 15;593(20):4531-48. doi: 10.1113/JP271102. Epub 2015 Sep 13.


Attenuated sarcomere lengthening of the aged murine left ventricle observed using two-photon fluorescence microscopy.

Nance ME, Whitfield JT, Zhu Y, Gibson AK, Hanft LM, Campbell KS, Meininger GA, McDonald KS, Segal SS, Domeier TL.

Am J Physiol Heart Circ Physiol. 2015 Sep;309(5):H918-25. doi: 10.1152/ajpheart.00315.2015. Epub 2015 Jul 24.


Depressed perivascular sensory innervation of mouse mesenteric arteries with advanced age.

Boerman EM, Segal SS.

J Physiol. 2016 Apr 15;594(8):2323-38. doi: 10.1113/JP270710. Epub 2015 Jun 30.


Advanced age protects microvascular endothelium from aberrant Ca(2+) influx and cell death induced by hydrogen peroxide.

Socha MJ, Boerman EM, Behringer EJ, Shaw RL, Domeier TL, Segal SS.

J Physiol. 2015 May 1;593(9):2155-69. doi: 10.1113/JP270169. Epub 2015 Mar 19.


Blood flow restriction without sympathetic vasoconstriction in ageing skeletal muscle during exercise.

Segal SS.

J Physiol. 2014 Nov 1;592(21):4607-8. doi: 10.1113/jphysiol.2014.284018. No abstract available.


Dantrolene suppresses spontaneous Ca2+ release without altering excitation-contraction coupling in cardiomyocytes of aged mice.

Domeier TL, Roberts CJ, Gibson AK, Hanft LM, McDonald KS, Segal SS.

Am J Physiol Heart Circ Physiol. 2014 Sep 15;307(6):H818-29. doi: 10.1152/ajpheart.00287.2014. Epub 2014 Jul 18.


Aging alters reactivity of microvascular resistance networks in mouse gluteus maximus muscle.

Sinkler SY, Segal SS.

Am J Physiol Heart Circ Physiol. 2014 Sep 15;307(6):H830-9. doi: 10.1152/ajpheart.00368.2014. Epub 2014 Jul 11.


Aging increases capacitance and spontaneous transient outward current amplitude of smooth muscle cells from murine superior epigastric arteries.

Hayoz S, Bradley V, Boerman EM, Nourian Z, Segal SS, Jackson WF.

Am J Physiol Heart Circ Physiol. 2014 Jun 1;306(11):H1512-24. doi: 10.1152/ajpheart.00492.2013. Epub 2014 Apr 4.


Isolation of microvascular endothelial tubes from mouse resistance arteries.

Socha MJ, Segal SS.

J Vis Exp. 2013 Nov 25;(81):e50759. doi: 10.3791/50759.


β1-integrin is essential for vasoregulation and smooth muscle survival in vivo.

Turlo KA, Scapa J, Bagher P, Jones AW, Feil R, Korthuis RJ, Segal SS, Iruela-Arispe ML.

Arterioscler Thromb Vasc Biol. 2013 Oct;33(10):2325-35. doi: 10.1161/ATVBAHA.112.300648. Epub 2013 Jul 25.


Aging impairs electrical conduction along endothelium of resistance arteries through enhanced Ca2+-activated K+ channel activation.

Behringer EJ, Shaw RL, Westcott EB, Socha MJ, Segal SS.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1892-901. doi: 10.1161/ATVBAHA.113.301514. Epub 2013 May 30.


Perivascular innervation: a multiplicity of roles in vasomotor control and myoendothelial signaling.

Westcott EB, Segal SS.

Microcirculation. 2013 Apr;20(3):217-38. doi: 10.1111/micc.12035. Review.


Ageing alters perivascular nerve function of mouse mesenteric arteries in vivo.

Westcott EB, Segal SS.

J Physiol. 2013 Mar 1;591(5):1251-63. doi: 10.1113/jphysiol.2012.244483. Epub 2012 Dec 17.


Spreading the signal for vasodilatation: implications for skeletal muscle blood flow control and the effects of ageing.

Behringer EJ, Segal SS.

J Physiol. 2012 Dec 15;590(24):6277-84. doi: 10.1113/jphysiol.2012.239673. Epub 2012 Aug 13. Review.


Coordination of intercellular Ca(2+) signaling in endothelial cell tubes of mouse resistance arteries.

Socha MJ, Domeier TL, Behringer EJ, Segal SS.

Microcirculation. 2012 Nov;19(8):757-70. doi: 10.1111/micc.12000. Erratum in: Microcirculation. 2013 Jan;20(1):115.


Tuning electrical conduction along endothelial tubes of resistance arteries through Ca(2+)-activated K(+) channels.

Behringer EJ, Segal SS.

Circ Res. 2012 May 11;110(10):1311-21. doi: 10.1161/CIRCRESAHA.111.262592. Epub 2012 Apr 5.


Function and expression of ryanodine receptors and inositol 1,4,5-trisphosphate receptors in smooth muscle cells of murine feed arteries and arterioles.

Westcott EB, Goodwin EL, Segal SS, Jackson WF.

J Physiol. 2012 Apr 15;590(8):1849-69. doi: 10.1113/jphysiol.2011.222083. Epub 2012 Feb 13.


Neurovascular proximity in the diaphragm muscle of adult mice.

Correa D, Segal SS.

Microcirculation. 2012 May;19(4):306-15. doi: 10.1111/j.1549-8719.2012.00163.x.


Electrical conduction along endothelial cell tubes from mouse feed arteries: confounding actions of glycyrrhetinic acid derivatives.

Behringer EJ, Socha MJ, Polo-Parada L, Segal SS.

Br J Pharmacol. 2012 May;166(2):774-87. doi: 10.1111/j.1476-5381.2011.01814.x.


Calcium and electrical signalling along endothelium of the resistance vasculature.

Socha MJ, Behringer EJ, Segal SS.

Basic Clin Pharmacol Toxicol. 2012 Jan;110(1):80-6. doi: 10.1111/j.1742-7843.2011.00798.x. Epub 2011 Oct 20. Review.


Temperature effects on morphological integrity and Ca²⁺ signaling in freshly isolated murine feed artery endothelial cell tubes.

Socha MJ, Hakim CH, Jackson WF, Segal SS.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H773-83. doi: 10.1152/ajpheart.00214.2011. Epub 2011 Jun 24.


Microiontophoresis and micromanipulation for intravital fluorescence imaging of the microcirculation.

Bagher P, Polo-Parada L, Segal SS.

J Vis Exp. 2011 Jun 10;(52). pii: 2900. doi: 10.3791/2900.


The mouse cremaster muscle preparation for intravital imaging of the microcirculation.

Bagher P, Segal SS.

J Vis Exp. 2011 Jun 10;(52). pii: 2874. doi: 10.3791/2874.


Visualizing calcium responses to acetylcholine convection along endothelium of arteriolar networks in Cx40BAC-GCaMP2 transgenic mice.

Bagher P, Davis MJ, Segal SS.

Am J Physiol Heart Circ Physiol. 2011 Sep;301(3):H794-802. doi: 10.1152/ajpheart.00425.2011. Epub 2011 Jun 10.


Regulation of blood flow in the microcirculation: role of conducted vasodilation.

Bagher P, Segal SS.

Acta Physiol (Oxf). 2011 Jul;202(3):271-84. doi: 10.1111/j.1748-1716.2010.02244.x. Epub 2011 Mar 1. Review.


Evidence for impaired neurovascular transmission in a murine model of Duchenne muscular dystrophy.

Bagher P, Duan D, Segal SS.

J Appl Physiol (1985). 2011 Mar;110(3):601-9. doi: 10.1152/japplphysiol.01106.2010. Epub 2010 Nov 25.


Regional heterogeneity of α-adrenoreceptor subtypes in arteriolar networks of mouse skeletal muscle.

Moore AW, Jackson WF, Segal SS.

J Physiol. 2010 Nov 1;588(Pt 21):4261-74. doi: 10.1113/jphysiol.2010.194993.


Regional activation of rapid onset vasodilatation in mouse skeletal muscle: regulation through α-adrenoreceptors.

Moore AW, Bearden SE, Segal SS.

J Physiol. 2010 Sep 1;588(Pt 17):3321-31. doi: 10.1113/jphysiol.2010.193672. Epub 2010 Jul 12.


Blunting of rapid onset vasodilatation and blood flow restriction in arterioles of exercising skeletal muscle with ageing in male mice.

Jackson DN, Moore AW, Segal SS.

J Physiol. 2010 Jun 15;588(Pt 12):2269-82. doi: 10.1113/jphysiol.2010.189811. Epub 2010 Apr 7.


Frontiers in microcirculation: control processes and clinical applications.

Segal SS.

Microcirculation. 2010 Apr;17(3):159-63. doi: 10.1111/j.1549-8719.2010.00028.x.


Intravenous hemostat: nanotechnology to halt bleeding.

Bertram JP, Williams CA, Robinson R, Segal SS, Flynn NT, Lavik EB.

Sci Transl Med. 2009 Dec 16;1(11):11ra22. doi: 10.1126/scitranslmed.3000397.


Regulation of myoendothelial junction formation: bridging the gap.

Segal SS, Bagher P.

Circ Res. 2010 Apr 2;106(6):1014-6. doi: 10.1161/CIRCRESAHA.110.217786. No abstract available.


Quantifying perivascular sympathetic innervation: regional differences in male C57BL/6 mice at 3 and 20 months.

Long JB, Segal SS.

J Neurosci Methods. 2009 Oct 30;184(1):124-8. doi: 10.1016/j.jneumeth.2009.07.028. Epub 2009 Aug 3.


VEGF-A and Semaphorin3A: modulators of vascular sympathetic innervation.

Long JB, Jay SM, Segal SS, Madri JA.

Dev Biol. 2009 Oct 1;334(1):119-32. doi: 10.1016/j.ydbio.2009.07.023. Epub 2009 Jul 23.

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