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Items: 1 to 50 of 96


A transatlantic cooperation for enriched neuroscience training.

Witter MP, Karagogeos D, Van Bockstaele EJ, Segal RA.

Eur J Neurosci. 2018 Jul;48(2):1717-1719. doi: 10.1111/ejn.14056. Epub 2018 Jul 4. No abstract available.


Paclitaxel Reduces Axonal Bclw to Initiate IP3R1-Dependent Axon Degeneration.

Pease-Raissi SE, Pazyra-Murphy MF, Li Y, Wachter F, Fukuda Y, Fenstermacher SJ, Barclay LA, Bird GH, Walensky LD, Segal RA.

Neuron. 2017 Oct 11;96(2):373-386.e6. doi: 10.1016/j.neuron.2017.09.034.


A Transposon Screen Identifies Loss of Primary Cilia as a Mechanism of Resistance to SMO Inhibitors.

Zhao X, Pak E, Ornell KJ, Pazyra-Murphy MF, MacKenzie EL, Chadwick EJ, Ponomaryov T, Kelleher JF, Segal RA.

Cancer Discov. 2017 Dec;7(12):1436-1449. doi: 10.1158/2159-8290.CD-17-0281. Epub 2017 Sep 18.


A Mechanistic Understanding of Axon Degeneration in Chemotherapy-Induced Peripheral Neuropathy.

Fukuda Y, Li Y, Segal RA.

Front Neurosci. 2017 Aug 31;11:481. doi: 10.3389/fnins.2017.00481. eCollection 2017. Review.


A brain-penetrant RAF dimer antagonist for the noncanonical BRAF oncoprotein of pediatric low-grade astrocytomas.

Sun Y, Alberta JA, Pilarz C, Calligaris D, Chadwick EJ, Ramkissoon SH, Ramkissoon LA, Garcia VM, Mazzola E, Goumnerova L, Kane M, Yao Z, Kieran MW, Ligon KL, Hahn WC, Garraway LA, Rosen N, Gray NS, Agar NY, Buhrlage SJ, Segal RA, Stiles CD.

Neuro Oncol. 2017 Jun 1;19(6):774-785. doi: 10.1093/neuonc/now261.


Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy.

Pak E, Segal RA.

Dev Cell. 2016 Aug 22;38(4):333-44. doi: 10.1016/j.devcel.2016.07.026. Review.


Tyrosine receptor kinase B is a drug target in astrocytomas.

Ni J, Xie S, Ramkissoon SH, Luu V, Sun Y, Bandopadhayay P, Beroukhim R, Roberts TM, Stiles CD, Segal RA, Ligon KL, Hahn WC, Zhao JJ.

Neuro Oncol. 2017 Jan;19(1):22-30. doi: 10.1093/neuonc/now139. Epub 2016 Jul 10.


There and back again: coordinated transcription, translation and transport in axonal survival and regeneration.

Tasdemir-Yilmaz OE, Segal RA.

Curr Opin Neurobiol. 2016 Aug;39:62-8. doi: 10.1016/j.conb.2016.04.006. Epub 2016 Apr 28. Review.


The RNA-binding protein SFPQ orchestrates an RNA regulon to promote axon viability.

Cosker KE, Fenstermacher SJ, Pazyra-Murphy MF, Elliott HL, Segal RA.

Nat Neurosci. 2016 May;19(5):690-696. doi: 10.1038/nn.4280. Epub 2016 Mar 28.


Lessons from a bridge generation.

Segal RA.

Science. 2016 Mar 25;351(6280):1494. doi: 10.1126/science.351.6280.1494. No abstract available.


A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies.

Chadwick EJ, Yang DP, Filbin MG, Mazzola E, Sun Y, Behar O, Pazyra-Murphy MF, Goumnerova L, Ligon KL, Stiles CD, Segal RA.

J Vis Exp. 2015 Nov 7;(105):e53304. doi: 10.3791/53304.


Prolyl Isomerase Pin1 Regulates Axon Guidance by Stabilizing CRMP2A Selectively in Distal Axons.

Balastik M, Zhou XZ, Alberich-Jorda M, Weissova R, Žiak J, Pazyra-Murphy MF, Cosker KE, Machonova O, Kozmikova I, Chen CH, Pastorino L, Asara JM, Cole A, Sutherland C, Segal RA, Lu KP.

Cell Rep. 2015 Oct 27;13(4):812-828. doi: 10.1016/j.celrep.2015.09.026. Epub 2015 Oct 17.


A Polyamine Twist on Hedgehog Signaling.

Zhao X, Segal RA.

Dev Cell. 2015 Oct 12;35(1):1-2. doi: 10.1016/j.devcel.2015.09.024.


How neuronal activity regulates glioma cell proliferation.

Filbin MG, Segal RA.

Neuro Oncol. 2015 Dec;17(12):1543-4. doi: 10.1093/neuonc/nov188. Epub 2015 Sep 10. No abstract available.


RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors.

Zhao X, Ponomaryov T, Ornell KJ, Zhou P, Dabral SK, Pak E, Li W, Atwood SX, Whitson RJ, Chang AL, Li J, Oro AE, Chan JA, Kelleher JF, Segal RA.

Cancer Res. 2015 Sep 1;75(17):3623-35. doi: 10.1158/0008-5472.CAN-14-2999-T. Epub 2015 Jun 30.


The Eya1 phosphatase promotes Shh signaling during hindbrain development and oncogenesis.

Eisner A, Pazyra-Murphy MF, Durresi E, Zhou P, Zhao X, Chadwick EC, Xu PX, Hillman RT, Scott MP, Greenberg ME, Segal RA.

Dev Cell. 2015 Apr 6;33(1):22-35. doi: 10.1016/j.devcel.2015.01.033. Epub 2015 Mar 26.


Modeling the effects of systemic mediators on the inflammatory phase of wound healing.

Cooper RL, Segal RA, Diegelmann RF, Reynolds AM.

J Theor Biol. 2015 Feb 21;367:86-99. doi: 10.1016/j.jtbi.2014.11.008. Epub 2014 Nov 20.


Preserve and protect: maintaining axons within functional circuits.

Pease SE, Segal RA.

Trends Neurosci. 2014 Oct;37(10):572-82. doi: 10.1016/j.tins.2014.07.007. Epub 2014 Aug 26. Review.


Shh-proteoglycan interactions regulate maturation of olfactory glomerular circuitry.

Persson L, Witt RM, Galligan M, Greer PL, Eisner A, Pazyra-Murphy MF, Datta SR, Segal RA.

Dev Neurobiol. 2014 Dec;74(12):1255-67. doi: 10.1002/dneu.22202. Epub 2014 Jun 27.


Pediatric low-grade gliomas: how modern biology reshapes the clinical field.

Bergthold G, Bandopadhayay P, Bi WL, Ramkissoon L, Stiles C, Segal RA, Beroukhim R, Ligon KL, Grill J, Kieran MW.

Biochim Biophys Acta. 2014 Apr;1845(2):294-307. doi: 10.1016/j.bbcan.2014.02.004. Epub 2014 Feb 28. Review.


Neuronal signaling through endocytosis.

Cosker KE, Segal RA.

Cold Spring Harb Perspect Biol. 2014 Feb 1;6(2). pii: a020669. doi: 10.1101/cshperspect.a020669. Review.


New progenitors NESTIN(g) in the EGL.

Pak E, Segal RA, Stiles CD.

Nat Neurosci. 2013 Dec;16(12):1710-2. doi: 10.1038/nn.3580. No abstract available.


Coordinate activation of Shh and PI3K signaling in PTEN-deficient glioblastoma: new therapeutic opportunities.

Filbin MG, Dabral SK, Pazyra-Murphy MF, Ramkissoon S, Kung AL, Pak E, Chung J, Theisen MA, Sun Y, Franchetti Y, Sun Y, Shulman DS, Redjal N, Tabak B, Beroukhim R, Wang Q, Zhao J, Dorsch M, Buonamici S, Ligon KL, Kelleher JF, Segal RA.

Nat Med. 2013 Nov;19(11):1518-23. doi: 10.1038/nm.3328. Epub 2013 Sep 29.


Heparan sulfate proteoglycans containing a glypican 5 core and 2-O-sulfo-iduronic acid function as Sonic Hedgehog co-receptors to promote proliferation.

Witt RM, Hecht ML, Pazyra-Murphy MF, Cohen SM, Noti C, van Kuppevelt TH, Fuller M, Chan JA, Hopwood JJ, Seeberger PH, Segal RA.

J Biol Chem. 2013 Sep 6;288(36):26275-88. doi: 10.1074/jbc.M112.438937. Epub 2013 Jul 18.


Target-derived neurotrophins coordinate transcription and transport of bclw to prevent axonal degeneration.

Cosker KE, Pazyra-Murphy MF, Fenstermacher SJ, Segal RA.

J Neurosci. 2013 Mar 20;33(12):5195-207. doi: 10.1523/JNEUROSCI.3862-12.2013.


A differential equation model of collagen accumulation in a healing wound.

Segal RA, Diegelmann RF, Ward KR, Reynolds A.

Bull Math Biol. 2012 Sep;74(9):2165-82. doi: 10.1007/s11538-012-9751-z. Epub 2012 Jul 19.


From synapse to nucleus and back again--communication over distance within neurons.

Fainzilber M, Budnik V, Segal RA, Kreutz MR.

J Neurosci. 2011 Nov 9;31(45):16045-8. doi: 10.1523/JNEUROSCI.4006-11.2011.


Numb links extracellular cues to intracellular polarity machinery to promote chemotaxis.

Zhou P, Alfaro J, Chang EH, Zhao X, Porcionatto M, Segal RA.

Dev Cell. 2011 May 17;20(5):610-22. doi: 10.1016/j.devcel.2011.04.006.


Neuromuscular junction defects in mice with mutation of dynein heavy chain 1.

Courchesne SL, Pazyra-Murphy MF, Lee DJ, Segal RA.

PLoS One. 2011 Feb 4;6(2):e16753. doi: 10.1371/journal.pone.0016753.


Sensory neuropathy attributable to loss of Bcl-w.

Courchesne SL, Karch C, Pazyra-Murphy MF, Segal RA.

J Neurosci. 2011 Feb 2;31(5):1624-34. doi: 10.1523/JNEUROSCI.3347-10.2011.


Reply to Roderick Main and George Hogenson.

Segal RA.

J Anal Psychol. 2010 Jun;55(3):394-7. doi: 10.1111/j.1468-5922.2010.01851.x. No abstract available.


Jung as psychologist of religion and Jung as philosopher of religion.

Segal RA.

J Anal Psychol. 2010 Jun;55(3):361-84. doi: 10.1111/j.1468-5922.2010.01848.x.


The longer U(T)R, the further you go.

Cosker KE, Segal RA.

Nat Neurosci. 2010 Mar;13(3):273-5. doi: 10.1038/nn0310-273. No abstract available.


An in silico approach to the analysis of acute wound healing.

Menke NB, Cain JW, Reynolds A, Chan DM, Segal RA, Witten TM, Bonchev DG, Diegelmann RF, Ward KR; Virginia Commonwealth University Reanimation, Engineering Shock Center, The Wound Healing Group.

Wound Repair Regen. 2010 Jan-Feb;18(1):105-13. doi: 10.1111/j.1524-475X.2009.00549.x. Epub 2009 Dec 11.


Live or let die: CCM2 provides the link.

Gruber-Olipitz M, Segal RA.

Neuron. 2009 Sep 10;63(5):559-60. doi: 10.1016/j.neuron.2009.08.030.


Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.

Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Ménager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K.

Dev Cell. 2009 May;16(5):675-86. doi: 10.1016/j.devcel.2009.03.005.


Dosimetry of nasal uptake of water-soluble and reactive gases: a first study of interhuman variability.

Garcia GJ, Schroeter JD, Segal RA, Stanek J, Foureman GL, Kimbell JS.

Inhal Toxicol. 2009 Jun;21(7):607-18. doi: 10.1080/08958370802320186.


A retrograde neuronal survival response: target-derived neurotrophins regulate MEF2D and bcl-w.

Pazyra-Murphy MF, Hans A, Courchesne SL, Karch C, Cosker KE, Heerssen HM, Watson FL, Kim T, Greenberg ME, Segal RA.

J Neurosci. 2009 May 20;29(20):6700-9. doi: 10.1523/JNEUROSCI.0233-09.2009.


Proteoglycan interactions with Sonic Hedgehog specify mitogenic responses.

Chan JA, Balasubramanian S, Witt RM, Nazemi KJ, Choi Y, Pazyra-Murphy MF, Walsh CO, Thompson M, Segal RA.

Nat Neurosci. 2009 Apr;12(4):409-17. doi: 10.1038/nn.2287. Epub 2009 Mar 15.


Preparation and maintenance of dorsal root ganglia neurons in compartmented cultures.

Pazyra-Murphy MF, Segal RA.

J Vis Exp. 2008 Oct 17;(20). pii: 951. doi: 10.3791/951.


Action in the axon: generation and transport of signaling endosomes.

Cosker KE, Courchesne SL, Segal RA.

Curr Opin Neurobiol. 2008 Jun;18(3):270-5. doi: 10.1016/j.conb.2008.08.005. Review.


Effects of differences in nasal anatomy on airflow distribution: a comparison of four individuals at rest.

Segal RA, Kepler GM, Kimbell JS.

Ann Biomed Eng. 2008 Nov;36(11):1870-82. doi: 10.1007/s10439-008-9556-2. Epub 2008 Sep 6.


A neuron-specific cytoplasmic dynein isoform preferentially transports TrkB signaling endosomes.

Ha J, Lo KW, Myers KR, Carr TM, Humsi MK, Rasoul BA, Segal RA, Pfister KK.

J Cell Biol. 2008 Jun 16;181(6):1027-39. doi: 10.1083/jcb.200803150.


Generation and utilization of phosphorylation state-specific antibodies to investigate signaling pathways.

Alberta JA, Segal RA.

Curr Protoc Neurosci. 2001 May;Chapter 3:Unit 3.14. doi: 10.1002/0471142301.ns0314s04.


Jung and Lévy-Bruhl.

Segal RA.

J Anal Psychol. 2007 Nov;52(5):635-58; discussion 659-65, 667-71.


Polarized signaling endosomes coordinate BDNF-induced chemotaxis of cerebellar precursors.

Zhou P, Porcionatto M, Pilapil M, Chen Y, Choi Y, Tolias KF, Bikoff JB, Hong EJ, Greenberg ME, Segal RA.

Neuron. 2007 Jul 5;55(1):53-68.


Characterization of deposition from nasal spray devices using a computational fluid dynamics model of the human nasal passages.

Kimbell JS, Segal RA, Asgharian B, Wong BA, Schroeter JD, Southall JP, Dickens CJ, Brace G, Miller FJ.

J Aerosol Med. 2007 Spring;20(1):59-74.


CXCR4 inhibition synergizes with cytotoxic chemotherapy in gliomas.

Redjal N, Chan JA, Segal RA, Kung AL.

Clin Cancer Res. 2006 Nov 15;12(22):6765-71.


Migration from a mitogenic niche promotes cell-cycle exit.

Choi Y, Borghesani PR, Chan JA, Segal RA.

J Neurosci. 2005 Nov 9;25(45):10437-45.


Subtracting the Math: prominin-positive cerebellar stem cells in white matter.

Kenney AM, Segal RA.

Nat Neurosci. 2005 Jun;8(6):699-701. No abstract available.


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