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Items: 34


The microbiome and tuberculosis: state of the art, potential applications, and defining the clinical research agenda.

Naidoo CC, Nyawo GR, Wu BG, Walzl G, Warren RM, Segal LN, Theron G.

Lancet Respir Med. 2019 Mar 22. pii: S2213-2600(18)30501-0. doi: 10.1016/S2213-2600(18)30501-0. [Epub ahead of print] Review.


The Challenging Road of Moving from Association to Causation for Microbiome Research in Idiopathic Pulmonary Fibrosis.

Segal LN, Molyneaux PL.

Am J Respir Crit Care Med. 2019 May 1;199(9):1054-1056. doi: 10.1164/rccm.201902-0318ED. No abstract available.


Could the Sputum Microbiota Be a Biomarker That Predicts Mortality after Acute Exacerbations of Chronic Obstructive Pulmonary Disease?

Tsay JJ, Segal LN.

Am J Respir Crit Care Med. 2019 May 15;199(10):1175-1176. doi: 10.1164/rccm.201811-2138ED. No abstract available.


The Lung Microbiome and Its Role in Pneumonia.

Wu BG, Segal LN.

Clin Chest Med. 2018 Dec;39(4):677-689. doi: 10.1016/j.ccm.2018.07.003. Review.


Airway and esophageal eosinophils in children with severe uncontrolled asthma.

Erkman J, Vaynblat A, Thomas K, Segal LN, Levine J, Moy L, Greifer M, Giusti R, Shah R, Kazachkov M.

Pediatr Pulmonol. 2018 Dec;53(12):1598-1603. doi: 10.1002/ppul.24180. Epub 2018 Oct 23.


Smoking is associated with quantifiable differences in the human lung DNA virome and metabolome.

Gregory AC, Sullivan MB, Segal LN, Keller BC.

Respir Res. 2018 Sep 12;19(1):174. doi: 10.1186/s12931-018-0878-9.


Evaluation of the airway microbiome in nontuberculous mycobacteria disease.

Sulaiman I, Wu BG, Li Y, Scott AS, Malecha P, Scaglione B, Wang J, Basavaraj A, Chung S, Bantis K, Carpenito J, Clemente JC, Shen N, Bessich J, Rafeq S, Michaud G, Donington J, Naidoo C, Theron G, Schattner G, Garofano S, Condos R, Kamelhar D, Addrizzo-Harris D, Segal LN.

Eur Respir J. 2018 Oct 25;52(4). pii: 1800810. doi: 10.1183/13993003.00810-2018. Print 2018 Oct.


Aerodigestive dysbiosis in children with chronic cough.

Kazachkov M, Kapoor BC, Malecha PW, Wu BG, Li Y, Levine J, Erkman J, Fitzgerald K, Moy L, Segal LN.

Pediatr Pulmonol. 2018 Sep;53(9):1288-1298. doi: 10.1002/ppul.24115. Epub 2018 Jul 8.


Severe Obstructive Sleep Apnea Is Associated with Alterations in the Nasal Microbiome and an Increase in Inflammation.

Wu BG, Sulaiman I, Wang J, Shen N, Clemente JC, Li Y, Laumbach RJ, Lu SE, Udasin I, Le-Hoang O, Perez A, Alimokhtari S, Black K, Plietz M, Twumasi A, Sanders H, Malecha P, Kapoor B, Scaglione BD, Wang A, Blazoski C, Weiden MD, Rapoport DM, Harrison D, Chitkara N, Vicente E, Marin JM, Sunderram J, Ayappa I, Segal LN.

Am J Respir Crit Care Med. 2019 Jan 1;199(1):99-109. doi: 10.1164/rccm.201801-0119OC.


The Road to Precision Medicine in Chronic Obstructive Pulmonary Disease: Squeezing More Out of Chest Computed Tomography Scans.

Wu BG, Segal LN.

Ann Am Thorac Soc. 2018 Apr;15(4):428-429. doi: 10.1513/AnnalsATS.201712-945ED. No abstract available.


Chronic obstructive pulmonary disease subpopulations and phenotyping.

Segal LN, Martinez FJ.

J Allergy Clin Immunol. 2018 Jun;141(6):1961-1971. doi: 10.1016/j.jaci.2018.02.035. Review.


Airway Microbiota Is Associated with Upregulation of the PI3K Pathway in Lung Cancer.

Tsay JJ, Wu BG, Badri MH, Clemente JC, Shen N, Meyn P, Li Y, Yie TA, Lhakhang T, Olsen E, Murthy V, Michaud G, Sulaiman I, Tsirigos A, Heguy A, Pass H, Weiden MD, Rom WN, Sterman DH, Bonneau R, Blaser MJ, Segal LN.

Am J Respir Crit Care Med. 2018 Nov 1;198(9):1188-1198. doi: 10.1164/rccm.201710-2118OC.


At the Root: Defining and Halting Progression of Early Chronic Obstructive Pulmonary Disease.

Martinez FJ, Han MK, Allinson JP, Barr RG, Boucher RC, Calverley PMA, Celli BR, Christenson SA, Crystal RG, Fagerås M, Freeman CM, Groenke L, Hoffman EA, Kesimer M, Kostikas K, Paine R 3rd, Rafii S, Rennard SI, Segal LN, Shaykhiev R, Stevenson C, Tal-Singer R, Vestbo J, Woodruff PG, Curtis JL, Wedzicha JA.

Am J Respir Crit Care Med. 2018 Jun 15;197(12):1540-1551. doi: 10.1164/rccm.201710-2028PP. No abstract available. Erratum in: Am J Respir Crit Care Med. 2018 Dec 1;198(11):1463.


Gut Microbiota Perturbations in Reactive Arthritis and Postinfectious Spondyloarthritis.

Manasson J, Shen N, Garcia Ferrer HR, Ubeda C, Iraheta I, Heguy A, Von Feldt JM, Espinoza LR, Garcia Kutzbach A, Segal LN, Ogdie A, Clemente JC, Scher JU.

Arthritis Rheumatol. 2018 Feb;70(2):242-254. doi: 10.1002/art.40359. Epub 2018 Jan 3.


Lung microbiome and host immune tone in subjects with idiopathic pulmonary fibrosis treated with inhaled interferon-γ.

Wang J, Lesko M, Badri MH, Kapoor BC, Wu BG, Li Y, Smaldone GC, Bonneau R, Kurtz ZD, Condos R, Segal LN.

ERJ Open Res. 2017 Jul 12;3(3). pii: 00008-2017. doi: 10.1183/23120541.00008-2017. eCollection 2017 Jul.


Lung Microbiota and Its Impact on the Mucosal Immune Phenotype.

Wu BG, Segal LN.

Microbiol Spectr. 2017 Jun;5(3). doi: 10.1128/microbiolspec.BAD-0005-2016. Review.


Anaerobic Bacterial Fermentation Products Increase Tuberculosis Risk in Antiretroviral-Drug-Treated HIV Patients.

Segal LN, Clemente JC, Li Y, Ruan C, Cao J, Danckers M, Morris A, Tapyrik S, Wu BG, Diaz P, Calligaro G, Dawson R, van Zyl-Smit RN, Dheda K, Rom WN, Weiden MD.

Cell Host Microbe. 2017 Apr 12;21(4):530-537.e4. doi: 10.1016/j.chom.2017.03.003. Epub 2017 Mar 30.


Distal airway dysfunction identifies pulmonary inflammation in asymptomatic smokers.

Berger KI, Pradhan DR, Goldring RM, Oppenheimer BW, Rom WN, Segal LN.

ERJ Open Res. 2016 Nov 29;2(4). pii: 00066-2016. eCollection 2016 Oct.


The lung microbiota in early rheumatoid arthritis and autoimmunity.

Scher JU, Joshua V, Artacho A, Abdollahi-Roodsaz S, Öckinger J, Kullberg S, Sköld M, Eklund A, Grunewald J, Clemente JC, Ubeda C, Segal LN, Catrina AI.

Microbiome. 2016 Nov 17;4(1):60.


Enrichment of the lung microbiome with oral taxa is associated with lung inflammation of a Th17 phenotype.

Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, Li Y, Shen N, Ghedin E, Morris A, Diaz P, Huang L, Wikoff WR, Ubeda C, Artacho A, Rom WN, Sterman DH, Collman RG, Blaser MJ, Weiden MD.

Nat Microbiol. 2016 Apr 4;1:16031. doi: 10.1038/nmicrobiol.2016.31.


Randomised, double-blind, placebo-controlled trial with azithromycin selects for anti-inflammatory microbial metabolites in the emphysematous lung.

Segal LN, Clemente JC, Wu BG, Wikoff WR, Gao Z, Li Y, Ko JP, Rom WN, Blaser MJ, Weiden MD.

Thorax. 2017 Jan;72(1):13-22. doi: 10.1136/thoraxjnl-2016-208599. Epub 2016 Aug 2.


The Lung Microbiome in HIV. Getting to the HAART of the Host-Microbe Interface.

Segal LN, Dickson RP.

Am J Respir Crit Care Med. 2016 Jul 15;194(2):136-7. doi: 10.1164/rccm.201602-0280ED. No abstract available.


Pulmonary Vascular Congestion: A Mechanism for Distal Lung Unit Dysfunction in Obesity.

Oppenheimer BW, Berger KI, Ali S, Segal LN, Donnino R, Katz S, Parikh M, Goldring RM.

PLoS One. 2016 Apr 1;11(4):e0152769. doi: 10.1371/journal.pone.0152769. eCollection 2016.


Harnessing the Early-Life Microbiota to Protect Children with Cystic Fibrosis.

Segal LN, Blaser MJ.

J Pediatr. 2015 Jul;167(1):16-18.e1. doi: 10.1016/j.jpeds.2015.03.055. Epub 2015 Apr 29. No abstract available.


Airway dysfunction in obesity: response to voluntary restoration of end expiratory lung volume.

Oppenheimer BW, Berger KI, Segal LN, Stabile A, Coles KD, Parikh M, Goldring RM.

PLoS One. 2014 Feb 4;9(2):e88015. doi: 10.1371/journal.pone.0088015. eCollection 2014.


Lung microbiome for clinicians. New discoveries about bugs in healthy and diseased lungs.

Segal LN, Rom WN, Weiden MD.

Ann Am Thorac Soc. 2014 Jan;11(1):108-16. doi: 10.1513/AnnalsATS.201310-339FR. Review.


Enrichment of lung microbiome with supraglottic taxa is associated with increased pulmonary inflammation.

Segal LN, Alekseyenko AV, Clemente JC, Kulkarni R, Wu B, Gao Z, Chen H, Berger KI, Goldring RM, Rom WN, Blaser MJ, Weiden MD.

Microbiome. 2013 Jul 1;1(1):19. doi: 10.1186/2049-2618-1-19. Erratum in: Microbiome. 2014;2:21. Gao, Zhan [added].


A brave new world: the lung microbiota in an era of change.

Segal LN, Blaser MJ.

Ann Am Thorac Soc. 2014 Jan;11 Suppl 1:S21-7. doi: 10.1513/AnnalsATS.201306-189MG.


Comparison of WTC dust size on macrophage inflammatory cytokine release in vivo and in vitro.

Weiden MD, Naveed B, Kwon S, Segal LN, Cho SJ, Tsukiji J, Kulkarni R, Comfort AL, Kasturiarachchi KJ, Prophete C, Cohen MD, Chen LC, Rom WN, Prezant DJ, Nolan A.

PLoS One. 2012;7(7):e40016. doi: 10.1371/journal.pone.0040016. Epub 2012 Jul 18.


HIV-1 and bacterial pneumonia in the era of antiretroviral therapy.

Segal LN, Methé BA, Nolan A, Hoshino Y, Rom WN, Dawson R, Bateman E, Weiden MD.

Proc Am Thorac Soc. 2011 Jun;8(3):282-7. doi: 10.1513/pats.201006-044WR. Review.


Disparity between proximal and distal airway reactivity during methacholine challenge.

Segal LN, Goldring RM, Oppenheimer BW, Stabile A, Reibman J, Rom WN, Weiden MD, Berger KI.

COPD. 2011 Jun;8(3):145-52. doi: 10.3109/15412555.2011.560127. Epub 2011 Apr 22.


Neutrophils activate alveolar macrophages by producing caspase-6-mediated cleavage of IL-1 receptor-associated kinase-M.

Kobayashi H, Nolan A, Naveed B, Hoshino Y, Segal LN, Fujita Y, Rom WN, Weiden MD.

J Immunol. 2011 Jan 1;186(1):403-10. doi: 10.4049/jimmunol.1001906. Epub 2010 Nov 22.


Snoring and the risk of obstructive sleep apnea in patients with pulmonary embolism.

Epstein MD, Segal LN, Ibrahim SM, Friedman N, Bustami R.

Sleep. 2010 Aug;33(8):1069-74.


Evolution of pattern of breathing during a spontaneous breathing trial predicts successful extubation.

Segal LN, Oei E, Oppenheimer BW, Goldring RM, Bustami RT, Ruggiero S, Berger KI, Fiel SB.

Intensive Care Med. 2010 Mar;36(3):487-95. doi: 10.1007/s00134-009-1735-6. Epub 2009 Nov 28.


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