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Items: 47


Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells.

Niven J, Madelon N, Page N, Caruso A, Harlé G, Lemeille S, Seemayer CA, Hugues S, Gannagé M.

Cell Rep. 2019 Jul 2;28(1):21-29.e6. doi: 10.1016/j.celrep.2019.05.110.


Nanocrystals of a potent p38 MAPK inhibitor embedded in microparticles: Therapeutic effects in inflammatory and mechanistic murine models of osteoarthritis.

Maudens P, Seemayer CA, Pfefferlé F, Jordan O, Allémann E.

J Control Release. 2018 Apr 28;276:102-112. doi: 10.1016/j.jconrel.2018.03.007. Epub 2018 Mar 7.


Nanocrystal-Polymer Particles: Extended Delivery Carriers for Osteoarthritis Treatment.

Maudens P, Seemayer CA, Thauvin C, Gabay C, Jordan O, Allémann E.

Small. 2018 Feb;14(8). doi: 10.1002/smll.201703108. Epub 2018 Jan 12.


Self-assembled thermoresponsive nanostructures of hyaluronic acid conjugates for osteoarthritis therapy.

Maudens P, Meyer S, Seemayer CA, Jordan O, Allémann E.

Nanoscale. 2018 Jan 25;10(4):1845-1854. doi: 10.1039/c7nr07614b.


Deficiency in IL-1 Receptor Type 2 Aggravates K/BxN Serum Transfer-Induced Arthritis in Mice but Has No Impact on Systemic Inflammatory Responses.

Martin P, Palmer G, Rodriguez E, Seemayer CA, Palomo J, Talabot-Ayer D, Gabay C.

J Immunol. 2017 Apr 1;198(7):2916-2926. doi: 10.4049/jimmunol.1600855. Epub 2017 Feb 24.


Modeling the Effect of the Selective S1P1 Receptor Modulator Ponesimod on Subsets of Blood Lymphocytes.

Lott D, Krause A, Seemayer CA, Strasser DS, Dingemanse J, Lehr T.

Pharm Res. 2017 Mar;34(3):599-609. doi: 10.1007/s11095-016-2087-x. Epub 2016 Dec 27.


Effect of particle size on the biodistribution of nano- and microparticles following intra-articular injection in mice.

Pradal J, Maudens P, Gabay C, Seemayer CA, Jordan O, Allémann E.

Int J Pharm. 2016 Feb 10;498(1-2):119-29. doi: 10.1016/j.ijpharm.2015.12.015. Epub 2015 Dec 10.


Intra-articular bioactivity of a p38 MAPK inhibitor and development of an extended-release system.

Pradal J, Zuluaga MF, Maudens P, Waldburger JM, Seemayer CA, Doelker E, Gabay C, Jordan O, Allémann E.

Eur J Pharm Biopharm. 2015 Jun;93:110-7. doi: 10.1016/j.ejpb.2015.03.017. Epub 2015 Mar 30.


Severe neutrophil-dominated inflammation and enhanced myelopoiesis in IL-33-overexpressing CMV/IL33 mice.

Talabot-Ayer D, Martin P, Vesin C, Seemayer CA, Vigne S, Gabay C, Palmer G.

J Immunol. 2015 Jan 15;194(2):750-60. doi: 10.4049/jimmunol.1402057. Epub 2014 Dec 10.


Immune-mediated experimental arthritis in IL-33 deficient mice.

Talabot-Ayer D, Martin P, Seemayer CA, Vigne S, Lamacchia C, Finckh A, Saiji E, Gabay C, Palmer G.

Cytokine. 2014 Sep;69(1):68-74. doi: 10.1016/j.cyto.2014.05.007. Epub 2014 Jun 11.


The severity of experimental arthritis is independent of IL-36 receptor signaling.

Lamacchia C, Palmer G, Rodriguez E, Martin P, Vigne S, Seemayer CA, Talabot-Ayer D, Towne JE, Gabay C.

Arthritis Res Ther. 2013 Mar 1;15(2):R38. doi: 10.1186/ar4192.


Disease severity in K/BxN serum transfer-induced arthritis is not affected by IL-33 deficiency.

Martin P, Talabot-Ayer D, Seemayer CA, Vigne S, Lamacchia C, Rodriguez E, Finckh A, Smith DE, Gabay C, Palmer G.

Arthritis Res Ther. 2013 Jan 16;15(1):R13. doi: 10.1186/ar4143.


Mice deficient in hepatocyte-specific IL-1Ra show delayed resolution of concanavalin A-induced hepatitis.

Lamacchia C, Rodriguez E, Palmer G, Vesin C, Seemayer CA, Rubbia-Brandt L, Gabay C.

Eur J Immunol. 2012 May;42(5):1294-303. doi: 10.1002/eji.201142204.


Articular inflammation is controlled by myeloid cell-derived interleukin 1 receptor antagonist during the acute phase of arthritis in mice.

Lamacchia C, Rodriguez E, Palmer G, Vigne S, Martin P, Talabot-Ayer D, Seemayer CA, Gabay C.

Ann Rheum Dis. 2012 Feb;71(2):281-7. doi: 10.1136/annrheumdis-2011-200429. Epub 2011 Nov 9.


Adeno-associated virus type 5-mediated intraarticular administration of tumor necrosis factor small interfering RNA improves collagen-induced arthritis.

Khoury M, Courties G, Fabre S, Bouffi C, Seemayer CA, Vervoordeldonk MJ, Tak PP, Jorgensen C, Apparailly F.

Arthritis Rheum. 2010 Mar;62(3):765-70. doi: 10.1002/art.27302.


Enhanced Th1 and Th17 responses and arthritis severity in mice with a deficiency of myeloid cell-specific interleukin-1 receptor antagonist.

Lamacchia C, Palmer G, Seemayer CA, Talabot-Ayer D, Gabay C.

Arthritis Rheum. 2010 Feb;62(2):452-62. doi: 10.1002/art.27235.


Synovial tissues concentrate secreted APRIL.

Gabay C, Krenn V, Bosshard C, Seemayer CA, Chizzolini C, Huard B.

Arthritis Res Ther. 2009;11(5):R144. doi: 10.1186/ar2817. Epub 2009 Sep 29.


Magnetically retainable microparticles for drug delivery to the joint: efficacy studies in an antigen-induced arthritis model in mice.

Butoescu N, Seemayer CA, Palmer G, Guerne PA, Gabay C, Doelker E, Jordan O.

Arthritis Res Ther. 2009;11(3):R72. doi: 10.1186/ar2701. Epub 2009 May 19.


Inhibition of interleukin-33 signaling attenuates the severity of experimental arthritis.

Palmer G, Talabot-Ayer D, Lamacchia C, Toy D, Seemayer CA, Viatte S, Finckh A, Smith DE, Gabay C.

Arthritis Rheum. 2009 Mar;60(3):738-49. doi: 10.1002/art.24305.


Dexamethasone-containing PLGA superparamagnetic microparticles as carriers for the local treatment of arthritis.

Butoescu N, Seemayer CA, Foti M, Jordan O, Doelker E.

Biomaterials. 2009 Mar;30(9):1772-80. doi: 10.1016/j.biomaterials.2008.12.017. Epub 2009 Jan 8.


BK virus large T and VP-1 expression in infected human renal allografts.

Seemayer CA, Seemayer NH, Dürmüller U, Gudat F, Schaub S, Hirsch HH, Mihatsch MJ.

Nephrol Dial Transplant. 2008 Dec;23(12):3752-61. doi: 10.1093/ndt/gfn470. Epub 2008 Sep 9. Review.


Lack of protein expression of the Simian virus 40 large T antigen in human lymphomas.

Went P, Seemayer CA, Pileri S, Maurer R, Tzankov A, Dirnhofer S.

J Med Virol. 2008 Jun;80(6):1112-5. doi: 10.1002/jmv.21199.


In situ hybridization of synovial tissue.

Kuchen S, Seemayer CA, Neidhart M, Gay RE, Gay S.

Methods Mol Med. 2007;135:65-75.


Low prevalence of SV40 in Swiss mesothelioma patients after elimination of false-positive PCR results.

Ziegler A, Seemayer CA, Hinterberger M, Vogt P, Bigosch C, Gautschi O, Tornillo L, Betticher DC, Moch H, Stahel RA.

Lung Cancer. 2007 Sep;57(3):282-91. Epub 2007 May 21.


Close association between HER-2 amplification and overexpression in human tumors of non-breast origin.

Tapia C, Glatz K, Novotny H, Lugli A, Horcic M, Seemayer CA, Tornillo L, Terracciano L, Spichtin H, Mirlacher M, Simon R, Sauter G.

Mod Pathol. 2007 Feb;20(2):192-8.


C4d staining of renal allograft biopsies: a comparative analysis of different staining techniques.

Seemayer CA, Gaspert A, Nickeleit V, Mihatsch MJ.

Nephrol Dial Transplant. 2007 Feb;22(2):568-76. Epub 2006 Dec 12.


No indication for activation of exogenous retroviruses in patients with renal allograft rejection.

Seemayer CA, Böni J, Steiger J, Schüpbach J, Mihatsch MJ.

Clin Nephrol. 2006 May;65(5):324-7.


Trichostatin A sensitises rheumatoid arthritis synovial fibroblasts for TRAIL-induced apoptosis.

Jüngel A, Baresova V, Ospelt C, Simmen BR, Michel BA, Gay RE, Gay S, Seemayer CA, Neidhart M.

Ann Rheum Dis. 2006 Jul;65(7):910-2. Epub 2005 Nov 10.


The induction of matrix metalloproteinase and cytokine expression in synovial fibroblasts stimulated with immune cell microparticles.

Distler JH, Jüngel A, Huber LC, Seemayer CA, Reich CF 3rd, Gay RE, Michel BA, Fontana A, Gay S, Pisetsky DS, Distler O.

Proc Natl Acad Sci U S A. 2005 Feb 22;102(8):2892-7. Epub 2005 Feb 8.


Targeting cathepsin L (CL) by specific ribozymes decreases CL protein synthesis and cartilage destruction in rheumatoid arthritis.

Schedel J, Seemayer CA, Pap T, Neidhart M, Kuchen S, Michel BA, Gay RE, Müller-Ladner U, Gay S, Zacharias W.

Gene Ther. 2004 Jul;11(13):1040-7.


Expression of interleukin-21 receptor, but not interleukin-21, in synovial fibroblasts and synovial macrophages of patients with rheumatoid arthritis.

Jüngel A, Distler JH, Kurowska-Stolarska M, Seemayer CA, Seibl R, Forster A, Michel BA, Gay RE, Emmrich F, Gay S, Distler O.

Arthritis Rheum. 2004 May;50(5):1468-76.


Ribozymes that inhibit the production of matrix metalloproteinase 1 reduce the invasiveness of rheumatoid arthritis synovial fibroblasts.

Rutkauskaite E, Zacharias W, Schedel J, Müller-Ladner U, Mawrin C, Seemayer CA, Alexander D, Gay RE, Aicher WK, Michel BA, Gay S, Pap T.

Arthritis Rheum. 2004 May;50(5):1448-56.


The L1 retroelement-related p40 protein induces p38delta MAP kinase.

Kuchen S, Seemayer CA, Rethage J, von Knoch R, Kuenzler P, Beat AM, Gay RE, Gay S, Neidhart M.

Autoimmunity. 2004 Feb;37(1):57-65.


p53 in rheumatoid arthritis synovial fibroblasts at sites of invasion.

Seemayer CA, Kuchen S, Neidhart M, Kuenzler P, Rihosková V, Neumann E, Pruschy M, Aicher WK, Müller-Ladner U, Gay RE, Michel BA, Firestein GS, Gay S.

Ann Rheum Dis. 2003 Dec;62(12):1139-44.


Galectin 3 and its binding protein in rheumatoid arthritis.

Ohshima S, Kuchen S, Seemayer CA, Kyburz D, Hirt A, Klinzing S, Michel BA, Gay RE, Liu FT, Gay S, Neidhart M.

Arthritis Rheum. 2003 Oct;48(10):2788-95.


Induction of p16 at sites of cartilage invasion in the SCID mouse coimplantation model of rheumatoid arthritis.

Kuenzler P, Kuchen S, Rihosková V, Michel BA, Gay RE, Neidhart M, Gay S, Seemayer CA.

Arthritis Rheum. 2003 Jul;48(7):2069-73. No abstract available.


Functional characterization of adherent synovial fluid cells in rheumatoid arthritis: destructive potential in vitro and in vivo.

Neidhart M, Seemayer CA, Hummel KM, Michel BA, Gay RE, Gay S.

Arthritis Rheum. 2003 Jul;48(7):1873-80.


Cartilage destruction mediated by synovial fibroblasts does not depend on proliferation in rheumatoid arthritis.

Seemayer CA, Kuchen S, Kuenzler P, Rihosková V, Rethage J, Aicher WK, Michel BA, Gay RE, Kyburz D, Neidhart M, Gay S.

Am J Pathol. 2003 May;162(5):1549-57.


Cartilage degradation and invasion by rheumatoid synovial fibroblasts is inhibited by gene transfer of TIMP-1 and TIMP-3.

van der Laan WH, Quax PH, Seemayer CA, Huisman LG, Pieterman EJ, Grimbergen JM, Verheijen JH, Breedveld FC, Gay RE, Gay S, Huizinga TW, Pap T.

Gene Ther. 2003 Feb;10(3):234-42.


Absence of inducible retroviruses from synovial fibroblasts and synovial fluid cells of patients with rheumatoid arthritis.

Seemayer CA, Kolb SA, Neidhart M, Ohshima S, Gay RE, Michel BA, Gay S, Böni J, Schüpbach J.

Arthritis Rheum. 2002 Oct;46(10):2811-3. No abstract available.


Incidence and tumour stages of breast cancer in the region of Aachen, Germany.

Seemayer CA, Breuer E, Kroll G, Markus-Sellhaus S, Reineke TH, Mittermayer C.

Eur J Cancer Care (Engl). 2002 Mar;11(1):16-24.


Gene transfer of protective cytokines in rheumatoid arthritis.

Distler O, Seemayer CA, Pap T, Gay RE, Neidhart M, Müller-Ladner U, Gay S.

Adv Exp Med Biol. 2001;495:231-40. No abstract available.


[Rheumatoid arthritis: new developments in the pathogenesis with special reference to synovial fibroblasts].

Seemayer CA, Distler O, Kuchen S, Müller-Ladner U, Michel BA, Neidhart M, Gay RE, Gay S.

Z Rheumatol. 2001 Oct;60(5):309-18. Review. German.


Prevalence of TTV DNA and GBV-C RNA in patients with systemic sclerosis, rheumatoid arthritis, and osteoarthritis does not differ from that in healthy blood donors.

Seemayer CA, Viazov S, Neidhart M, Brühlmann P, Michel BA, Gay RE, Roggendorf M, Gay S.

Ann Rheum Dis. 2001 Aug;60(8):806-9.


Lack of association between GBV-C infection and spontaneous abortion.

Viazov S, Alberts KR, Ross RS, Seemayer CA, Roggendorf M.

Eur J Clin Microbiol Infect Dis. 1999 Jun;18(6):458-9. No abstract available.


Detection of GBV-C/HGV RNA in saliva and serum, but not in urine of infected patients.

Seemayer CA, Viazov S, Philipp T, Roggendorf M.

Infection. 1998 Jan-Feb;26(1):39-41.


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