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Items: 1 to 50 of 145

1.

The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.

Milenkovic A, Schmied D, Tanimoto N, Seeliger MW, Sparrow JR, Weber BHF.

Biol Open. 2019 Jul 2;8(7). pii: bio041335. doi: 10.1242/bio.041335.

2.

A retinal model of cerebral malaria.

Paquet-Durand F, Beck SC, Das S, Huber G, Le Chang, Schubert T, Tanimoto N, Garcia-Garrido M, Mühlfriedel R, Bolz S, Hoffmann W, Schraermeyer U, Mordmüller B, Seeliger MW.

Sci Rep. 2019 Mar 5;9(1):3470. doi: 10.1038/s41598-019-39143-z.

3.

Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.

Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P.

J Clin Invest. 2018 Dec 3;128(12):5663-5675. doi: 10.1172/JCI96098. Epub 2018 Nov 12.

4.

Optimized Subretinal Injection Technique for Gene Therapy Approaches.

Mühlfriedel R, Michalakis S, Garrido MG, Sothilingam V, Schön C, Biel M, Seeliger MW.

Methods Mol Biol. 2019;1834:405-412. doi: 10.1007/978-1-4939-8669-9_26.

PMID:
30324458
5.

Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina.

Beck SC, Karlstetter M, Garcia Garrido M, Feng Y, Dannhausen K, Mühlfriedel R, Sothilingam V, Seebauer B, Berger W, Hammes HP, Seeliger MW, Langmann T.

Sci Rep. 2018 Apr 13;8(1):5970. doi: 10.1038/s41598-018-24476-y.

6.

Assessment of the Absolute Excitatory Level of the Retina by Flicker ERG.

Tanimoto N, Seeliger MW.

Methods Mol Biol. 2018;1753:191-202. doi: 10.1007/978-1-4939-7720-8_13.

PMID:
29564790
7.

Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.

Front Mol Neurosci. 2018 Jan 9;10:436. doi: 10.3389/fnmol.2017.00436. eCollection 2017.

8.

Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, Consortium RC.

Hum Gene Ther. 2017 Dec 7. doi: 10.1089/hum.2017.156. [Epub ahead of print]

PMID:
29212391
9.

Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa.

Occelli LM, Schön C, Seeliger MW, Biel M, Michalakis S, Petersen-Jones S, Consortium RC.

Hum Gene Ther. 2017 Dec 6. doi: 10.1089/hum.2017.155. [Epub ahead of print]

PMID:
29212382
10.

Patients and animal models of CNGβ1-deficient retinitis pigmentosa support gene augmentation approach.

Petersen-Jones SM, Occelli LM, Winkler PA, Lee W, Sparrow JR, Tsukikawa M, Boye SL, Chiodo V, Capasso JE, Becirovic E, Schön C, Seeliger MW, Levin AV, Michalakis S, Hauswirth WW, Tsang SH.

J Clin Invest. 2018 Jan 2;128(1):190-206. doi: 10.1172/JCI95161. Epub 2017 Nov 20.

11.

Advanced Ocular Injection Techniques for Therapy Approaches.

Mühlfriedel R, Garrido MG, Wallrapp C, Seeliger MW.

Methods Mol Biol. 2018;1715:215-223. doi: 10.1007/978-1-4939-7522-8_15.

PMID:
29188516
12.

In-Depth Functional Analysis of Rodents by Full-Field Electroretinography.

Sothilingam V, Mühlfriedel R, Tanimoto N, Seeliger MW.

Methods Mol Biol. 2018;1715:207-213. doi: 10.1007/978-1-4939-7522-8_14.

PMID:
29188515
13.

AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects.

Mühlfriedel R, Tanimoto N, Schön C, Sothilingam V, Garcia Garrido M, Beck SC, Huber G, Biel M, Seeliger MW, Michalakis S.

Front Neurosci. 2017 May 24;11:292. doi: 10.3389/fnins.2017.00292. eCollection 2017.

14.

Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease.

Beck SC, Feng Y, Sothilingam V, Garcia Garrido M, Tanimoto N, Acar N, Shan S, Seebauer B, Berger W, Hammes HP, Seeliger MW.

PLoS One. 2017 Jun 2;12(6):e0178753. doi: 10.1371/journal.pone.0178753. eCollection 2017.

15.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garrido MG, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA.

Hum Mol Genet. 2017 Jan 15;26(2):466. doi: 10.1093/hmg/ddw424. No abstract available.

PMID:
28365780
16.

[Gene Replacement Therapy for Inherited Retinal Dystrophies].

Mühlfriedel R, Sothilingam V, Tanimoto N, Seeliger MW.

Klin Monbl Augenheilkd. 2017 Mar;234(3):320-328. doi: 10.1055/s-0043-101817. Epub 2017 Mar 29. Review. German.

PMID:
28355661
17.

Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation.

Stojic A, Fairless R, Beck SC, Sothilingam V, Weissgerber P, Wissenbach U, Gimmy V, Seeliger MW, Flockerzi V, Diem R, Williams SK.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):318-328. doi: 10.1167/iovs.16-20419.

PMID:
28114593
18.

Differentiation of murine models of "negative ERG" by single and repetitive light stimuli.

Tanimoto N, Akula JD, Fulton AB, Weber BH, Seeliger MW.

Doc Ophthalmol. 2016 Apr;132(2):101-9. doi: 10.1007/s10633-016-9534-1. Epub 2016 Mar 21.

PMID:
26996188
19.

HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.

Sothilingam V, Michalakis S, Garcia Garrido M, Biel M, Tanimoto N, Seeliger MW.

PLoS One. 2016 Jan 25;11(1):e0147728. doi: 10.1371/journal.pone.0147728. eCollection 2016.

20.

Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.

Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S.

Hum Mol Genet. 2016 Mar 15;25(6):1165-75. doi: 10.1093/hmg/ddv639. Epub 2016 Jan 5.

PMID:
26740549
21.

In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.

Tanimoto N, Michalakis S, Weber BH, Wahl-Schott CA, Hammes HP, Seeliger MW.

Adv Exp Med Biol. 2016;854:619-25. doi: 10.1007/978-3-319-17121-0_82.

PMID:
26427467
22.

Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin.

Wunderlich KA, Tanimoto N, Grosche A, Zrenner E, Pekny M, Reichenbach A, Seeliger MW, Pannicke T, Perez MT.

FASEB J. 2015 Dec;29(12):4815-28. doi: 10.1096/fj.15-272963. Epub 2015 Aug 6.

PMID:
26251181
23.

Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

Sothilingam V, Garcia Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F.

Hum Mol Genet. 2015 Oct 1;24(19):5486-99. doi: 10.1093/hmg/ddv275. Epub 2015 Jul 17.

PMID:
26188004
24.

Scale Adjustments to Facilitate Two-Dimensional Measurements in OCT Images.

Garcia Garrido M, Mühlfriedel RL, Beck SC, Wallrapp C, Seeliger MW.

PLoS One. 2015 Jun 25;10(6):e0131154. doi: 10.1371/journal.pone.0131154. eCollection 2015.

25.

Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.

Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH.

Nat Genet. 2015 Jul;47(7):757-65. doi: 10.1038/ng.3319. Epub 2015 Jun 1.

26.

Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice.

Tanimoto N, Sothilingam V, Kondo M, Biel M, Humphries P, Seeliger MW.

Sci Rep. 2015 Jun 1;5:10731. doi: 10.1038/srep10731.

27.

Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses.

Katiyar R, Weissgerber P, Roth E, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger MW, Beck A, Schmitz F, Flockerzi V.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2312-24. doi: 10.1167/iovs.15-16654.

PMID:
25766584
28.

Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory.

Brennenstuhl C, Tanimoto N, Burkard M, Wagner R, Bolz S, Trifunovic D, Kabagema-Bilan C, Paquet-Durand F, Beck SC, Huber G, Seeliger MW, Ruth P, Wissinger B, Lukowski R.

J Biol Chem. 2015 Apr 17;290(16):10242-55. doi: 10.1074/jbc.M114.611921. Epub 2015 Mar 4.

29.

Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A.

PLoS One. 2014 Sep 9;9(9):e107048. doi: 10.1371/journal.pone.0107048. eCollection 2014.

30.

Towards a quantitative OCT image analysis.

Garcia Garrido M, Beck SC, Mühlfriedel R, Julien S, Schraermeyer U, Seeliger MW.

PLoS One. 2014 Jun 13;9(6):e100080. doi: 10.1371/journal.pone.0100080. eCollection 2014.

31.

Knockout of PARG110 confers resistance to cGMP-induced toxicity in mammalian photoreceptors.

Sahaboglu A, Tanimoto N, Bolz S, Garrido MG, Ueffing M, Seeliger MW, Löwenheim H, Ekström P, Paquet-Durand F.

Cell Death Dis. 2014 May 22;5:e1234. doi: 10.1038/cddis.2014.208.

32.

Gene therapy restores vision and delays degeneration in the CNGB1(-/-) mouse model of retinitis pigmentosa.

Michalakis S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Schulze E, Becirovic E, Koch F, Seide C, Beck SC, Seeliger MW, Mühlfriedel R, Biel M.

Adv Exp Med Biol. 2014;801:733-9. doi: 10.1007/978-1-4614-3209-8_92.

PMID:
24664765
33.

[Gene replacement therapy in achromatopsia type 2].

Mühlfriedel R, Tanimoto N, Seeliger MW.

Klin Monbl Augenheilkd. 2014 Mar;231(3):232-40. doi: 10.1055/s-0034-1368180. Epub 2014 Mar 21. Review. German.

34.

CRB2 acts as a modifying factor of CRB1-related retinal dystrophies in mice.

Pellissier LP, Lundvig DM, Tanimoto N, Klooster J, Vos RM, Richard F, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2014 Jul 15;23(14):3759-71. doi: 10.1093/hmg/ddu089. Epub 2014 Feb 23.

PMID:
24565864
35.

Targeted ablation of Crb2 in photoreceptor cells induces retinitis pigmentosa.

Alves CH, Pellissier LP, Vos RM, Garcia Garrido M, Sothilingam V, Seide C, Beck SC, Klooster J, Furukawa T, Flannery JG, Verhaagen J, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2014 Jul 1;23(13):3384-401. doi: 10.1093/hmg/ddu048. Epub 2014 Feb 2.

36.

Targeted ablation of CRB1 and CRB2 in retinal progenitor cells mimics Leber congenital amaurosis.

Pellissier LP, Alves CH, Quinn PM, Vos RM, Tanimoto N, Lundvig DM, Dudok JJ, Hooibrink B, Richard F, Beck SC, Huber G, Sothilingam V, Garcia Garrido M, Le Bivic A, Seeliger MW, Wijnholds J.

PLoS Genet. 2013;9(12):e1003976. doi: 10.1371/journal.pgen.1003976. Epub 2013 Dec 5.

37.

Auditory event-related signals in mouse ERG recordings.

Tanimoto N, Sothilingam V, Gloeckner G, Bryda EC, Humphries P, Biel M, Seeliger MW.

Doc Ophthalmol. 2014 Feb;128(1):25-32. doi: 10.1007/s10633-013-9417-7. Epub 2013 Nov 13.

PMID:
24221507
38.

Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garcia Garrido M, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA.

Hum Mol Genet. 2014 Mar 15;23(6):1538-50. doi: 10.1093/hmg/ddt541. Epub 2013 Oct 26. Erratum in: Hum Mol Genet. 2017 Jan 15;26(2):466.

39.

Myosin7a deficiency results in reduced retinal activity which is improved by gene therapy.

Colella P, Sommella A, Marrocco E, Di Vicino U, Polishchuk E, Garcia Garrido M, Seeliger MW, Polishchuk R, Auricchio A.

PLoS One. 2013 Aug 26;8(8):e72027. doi: 10.1371/journal.pone.0072027. eCollection 2013.

40.

MPP3 regulates levels of PALS1 and adhesion between photoreceptors and Müller cells.

Dudok JJ, Sanz AS, Lundvig DM, Sothilingam V, Garcia Garrido M, Klooster J, Seeliger MW, Wijnholds J.

Glia. 2013 Oct;61(10):1629-44. doi: 10.1002/glia.22545. Epub 2013 Jul 25.

PMID:
23893895
41.

Alterations of the tunica vasculosa lentis in the rat model of retinopathy of prematurity.

Favazza TL, Tanimoto N, Munro RJ, Beck SC, Garcia Garrido M, Seide C, Sothilingam V, Hansen RM, Fulton AB, Seeliger MW, Akula JD.

Doc Ophthalmol. 2013 Aug;127(1):3-11. doi: 10.1007/s10633-013-9392-z. Epub 2013 Jun 8.

42.

Endothelial SRF/MRTF ablation causes vascular disease phenotypes in murine retinae.

Weinl C, Riehle H, Park D, Stritt C, Beck S, Huber G, Wolburg H, Olson EN, Seeliger MW, Adams RH, Nordheim A.

J Clin Invest. 2013 May;123(5):2193-206. doi: 10.1172/JCI64201. Epub 2013 Apr 8.

43.

Successful subretinal delivery and monitoring of MicroBeads in mice.

Fischer MD, Goldmann T, Wallrapp C, Mühlfriedel R, Beck SC, Stern-Schneider G, Ueffing M, Wolfrum U, Seeliger MW.

PLoS One. 2013;8(1):e55173. doi: 10.1371/journal.pone.0055173. Epub 2013 Jan 28.

44.

Long-term in vivo imaging of fibrillar tau in the retina of P301S transgenic mice.

Schön C, Hoffmann NA, Ochs SM, Burgold S, Filser S, Steinbach S, Seeliger MW, Arzberger T, Goedert M, Kretzschmar HA, Schmidt B, Herms J.

PLoS One. 2012;7(12):e53547. doi: 10.1371/journal.pone.0053547. Epub 2012 Dec 31.

45.

Optimized technique for subretinal injections in mice.

Mühlfriedel R, Michalakis S, Garcia Garrido M, Biel M, Seeliger MW.

Methods Mol Biol. 2013;935:343-9. doi: 10.1007/978-1-62703-080-9_24.

PMID:
23150380
46.

Functional phenotyping of mouse models with ERG.

Tanimoto N, Sothilingam V, Seeliger MW.

Methods Mol Biol. 2013;935:69-78. doi: 10.1007/978-1-62703-080-9_4.

PMID:
23150360
47.

Lack of the sodium-driven chloride bicarbonate exchanger NCBE impairs visual function in the mouse retina.

Hilgen G, Huebner AK, Tanimoto N, Sothilingam V, Seide C, Garcia Garrido M, Schmidt KF, Seeliger MW, Löwel S, Weiler R, Hübner CA, Dedek K.

PLoS One. 2012;7(10):e46155. doi: 10.1371/journal.pone.0046155. Epub 2012 Oct 9.

48.

Constitutive overexpression of Norrin activates Wnt/β-catenin and endothelin-2 signaling to protect photoreceptors from light damage.

Braunger BM, Ohlmann A, Koch M, Tanimoto N, Volz C, Yang Y, Bösl MR, Cvekl A, Jägle H, Seeliger MW, Tamm ER.

Neurobiol Dis. 2013 Feb;50:1-12. doi: 10.1016/j.nbd.2012.09.008. Epub 2012 Sep 23.

PMID:
23009755
49.

Loss of CRB2 in the mouse retina mimics human retinitis pigmentosa due to mutations in the CRB1 gene.

Alves CH, Sanz AS, Park B, Pellissier LP, Tanimoto N, Beck SC, Huber G, Murtaza M, Richard F, Sridevi Gurubaran I, Garcia Garrido M, Levelt CN, Rashbass P, Le Bivic A, Seeliger MW, Wijnholds J.

Hum Mol Genet. 2013 Jan 1;22(1):35-50. doi: 10.1093/hmg/dds398. Epub 2012 Sep 21.

PMID:
23001562
50.

Detailed functional and structural characterization of a macular lesion in a rhesus macaque.

Dominik Fischer M, Zobor D, Keliris GA, Shao Y, Seeliger MW, Haverkamp S, Jägle H, Logothetis NK, Smirnakis SM.

Doc Ophthalmol. 2012 Dec;125(3):179-94. doi: 10.1007/s10633-012-9340-3. Epub 2012 Aug 26.

PMID:
22923360

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