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IRE1β negatively regulates IRE1α signaling in response to endoplasmic reticulum stress.

Grey MJ, Cloots E, Simpson MS, LeDuc N, Serebrenik YV, De Luca H, De Sutter D, Luong P, Thiagarajah JR, Paton AW, Paton JC, Seeliger MA, Eyckerman S, Janssens S, Lencer WI.

J Cell Biol. 2020 Feb 3;219(2). pii: e201904048. doi: 10.1083/jcb.201904048.


The Y227N mutation affects bestrophin-1 protein stability and impairs sperm function in a mouse model of Best vitelliform macular dystrophy.

Milenkovic A, Schmied D, Tanimoto N, Seeliger MW, Sparrow JR, Weber BHF.

Biol Open. 2019 Jul 2;8(7). pii: bio041335. doi: 10.1242/bio.041335.


Substrate-selective inhibitors that reprogram the activity of insulin-degrading enzyme.

Maianti JP, Tan GA, Vetere A, Welsh AJ, Wagner BK, Seeliger MA, Liu DR.

Nat Chem Biol. 2019 Jun;15(6):565-574. doi: 10.1038/s41589-019-0271-0. Epub 2019 May 13.


A retinal model of cerebral malaria.

Paquet-Durand F, Beck SC, Das S, Huber G, Le Chang, Schubert T, Tanimoto N, Garcia-Garrido M, Mühlfriedel R, Bolz S, Hoffmann W, Schraermeyer U, Mordmüller B, Seeliger MW.

Sci Rep. 2019 Mar 5;9(1):3470. doi: 10.1038/s41598-019-39143-z.


Prolyl isomerization of FAAP20 catalyzed by PIN1 regulates the Fanconi anemia pathway.

Wang J, Chan B, Tong M, Paung Y, Jo U, Martin D, Seeliger M, Haley J, Kim H.

PLoS Genet. 2019 Feb 21;15(2):e1007983. doi: 10.1371/journal.pgen.1007983. eCollection 2019 Feb.


What Makes a Kinase Promiscuous for Inhibitors?

Hanson SM, Georghiou G, Thakur MK, Miller WT, Rest JS, Chodera JD, Seeliger MA.

Cell Chem Biol. 2019 Mar 21;26(3):390-399.e5. doi: 10.1016/j.chembiol.2018.11.005. Epub 2019 Jan 3.


Accessory heterozygous mutations in cone photoreceptor CNGA3 exacerbate CNG channel-associated retinopathy.

Burkard M, Kohl S, Krätzig T, Tanimoto N, Brennenstuhl C, Bausch AE, Junger K, Reuter P, Sothilingam V, Beck SC, Huber G, Ding XQ, Mayer AK, Baumann B, Weisschuh N, Zobor D, Hahn GA, Kellner U, Venturelli S, Becirovic E, Charbel Issa P, Koenekoop RK, Rudolph G, Heckenlively J, Sieving P, Weleber RG, Hamel C, Zong X, Biel M, Lukowski R, Seeliger MW, Michalakis S, Wissinger B, Ruth P.

J Clin Invest. 2018 Dec 3;128(12):5663-5675. doi: 10.1172/JCI96098. Epub 2018 Nov 12.


More Diversity Yields a Clearer Picture into the Architecture of the Protein Kinase Domain.

Seeliger MA.

Cell Syst. 2018 Oct 24;7(4):356-357. doi: 10.1016/j.cels.2018.10.002.


Optimized Subretinal Injection Technique for Gene Therapy Approaches.

Mühlfriedel R, Michalakis S, Garrido MG, Sothilingam V, Schön C, Biel M, Seeliger MW.

Methods Mol Biol. 2019;1834:405-412. doi: 10.1007/978-1-4939-8669-9_26.


KA1 Domains: Unity in Mechanistic Diversity.

Paung Y, Seeliger MA.

Structure. 2018 Aug 7;26(8):1045-1047. doi: 10.1016/j.str.2018.07.002.


An Open Library of Human Kinase Domain Constructs for Automated Bacterial Expression.

Albanese SK, Parton DL, Işık M, Rodríguez-Laureano L, Hanson SM, Behr JM, Gradia S, Jeans C, Levinson NM, Seeliger MA, Chodera JD.

Biochemistry. 2018 Aug 7;57(31):4675-4689. doi: 10.1021/acs.biochem.7b01081. Epub 2018 Jul 26.


Cystoid edema, neovascularization and inflammatory processes in the murine Norrin-deficient retina.

Beck SC, Karlstetter M, Garcia Garrido M, Feng Y, Dannhausen K, Mühlfriedel R, Sothilingam V, Seebauer B, Berger W, Hammes HP, Seeliger MW, Langmann T.

Sci Rep. 2018 Apr 13;8(1):5970. doi: 10.1038/s41598-018-24476-y.


Assessment of the Absolute Excitatory Level of the Retina by Flicker ERG.

Tanimoto N, Seeliger MW.

Methods Mol Biol. 2018;1753:191-202. doi: 10.1007/978-1-4939-7720-8_13.


Disturbed Processing of Contextual Information in HCN3 Channel Deficient Mice.

Stieglitz MS, Fenske S, Hammelmann V, Becirovic E, Schöttle V, Delorme JE, Schöll-Weidinger M, Mader R, Deussing J, Wolfer DP, Seeliger MW, Albrecht U, Wotjak CT, Biel M, Michalakis S, Wahl-Schott C.

Front Mol Neurosci. 2018 Jan 9;10:436. doi: 10.3389/fnmol.2017.00436. eCollection 2017.


Survey of solution dynamics in Src kinase reveals allosteric cross talk between the ligand binding and regulatory sites.

Tong M, Pelton JG, Gill ML, Zhang W, Picart F, Seeliger MA.

Nat Commun. 2017 Dec 18;8(1):2160. doi: 10.1038/s41467-017-02240-6.


Gene therapy successfully delays degeneration in a mouse model of PDE6A-linked retinitis pigmentosa (RP 43).

Schön C, Sothilingam V, Mühlfriedel R, Garcia Garrido M, Beck SC, Tanimoto N, Wissinger B, Paquet-Durand F, Biel M, Michalakis S, Seeliger MW, Consortium RC.

Hum Gene Ther. 2017 Dec 7. doi: 10.1089/hum.2017.156. [Epub ahead of print]


Gene Supplementation Rescues Rod Function and Preserves Photoreceptor and Retinal Morphology in Dogs, Leading the Way Towards Treating Human PDE6A-Retinitis Pigmentosa.

Occelli LM, Schön C, Seeliger MW, Biel M, Michalakis S, Petersen-Jones S, Consortium RC.

Hum Gene Ther. 2017 Dec 6. doi: 10.1089/hum.2017.155. [Epub ahead of print]


Patients and animal models of CNGβ1-deficient retinitis pigmentosa support gene augmentation approach.

Petersen-Jones SM, Occelli LM, Winkler PA, Lee W, Sparrow JR, Tsukikawa M, Boye SL, Chiodo V, Capasso JE, Becirovic E, Schön C, Seeliger MW, Levin AV, Michalakis S, Hauswirth WW, Tsang SH.

J Clin Invest. 2018 Jan 2;128(1):190-206. doi: 10.1172/JCI95161. Epub 2017 Nov 20.


Advanced Ocular Injection Techniques for Therapy Approaches.

Mühlfriedel R, Garrido MG, Wallrapp C, Seeliger MW.

Methods Mol Biol. 2018;1715:215-223. doi: 10.1007/978-1-4939-7522-8_15.


In-Depth Functional Analysis of Rodents by Full-Field Electroretinography.

Sothilingam V, Mühlfriedel R, Tanimoto N, Seeliger MW.

Methods Mol Biol. 2018;1715:207-213. doi: 10.1007/978-1-4939-7522-8_14.


Targeting the Hemopexin-like Domain of Latent Matrix Metalloproteinase-9 (proMMP-9) with a Small Molecule Inhibitor Prevents the Formation of Focal Adhesion Junctions.

Alford VM, Kamath A, Ren X, Kumar K, Gan Q, Awwa M, Tong M, Seeliger MA, Cao J, Ojima I, Sampson NS.

ACS Chem Biol. 2017 Nov 17;12(11):2788-2803. doi: 10.1021/acschembio.7b00758. Epub 2017 Oct 10.


AAV-Mediated Gene Supplementation Therapy in Achromatopsia Type 2: Preclinical Data on Therapeutic Time Window and Long-Term Effects.

Mühlfriedel R, Tanimoto N, Schön C, Sothilingam V, Garcia Garrido M, Beck SC, Huber G, Biel M, Seeliger MW, Michalakis S.

Front Neurosci. 2017 May 24;11:292. doi: 10.3389/fnins.2017.00292. eCollection 2017.


Long-term consequences of developmental vascular defects on retinal vessel homeostasis and function in a mouse model of Norrie disease.

Beck SC, Feng Y, Sothilingam V, Garcia Garrido M, Tanimoto N, Acar N, Shan S, Seebauer B, Berger W, Hammes HP, Seeliger MW.

PLoS One. 2017 Jun 2;12(6):e0178753. doi: 10.1371/journal.pone.0178753. eCollection 2017.


Mosaic synaptopathy and functional defects in Cav1.4 heterozygous mice and human carriers of CSNB2.

Michalakis S, Shaltiel L, Sothilingam V, Koch S, Schludi V, Krause S, Zeitz C, Audo I, Lancelot ME, Hamel C, Meunier I, Preising MN, Friedburg C, Lorenz B, Zabouri N, Haverkamp S, Garrido MG, Tanimoto N, Seeliger MW, Biel M, Wahl-Schott CA.

Hum Mol Genet. 2017 Jan 15;26(2):466. doi: 10.1093/hmg/ddw424. No abstract available.


[Gene Replacement Therapy for Inherited Retinal Dystrophies].

Mühlfriedel R, Sothilingam V, Tanimoto N, Seeliger MW.

Klin Monbl Augenheilkd. 2017 Mar;234(3):320-328. doi: 10.1055/s-0043-101817. Epub 2017 Mar 29. Review. German.


Selective Targeting of SH2 Domain-Phosphotyrosine Interactions of Src Family Tyrosine Kinases with Monobodies.

Kükenshöner T, Schmit NE, Bouda E, Sha F, Pojer F, Koide A, Seeliger M, Koide S, Hantschel O.

J Mol Biol. 2017 May 5;429(9):1364-1380. doi: 10.1016/j.jmb.2017.03.023. Epub 2017 Mar 25.


Murine Autoimmune Optic Neuritis Is Not Phenotypically Altered by the Retinal Degeneration 8 Mutation.

Stojic A, Fairless R, Beck SC, Sothilingam V, Weissgerber P, Wissenbach U, Gimmy V, Seeliger MW, Flockerzi V, Diem R, Williams SK.

Invest Ophthalmol Vis Sci. 2017 Jan 1;58(1):318-328. doi: 10.1167/iovs.16-20419.


Measuring Phospholipase D Enzymatic Activity Through Biochemical and Imaging Methods.

Philip F, Ha EE, Seeliger MA, Frohman MA.

Methods Enzymol. 2017;583:309-325. doi: 10.1016/bs.mie.2016.09.041. Epub 2016 Oct 22.


Enzymatic Activity and Thermodynamic Stability of Biliverdin IXβ Reductase Are Maintained by an Active Site Serine.

Chu WT, Nesbitt NM, Gnatenko DV, Li Z, Zhang B, Seeliger MA, Browne S, Mantle TJ, Bahou WF, Wang J.

Chemistry. 2017 Feb 3;23(8):1891-1900. doi: 10.1002/chem.201604517. Epub 2017 Jan 11.


Dynamically Coupled Residues within the SH2 Domain of FYN Are Key to Unlocking Its Activity.

Huculeci R, Cilia E, Lyczek A, Buts L, Houben K, Seeliger MA, van Nuland N, Lenaerts T.

Structure. 2016 Nov 1;24(11):1947-1959. doi: 10.1016/j.str.2016.08.016. Epub 2016 Sep 29.


Structural and Biochemical Basis for Intracellular Kinase Inhibition by Src-specific Peptidic Macrocycles.

Aleem S, Georghiou G, Kleiner RE, Guja K, Craddock BP, Lyczek A, Chan AI, Garcia-Diaz M, Miller WT, Liu DR, Seeliger MA.

Cell Chem Biol. 2016 Sep 22;23(9):1103-1112. doi: 10.1016/j.chembiol.2016.07.017. Epub 2016 Sep 1.


A Novel In Vitro CypD-Mediated p53 Aggregation Assay Suggests a Model for Mitochondrial Permeability Transition by Chaperone Systems.

Lebedev I, Nemajerova A, Foda ZH, Kornaj M, Tong M, Moll UM, Seeliger MA.

J Mol Biol. 2016 Oct 9;428(20):4154-4167. doi: 10.1016/j.jmb.2016.08.001. Epub 2016 Aug 8.


Structural and Functional Analysis of the Allosteric Inhibition of IRE1α with ATP-Competitive Ligands.

Feldman HC, Tong M, Wang L, Meza-Acevedo R, Gobillot TA, Lebedev I, Gliedt MJ, Hari SB, Mitra AK, Backes BJ, Papa FR, Seeliger MA, Maly DJ.

ACS Chem Biol. 2016 Aug 19;11(8):2195-205. doi: 10.1021/acschembio.5b00940. Epub 2016 Jun 9.


Differentiation of murine models of "negative ERG" by single and repetitive light stimuli.

Tanimoto N, Akula JD, Fulton AB, Weber BH, Seeliger MW.

Doc Ophthalmol. 2016 Apr;132(2):101-9. doi: 10.1007/s10633-016-9534-1. Epub 2016 Mar 21.


Conformation-Selective Analogues of Dasatinib Reveal Insight into Kinase Inhibitor Binding and Selectivity.

Kwarcinski FE, Brandvold KR, Phadke S, Beleh OM, Johnson TK, Meagher JL, Seeliger MA, Stuckey JA, Soellner MB.

ACS Chem Biol. 2016 May 20;11(5):1296-304. doi: 10.1021/acschembio.5b01018. Epub 2016 Mar 1.


HCN1 Channels Enhance Rod System Responsivity in the Retina under Conditions of Light Exposure.

Sothilingam V, Michalakis S, Garcia Garrido M, Biel M, Tanimoto N, Seeliger MW.

PLoS One. 2016 Jan 25;11(1):e0147728. doi: 10.1371/journal.pone.0147728. eCollection 2016.


Loss of HCN1 enhances disease progression in mouse models of CNG channel-linked retinitis pigmentosa and achromatopsia.

Schön C, Asteriti S, Koch S, Sothilingam V, Garcia Garrido M, Tanimoto N, Herms J, Seeliger MW, Cangiano L, Biel M, Michalakis S.

Hum Mol Genet. 2016 Mar 15;25(6):1165-75. doi: 10.1093/hmg/ddv639. Epub 2016 Jan 5.


In-Depth Functional Diagnostics of Mouse Models by Single-Flash and Flicker Electroretinograms without Adapting Background Illumination.

Tanimoto N, Michalakis S, Weber BH, Wahl-Schott CA, Hammes HP, Seeliger MW.

Adv Exp Med Biol. 2016;854:619-25. doi: 10.1007/978-3-319-17121-0_82.


Retinal functional alterations in mice lacking intermediate filament proteins glial fibrillary acidic protein and vimentin.

Wunderlich KA, Tanimoto N, Grosche A, Zrenner E, Pekny M, Reichenbach A, Seeliger MW, Pannicke T, Perez MT.

FASEB J. 2015 Dec;29(12):4815-28. doi: 10.1096/fj.15-272963. Epub 2015 Aug 6.


Fibronectin Interaction and Enhancement of Growth Factors: Importance for Wound Healing.

Sawicka KM, Seeliger M, Musaev T, Macri LK, Clark RA.

Adv Wound Care (New Rochelle). 2015 Aug 1;4(8):469-478. Review.


Retinitis pigmentosa: impact of different Pde6a point mutations on the disease phenotype.

Sothilingam V, Garcia Garrido M, Jiao K, Buena-Atienza E, Sahaboglu A, Trifunović D, Balendran S, Koepfli T, Mühlfriedel R, Schön C, Biel M, Heckmann A, Beck SC, Michalakis S, Wissinger B, Seeliger MW, Paquet-Durand F.

Hum Mol Genet. 2015 Oct 1;24(19):5486-99. doi: 10.1093/hmg/ddv275. Epub 2015 Jul 17.


Scale Adjustments to Facilitate Two-Dimensional Measurements in OCT Images.

Garcia Garrido M, Mühlfriedel RL, Beck SC, Wallrapp C, Seeliger MW.

PLoS One. 2015 Jun 25;10(6):e0131154. doi: 10.1371/journal.pone.0131154. eCollection 2015.


Mutations in the unfolded protein response regulator ATF6 cause the cone dysfunction disorder achromatopsia.

Kohl S, Zobor D, Chiang WC, Weisschuh N, Staller J, Gonzalez Menendez I, Chang S, Beck SC, Garcia Garrido M, Sothilingam V, Seeliger MW, Stanzial F, Benedicenti F, Inzana F, Héon E, Vincent A, Beis J, Strom TM, Rudolph G, Roosing S, Hollander AI, Cremers FP, Lopez I, Ren H, Moore AT, Webster AR, Michaelides M, Koenekoop RK, Zrenner E, Kaufman RJ, Tsang SH, Wissinger B, Lin JH.

Nat Genet. 2015 Jul;47(7):757-65. doi: 10.1038/ng.3319. Epub 2015 Jun 1.


Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice.

Tanimoto N, Sothilingam V, Kondo M, Biel M, Humphries P, Seeliger MW.

Sci Rep. 2015 Jun 1;5:10731. doi: 10.1038/srep10731.


VEGF Mediates ApoE4-Induced Neovascularization and Synaptic Pathology in the Choroid and Retina.

Antes R, Salomon-Zimri S, Beck SC, Garcia Garrido M, Livnat T, Maharshak I, Kadar T, Seeliger M, Weinberger D, Michaelson DM.

Curr Alzheimer Res. 2015;12(4):323-34.


Influence of the β2-Subunit of L-Type Voltage-Gated Cav Channels on the Structural and Functional Development of Photoreceptor Ribbon Synapses.

Katiyar R, Weissgerber P, Roth E, Dörr J, Sothilingam V, Garcia Garrido M, Beck SC, Seeliger MW, Beck A, Schmitz F, Flockerzi V.

Invest Ophthalmol Vis Sci. 2015 Apr;56(4):2312-24. doi: 10.1167/iovs.15-16654.


Targeted ablation of the Pde6h gene in mice reveals cross-species differences in cone and rod phototransduction protein isoform inventory.

Brennenstuhl C, Tanimoto N, Burkard M, Wagner R, Bolz S, Trifunovic D, Kabagema-Bilan C, Paquet-Durand F, Beck SC, Huber G, Seeliger MW, Ruth P, Wissinger B, Lukowski R.

J Biol Chem. 2015 Apr 17;290(16):10242-55. doi: 10.1074/jbc.M114.611921. Epub 2015 Mar 4.


A dynamically coupled allosteric network underlies binding cooperativity in Src kinase.

Foda ZH, Shan Y, Kim ET, Shaw DE, Seeliger MA.

Nat Commun. 2015 Jan 20;6:5939. doi: 10.1038/ncomms6939.


Targeting conformational plasticity of protein kinases.

Tong M, Seeliger MA.

ACS Chem Biol. 2015 Jan 16;10(1):190-200. doi: 10.1021/cb500870a. Epub 2014 Dec 19. Review.


Elk3 deficiency causes transient impairment in post-natal retinal vascular development and formation of tortuous arteries in adult murine retinae.

Weinl C, Wasylyk C, Garcia Garrido M, Sothilingam V, Beck SC, Riehle H, Stritt C, Roux MJ, Seeliger MW, Wasylyk B, Nordheim A.

PLoS One. 2014 Sep 9;9(9):e107048. doi: 10.1371/journal.pone.0107048. eCollection 2014.

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