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A rodent model of partial intestinal diversion: a novel metabolic operation.

Alvarez R, Sandoval DA, Seeley RJ.

Surg Obes Relat Dis. 2019 Nov 7. pii: S1550-7289(19)31080-9. doi: 10.1016/j.soard.2019.10.026. [Epub ahead of print]


Bromocriptine improves glucose tolerance independent of circadian timing, prolactin, or the melanocortin-4 receptor.

Framnes-DeBoer SN, Bakke E, Yalamanchili S, Peterson H, Sandoval DA, Seeley RJ, Arble DM.

Am J Physiol Endocrinol Metab. 2020 Jan 1;318(1):E62-E71. doi: 10.1152/ajpendo.00325.2019. Epub 2019 Dec 3.


Glucagon-like peptide 1 (GLP-1).

Müller TD, Finan B, Bloom SR, D'Alessio D, Drucker DJ, Flatt PR, Fritsche A, Gribble F, Grill HJ, Habener JF, Holst JJ, Langhans W, Meier JJ, Nauck MA, Perez-Tilve D, Pocai A, Reimann F, Sandoval DA, Schwartz TW, Seeley RJ, Stemmer K, Tang-Christensen M, Woods SC, DiMarchi RD, Tschöp MH.

Mol Metab. 2019 Dec;30:72-130. doi: 10.1016/j.molmet.2019.09.010. Epub 2019 Sep 30. Review.


Rapid hepatic metabolism blunts the endocrine action of portally infused GLP-1 in male rats.

Aulinger BA, Perabo M, Seeley RJ, Parhofer KG, D'Alessio DA.

Am J Physiol Endocrinol Metab. 2019 Nov 19. doi: 10.1152/ajpendo.00298.2019. [Epub ahead of print]


Glycemic effect of pancreatic preproglucagon in mouse sleeve gastrectomy.

Kim KS, Hutch CR, Wood L, Magrisso IJ, Seeley RJ, Sandoval DA.

JCI Insight. 2019 Oct 17;4(20). pii: 129452. doi: 10.1172/jci.insight.129452.


The Iminosugar AMP-DNM Improves Satiety and Activates Brown Adipose Tissue Through GLP1.

Herrera Moro Chao D, Wang Y, Foppen E, Ottenhoff R, van Roomen C, Parlevliet ET, van Eijk M, Verhoek M, Boot R, Marques AR, Scheij S, Mirzaian M, Kooijman S, Jansen K, Wang D, Mergen C, Seeley RJ, Tschöp MH, Overkleeft H, Rensen PCN, Kalsbeek A, Aerts JMFG, Yi CX.

Diabetes. 2019 Dec;68(12):2223-2234. doi: 10.2337/db19-0049. Epub 2019 Oct 2.


The role of GIP and pancreatic GLP-1 in the glucoregulatory effect of DPP-4 inhibition in mice.

Hutch CR, Roelofs K, Haller A, Sorrell J, Leix K, D'Alessio DD, Augustin R, Seeley RJ, Klein T, Sandoval DA.

Diabetologia. 2019 Oct;62(10):1928-1937. doi: 10.1007/s00125-019-4963-5. Epub 2019 Aug 14.


Nutrient and hormone composition of milk is altered in rodent dams post-bariatric surgery.

Deer EM, Welch B, Hernandez LL, Seeley RJ, Grayson BE.

J Dev Orig Health Dis. 2020 Feb;11(1):71-77. doi: 10.1017/S2040174419000424. Epub 2019 Aug 9.


Distinct Neural Sites of GLP-1R Expression Mediate Physiological versus Pharmacological Control of Incretin Action.

Varin EM, Mulvihill EE, Baggio LL, Koehler JA, Cao X, Seeley RJ, Drucker DJ.

Cell Rep. 2019 Jun 11;27(11):3371-3384.e3. doi: 10.1016/j.celrep.2019.05.055.


Reg3 Proteins as Gut Hormones?

Shin JH, Seeley RJ.

Endocrinology. 2019 Jun 1;160(6):1506-1514. doi: 10.1210/en.2019-00073. Review.


G-CSF partially mediates effects of sleeve gastrectomy on the bone marrow niche.

Li Z, Hardij J, Evers SS, Hutch CR, Choi SM, Shao Y, Learman BS, Lewis KT, Schill RL, Mori H, Bagchi DP, Romanelli SM, Kim KS, Bowers E, Griffin C, Seeley RJ, Singer K, Sandoval DA, Rosen CJ, MacDougald OA.

J Clin Invest. 2019 May 6;129(6):2404-2416. doi: 10.1172/JCI126173. eCollection 2019 May 6.


Glucagon-Like Peptide-1 Receptor Agonist Treatment Does Not Reduce Abuse-Related Effects of Opioid Drugs.

Bornebusch AB, Fink-Jensen A, Wörtwein G, Seeley RJ, Thomsen M.

eNeuro. 2019 Apr 24;6(2). pii: ENEURO.0443-18.2019. doi: 10.1523/ENEURO.0443-18.2019. eCollection 2019 Mar-Apr.


The Unconventional Role for Gastric Volume in the Response to Bariatric Surgery for Both Weight Loss and Glucose Lowering.

Evers SS, Lewis AG, Tong C, Shao Y, Alvarez R, Ridelman E, Grant B, Seeley RJ.

Ann Surg. 2019 Feb 20. doi: 10.1097/SLA.0000000000003240. [Epub ahead of print]


GDF15 acts synergistically with liraglutide but is not necessary for the weight loss induced by bariatric surgery in mice.

Frikke-Schmidt H, Hultman K, Galaske JW, Jørgensen SB, Myers MG Jr, Seeley RJ.

Mol Metab. 2019 Mar;21:13-21. doi: 10.1016/j.molmet.2019.01.003. Epub 2019 Jan 14.


Vertical sleeve gastrectomy improves ventilatory drive through a leptin-dependent mechanism.

Arble DM, Schwartz AR, Polotsky VY, Sandoval DA, Seeley RJ.

JCI Insight. 2019 Jan 10;4(1). pii: 124469. doi: 10.1172/jci.insight.124469. [Epub ahead of print]


Metabolic comparison of one-anastomosis gastric bypass, single-anastomosis duodenal-switch, Roux-en-Y gastric bypass, and vertical sleeve gastrectomy in rat.

Arble DM, Evers SS, Bozadjieva N, Frikke-Schmidt H, Myronovych A, Lewis A, Toure MH, Seeley RJ.

Surg Obes Relat Dis. 2018 Dec;14(12):1857-1867. doi: 10.1016/j.soard.2018.08.019. Epub 2018 Aug 29.


Assessment of mammographic breast density after sleeve gastrectomy.

Alvarez R, Ridelman E, Rizk N, White MS, Zhou C, Chan HP, Varban OA, Helvie MA, Seeley RJ.

Surg Obes Relat Dis. 2018 Nov;14(11):1643-1651. doi: 10.1016/j.soard.2018.07.024. Epub 2018 Aug 1.


Targeting FXR and FGF19 to Treat Metabolic Diseases-Lessons Learned From Bariatric Surgery.

Bozadjieva N, Heppner KM, Seeley RJ.

Diabetes. 2018 Sep;67(9):1720-1728. doi: 10.2337/dbi17-0007. Review.


A comparison of rodent models of vertical sleeve gastrectomy.

Alvarez R, Lewis AG, Toure MH, Seeley RJ.

Surg Obes Relat Dis. 2018 Oct;14(10):1471-1479. doi: 10.1016/j.soard.2018.06.022. Epub 2018 Jul 2.


GLP-2 receptor signaling controls circulating bile acid levels but not glucose homeostasis in Gcgr-/- mice and is dispensable for the metabolic benefits ensuing after vertical sleeve gastrectomy.

Patel A, Yusta B, Matthews D, Charron MJ, Seeley RJ, Drucker DJ.

Mol Metab. 2018 Oct;16:45-54. doi: 10.1016/j.molmet.2018.06.006. Epub 2018 Jun 9.


Specific subpopulations of hypothalamic leptin receptor-expressing neurons mediate the effects of early developmental leptin receptor deletion on energy balance.

Rupp AC, Allison MB, Jones JC, Patterson CM, Faber CL, Bozadjieva N, Heisler LK, Seeley RJ, Olson DP, Myers MG Jr.

Mol Metab. 2018 Aug;14:130-138. doi: 10.1016/j.molmet.2018.06.001. Epub 2018 Jun 6.


New horizons for future research - Critical issues to consider for maximizing research excellence and impact.

Langhans W, Adan R, Arnold M, Banks WA, Card JP, Dailey MJ, Daniels D, de Kloet AD, de Lartigue G, Dickson S, Fedele S, Grill HJ, Jansson JO, Kaufman S, Kolar G, Krause E, Lee SJ, Le Foll C, Levin BE, Lutz TA, Mansouri A, Moran TH, Pacheco-López G, Ramachandran D, Raybould H, Rinaman L, Samson WK, Sanchez-Watts G, Seeley RJ, Skibicka KP, Small D, Spector AC, Tamashiro KL, Templeton B, Trapp S, Tso P, Watts AG, Weissfeld N, Williams D, Wolfrum C, Yosten G, Woods SC.

Mol Metab. 2018 Aug;14:53-59. doi: 10.1016/j.molmet.2018.05.007. Epub 2018 May 12. No abstract available.


Expanding industry partnerships through an accelerated business engagement program.

Seeley RJ, Witbeck G, Mulholland MW.

Surgery. 2019 Aug;166(2):143-146. doi: 10.1016/j.surg.2018.03.015. Epub 2018 May 24. No abstract available.


Liraglutide Modulates Appetite and Body Weight Through Glucagon-Like Peptide 1 Receptor-Expressing Glutamatergic Neurons.

Adams JM, Pei H, Sandoval DA, Seeley RJ, Chang RB, Liberles SD, Olson DP.

Diabetes. 2018 Aug;67(8):1538-1548. doi: 10.2337/db17-1385. Epub 2018 May 18.


Refinement of Perioperative Feeding in a Mouse Model of Vertical Sleeve Gastrectomy.

Doerning CM, Burlingame LA, Lewis AG, Myronovych A, Seeley RJ, Lester PA.

J Am Assoc Lab Anim Sci. 2018 May 1;57(3):295-301. doi: 10.30802/AALAS-JAALAS-17-000162. Epub 2018 Apr 24.


Signalling from the periphery to the brain that regulates energy homeostasis.

Kim KS, Seeley RJ, Sandoval DA.

Nat Rev Neurosci. 2018 Apr;19(4):185-196. doi: 10.1038/nrn.2018.8. Epub 2018 Feb 22. Review.


How does 'metabolic surgery' work its magic? New evidence for gut microbiota.

Peck BCE, Seeley RJ.

Curr Opin Endocrinol Diabetes Obes. 2018 Apr;25(2):81-86. doi: 10.1097/MED.0000000000000392. Review.


A novel approach to glycemic control in type 2 diabetes mellitus, partial jejunal diversion: pre-clinical to clinical pathway.

Fried M, Dolezalova K, Chambers AP, Fegelman EJ, Scamuffa R, Schwiers ML, Waggoner JR, Haluzik M, Seeley RJ.

BMJ Open Diabetes Res Care. 2017 Sep 1;5(1):e000431. doi: 10.1136/bmjdrc-2017-000431. eCollection 2017.


The autonomic nervous system and cardiac GLP-1 receptors control heart rate in mice.

Baggio LL, Ussher JR, McLean BA, Cao X, Kabir MG, Mulvihill EE, Mighiu AS, Zhang H, Ludwig A, Seeley RJ, Heximer SP, Drucker DJ.

Mol Metab. 2017 Nov;6(11):1339-1349. doi: 10.1016/j.molmet.2017.08.010. Epub 2017 Sep 1.


Dietary Manipulations That Induce Ketosis Activate the HPA Axis in Male Rats and Mice: A Potential Role for Fibroblast Growth Factor-21.

Ryan KK, Packard AEB, Larson KR, Stout J, Fourman SM, Thompson AMK, Ludwick K, Habegger KM, Stemmer K, Itoh N, Perez-Tilve D, Tschöp MH, Seeley RJ, Ulrich-Lai YM.

Endocrinology. 2018 Jan 1;159(1):400-413. doi: 10.1210/en.2017-00486.


Enhanced AMPA Receptor Trafficking Mediates the Anorexigenic Effect of Endogenous Glucagon-like Peptide-1 in the Paraventricular Hypothalamus.

Liu J, Conde K, Zhang P, Lilascharoen V, Xu Z, Lim BK, Seeley RJ, Zhu JJ, Scott MM, Pang ZP.

Neuron. 2017 Nov 15;96(4):897-909.e5. doi: 10.1016/j.neuron.2017.09.042. Epub 2017 Oct 19.


Recombinant Incretin-Secreting Microbe Improves Metabolic Dysfunction in High-Fat Diet Fed Rodents.

Ryan PM, Patterson E, Kent RM, Stack H, O'Connor PM, Murphy K, Peterson VL, Mandal R, Wishart DS, Dinan TG, Cryan JF, Seeley RJ, Stanton C, Ross RP.

Sci Rep. 2017 Oct 19;7(1):13523. doi: 10.1038/s41598-017-14010-x.


Molecular Integration of Incretin and Glucocorticoid Action Reverses Immunometabolic Dysfunction and Obesity.

Quarta C, Clemmensen C, Zhu Z, Yang B, Joseph SS, Lutter D, Yi CX, Graf E, García-Cáceres C, Legutko B, Fischer K, Brommage R, Zizzari P, Franklin BS, Krueger M, Koch M, Vettorazzi S, Li P, Hofmann SM, Bakhti M, Bastidas-Ponce A, Lickert H, Strom TM, Gailus-Durner V, Bechmann I, Perez-Tilve D, Tuckermann J, Hrabě de Angelis M, Sandoval D, Cota D, Latz E, Seeley RJ, Müller TD, DiMarchi RD, Finan B, Tschöp MH.

Cell Metab. 2017 Oct 3;26(4):620-632.e6. doi: 10.1016/j.cmet.2017.08.023. Epub 2017 Sep 21.


Obesity Pathogenesis: An Endocrine Society Scientific Statement.

Schwartz MW, Seeley RJ, Zeltser LM, Drewnowski A, Ravussin E, Redman LM, Leibel RL.

Endocr Rev. 2017 Aug 1;38(4):267-296. doi: 10.1210/er.2017-00111. Review.


The glucagon-like peptide-1 receptor in the ventromedial hypothalamus reduces short-term food intake in male mice by regulating nutrient sensor activity.

Burmeister MA, Brown JD, Ayala JE, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE.

Am J Physiol Endocrinol Metab. 2017 Dec 1;313(6):E651-E662. doi: 10.1152/ajpendo.00113.2017. Epub 2017 Aug 15.


Dietary sugars, not lipids, drive hypothalamic inflammation.

Gao Y, Bielohuby M, Fleming T, Grabner GF, Foppen E, Bernhard W, Guzmán-Ruiz M, Layritz C, Legutko B, Zinser E, García-Cáceres C, Buijs RM, Woods SC, Kalsbeek A, Seeley RJ, Nawroth PP, Bidlingmaier M, Tschöp MH, Yi CX.

Mol Metab. 2017 Jun 20;6(8):897-908. doi: 10.1016/j.molmet.2017.06.008. eCollection 2017 Aug.


A leptin-regulated circuit controls glucose mobilization during noxious stimuli.

Flak JN, Arble D, Pan W, Patterson C, Lanigan T, Goforth PB, Sacksner J, Joosten M, Morgan DA, Allison MB, Hayes J, Feldman E, Seeley RJ, Olson DP, Rahmouni K, Myers MG Jr.

J Clin Invest. 2017 Aug 1;127(8):3103-3113. doi: 10.1172/JCI90147. Epub 2017 Jul 17.


Neonatal GLP1R activation limits adult adiposity by durably altering hypothalamic architecture.

Rozo AV, Babu DA, Suen PA, Groff DN, Seeley RJ, Simmons RA, Seale P, Ahima RS, Stoffers DA.

Mol Metab. 2017 May 15;6(7):748-759. doi: 10.1016/j.molmet.2017.05.006. eCollection 2017 Jul.


Central Nervous System GLP-1 Receptors Regulate Islet Hormone Secretion and Glucose Homeostasis in Male Rats.

Jessen L, Smith EP, Ulrich-Lai Y, Herman JP, Seeley RJ, Sandoval D, D'Alessio D.

Endocrinology. 2017 Jul 1;158(7):2124-2133. doi: 10.1210/en.2016-1826.


Weight loss independent changes in adipose tissue macrophage and T cell populations after sleeve gastrectomy in mice.

Frikke-Schmidt H, Zamarron BF, O'Rourke RW, Sandoval DA, Lumeng CN, Seeley RJ.

Mol Metab. 2017 Feb 16;6(4):317-326. doi: 10.1016/j.molmet.2017.02.004. eCollection 2017 Apr.


The Role of Pancreatic Preproglucagon in Glucose Homeostasis in Mice.

Chambers AP, Sorrell JE, Haller A, Roelofs K, Hutch CR, Kim KS, Gutierrez-Aguilar R, Li B, Drucker DJ, D'Alessio DA, Seeley RJ, Sandoval DA.

Cell Metab. 2017 Apr 4;25(4):927-934.e3. doi: 10.1016/j.cmet.2017.02.008. Epub 2017 Mar 16.


Gut-Brain Cross-Talk in Metabolic Control.

Clemmensen C, Müller TD, Woods SC, Berthoud HR, Seeley RJ, Tschöp MH.

Cell. 2017 Feb 23;168(5):758-774. doi: 10.1016/j.cell.2017.01.025. Review.


Physiology: Gut feeling for food choice.

Sandoval DA, Seeley RJ.

Nature. 2017 Feb 16;542(7641):302-303. doi: 10.1038/nature21499. Epub 2017 Feb 8. No abstract available.


Bariatric surgery emphasizes biological sex differences in rodent hepatic lipid handling.

Grayson BE, Gutierrez-Aguilar R, Sorrell JE, Matter EK, Adams MR, Howles P, Karns R, Seeley RJ, Sandoval DA.

Biol Sex Differ. 2017 Jan 28;8:4. doi: 10.1186/s13293-017-0126-x. eCollection 2017.


Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.

Ghosal S, Packard AEB, Mahbod P, McKlveen JM, Seeley RJ, Myers B, Ulrich-Lai Y, Smith EP, D'Alessio DA, Herman JP.

J Neurosci. 2017 Jan 4;37(1):184-193. doi: 10.1523/JNEUROSCI.1104-16.2016.


The Physiology and Molecular Underpinnings of the Effects of Bariatric Surgery on Obesity and Diabetes.

Evers SS, Sandoval DA, Seeley RJ.

Annu Rev Physiol. 2017 Feb 10;79:313-334. doi: 10.1146/annurev-physiol-022516-034423. Epub 2016 Nov 28. Review.


The Hypothalamic Glucagon-Like Peptide 1 Receptor Is Sufficient but Not Necessary for the Regulation of Energy Balance and Glucose Homeostasis in Mice.

Burmeister MA, Ayala JE, Smouse H, Landivar-Rocha A, Brown JD, Drucker DJ, Stoffers DA, Sandoval DA, Seeley RJ, Ayala JE.

Diabetes. 2017 Feb;66(2):372-384. doi: 10.2337/db16-1102. Epub 2016 Dec 1.


How Strongly Does Appetite Counter Weight Loss? Quantification of the Feedback Control of Human Energy Intake.

Polidori D, Sanghvi A, Seeley RJ, Hall KD.

Obesity (Silver Spring). 2016 Nov;24(11):2289-2295. doi: 10.1002/oby.21653.


The role of proximal versus distal stomach resection in the weight loss seen after vertical sleeve gastrectomy.

Kulkarni BV, LaSance K, Sorrell JE, Lemen L, Woods SC, Seeley RJ, Sandoval D.

Am J Physiol Regul Integr Comp Physiol. 2016 Nov 1;311(5):R979-R987. doi: 10.1152/ajpregu.00125.2016. Epub 2016 Aug 31.


Targeting the brain as a cure for type 2 diabetes.

Seeley RJ, Sandoval DA.

Nat Med. 2016 Jul 7;22(7):709-11. doi: 10.1038/nm.4137. No abstract available.


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