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Items: 1 to 50 of 56

1.

PIKfyve Deficiency in Myeloid Cells Impairs Lysosomal Homeostasis in Macrophages and Promotes Systemic Inflammation in Mice.

Min SH, Suzuki A, Weaver L, Guzman J, Chung Y, Jin H, Gonzalez F, Trasorras C, Zhao L, Spruce LA, Seeholzer SH, Behrens EM, Abrams CS.

Mol Cell Biol. 2019 Oct 11;39(21). pii: e00158-19. doi: 10.1128/MCB.00158-19. Print 2019 Nov 1.

PMID:
31427458
2.

The E3 ubiquitin ligase Itch restricts antigen-driven B cell responses.

Moser EK, Roof J, Dybas JM, Spruce LA, Seeholzer SH, Cancro MP, Oliver PM.

J Exp Med. 2019 Sep 2;216(9):2170-2183. doi: 10.1084/jem.20181953. Epub 2019 Jul 16.

PMID:
31311822
3.

SAMHD1 Modulates Early Steps during Human Cytomegalovirus Infection by Limiting NF-κB Activation.

Kim ET, Roche KL, Kulej K, Spruce LA, Seeholzer SH, Coen DM, Diaz-Griffero F, Murphy EA, Weitzman MD.

Cell Rep. 2019 Jul 9;28(2):434-448.e6. doi: 10.1016/j.celrep.2019.06.027.

4.

Integrative proteomics reveals an increase in non-degradative ubiquitylation in activated CD4+ T cells.

Dybas JM, O'Leary CE, Ding H, Spruce LA, Seeholzer SH, Oliver PM.

Nat Immunol. 2019 Jun;20(6):747-755. doi: 10.1038/s41590-019-0381-6. Epub 2019 May 6.

PMID:
31061531
5.

The Pediatric Cell Atlas: Defining the Growth Phase of Human Development at Single-Cell Resolution.

Taylor DM, Aronow BJ, Tan K, Bernt K, Salomonis N, Greene CS, Frolova A, Henrickson SE, Wells A, Pei L, Jaiswal JK, Whitsett J, Hamilton KE, MacParland SA, Kelsen J, Heuckeroth RO, Potter SS, Vella LA, Terry NA, Ghanem LR, Kennedy BC, Helbig I, Sullivan KE, Castelo-Soccio L, Kreigstein A, Herse F, Nawijn MC, Koppelman GH, Haendel M, Harris NL, Rokita JL, Zhang Y, Regev A, Rozenblatt-Rosen O, Rood JE, Tickle TL, Vento-Tormo R, Alimohamed S, Lek M, Mar JC, Loomes KM, Barrett DM, Uapinyoying P, Beggs AH, Agrawal PB, Chen YW, Muir AB, Garmire LX, Snapper SB, Nazarian J, Seeholzer SH, Fazelinia H, Singh LN, Faryabi RB, Raman P, Dawany N, Xie HM, Devkota B, Diskin SJ, Anderson SA, Rappaport EF, Peranteau W, Wikenheiser-Brokamp KA, Teichmann S, Wallace D, Peng T, Ding YY, Kim MS, Xing Y, Kong SW, Bönnemann CG, Mandl KD, White PS.

Dev Cell. 2019 Apr 8;49(1):10-29. doi: 10.1016/j.devcel.2019.03.001. Epub 2019 Mar 28. Review.

6.

CD19 Alterations Emerging after CD19-Directed Immunotherapy Cause Retention of the Misfolded Protein in the Endoplasmic Reticulum.

Bagashev A, Sotillo E, Tang CH, Black KL, Perazzelli J, Seeholzer SH, Argon Y, Barrett DM, Grupp SA, Hu CC, Thomas-Tikhonenko A.

Mol Cell Biol. 2018 Oct 15;38(21). pii: e00383-18. doi: 10.1128/MCB.00383-18. Print 2018 Nov 1.

7.

Sustained release of endothelial progenitor cell-derived extracellular vesicles from shear-thinning hydrogels improves angiogenesis and promotes function after myocardial infarction.

Chen CW, Wang LL, Zaman S, Gordon J, Arisi MF, Venkataraman CM, Chung JJ, Hung G, Gaffey AC, Spruce LA, Fazelinia H, Gorman RC, Seeholzer SH, Burdick JA, Atluri P.

Cardiovasc Res. 2018 Jun 1;114(7):1029-1040. doi: 10.1093/cvr/cvy067.

8.

Population pharmacokinetics of exendin-(9-39) and clinical dose selection in patients with congenital hyperinsulinism.

Ng CM, Tang F, Seeholzer SH, Zou Y, De León DD.

Br J Clin Pharmacol. 2018 Mar;84(3):520-532. doi: 10.1111/bcp.13463. Epub 2017 Dec 6.

9.

Reply to: Medication contaminants as a potential cause of anaphylaxis to vincristine: What about drug specific antigens?

Hill DA, Leahy AB, Sciasci J, O'Neill SP, Reilly A, Balamuth N, Seeholzer SH, Spergel JM, Brown-Whitehorn TF.

Pediatr Blood Cancer. 2018 Feb;65(2). doi: 10.1002/pbc.26868. Epub 2017 Oct 19. No abstract available.

10.

Identifying Host Factors Associated with DNA Replicated During Virus Infection.

Reyes ED, Kulej K, Pancholi NJ, Akhtar LN, Avgousti DC, Kim ET, Bricker DK, Spruce LA, Koniski SA, Seeholzer SH, Isaacs SN, Garcia BA, Weitzman MD.

Mol Cell Proteomics. 2017 Dec;16(12):2079-2097. doi: 10.1074/mcp.M117.067116. Epub 2017 Oct 2.

11.

Medication contaminants as a potential cause of anaphylaxis to vincristine.

Hill DA, Leahy AB, Sciasci J, O'Neill SP, Reilly A, Balamuth N, Seeholzer SH, Spergel JM, Brown-Whitehorn TF.

Pediatr Blood Cancer. 2018 Jan;65(1). doi: 10.1002/pbc.26761. Epub 2017 Aug 22.

12.

The Neuroprotective Marine Compound Psammaplysene A Binds the RNA-Binding Protein HNRNPK.

Boccitto M, Lee N, Sakamoto S, Spruce LA, Handa H, Clardy J, Seeholzer SH, Kalb RG.

Mar Drugs. 2017 Aug 7;15(8). pii: E246. doi: 10.3390/md15080246.

13.

Unbiased Proteomics of Early Lewy Body Formation Model Implicates Active Microtubule Affinity-Regulating Kinases (MARKs) in Synucleinopathies.

Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY.

J Neurosci. 2017 Jun 14;37(24):5870-5884. doi: 10.1523/JNEUROSCI.2705-16.2017. Epub 2017 May 18.

14.

Improved surfaceome coverage with a label-free nonaffinity-purified workflow.

Glisovic-Aplenc T, Gill S, Spruce LA, Smith IR, Fazelinia H, Shestova O, Ding H, Tasian SK, Aplenc R, Seeholzer SH.

Proteomics. 2017 Apr;17(7). doi: 10.1002/pmic.201600344. Epub 2017 Mar 6.

15.

Corticotropin-releasing factor overexpression gives rise to sex differences in Alzheimer's disease-related signaling.

Bangasser DA, Dong H, Carroll J, Plona Z, Ding H, Rodriguez L, McKennan C, Csernansky JG, Seeholzer SH, Valentino RJ.

Mol Psychiatry. 2017 Aug;22(8):1126-1133. doi: 10.1038/mp.2016.185. Epub 2016 Oct 18.

16.

Neutrophils promote alveolar epithelial regeneration by enhancing type II pneumocyte proliferation in a model of acid-induced acute lung injury.

Paris AJ, Liu Y, Mei J, Dai N, Guo L, Spruce LA, Hudock KM, Brenner JS, Zacharias WJ, Mei HD, Slamowitz AR, Bhamidipati K, Beers MF, Seeholzer SH, Morrisey EE, Worthen GS.

Am J Physiol Lung Cell Mol Physiol. 2016 Dec 1;311(6):L1062-L1075. doi: 10.1152/ajplung.00327.2016. Epub 2016 Sep 30.

17.

A core viral protein binds host nucleosomes to sequester immune danger signals.

Avgousti DC, Herrmann C, Kulej K, Pancholi NJ, Sekulic N, Petrescu J, Molden RC, Blumenthal D, Paris AJ, Reyes ED, Ostapchuk P, Hearing P, Seeholzer SH, Worthen GS, Black BE, Garcia BA, Weitzman MD.

Nature. 2016 Jul 7;535(7610):173-7. Epub 2016 Jun 29.

18.

Human neutrophil peptides inhibit cleavage of von Willebrand factor by ADAMTS13: a potential link of inflammation to TTP.

Pillai VG, Bao J, Zander CB, McDaniel JK, Chetty PS, Seeholzer SH, Bdeir K, Cines DB, Zheng XL.

Blood. 2016 Jul 7;128(1):110-9. doi: 10.1182/blood-2015-12-688747. Epub 2016 May 13.

19.

Ndfip-mediated degradation of Jak1 tunes cytokine signalling to limit expansion of CD4+ effector T cells.

O'Leary CE, Riling CR, Spruce LA, Ding H, Kumar S, Deng G, Liu Y, Seeholzer SH, Oliver PM.

Nat Commun. 2016 Apr 18;7:11226. doi: 10.1038/ncomms11226.

20.

Integrated analysis of proteome and transcriptome changes in the mucopolysaccharidosis type VII mouse hippocampus.

Parente MK, Rozen R, Seeholzer SH, Wolfe JH.

Mol Genet Metab. 2016 May;118(1):41-54. doi: 10.1016/j.ymgme.2016.03.003. Epub 2016 Mar 7.

21.

The Kringle-like Domain Facilitates Post-endoplasmic Reticulum Changes to Premelanosome Protein (PMEL) Oligomerization and Disulfide Bond Configuration and Promotes Amyloid Formation.

Ho T, Watt B, Spruce LA, Seeholzer SH, Marks MS.

J Biol Chem. 2016 Feb 12;291(7):3595-612. doi: 10.1074/jbc.M115.692442. Epub 2015 Dec 22.

22.

Unconventional N-Linked Glycosylation Promotes Trimeric Autotransporter Function in Kingella kingae and Aggregatibacter aphrophilus.

Rempe KA, Spruce LA, Porsch EA, Seeholzer SH, Nørskov-Lauritsen N, St Geme JW 3rd.

MBio. 2015 Aug 25;6(4). pii: e01206-15. doi: 10.1128/mBio.01206-15.

23.

Loss of PIKfyve in platelets causes a lysosomal disease leading to inflammation and thrombosis in mice.

Min SH, Suzuki A, Stalker TJ, Zhao L, Wang Y, McKennan C, Riese MJ, Guzman JF, Zhang S, Lian L, Joshi R, Meng R, Seeholzer SH, Choi JK, Koretzky G, Marks MS, Abrams CS.

Nat Commun. 2014 Sep 2;5:4691. doi: 10.1038/ncomms5691.

24.

The diabetes susceptibility gene Clec16a regulates mitophagy.

Soleimanpour SA, Gupta A, Bakay M, Ferrari AM, Groff DN, Fadista J, Spruce LA, Kushner JA, Groop L, Seeholzer SH, Kaufman BA, Hakonarson H, Stoffers DA.

Cell. 2014 Jun 19;157(7):1577-90. doi: 10.1016/j.cell.2014.05.016.

25.

Quaternary arrangement of an active, native group II intron ribonucleoprotein complex revealed by small-angle X-ray scattering.

Gupta K, Contreras LM, Smith D, Qu G, Huang T, Spruce LA, Seeholzer SH, Belfort M, Van Duyne GD.

Nucleic Acids Res. 2014 Apr;42(8):5347-60. doi: 10.1093/nar/gku140. Epub 2014 Feb 24.

26.

A liquid chromatography-mass spectrometry assay for quantification of Exendin[9-39] in human plasma.

Lasaosa M, Patel P, Givler S, De León DD, Seeholzer SH.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Feb 1;947-948:186-91. doi: 10.1016/j.jchromb.2013.12.010. Epub 2013 Dec 16.

27.

Site specific identification of endogenous S-nitrosocysteine proteomes.

Doulias PT, Tenopoulou M, Raju K, Spruce LA, Seeholzer SH, Ischiropoulos H.

J Proteomics. 2013 Oct 30;92:195-203. doi: 10.1016/j.jprot.2013.05.033. Epub 2013 Jun 5.

28.

Quantitative phosphoproteomics reveals extensive cellular reprogramming during HIV-1 entry.

Wojcechowskyj JA, Didigu CA, Lee JY, Parrish NF, Sinha R, Hahn BH, Bushman FD, Jensen ST, Seeholzer SH, Doms RW.

Cell Host Microbe. 2013 May 15;13(5):613-623. doi: 10.1016/j.chom.2013.04.011.

29.

The HtrA protease from Streptococcus pneumoniae digests both denatured proteins and the competence-stimulating peptide.

Cassone M, Gagne AL, Spruce LA, Seeholzer SH, Sebert ME.

J Biol Chem. 2012 Nov 9;287(46):38449-59. doi: 10.1074/jbc.M112.391482. Epub 2012 Sep 25.

30.

Biochemical fractionation and stable isotope dilution liquid chromatography-mass spectrometry for targeted and microdomain-specific protein quantification in human postmortem brain tissue.

MacDonald ML, Ciccimaro E, Prakash A, Banerjee A, Seeholzer SH, Blair IA, Hahn CG.

Mol Cell Proteomics. 2012 Dec;11(12):1670-81. doi: 10.1074/mcp.M112.021766. Epub 2012 Aug 31.

31.

Anti-NMDA receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain.

Gleichman AJ, Spruce LA, Dalmau J, Seeholzer SH, Lynch DR.

J Neurosci. 2012 Aug 8;32(32):11082-94. doi: 10.1523/JNEUROSCI.0064-12.2012.

32.

Quantitative phosphoproteomics of CXCL12 (SDF-1) signaling.

Wojcechowskyj JA, Lee JY, Seeholzer SH, Doms RW.

PLoS One. 2011;6(9):e24918. doi: 10.1371/journal.pone.0024918. Epub 2011 Sep 20.

33.

APC +/- alters colonic fibroblast proteome in FAP.

Patel BB, Li XM, Dixon MP, Blagoi EL, Nicolas E, Seeholzer SH, Cheng D, He YA, Coudry RA, Howard SD, Riddle DM, Cooper HC, Boman BM, Conrad P, Crowell JA, Bellacosa A, Knudson A, Yeung AT, Kopelovich L.

Oncotarget. 2011 Mar;2(3):197-208.

34.

Hb Baden: structural and functional characterization.

Abdulmalik O, Safo MK, Seeholzer SH, Asakura T, Hasbrouck NC, Russell JE.

Am J Hematol. 2010 Nov;85(11):848-52. doi: 10.1002/ajh.21831.

35.

Structural profiling of endogenous S-nitrosocysteine residues reveals unique features that accommodate diverse mechanisms for protein S-nitrosylation.

Doulias PT, Greene JL, Greco TM, Tenopoulou M, Seeholzer SH, Dunbrack RL, Ischiropoulos H.

Proc Natl Acad Sci U S A. 2010 Sep 28;107(39):16958-63. doi: 10.1073/pnas.1008036107. Epub 2010 Sep 13.

36.

Quantitative mass spectrometry-based proteomics reveals the dynamic range of primary mouse astrocyte protein secretion.

Greco TM, Seeholzer SH, Mak A, Spruce L, Ischiropoulos H.

J Proteome Res. 2010 May 7;9(5):2764-74. doi: 10.1021/pr100134n.

37.

One-hit effects in cancer: altered proteome of morphologically normal colon crypts in familial adenomatous polyposis.

Yeung AT, Patel BB, Li XM, Seeholzer SH, Coudry RA, Cooper HS, Bellacosa A, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A.

Cancer Res. 2008 Sep 15;68(18):7579-86. doi: 10.1158/0008-5472.CAN-08-0856.

38.

Cellular nonmuscle myosins NMHC-IIA and NMHC-IIB and vertebrate heart looping.

Lu W, Seeholzer SH, Han M, Arnold AS, Serrano M, Garita B, Philp NJ, Farthing C, Steele P, Chen J, Linask KK.

Dev Dyn. 2008 Dec;237(12):3577-90. doi: 10.1002/dvdy.21645.

39.

Antigen receptor editing in anti-DNA transitional B cells deficient for surface IgM.

Kiefer K, Nakajima PB, Oshinsky J, Seeholzer SH, Radic M, Bosma GC, Bosma MJ.

J Immunol. 2008 May 1;180(9):6094-106.

40.

Searchable high-resolution 2D gel proteome of the human colon crypt.

Patel BB, Li XM, Dixon MP, Blagoi EL, Seeholzer SH, Chen Y, Miller CG, He YA, Tetruashvily M, Chaudhry AH, Ke E, Xie J, Cooper H, Bellacosa A, Clapper ML, Boman BM, Zhang T, Litwin S, Ross EA, Conrad P, Crowell JA, Kopelovich L, Knudson A, Yeung AT.

J Proteome Res. 2007 Jun;6(6):2232-8. Epub 2007 Apr 20.

PMID:
17444668
41.

Analyzing alkaline proteins in human colon crypt proteome.

Li XM, Patel BB, Blagoi EL, Patterson MD, Seeholzer SH, Zhang T, Damle S, Gao Z, Boman B, Yeung AT.

J Proteome Res. 2004 Jul-Aug;3(4):821-33. Erratum in: J Proteome Res. 2004 Nov-Dec;3(6):1300. Seehozer, Steven H [corrected to Seeholzer, Steven H].

PMID:
15359737
42.

A strategy for the comparative analysis of serum proteomes for the discovery of biomarkers for hepatocellular carcinoma.

Steel LF, Shumpert D, Trotter M, Seeholzer SH, Evans AA, London WT, Dwek R, Block TM.

Proteomics. 2003 May;3(5):601-9.

PMID:
12748940
43.

The synthesis and radiolabeling of 2-nitroimidazole derivatives of cyclam and their preclinical evaluation as positive markers of tumor hypoxia.

Engelhardt EL, Schneider RF, Seeholzer SH, Stobbe CC, Chapman JD.

J Nucl Med. 2002 Jun;43(6):837-50.

44.
45.

Investigation of the substrate spectrum of the human mismatch-specific DNA N-glycosylase MED1 (MBD4): fundamental role of the catalytic domain.

Petronzelli F, Riccio A, Markham GD, Seeholzer SH, Genuardi M, Karbowski M, Yeung AT, Matsumoto Y, Bellacosa A.

J Cell Physiol. 2000 Dec;185(3):473-80.

PMID:
11056019
46.

Direct evidence for the cooperative unfolding of cytochrome c in lipid membranes from H-(2)H exchange kinetics.

Pinheiro TJ, Cheng H, Seeholzer SH, Roder H.

J Mol Biol. 2000 Nov 3;303(4):617-26.

PMID:
11054296
47.

Biphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylase.

Petronzelli F, Riccio A, Markham GD, Seeholzer SH, Stoerker J, Genuardi M, Yeung AT, Matsumoto Y, Bellacosa A.

J Biol Chem. 2000 Oct 20;275(42):32422-9.

48.

Structural determinants of metal-induced conformational changes in HIV-1 integrase.

Asante-Appiah E, Seeholzer SH, Skalka AM.

J Biol Chem. 1998 Dec 25;273(52):35078-87.

49.

Phosphoglucose isomerase: a ketol isomerase with aldol C2-epimerase activity.

Seeholzer SH.

Proc Natl Acad Sci U S A. 1993 Feb 15;90(4):1237-41.

50.

Enolpyruvate: chemical determination as a pyruvate kinase intermediate.

Seeholzer SH, Jaworowski A, Rose IA.

Biochemistry. 1991 Jan 22;30(3):727-32.

PMID:
1988060

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