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Items: 1 to 50 of 283

1.

Chondrocyte-derived apoptotic bodies and calcification of articular cartilage.

Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R, Lotz M.

Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3094-9.

2.

Differential effects of aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate production and decreased cell proliferation.

Rosen F, McCabe G, Quach J, Solan J, Terkeltaub R, Seegmiller JE, Lotz M.

Arthritis Rheum. 1997 Jul;40(7):1275-81.

PMID:
9214428
3.

Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate (PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes.

Lotz M, Rosen F, McCabe G, Quach J, Blanco F, Dudler J, Solan J, Goding J, Seegmiller JE, Terkeltaub R.

Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10364-8.

4.
5.

Determination of the mutations responsible for the Lesch-Nyhan syndrome in 17 subjects.

Tarlé SA, Davidson BL, Wu VC, Zidar FJ, Seegmiller JE, Kelley WN, Palella TD.

Genomics. 1991 Jun;10(2):499-501.

6.

Increased gene expression of Alzheimer disease beta-amyloid precursor protein in senescent cultured fibroblasts.

Adler MJ, Coronel C, Shelton E, Seegmiller JE, Dewji NN.

Proc Natl Acad Sci U S A. 1991 Jan 1;88(1):16-20.

7.

Fructose-induced aberration of metabolism in familial gout identified by 31P magnetic resonance spectroscopy.

Seegmiller JE, Dixon RM, Kemp GJ, Angus PW, McAlindon TE, Dieppe P, Rajagopalan B, Radda GK.

Proc Natl Acad Sci U S A. 1990 Nov;87(21):8326-30.

8.

An aberration of fructose metabolism in familial gout identified by 31P magnetic resonance spectroscopy of the liver.

Seegmiller JE, Dixon RM, Kemp GJ, Angus PW, McAlindon TE, Dieppe P, Rajagopalan B, Radda GK.

Trans Assoc Am Physicians. 1990;103:298-306. No abstract available.

PMID:
2132540
9.

Processing of Alzheimer's disease-associated beta-amyloid precursor protein.

Dewji NN, Shelton ER, Adler MJ, Chan HW, Seegmiller JE, Coronel C.

J Mol Neurosci. 1990;2(1):19-27.

PMID:
2124135
10.

Effects of ascorbic acid in alkaptonuria: alterations in benzoquinone acetic acid and an ontogenic effect in infancy.

Wolff JA, Barshop B, Nyhan WL, Leslie J, Seegmiller JE, Gruber H, Garst M, Winter S, Michals K, Matalon R.

Pediatr Res. 1989 Aug;26(2):140-4.

PMID:
2771520
11.

Ochronosis: a report of a case and a review of literature.

Konttinen YT, Hoikka V, Landtman M, Saari H, Santavirta S, Metsärinne K, Seegmiller JE.

Clin Exp Rheumatol. 1989 Jul-Aug;7(4):435-44. Review.

PMID:
2686878
12.

Chondrocyte growth inhibition induced by homogentisic acid and its partial prevention with ascorbic acid.

Angeles AP, Badger R, Gruber HE, Seegmiller JE.

J Rheumatol. 1989 Apr;16(4):512-7.

PMID:
2746590
13.

Contributions of Lesch-Nyhan syndrome to the understanding of purine metabolism.

Seegmiller JE.

J Inherit Metab Dis. 1989;12(2):184-96. No abstract available.

PMID:
2502677
14.

2,8-dihydroxyadenine urolithiasis: report of a case first diagnosed after renal transplant.

Glicklich D, Gruber HE, Matas AJ, Tellis VA, Karwa G, Finley K, Salem C, Soberman R, Seegmiller JE.

Q J Med. 1988 Oct;68(258):785-93. Review.

PMID:
3077470
16.

Clinical correlations in partial hypoxanthine guanine phosphoribosyltransferase deficiency.

Hersh JH, Page T, Hand ME, Seegmiller JE, Nyhan WL, Weisskopf B.

Pediatr Neurol. 1986 Sep-Oct;2(5):302-4.

PMID:
3508703
18.

The biochemical mechanism of metabolic cooperation.

Koenker R, Luchtman LA, Willis RC, Seegmiller JE, Gruber HE.

Adv Exp Med Biol. 1986;195 Pt A:183-7. No abstract available.

PMID:
3728150
19.

An appreciation of DeWitt Stetten, Jr.

Seegmiller JE.

Adv Exp Med Biol. 1986;195 Pt A:17-9. No abstract available.

PMID:
3524133
20.

Insertion of hypoxanthine phosphoribosyltransferase cDNA into human bone marrow cells by a retrovirus.

Gruber HE, Finley KD, Luchtman LA, Hershberg RM, Katzman SS, Laikind PK, Meyers EN, Seegmiller JE, Friedmann T, Yee JK, et al.

Adv Exp Med Biol. 1986;195 Pt A:171-5. No abstract available.

PMID:
3014831
21.

Purine biosynthesis in Chinese hamster cell mutants and human fibroblasts partially deficient in adenylosuccinate lyase.

Laikind PK, Gruber HE, Jansen I, Miller L, Hoffer M, Seegmiller JE, Willis RC, Jaeken J, Van den Berghe G.

Adv Exp Med Biol. 1986;195 Pt B:363-9. No abstract available.

PMID:
2876593
22.

Retroviral vector-mediated gene transfer into human hematopoietic progenitor cells.

Gruber HE, Finley KD, Hershberg RM, Katzman SS, Laikind PK, Seegmiller JE, Friedmann T, Yee JK, Jolly DJ.

Science. 1985 Nov 29;230(4729):1057-61.

PMID:
3864246
23.

Glial cells metabolically cooperate: a potential requirement for gene replacement therapy.

Gruber HE, Koenker R, Luchtman LA, Willis RC, Seegmiller JE.

Proc Natl Acad Sci U S A. 1985 Oct;82(19):6662-6.

24.

Alterations of inosinate branchpoint enzymes in cultured human lymphoblasts.

Gruber HE, Jansen I, Willis RC, Seegmiller JE.

Biochim Biophys Acta. 1985 Jul 30;846(1):135-44.

PMID:
2861860
25.

Overview of possible relation of defects in purine metabolism to immune deficiency.

Seegmiller JE.

Ann N Y Acad Sci. 1985;451:9-19. Review. No abstract available.

PMID:
3935028
26.

The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of adenosine deaminase deficiency.

Albert D, Bluestein HG, Thompson L, Seegmiller JE.

Cell Immunol. 1984 Jul;86(2):510-7.

PMID:
6610485
27.

The mechanism of inhibition and "reversal" of mitogen-induced lymphocyte activation in a model of purine-nucleoside phosphorylase deficiency.

Albert D, Bluestein HG, Willis RC, Nette K, Seegmiller JE.

Cell Immunol. 1984 Jul;86(2):501-9.

PMID:
6428752
28.

Partial phenotypic correction of human Lesch-Nyhan (hypoxanthine-guanine phosphoribosyltransferase-deficient) lymphoblasts with a transmissible retroviral vector.

Willis RC, Jolly DJ, Miller AD, Plent MM, Esty AC, Anderson PJ, Chang HC, Jones OW, Seegmiller JE, Friedmann T.

J Biol Chem. 1984 Jun 25;259(12):7842-9.

29.

Purine nucleotide reutilization by human lymphoblast lines with aberrations of the inosinate cycle.

Willis RC, Kaufman AH, Seegmiller JE.

J Biol Chem. 1984 Apr 10;259(7):4157-61.

30.

Clinical and biochemical correlates of a new HPRT mutation.

Gruber HE, Vuchinich M, Marlow TA, Plent MM, Willis RC, Seegmiller JE, Bartley J, Hanson JW, Zellweger H.

Adv Exp Med Biol. 1984;165 Pt A:19-22. No abstract available.

PMID:
6720378
31.

Regulation of human lymphoblast ecto-5'-nucleotidase by zinc.

Pilz RB, Willis RC, Wanlass S, Seegmiller JE.

Adv Exp Med Biol. 1984;165 Pt B:147-52. No abstract available.

PMID:
6326497
32.

Synthesis of (14C)-ribose-5-phosphate and (14C)-phosphoribosylpyrophosphate and their use in new enzyme assays.

Boss GR, Idriss SD, Willis RC, Seegmiller JE.

Adv Exp Med Biol. 1984;165 Pt B:11-3. No abstract available.

PMID:
6202119
33.

In vitro stabilization of the unoccupied glucocorticoid receptor by adenosine 5'-diphosphate.

Barnett CA, Palmour RM, Litwack G, Seegmiller JE.

Endocrinology. 1983 Jun;112(6):2059-68.

PMID:
6851939
34.

Assay of glutamine phosphoribosylpyrophosphate amidotransferase using [1-14C]phosphoribosylpyrophosphate.

Boss GR, Idriss SD, Willis RC, Seegmiller JE.

Anal Biochem. 1983 Apr 1;130(1):283-6.

PMID:
6191593
35.

Regulation of human lymphoblast plasma membrane 5'-nucleotidase by zinc.

Pilz RB, Willis RC, Seegmiller JE.

J Biol Chem. 1982 Nov 25;257(22):13544-9. No abstract available.

36.

Genetic defects in human purine and pyrimidine metabolism.

Boss GR, Seegmiller JE.

Annu Rev Genet. 1982;16:297-328. Review. No abstract available.

PMID:
6297375
37.

Age-related physiological changes and their clinical significance.

Boss GR, Seegmiller JE.

West J Med. 1981 Dec;135(6):434-40.

38.
39.

Increased pyrophosphate in fibroblasts and lymphoblasts from patients with hereditary diffuse articular chondrocalcinosis.

Lust G, Faure G, Netter P, Seegmiller JE.

Science. 1981 Nov 13;214(4522):809-10.

PMID:
6270793
40.

A long-term study of the absorption of large oral doses of folic acid.

Zettner A, Boss GR, Seegmiller JE.

Ann Clin Lab Sci. 1981 Nov-Dec;11(6):516-24.

PMID:
7325593
41.

Stethoscopes on airplanes.

Seegmiller JE.

N Engl J Med. 1981 Jul 30;305(5):289. No abstract available.

PMID:
7242630
42.

Ecto-5'-nucleotidase deficiency: association with adenosine deaminase deficiency and nonassociation with deoxyadenosine toxicity.

Boss GR, Thompson LF, O'Connor RD, Ziering RW, Seegmiller JE.

Clin Immunol Immunopathol. 1981 Apr;19(1):1-7. No abstract available.

PMID:
6260402
43.

Failure of folic acid (pteroylglutamic acid) to affect hyperuricemia.

Boss GR, Ragsdale RA, Zettner A, Seegmiller JE.

J Lab Clin Med. 1980 Nov;96(5):783-9.

PMID:
6893465
45.
46.

Thymidine as a chemotherapeutic agent: pharmacologic, cytokinetic, and biochemical studies in a patient with T-cell acute lymphocytic leukemia.

Howell SB, Chu B, Mendelsohn J, Carson DA, Kung FH, Seegmiller JE.

J Natl Cancer Inst. 1980 Aug;65(2):277-84.

PMID:
6967527
47.

Age-dependency of lymphocyte ecto-5'-nucleotidase activity.

Boss GR, Thompson LF, Spiegelberg HL, Pichler WJ, Seegmiller JE.

J Immunol. 1980 Aug;125(2):679-82.

PMID:
6248594
48.

Ecto-5'-nucleotidase activity in lymphoblastoid cell lines derived from heterozygotes for congenital X-linked agammaglobulinemia.

Thompson LF, Boss GR, Spiegelberg HL, Bianchino A, Seegmiller JE.

J Immunol. 1980 Jul;125(1):190-3.

PMID:
6247393
49.
50.

Altered regulation of Epstein-Barr virus induced lymphoblast proliferation in rheumatoid arthritis lymphoid cells.

Bardwick PA, Bluestein HG, Zvaifler NJ, Depper JM, Seegmiller JE.

Arthritis Rheum. 1980 Jun;23(6):626-32. No abstract available.

PMID:
6248075

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