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Items: 1 to 50 of 154

1.

Midazolam is effective to reduce cortical network activity in organotypic cultures during severe cholinergic overstimulation with soman.

Drexler B, Seeger T, Worek F, Thiermann H, Antkowiak B, Grasshoff C.

Toxicol Lett. 2018 Nov;297:19-23. doi: 10.1016/j.toxlet.2018.08.016. Epub 2018 Aug 27.

PMID:
30165091
2.

Telomere shortening is a hallmark of genetic cardiomyopathies.

Chang ACY, Chang ACH, Kirillova A, Sasagawa K, Su W, Weber G, Lin J, Termglinchan V, Karakikes I, Seeger T, Dainis AM, Hinson JT, Seidman J, Seidman CE, Day JW, Ashley E, Wu JC, Blau HM.

Proc Natl Acad Sci U S A. 2018 Sep 11;115(37):9276-9281. doi: 10.1073/pnas.1714538115. Epub 2018 Aug 27.

3.

Synthesis of a Series of Structurally Diverse MB327 Derivatives and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor.

Rappenglück S, Sichler S, Höfner G, Wein T, Niessen KV, Seeger T, Paintner FF, Worek F, Thiermann H, Wanner KT.

ChemMedChem. 2018 Sep 6;13(17):1806-1816. doi: 10.1002/cmdc.201800325. Epub 2018 Aug 1.

PMID:
29974635
4.

New Resensitizers for the Nicotinic Acetylcholine Receptor by Ligand-based Pharmacophore Modeling.

Wein T, Wanner KT, Rappengluck S, Sichler S, Niessen KV, Seeger T, Worek F, Thiermann H.

Curr Comput Aided Drug Des. 2018 Jul 3. doi: 10.2174/1573409914666180703120201. [Epub ahead of print]

PMID:
29968541
5.

Impact of Ionizing Radiation on Electrophysiological Behavior of Human-induced Ipsc-derived Cardiomyocytes on Multielectrode Arrays.

Becker BV, Seeger T, Beiert T, Antwerpen M, Palnek A, Port M, Ullmann R.

Health Phys. 2018 Jul;115(1):21-28. doi: 10.1097/HP.0000000000000817.

PMID:
29787427
6.

Epigenetic regulation of NFE2 overexpression in myeloproliferative neoplasms.

Peeken JC, Jutzi JS, Wehrle J, Koellerer C, Staehle HF, Becker H, Schoenwandt E, Seeger TS, Schanne DH, Gothwal M, Ott CJ, Gründer A, Pahl HL.

Blood. 2018 May 3;131(18):2065-2073. doi: 10.1182/blood-2017-10-810622. Epub 2018 Mar 8.

PMID:
29519804
7.

Counteracting desensitization of human α7-nicotinic acetylcholine receptors with bispyridinium compounds as an approach against organophosphorus poisoning.

Scheffel C, Niessen KV, Rappenglück S, Wanner KT, Thiermann H, Worek F, Seeger T.

Toxicol Lett. 2018 Sep 1;293:149-156. doi: 10.1016/j.toxlet.2017.12.005. Epub 2017 Dec 14.

PMID:
29248576
8.

Electrophysiological investigation of the effect of structurally different bispyridinium non-oxime compounds on human α7-nicotinic acetylcholine receptor activity-An in vitro structure-activity analysis.

Scheffel C, Niessen KV, Rappenglück S, Wanner KT, Thiermann H, Worek F, Seeger T.

Toxicol Lett. 2018 Sep 1;293:157-166. doi: 10.1016/j.toxlet.2017.11.025. Epub 2017 Nov 27.

PMID:
29191791
9.

Development of MS Binding Assays targeting the binding site of MB327 at the nicotinic acetylcholine receptor.

Sichler S, Höfner G, Rappenglück S, Wein T, Niessen KV, Seeger T, Worek F, Thiermann H, Paintner FF, Wanner KT.

Toxicol Lett. 2018 Sep 1;293:172-183. doi: 10.1016/j.toxlet.2017.11.013. Epub 2017 Nov 14.

PMID:
29146291
10.

Searching for putative binding sites of the bispyridinium compound MB327 in the nicotinic acetylcholine receptor.

Wein T, Höfner G, Rappenglück S, Sichler S, Niessen KV, Seeger T, Worek F, Thiermann H, Wanner KT.

Toxicol Lett. 2018 Sep 1;293:184-189. doi: 10.1016/j.toxlet.2017.10.024. Epub 2017 Oct 31.

PMID:
29097222
11.

In vitro pharmacological characterization of the bispyridinium non-oxime compound MB327 and its 2- and 3-regioisomers.

Niessen KV, Seeger T, Rappenglück S, Wein T, Höfner G, Wanner KT, Thiermann H, Worek F.

Toxicol Lett. 2018 Sep 1;293:190-197. doi: 10.1016/j.toxlet.2017.10.009. Epub 2017 Oct 10.

PMID:
29024789
12.

Immediate responses of the cockroach Blaptica dubia after the exposure to sulfur mustard.

Popp T, Lüling R, Boekhoff I, Seeger T, Branoner F, Gudermann T, Thiermann H, Worek F, Steinritz D.

Arch Toxicol. 2018 Jan;92(1):337-346. doi: 10.1007/s00204-017-2064-0. Epub 2017 Sep 20.

PMID:
28932886
13.

Laser applications to chemical, security, and environmental analysis: introduction to the feature issue.

Seeger T, Dreier T, Chen W, Kearny S, Kulatilaka W.

Appl Opt. 2017 Apr 10;56(11):LAC1-LAC3. doi: 10.1364/AO.56.00LAC1.

PMID:
28414389
14.

Three-color vibrational CARS thermometry of fuel-rich ethylene/air flames using a potassium gadolinium tungstate Raman-active crystal as a source of narrowband probe radiation.

Meißner C, Tröger JW, Kozlov DN, Beyrau F, Seeger T.

Appl Opt. 2017 Apr 10;56(11):E77-E83. doi: 10.1364/AO.56.000E77.

PMID:
28414345
15.

The geometrical shape of mesenchymal stromal cells measured by quantitative shape descriptors is determined by the stiffness of the biomaterial and by cyclic tensile forces.

Uynuk-Ool T, Rothdiener M, Walters B, Hegemann M, Palm J, Nguyen P, Seeger T, Stöckle U, Stegemann JP, Aicher WK, Kurz B, Hart ML, Klein G, Rolauffs B.

J Tissue Eng Regen Med. 2017 Dec;11(12):3508-3522. doi: 10.1002/term.2263. Epub 2017 Mar 29.

PMID:
28371409
16.

Genome Editing in Cardiovascular Biology.

Seeger T, Porteus M, Wu JC.

Circ Res. 2017 Mar 3;120(5):778-780. doi: 10.1161/CIRCRESAHA.116.310197. No abstract available.

17.

A Comprehensive TALEN-Based Knockout Library for Generating Human-Induced Pluripotent Stem Cell-Based Models for Cardiovascular Diseases.

Karakikes I, Termglinchan V, Cepeda DA, Lee J, Diecke S, Hendel A, Itzhaki I, Ameen M, Shrestha R, Wu H, Ma N, Shao NY, Seeger T, Woo N, Wilson KD, Matsa E, Porteus MH, Sebastiano V, Wu JC.

Circ Res. 2017 May 12;120(10):1561-1571. doi: 10.1161/CIRCRESAHA.116.309948. Epub 2017 Feb 28. Review.

18.

Determination of cadmium and lead at sub-ppt level in soft drinks: An efficient combination between dispersive liquid-liquid microextraction and graphite furnace atomic absorption spectrometry.

Mandlate JS, Soares BM, Seeger TS, Vecchia PD, Mello PA, Flores EMM, Duarte FA.

Food Chem. 2017 Apr 15;221:907-912. doi: 10.1016/j.foodchem.2016.11.075. Epub 2016 Nov 19.

19.

Cortical excitability after pediatric mild traumatic brain injury.

Seeger TA, Kirton A, Esser MJ, Gallagher C, Dunn J, Zewdie E, Damji O, Ciechanski P, Barlow KM.

Brain Stimul. 2017 Mar - Apr;10(2):305-314. doi: 10.1016/j.brs.2016.11.011. Epub 2016 Nov 19.

PMID:
27916406
20.

Efficient Genome Editing in Induced Pluripotent Stem Cells with Engineered Nucleases In Vitro.

Termglinchan V, Seeger T, Chen C, Wu JC, Karakikes I.

Methods Mol Biol. 2017;1521:55-68.

PMID:
27910041
21.

Contralesional Corticomotor Neurophysiology in Hemiparetic Children With Perinatal Stroke.

Zewdie E, Damji O, Ciechanski P, Seeger T, Kirton A.

Neurorehabil Neural Repair. 2017 Mar;31(3):261-271. doi: 10.1177/1545968316680485. Epub 2016 Nov 24.

PMID:
27885162
22.

Stretching human mesenchymal stromal cells on stiffness-customized collagen type I generates a smooth muscle marker profile without growth factor addition.

Rothdiener M, Hegemann M, Uynuk-Ool T, Walters B, Papugy P, Nguyen P, Claus V, Seeger T, Stoeckle U, Boehme KA, Aicher WK, Stegemann JP, Hart ML, Kurz B, Klein G, Rolauffs B.

Sci Rep. 2016 Oct 24;6:35840. doi: 10.1038/srep35840.

23.

Blaptica dubia as sentinels for exposure to chemical warfare agents - a pilot study.

Worek F, Seeger T, Neumaier K, Wille T, Thiermann H.

Toxicol Lett. 2016 Nov 16;262:12-16. doi: 10.1016/j.toxlet.2016.09.006. Epub 2016 Sep 14.

PMID:
27639501
24.

Inhibition of let-7 augments the recruitment of epicardial cells and improves cardiac function after myocardial infarction.

Seeger T, Xu QF, Muhly-Reinholz M, Fischer A, Kremp EM, Zeiher AM, Dimmeler S.

J Mol Cell Cardiol. 2016 May;94:145-152. doi: 10.1016/j.yjmcc.2016.04.002. Epub 2016 Apr 9.

PMID:
27071338
25.

Editorial.

Steinritz D, Seeger T, Thiermann H.

Toxicol Lett. 2016 Feb 26;244:1. doi: 10.1016/j.toxlet.2015.11.017. No abstract available.

PMID:
26873068
26.

Functional analysis of Torpedo californica nicotinic acetylcholine receptors in multiple activation states by SSM-based electrophysiology.

Niessen KV, Muschik S, Langguth F, Rappenglück S, Seeger T, Thiermann H, Worek F.

Toxicol Lett. 2016 Apr 15;247:1-10. doi: 10.1016/j.toxlet.2016.02.002. Epub 2016 Feb 3.

PMID:
26851639
27.

Smooth Muscle-Like Cells Generated from Human Mesenchymal Stromal Cells Display Marker Gene Expression and Electrophysiological Competence Comparable to Bladder Smooth Muscle Cells.

Brun J, Lutz KA, Neumayer KM, Klein G, Seeger T, Uynuk-Ool T, Wörgötter K, Schmid S, Kraushaar U, Guenther E, Rolauffs B, Aicher WK, Hart ML.

PLoS One. 2015 Dec 16;10(12):e0145153. doi: 10.1371/journal.pone.0145153. eCollection 2015.

28.

Mesenchymal Stromal Cells for Sphincter Regeneration: Role of Laminin Isoforms upon Myogenic Differentiation.

Seeger T, Hart M, Patarroyo M, Rolauffs B, Aicher WK, Klein G.

PLoS One. 2015 Sep 25;10(9):e0137419. doi: 10.1371/journal.pone.0137419. eCollection 2015.

29.

Anesthetic actions of thiopental remain largely unaffected during cholinergic overstimulation in cultured cortical networks.

Weimer I, Worek F, Seeger T, Thiermann H, Grasshoff C, Antkowiak B, Balk M.

Toxicol Lett. 2016 Feb 26;244:129-35. doi: 10.1016/j.toxlet.2015.08.1106. Epub 2015 Aug 29.

PMID:
26325215
30.

Self-regeneration of neuromuscular function following soman and VX poisoning in spinal cord-skeletal muscle cocultures.

Weimer I, Worek F, Seeger T, Thiermann H, Eckle VS, Grasshoff C, Antkowiak B.

Toxicol Lett. 2016 Feb 26;244:149-53. doi: 10.1016/j.toxlet.2015.08.004. Epub 2015 Aug 6.

PMID:
26256036
31.

MicroRNAs in cardiovascular ageing.

Seeger T, Boon RA.

J Physiol. 2016 Apr 15;594(8):2085-94. doi: 10.1113/JP270557. Epub 2015 Jul 5. Review.

32.

Simultaneous measurement of speed of sound, thermal diffusivity, and bulk viscosity of 1-ethyl-3-methylimidazolium-based ionic liquids using laser-induced gratings.

Kozlov DN, Kiefer J, Seeger T, Fröba AP, Leipertz A.

J Phys Chem B. 2014 Dec 11;118(49):14493-501. doi: 10.1021/jp510186x. Epub 2014 Dec 2.

PMID:
25415848
33.

Occipital Nerve Blocks for Pediatric Posttraumatic Headache: A Case Series.

Seeger TA, Orr S, Bodell L, Lockyer L, Rajapakse T, Barlow KM.

J Child Neurol. 2015 Aug;30(9):1142-6. doi: 10.1177/0883073814553973. Epub 2014 Nov 18.

PMID:
25406154
34.

Post-exposure treatment of VX poisoned guinea pigs with the engineered phosphotriesterase mutant C23: a proof-of-concept study.

Worek F, Seeger T, Reiter G, Goldsmith M, Ashani Y, Leader H, Sussman JL, Aggarwal N, Thiermann H, Tawfik DS.

Toxicol Lett. 2014 Nov 18;231(1):45-54. doi: 10.1016/j.toxlet.2014.09.003. Epub 2014 Sep 6.

PMID:
25195526
35.

Long-term inhibition of miR-21 leads to reduction of obesity in db/db mice.

Seeger T, Fischer A, Muhly-Reinholz M, Zeiher AM, Dimmeler S.

Obesity (Silver Spring). 2014 Nov;22(11):2352-60. doi: 10.1002/oby.20852. Epub 2014 Aug 20.

36.

Spinal cord--skeletal muscle cocultures detect muscle-relaxant action of botulinum neurotoxin A.

Eckle VS, Drexler B, Grasshoff C, Seeger T, Thiermann H, Antkowiak B.

ALTEX. 2014;31(4):433-40. doi: 10.14573/altex.1304291. Epub 2014 Aug 14.

37.

A double-blind, placebo-controlled intervention trial of 3 and 10 mg sublingual melatonin for post-concussion syndrome in youths (PLAYGAME): study protocol for a randomized controlled trial.

Barlow KM, Brooks BL, MacMaster FP, Kirton A, Seeger T, Esser M, Crawford S, Nettel-Aguirre A, Zemek R, Angelo M, Kirk V, Emery CA, Johnson D, Hill MD, Buchhalter J, Turley B, Richer L, Platt R, Hutchison J, Dewey D.

Trials. 2014 Jul 7;15:271. doi: 10.1186/1745-6215-15-271.

38.

NFE2 regulates transcription of multiple enzymes in the heme biosynthesis pathway.

Rheinemann L, Seeger TS, Wehrle J, Pahl HL.

Haematologica. 2014 Oct;99(10):e208-10. doi: 10.3324/haematol.2014.106393. Epub 2014 Jun 20. No abstract available.

39.

Mice with cardiac-restricted overexpression of Myozap are sensitized to biomechanical stress and develop a protein-aggregate-associated cardiomyopathy.

Frank D, Rangrez AY, Poyanmehr R, Seeger TS, Kuhn C, Eden M, Stiebeling K, Bernt A, Grund C, Franke WW, Frey N.

J Mol Cell Cardiol. 2014 Jul;72:196-207. doi: 10.1016/j.yjmcc.2014.03.016. Epub 2014 Mar 31.

PMID:
24698889
40.

Effectiveness of a substituted β-cyclodextrin to prevent cyclosarin toxicity in vivo.

Worek F, Seeger T, Zengerle M, Kubik S, Thiermann H, Wille T.

Toxicol Lett. 2014 Apr 21;226(2):222-7. doi: 10.1016/j.toxlet.2014.02.010. Epub 2014 Feb 20.

PMID:
24561299
41.

Efficacy of the rePON1 mutant IIG1 to prevent cyclosarin toxicity in vivo and to detoxify structurally different nerve agents in vitro.

Worek F, Seeger T, Goldsmith M, Ashani Y, Leader H, Sussman JS, Tawfik D, Thiermann H, Wille T.

Arch Toxicol. 2014 Jun;88(6):1257-66. doi: 10.1007/s00204-014-1204-z. Epub 2014 Jan 30.

PMID:
24477626
42.

Split-probe hybrid femtosecond/picosecond rotational CARS for time-domain measurement of S-branch Raman linewidths within a single laser shot.

Patterson BD, Gao Y, Seeger T, Kliewer CJ.

Opt Lett. 2013 Nov 15;38(22):4566-9. doi: 10.1364/OL.38.004566.

PMID:
24322075
43.

Affinities of bispyridinium non-oxime compounds to [(3)H]epibatidine binding sites of Torpedo californica nicotinic acetylcholine receptors depend on linker length.

Niessen KV, Seeger T, Tattersall JE, Timperley CM, Bird M, Green C, Thiermann H, Worek F.

Chem Biol Interact. 2013 Dec 5;206(3):545-54. doi: 10.1016/j.cbi.2013.10.012. Epub 2013 Oct 21.

PMID:
24157926
44.

Investigation of the chemical stability of the laser-induced fluorescence tracers acetone, diethylketone, and toluene under IC engine conditions using Raman spectroscopy.

Trost J, Zigan L, Eichmann SC, Seeger T, Leipertz A.

Appl Opt. 2013 Sep 1;52(25):6300-8. doi: 10.1364/AO.52.006300.

PMID:
24085091
45.

Flow cytometric detection of Mycobacterium avium subsp. paratuberculosis-specific antibodies in experimentally infected and naturally exposed calves.

Schillinger S, Bridger PS, Bulun H, Fischer M, Akineden O, Seeger T, Barth S, Henrich M, Doll K, Bülte M, Menge C, Bauerfeind R.

Clin Vaccine Immunol. 2013 Sep;20(9):1457-65. doi: 10.1128/CVI.00295-13. Epub 2013 Jul 24.

46.

MPN patients harbor recurrent truncating mutations in transcription factor NF-E2.

Jutzi JS, Bogeska R, Nikoloski G, Schmid CA, Seeger TS, Stegelmann F, Schwemmers S, Gründer A, Peeken JC, Gothwal M, Wehrle J, Aumann K, Hamdi K, Dierks C, Kamar Wang W, Döhner K, Jansen JH, Pahl HL.

J Exp Med. 2013 May 6;210(5):1003-19.

47.

Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms.

Wehrle J, Seeger TS, Schwemmers S, Pfeifer D, Bulashevska A, Pahl HL.

Haematologica. 2013 Jul;98(7):1073-80. doi: 10.3324/haematol.2012.071183. Epub 2013 Feb 26.

48.

MicroRNA-34a regulates cardiac ageing and function.

Boon RA, Iekushi K, Lechner S, Seeger T, Fischer A, Heydt S, Kaluza D, Tréguer K, Carmona G, Bonauer A, Horrevoets AJ, Didier N, Girmatsion Z, Biliczki P, Ehrlich JR, Katus HA, Müller OJ, Potente M, Zeiher AM, Hermeking H, Dimmeler S.

Nature. 2013 Mar 7;495(7439):107-10. doi: 10.1038/nature11919. Epub 2013 Feb 20.

PMID:
23426265
49.

Cost-effectiveness and economic impact of the KineSpring ® Knee Implant System in the treatment for knee osteoarthritis.

Li CS, Seeger T, Auhuber TC, Bhandari M.

Knee Surg Sports Traumatol Arthrosc. 2013 Nov;21(11):2629-37. doi: 10.1007/s00167-013-2427-x. Epub 2013 Feb 10.

PMID:
23397420
50.

Immunosenescence-associated microRNAs in age and heart failure.

Seeger T, Haffez F, Fischer A, Koehl U, Leistner DM, Seeger FH, Boon RA, Zeiher AM, Dimmeler S.

Eur J Heart Fail. 2013 Apr;15(4):385-93. doi: 10.1093/eurjhf/hfs184. Epub 2012 Dec 20.

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