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Theranostic markers for personalized therapy of spider phobia: Methods of a bicentric external cross-validation machine learning approach.

Schwarzmeier H, Leehr EJ, Böhnlein J, Seeger FR, Roesmann K, Gathmann B, Herrmann MJ, Siminski N, Junghöfer M, Straube T, Grotegerd D, Dannlowski U.

Int J Methods Psychiatr Res. 2019 Dec 8:e1812. doi: 10.1002/mpr.1812. [Epub ahead of print]


Hematopoietic alterations in chronic heart failure patients by somatic mutations leading to clonal hematopoiesis.

Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Abou-El-Ardat K, Kiefer KC, Hoffmann J, Seeger F, Bonig H, Dimmeler S, Zeiher AM, Rieger MA.

Haematologica. 2019 Nov 7. pii: haematol.2019.224402. doi: 10.3324/haematol.2019.224402. [Epub ahead of print]


Bone marrow and plasma FGF-23 in heart failure patients: novel insights into the heart-bone axis.

von Jeinsen B, Sopova K, Palapies L, Leistner DM, Fichtlscherer S, Seeger FH, Honold J, Dimmeler S, Aßmus B, Zeiher AM, Keller T.

ESC Heart Fail. 2019 Jun;6(3):536-544. doi: 10.1002/ehf2.12416. Epub 2019 Mar 25.


Association of Mutations Contributing to Clonal Hematopoiesis With Prognosis in Chronic Ischemic Heart Failure.

Dorsheimer L, Assmus B, Rasper T, Ortmann CA, Ecke A, Abou-El-Ardat K, Schmid T, Brüne B, Wagner S, Serve H, Hoffmann J, Seeger F, Dimmeler S, Zeiher AM, Rieger MA.

JAMA Cardiol. 2019 Jan 1;4(1):25-33. doi: 10.1001/jamacardio.2018.3965.


Use of Antiplatelet Agents Is Inversely Associated With Liver Fibrosis in Patients With Cardiovascular Disease.

Schwarzkopf K, Bojunga J, Rüschenbaum S, Martinez Y, Mücke MM, Seeger F, Schoelzel F, Zeuzem S, Friedrich-Rust M, Lange CM.

Hepatol Commun. 2018 Oct 5;2(12):1601-1609. doi: 10.1002/hep4.1254. eCollection 2018 Dec.


Clinical and Neurofunctional Substrates of Cognitive Behavioral Therapy on Secondary Social Anxiety Disorder in Primary Panic Disorder: A Longitudinal fMRI Study.

Seeger F, Yang Y, Straube B, Kircher T, Höfler M, Wittchen HU, Ströhle A, Wittmann A, Gerlach AL, Pfleiderer B, Arolt V, Hamm A, Lang T, Alpers GW, Fydrich T, Lueken U.

Psychother Psychosom. 2019;88(1):48-51. doi: 10.1159/000493756. Epub 2018 Oct 26. No abstract available.


Patatin-like phospholipase domain containing 3 variants differentially impact metabolic traits in individuals at high risk for cardiovascular events.

Rüschenbaum S, Schwarzkopf K, Friedrich-Rust M, Seeger F, Schoelzel F, Martinez Y, Zeuzem S, Bojunga J, Lange CM.

Hepatol Commun. 2018 Jun 6;2(7):798-806. doi: 10.1002/hep4.1183. eCollection 2018 Jul.


Severity of coronary artery disease is associated with non-alcoholic fatty liver dis-ease: A single-blinded prospective mono-center study.

Friedrich-Rust M, Schoelzel F, Maier S, Seeger F, Rey J, Fichtlscherer S, Herrmann E, Zeuzem S, Bojunga J.

PLoS One. 2017 Oct 26;12(10):e0186720. doi: 10.1371/journal.pone.0186720. eCollection 2017.


Minute Myocardial Injury as Measured by High-Sensitive Troponin T Serum Levels Predicts the Response to Intracoronary Infusion of Bone Marrow-Derived Mononuclear Cells in Patients With Stable Chronic Post-Infarction Heart Failure: Insights From the TOPCARE-CHD Registry.

Luu B, Leistner DM, Herrmann E, Seeger FH, Honold J, Fichtlscherer S, Zeiher AM, Assmus B.

Circ Res. 2017 Jun 9;120(12):1938-1946. doi: 10.1161/CIRCRESAHA.116.309938. Epub 2017 Mar 28.


Elevated Serum Glial Fibrillary Acidic Protein (GFAP) is Associated with Poor Functional Outcome After Cardiopulmonary Resuscitation.

Helwig K, Seeger F, Hölschermann H, Lischke V, Gerriets T, Niessner M, Foerch C.

Neurocrit Care. 2017 Aug;27(1):68-74. doi: 10.1007/s12028-016-0371-6.


Safety of transient elastography in patients with implanted cardiac rhythm devices.

Friedrich-Rust M, Schoelzel F, Linzbach S, Bojunga J, Zeuzem S, Seeger F.

Dig Liver Dis. 2017 Mar;49(3):314-316. doi: 10.1016/j.dld.2016.11.005. Epub 2016 Nov 17.


[Early onset pneumonia after successful resuscitation : Incidence after mild invasive hypothermia therapy].

Erath JW, Hodrius J, Bushoven P, Fichtlscherer S, Zeiher AM, Seeger FH, Honold J.

Med Klin Intensivmed Notfmed. 2017 Sep;112(6):519-526. doi: 10.1007/s00063-016-0228-y. Epub 2016 Nov 2. German.


A Decade of Transapical Aortic Valve Implantation.

Papadopoulos N, Wenzel R, Thudt M, Doss M, Wimmer-Greinecker G, Seeger F, El-Sayed Ahmad A, Fichtlscherer S, Moritz A, Zierer A.

Ann Thorac Surg. 2016 Sep;102(3):759-765. doi: 10.1016/j.athoracsur.2016.02.104. Epub 2016 May 4.


Metabolism Regulates Cellular Functions of Bone Marrow-Derived Cells used for Cardiac Therapy.

Derlet A, Rasper T, Roy Choudhury A, Bothur S, Rieger MA, Namgaladze D, Fischer A, Schürmann C, Brandes RP, Tschulena U, Steppan S, Assmus B, Dimmeler S, Zeiher AM, Seeger FH.

Stem Cells. 2016 Aug;34(8):2236-48. doi: 10.1002/stem.2394. Epub 2016 May 25.


Der geneigte Leser soll entscheiden.

Honold J, Fichtlscherer S, Seeger FH.

Med Klin Intensivmed Notfmed. 2015 Oct;110(7):535-6. doi: 10.1007/s00063-015-0054-7. German. No abstract available.


Heat Shock Protein 90 Associates with the Per-Arnt-Sim Domain of Heme-free Soluble Guanylate Cyclase: IMplications for Enzyme Maturation.

Sarkar A, Dai Y, Haque MM, Seeger F, Ghosh A, Garcin ED, Montfort WR, Hazen SL, Misra S, Stuehr DJ.

J Biol Chem. 2015 Aug 28;290(35):21615-28. doi: 10.1074/jbc.M115.645515. Epub 2015 Jul 1.


[Aspiration and pneumonia risk after preclinical invasive resuscitation: Endotracheal intubation and supraglottic airway management with the laryngeal tube S].

Honold J, Hodrius J, Schwietz T, Bushoven P, Zeiher AM, Fichtlscherer S, Seeger FH.

Med Klin Intensivmed Notfmed. 2015 Oct;110(7):526-33. doi: 10.1007/s00063-015-0018-y. Epub 2015 Apr 8. German.


The challenges of autologous cell therapy: systemic anti-thrombotic therapies interfering with serum coagulation may disable autologous serum-containing cell products for therapeutical use.

Seeger FH, Rasper T, Bönig H, Assmus B, Zeiher AM, Dimmeler S.

J Cardiovasc Transl Res. 2014 Oct;7(7):644-50. doi: 10.1007/s12265-014-9584-2. Epub 2014 Sep 13.


Complications associated with the prehospital use of laryngeal tubes--a systematic analysis of risk factors and strategies for prevention.

Schalk R, Seeger FH, Mutlak H, Schweigkofler U, Zacharowski K, Peter N, Byhahn C.

Resuscitation. 2014 Nov;85(11):1629-32. doi: 10.1016/j.resuscitation.2014.07.014. Epub 2014 Aug 7.


Occurrence and prognostic impact of systemic inflammatory response syndrome in transfemoral and transapical aortic valve implantation with balloon- and self-expandable valves.

Schwietz T, Behjati S, Gafoor S, Seeger F, Doss M, Sievert H, Zeiher AM, Fichtlscherer S, Lehmann R.

EuroIntervention. 2015 Apr;10(12):1468-73. doi: 10.4244/EIJY14M06_05.


Regulation of soluble guanylate cyclase by matricellular thrombospondins: implications for blood flow.

Rogers NM, Seeger F, Garcin ED, Roberts DD, Isenberg JS.

Front Physiol. 2014 Apr 4;5:134. doi: 10.3389/fphys.2014.00134. eCollection 2014. Review.


Interfacial residues promote an optimal alignment of the catalytic center in human soluble guanylate cyclase: heterodimerization is required but not sufficient for activity.

Seeger F, Quintyn R, Tanimoto A, Williams GJ, Tainer JA, Wysocki VH, Garcin ED.

Biochemistry. 2014 Apr 8;53(13):2153-65. doi: 10.1021/bi500129k. Epub 2014 Mar 26.


Does the integration of personalized ultrasound change patient management in critical care medicine? Observational trials.

Breitkreutz R, Campo Delľ Orto M, Hamm C, Cuca C, Zechner PM, Stenger T, Walcher F, Seeger FH.

Emerg Med Int. 2013;2013:946059. doi: 10.1155/2013/946059. Epub 2013 Dec 18.


Thorax, trachea, and lung ultrasonography in emergency and critical care medicine: assessment of an objective structured training concept.

Breitkreutz R, Dutiné M, Scheiermann P, Hempel D, Kujumdshiev S, Ackermann H, Seeger FH, Seibel A, Walcher F, Hirche TO.

Emerg Med Int. 2013;2013:312758. doi: 10.1155/2013/312758. Epub 2013 Nov 27.


MicroRNAs in stem cell function and regenerative therapy of the heart.

Seeger FH, Zeiher AM, Dimmeler S.

Arterioscler Thromb Vasc Biol. 2013 Aug;33(8):1739-46. doi: 10.1161/ATVBAHA.113.300138. Review.


An unbalanced monocyte polarisation in peripheral blood and bone marrow of patients with type 2 diabetes has an impact on microangiopathy.

Fadini GP, de Kreutzenberg SV, Boscaro E, Albiero M, Cappellari R, Kränkel N, Landmesser U, Toniolo A, Bolego C, Cignarella A, Seeger F, Dimmeler S, Zeiher A, Agostini C, Avogaro A.

Diabetologia. 2013 Aug;56(8):1856-66. doi: 10.1007/s00125-013-2918-9. Epub 2013 Apr 26.


Impact of intracoronary reinfusion of bone marrow-derived mononuclear progenitor cells on cardiopulmonary exercise capacity in patients with chronic postinfarction heart failure.

Honold J, Fischer-Rasokat U, Seeger FH, Leistner D, Lotz S, Dimmeler S, Zeiher AM, Assmus B.

Clin Res Cardiol. 2013 Sep;102(9):619-25. doi: 10.1007/s00392-013-0574-1. Epub 2013 Apr 24.


Effect of shock wave-facilitated intracoronary cell therapy on LVEF in patients with chronic heart failure: the CELLWAVE randomized clinical trial.

Assmus B, Walter DH, Seeger FH, Leistner DM, Steiner J, Ziegler I, Lutz A, Khaled W, Klotsche J, Tonn T, Dimmeler S, Zeiher AM.

JAMA. 2013 Apr 17;309(15):1622-31. doi: 10.1001/jama.2013.3527. Erratum in: JAMA. 2013 May 15;309(19):1994.


Tetanus in a patient with a maggot-colonised head tumor.

Fox H, Seeger FH.

Anaesth Intensive Care. 2013 Mar;41(2):272-3. No abstract available.


Comparison of the Seattle heart failure model and cardiopulmonary exercise capacity for prediction of death in patients with chronic ischemic heart failure and intracoronary progenitor cell application.

Honold J, DeRosa S, Spyridopoulos I, Fischer-Rasokat U, Seeger FH, Leistner D, Lotz S, Levy WC, Zeiher AM, Assmus B.

Clin Cardiol. 2013 Mar;36(3):153-9. doi: 10.1002/clc.22093. Epub 2013 Feb 3.


Procedural safety and predictors of acute outcome of intracoronary administration of progenitor cells in 775 consecutive procedures performed for acute myocardial infarction or chronic heart failure.

De Rosa S, Seeger FH, Honold J, Fischer-Rasokat U, Lehmann R, Fichtlscherer S, Schächinger V, Dimmeler S, Zeiher AM, Assmus B.

Circ Cardiovasc Interv. 2013 Feb;6(1):44-51. doi: 10.1161/CIRCINTERVENTIONS.112.971705. Epub 2013 Jan 29.


Immunosenescence-associated microRNAs in age and heart failure.

Seeger T, Haffez F, Fischer A, Koehl U, Leistner DM, Seeger FH, Boon RA, Zeiher AM, Dimmeler S.

Eur J Heart Fail. 2013 Apr;15(4):385-93. doi: 10.1093/eurjhf/hfs184. Epub 2012 Dec 20.


Stem cell compartmentalization in diabetes and high cardiovascular risk reveals the role of DPP-4 in diabetic stem cell mobilopathy.

Fadini GP, Albiero M, Seeger F, Poncina N, Menegazzo L, Angelini A, Castellani C, Thiene G, Agostini C, Cappellari R, Boscaro E, Zeiher A, Dimmeler S, Avogaro A.

Basic Res Cardiol. 2013 Jan;108(1):313. doi: 10.1007/s00395-012-0313-1. Epub 2012 Nov 22.


G-CSF stimulation and coronary reinfusion of mobilized circulating mononuclear proangiogenic cells in patients with chronic ischemic heart disease:five-year results of the TOPCARE-G-CSF trial.

Honold J, Fischer-Rasokat U, Lehmann R, Leistner DM, Seeger FH, Schachinger V, Martin H, Dimmeler S, Zeiher AM, Assmus B.

Cell Transplant. 2012;21(11):2325-37. doi: 10.3727/096368912X654957. Epub 2012 Sep 7.


Elevated levels of the mediator of catabolic bone remodeling RANKL in the bone marrow environment link chronic heart failure with osteoporosis.

Leistner DM, Seeger FH, Fischer A, Röxe T, Klotsche J, Iekushi K, Seeger T, Assmus B, Honold J, Karakas M, Badenhoop K, Frantz S, Dimmeler S, Zeiher AM.

Circ Heart Fail. 2012 Nov;5(6):769-77. doi: 10.1161/CIRCHEARTFAILURE.111.966093. Epub 2012 Aug 30.


Simplistic approach to prognosis after cardiopulmonary resuscitation-value of pH and lactate.

Seeger FH, Toenne M, Lehmann R, Ehrlich JR.

J Crit Care. 2013 Jun;28(3):317.e13-20. doi: 10.1016/j.jcrc.2012.05.004. Epub 2012 Jul 24.


Heparin disrupts the CXCR4/SDF-1 axis and impairs the functional capacity of bone marrow-derived mononuclear cells used for cardiovascular repair.

Seeger FH, Rasper T, Fischer A, Muhly-Reinholz M, Hergenreider E, Leistner DM, Sommer K, Manavski Y, Henschler R, Chavakis E, Assmus B, Zeiher AM, Dimmeler S.

Circ Res. 2012 Sep 14;111(7):854-62. doi: 10.1161/CIRCRESAHA.112.265678. Epub 2012 Jul 19.


Micro-RNA-34a contributes to the impaired function of bone marrow-derived mononuclear cells from patients with cardiovascular disease.

Xu Q, Seeger FH, Castillo J, Iekushi K, Boon RA, Farcas R, Manavski Y, Li YG, Assmus B, Zeiher AM, Dimmeler S.

J Am Coll Cardiol. 2012 Jun 5;59(23):2107-17. doi: 10.1016/j.jacc.2012.02.033.


[Regenerative treatment of advanced heart disease].

Leistner DM, Seeger FH, Dimmeler S, Zeiher AM, Assmus B.

Dtsch Med Wochenschr. 2012 Apr;137(14):732-7. doi: 10.1055/s-0031-1299037. Epub 2012 Mar 27. Review. German. No abstract available.


Regulation of cardiac microRNAs by bone marrow mononuclear cell therapy in myocardial infarction.

Iekushi K, Seeger F, Assmus B, Zeiher AM, Dimmeler S.

Circulation. 2012 Apr 10;125(14):1765-73, S1-7. doi: 10.1161/CIRCULATIONAHA.111.079699. Epub 2012 Mar 8.


[Veno-arterial ECMO as bridge to recovery. Cardiogenic shock and suspected myocarditis in a 37-year-old patient].

Fox H, Seeger FH, Schmitt J, Potente M, Dzemali O, Fichtlscherer S, Ehrlich JR.

Med Klin Intensivmed Notfmed. 2012 Apr;107(3):206-12. doi: 10.1007/s00063-011-0064-z. Epub 2012 Jan 12. German.


Early remodeling processes as predictors of diastolic function 5 years after reperfused acute myocardial infarction and intracoronary progenitor cell application.

Fischer-Rasokat U, Honold J, Seeger FH, Fichtlscherer S, Schächinger V, Dimmeler S, Zeiher AM, Assmus B.

Clin Res Cardiol. 2012 Mar;101(3):209-16. doi: 10.1007/s00392-011-0382-4. Epub 2011 Nov 22.


Transplantation of progenitor cells and regeneration enhancement in acute myocardial infarction (TOPCARE-AMI): final 5-year results suggest long-term safety and efficacy.

Leistner DM, Fischer-Rasokat U, Honold J, Seeger FH, Schächinger V, Lehmann R, Martin H, Burck I, Urbich C, Dimmeler S, Zeiher AM, Assmus B.

Clin Res Cardiol. 2011 Oct;100(10):925-34. doi: 10.1007/s00392-011-0327-y. Epub 2011 Jun 3.


Widespread increase in myeloid calcifying cells contributes to ectopic vascular calcification in type 2 diabetes.

Fadini GP, Albiero M, Menegazzo L, Boscaro E, Vigili de Kreutzenberg S, Agostini C, Cabrelle A, Binotto G, Rattazzi M, Bertacco E, Bertorelle R, Biasini L, Mion M, Plebani M, Ceolotto G, Angelini A, Castellani C, Menegolo M, Grego F, Dimmeler S, Seeger F, Zeiher A, Tiengo A, Avogaro A.

Circ Res. 2011 Apr 29;108(9):1112-21. doi: 10.1161/CIRCRESAHA.110.234088. Epub 2011 Mar 10.


Intraarterial administration of bone marrow mononuclear cells in patients with critical limb ischemia: a randomized-start, placebo-controlled pilot trial (PROVASA).

Walter DH, Krankenberg H, Balzer JO, Kalka C, Baumgartner I, Schlüter M, Tonn T, Seeger F, Dimmeler S, Lindhoff-Last E, Zeiher AM; PROVASA Investigators.

Circ Cardiovasc Interv. 2011 Feb 1;4(1):26-37. doi: 10.1161/CIRCINTERVENTIONS.110.958348. Epub 2011 Jan 4.


Focused echocardiographic evaluation in life support and peri-resuscitation of emergency patients: a prospective trial.

Breitkreutz R, Price S, Steiger HV, Seeger FH, Ilper H, Ackermann H, Rudolph M, Uddin S, Weigand MA, Müller E, Walcher F; Emergency Ultrasound Working Group of the Johann Wolfgang Goethe-University Hospital, Frankfurt am Main.

Resuscitation. 2010 Nov;81(11):1527-33. doi: 10.1016/j.resuscitation.2010.07.013.


Peri-resuscitation echocardiography: training the novice practitioner.

Price S, Ilper H, Uddin S, Steiger HV, Seeger FH, Schellhaas S, Heringer F, Ruesseler M, Ackermann H, Via G, Walcher F, Breitkreutz R.

Resuscitation. 2010 Nov;81(11):1534-9. doi: 10.1016/j.resuscitation.2010.07.001. Epub 2010 Aug 19.


Long-term diabetes impairs repopulation of hematopoietic progenitor cells and dysregulates the cytokine expression in the bone marrow microenvironment in mice.

Orlandi A, Chavakis E, Seeger F, Tjwa M, Zeiher AM, Dimmeler S.

Basic Res Cardiol. 2010 Nov;105(6):703-12. doi: 10.1007/s00395-010-0109-0. Epub 2010 Jul 22.


Kruppel-like factor 2 improves neovascularization capacity of aged proangiogenic cells.

Boon RA, Urbich C, Fischer A, Fontijn RD, Seeger FH, Koyanagi M, Horrevoets AJ, Dimmeler S.

Eur Heart J. 2011 Feb;32(3):371-7. doi: 10.1093/eurheartj/ehq137. Epub 2010 May 21.


Mechanism of improved cardiac function after bone marrow mononuclear cell therapy: role of cardiovascular lineage commitment.

Yoon CH, Koyanagi M, Iekushi K, Seeger F, Urbich C, Zeiher AM, Dimmeler S.

Circulation. 2010 May 11;121(18):2001-11. doi: 10.1161/CIRCULATIONAHA.109.909291. Epub 2010 Apr 26.


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