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Items: 1 to 50 of 129

1.

An Assay to Determine Mechanisms of Rapid Autoantibody-Induced Neurotransmitter Receptor Endocytosis and Vesicular Trafficking in Autoimmune Encephalitis.

Amedonu E, Brenker C, Barman S, Schreiber JA, Becker S, Peischard S, Strutz-Seebohm N, Strippel C, Dik A, Hartung HP, Budde T, Wiendl H, Strünker T, Wünsch B, Goebels N, Meuth SG, Seebohm G, Melzer N.

Front Neurol. 2019 Mar 1;10:178. doi: 10.3389/fneur.2019.00178. eCollection 2019.

2.

Familial Sinus Node Disease Caused by a Gain of GIRK (G-Protein Activated Inwardly Rectifying K+ Channel) Channel Function.

Kuß J, Stallmeyer B, Goldstein M, Rinné S, Pees C, Zumhagen S, Seebohm G, Decher N, Pott L, Kienitz MC, Schulze-Bahr E.

Circ Genom Precis Med. 2019 Jan;12(1):e002238. doi: 10.1161/CIRCGEN.118.002238.

PMID:
30645171
3.

Systematic variation of the benzoylhydrazine moiety of the GluN2A selective NMDA receptor antagonist TCN-201.

Schreiber JA, Müller SL, Westphälinger SE, Schepmann D, Strutz-Seebohm N, Seebohm G, Wünsch B.

Eur J Med Chem. 2018 Oct 5;158:259-269. doi: 10.1016/j.ejmech.2018.09.006. Epub 2018 Sep 6.

PMID:
30218911
4.

In Vitro Analyses of Novel HCN4 Gene Mutations.

Möller M, Silbernagel N, Wrobel E, Stallmayer B, Amedonu E, Rinné S, Peischard S, Meuth SG, Wünsch B, Strutz-Seebohm N, Decher N, Schulze-Bahr E, Seebohm G.

Cell Physiol Biochem. 2018;49(3):1197-1207. doi: 10.1159/000493301. Epub 2018 Sep 7.

5.

Bioelectric-calcineurin signaling module regulates allometric growth and size of the zebrafish fin.

Daane JM, Lanni J, Rothenberg I, Seebohm G, Higdon CW, Johnson SL, Harris MP.

Sci Rep. 2018 Jul 10;8(1):10391. doi: 10.1038/s41598-018-28450-6.

6.

Synthesis and Pharmacological Evaluation of Enantiomerically Pure GluN2B Selective NMDA Receptor Antagonists.

Börgel F, Szermerski M, Schreiber JA, Temme L, Strutz-Seebohm N, Lehmkuhl K, Schepmann D, Ametamey SM, Seebohm G, Schmidt TJ, Wünsch B.

ChemMedChem. 2018 Aug 10;13(15):1580-1587. doi: 10.1002/cmdc.201800214. Epub 2018 Jul 4.

PMID:
29806151
7.

Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.

Pfeiffer MJ, Quaranta R, Piccini I, Fell J, Rao J, Röpke A, Seebohm G, Greber B.

Nat Commun. 2018 Jan 30;9(1):440. doi: 10.1038/s41467-017-02812-6.

8.

Stress-Kinase Regulation of TASK-1 and TASK-3.

Rinné S, Kiper AK, Schmidt C, Ortiz-Bonnin B, Zwiener S, Seebohm G, Decher N.

Cell Physiol Biochem. 2017;44(3):1024-1037. doi: 10.1159/000485402. Epub 2017 Nov 27.

9.

NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody.

Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N.

Ann Clin Transl Neurol. 2017 Oct 3;4(11):768-783. doi: 10.1002/acn3.444. eCollection 2017 Nov.

10.

Adrenergic Stress Protection of Human iPS Cell-Derived Cardiomyocytes by Fast Kv7.1 Recycling.

Piccini I, Fehrmann E, Frank S, Müller FU, Greber B, Seebohm G.

Front Physiol. 2017 Sep 14;8:705. doi: 10.3389/fphys.2017.00705. eCollection 2017.

11.

Impact of presynaptic sympathetic imbalance in long-QT syndrome by positron emission tomography.

Zumhagen S, Vrachimis A, Stegger L, Kies P, Wenning C, Ernsting M, Müller J, Seebohm G, Paul M, Schäfers K, Stallmeyer B, Schäfers M, Schulze-Bahr E.

Heart. 2018 Feb;104(4):332-339. doi: 10.1136/heartjnl-2017-311667. Epub 2017 Sep 1.

PMID:
28864717
12.

Design, Synthesis, Pharmacological Evaluation and Docking Studies of GluN2B-Selective NMDA Receptor Antagonists with a Benzo[7]annulen-7-amine Scaffold.

Gawaskar S, Temme L, Schreiber JA, Schepmann D, Bonifazi A, Robaa D, Sippl W, Strutz-Seebohm N, Seebohm G, Wünsch B.

ChemMedChem. 2017 Aug 8;12(15):1212-1222. doi: 10.1002/cmdc.201700311. Epub 2017 Jul 27.

PMID:
28749574
13.

Cardiac Subtype-Specific Modeling of Kv1.5 Ion Channel Deficiency Using Human Pluripotent Stem Cells.

Marczenke M, Piccini I, Mengarelli I, Fell J, Röpke A, Seebohm G, Verkerk AO, Greber B.

Front Physiol. 2017 Jul 6;8:469. doi: 10.3389/fphys.2017.00469. eCollection 2017.

14.

Deconstruction - reconstruction approach to analyze the essential structural elements of tetrahydro-3-benzazepine-based antagonists of GluN2B subunit containing NMDA receptors.

Dey S, Temme L, Schreiber JA, Schepmann D, Frehland B, Lehmkuhl K, Strutz-Seebohm N, Seebohm G, Wünsch B.

Eur J Med Chem. 2017 Sep 29;138:552-564. doi: 10.1016/j.ejmech.2017.06.068. Epub 2017 Jul 1.

PMID:
28704758
15.

Generation and cardiac subtype-specific differentiation of PITX2-deficient human iPS cell lines for exploring familial atrial fibrillation.

Marczenke M, Fell J, Piccini I, Röpke A, Seebohm G, Greber B.

Stem Cell Res. 2017 May;21:26-28. doi: 10.1016/j.scr.2017.03.015. Epub 2017 Mar 23.

16.

Electrophysiological alterations in a murine model of chronic coxsackievirus B3 myocarditis.

Kaese S, Larbig R, Rohrbeck M, Frommeyer G, Dechering D, Olligs J, Schönhofer-Merl S, Wessely R, Klingel K, Seebohm G, Eckardt L.

PLoS One. 2017 Jun 23;12(6):e0180029. doi: 10.1371/journal.pone.0180029. eCollection 2017.

17.

Molecular genetic diagnostics for ventricular arrhythmias and sudden cardiac death syndromes.

Stallmeyer B, Dittmann S, Seebohm G, Müller J, Schulze-Bahr E.

Herz. 2017 Aug;42(5):476-484. doi: 10.1007/s00059-017-4583-0. Review.

PMID:
28616646
18.

From iPSC towards cardiac tissue-a road under construction.

Peischard S, Piccini I, Strutz-Seebohm N, Greber B, Seebohm G.

Pflugers Arch. 2017 Oct;469(10):1233-1243. doi: 10.1007/s00424-017-2003-1. Epub 2017 Jun 1. Review.

19.

Structural interplay of KV7.1 and KCNE1 is essential for normal repolarization and is compromised in short QT syndrome 2 (KV7.1-A287T).

Rothenberg I, Piccini I, Wrobel E, Stallmeyer B, Müller J, Greber B, Strutz-Seebohm N, Schulze-Bahr E, Schmitt N, Seebohm G.

HeartRhythm Case Rep. 2016 Sep 12;2(6):521-529. doi: 10.1016/j.hrcr.2016.08.015. eCollection 2016 Nov. No abstract available.

20.

Through modulation of cardiac Ca2+ handling, UCP2 affects cardiac electrophysiology and influences the susceptibility for Ca2+ -mediated arrhythmias.

Larbig R, Reda S, Paar V, Trost A, Leitner J, Weichselbaumer S, Motloch KA, Wernly B, Arrer A, Strauss B, Lichtenauer M, Reitsamer HA, Eckardt L, Seebohm G, Hoppe UC, Motloch LJ.

Exp Physiol. 2017 Jun 1;102(6):650-662. doi: 10.1113/EP086209.

21.

Systematic variation of the benzenesulfonamide part of the GluN2A selective NMDA receptor antagonist TCN-201.

Müller SL, Schreiber JA, Schepmann D, Strutz-Seebohm N, Seebohm G, Wünsch B.

Eur J Med Chem. 2017 Mar 31;129:124-134. doi: 10.1016/j.ejmech.2017.02.018. Epub 2017 Feb 14.

PMID:
28222314
22.

A Mutation in the G-Protein Gene GNB2 Causes Familial Sinus Node and Atrioventricular Conduction Dysfunction.

Stallmeyer B, Kuß J, Kotthoff S, Zumhagen S, Vowinkel K, Rinné S, Matschke LA, Friedrich C, Schulze-Bahr E, Rust S, Seebohm G, Decher N, Schulze-Bahr E.

Circ Res. 2017 May 12;120(10):e33-e44. doi: 10.1161/CIRCRESAHA.116.310112. Epub 2017 Feb 20.

PMID:
28219978
23.

The Natural Plant Product Rottlerin Activates Kv7.1/KCNE1 Channels.

Matschke V, Piccini I, Schubert J, Wrobel E, Lang F, Matschke J, Amedonu E, Meuth SG, Strünker T, Strutz-Seebohm N, Greber B, Scherkenbeck J, Seebohm G.

Cell Physiol Biochem. 2016;40(6):1549-1558. doi: 10.1159/000453205. Epub 2016 Dec 21.

24.

Comparison of cellular effects of starch-coated SPIONs and poly(lactic-co-glycolic acid) matrix nanoparticles on human monocytes.

Gonnissen D, Qu Y, Langer K, Öztürk C, Zhao Y, Chen C, Seebohm G, Düfer M, Fuchs H, Galla HJ, Riehemann K.

Int J Nanomedicine. 2016 Oct 14;11:5221-5236. eCollection 2016.

25.

14-3-3 Proteins regulate K2P 5.1 surface expression on T lymphocytes.

Fernández-Orth J, Ehling P, Ruck T, Pankratz S, Hofmann MS, Landgraf P, Dieterich DC, Smalla KH, Kähne T, Seebohm G, Budde T, Wiendl H, Bittner S, Meuth SG.

Traffic. 2017 Jan;18(1):29-43. doi: 10.1111/tra.12455. Epub 2016 Nov 27.

26.

KCNE1 induces fenestration in the Kv7.1/KCNE1 channel complex that allows for highly specific pharmacological targeting.

Wrobel E, Rothenberg I, Krisp C, Hundt F, Fraenzel B, Eckey K, Linders JT, Gallacher DJ, Towart R, Pott L, Pusch M, Yang T, Roden DM, Kurata HT, Schulze-Bahr E, Strutz-Seebohm N, Wolters D, Seebohm G.

Nat Commun. 2016 Oct 12;7:12795. doi: 10.1038/ncomms12795.

27.

Functional high-resolution time-course expression analysis of human embryonic stem cells undergoing cardiac induction.

Piccini I, Araúzo-Bravo M, Seebohm G, Greber B.

Genom Data. 2016 Sep 28;10:71-74. eCollection 2016 Dec.

28.

Tau Tubulin Kinase TTBK2 Sensitivity of Glutamate Receptor GluK2.

Nieding K, Matschke V, Meuth SG, Lang F, Seebohm G, Strutz-Seebohm N.

Cell Physiol Biochem. 2016;39(4):1444-52. doi: 10.1159/000447847. Epub 2016 Sep 9.

29.

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel S, Schöler HR, Seebohm G, Greber B.

Cell Stem Cell. 2016 Apr 7;18(4):554-6. doi: 10.1016/j.stem.2016.03.008. No abstract available.

30.

Stepwise Clearance of Repressive Roadblocks Drives Cardiac Induction in Human ESCs.

Rao J, Pfeiffer MJ, Frank S, Adachi K, Piccini I, Quaranta R, Araúzo-Bravo M, Schwarz J, Schade D, Leidel S, Schöler HR, Seebohm G, Greber B.

Cell Stem Cell. 2016 Mar 3;18(3):341-53. doi: 10.1016/j.stem.2015.11.019. Epub 2015 Dec 31. Erratum in: Cell Stem Cell. 2016 Apr 7;18(4):554-6.

31.

Early repolarization pattern: a marker of increased risk in patients with catecholaminergic polymorphic ventricular tachycardia.

Tülümen E, Schulze-Bahr E, Zumhagen S, Stallmeyer B, Seebohm G, Beckmann BM, Kääb S, Rudic B, Liebe V, Wolpert C, Herrera-Siklody C, Veltmann C, Schimpf R, Borggrefe M.

Europace. 2016 Oct;18(10):1587-1592. Epub 2015 Dec 23.

PMID:
26705564
32.

NDRG2 phosphorylation provides negative feedback for SGK1-dependent regulation of a kainate receptor in astrocytes.

Matschke V, Theiss C, Hollmann M, Schulze-Bahr E, Lang F, Seebohm G, Strutz-Seebohm N.

Front Cell Neurosci. 2015 Oct 6;9:387. doi: 10.3389/fncel.2015.00387. eCollection 2015.

33.

Human pluripotent stem cell-derived cardiomyocytes: Genome-wide expression profiling of long-term in vitro maturation in comparison to human heart tissue.

Piccini I, Rao J, Seebohm G, Greber B.

Genom Data. 2015 Apr 1;4:69-72. doi: 10.1016/j.gdata.2015.03.008. eCollection 2015 Jun.

34.

Atomic basis for therapeutic activation of neuronal potassium channels.

Kim RY, Yau MC, Galpin JD, Seebohm G, Ahern CA, Pless SA, Kurata HT.

Nat Commun. 2015 Sep 3;6:8116. doi: 10.1038/ncomms9116.

35.

Paving the Way to Understand Autoantibody-Mediated Epilepsy on the Molecular Level.

Seebohm G, Piccini I, Strutz-Seebohm N.

Front Neurol. 2015 Jul 6;6:149. doi: 10.3389/fneur.2015.00149. eCollection 2015. Review.

36.

Solid phase synthesis, NMR structure determination of α-KTx3.8, its in silico docking to Kv1.x potassium channels, and electrophysiological analysis provide insights into toxin-channel selectivity.

Kohl B, Rothenberg I, Ali SA, Alam M, Seebohm G, Kalbacher H, Voelter W, Stoll R.

Toxicon. 2015 Jul;101:70-8. doi: 10.1016/j.toxicon.2015.04.018. Epub 2015 May 5.

PMID:
25953725
37.

Reply to Christ et al.: LQT1 and JLNS phenotypes in hiPSC-derived cardiomyocytes are due to KCNQ1 mutations.

Greber B, Verkerk AO, Seebohm G, Mummery CL, Bellin M.

Proc Natl Acad Sci U S A. 2015 Apr 21;112(16):E1969. doi: 10.1073/pnas.1503762112. Epub 2015 Mar 20. No abstract available.

38.

Universal cardiac induction of human pluripotent stem cells in two and three-dimensional formats: implications for in vitro maturation.

Zhang M, Schulte JS, Heinick A, Piccini I, Rao J, Quaranta R, Zeuschner D, Malan D, Kim KP, Röpke A, Sasse P, Araúzo-Bravo M, Seebohm G, Schöler H, Fabritz L, Kirchhof P, Müller FU, Greber B.

Stem Cells. 2015 May;33(5):1456-69. doi: 10.1002/stem.1964.

39.

Gain-of-function mutations in the calcium channel CACNA1C (Cav1.2) cause non-syndromic long-QT but not Timothy syndrome.

Wemhöner K, Friedrich C, Stallmeyer B, Coffey AJ, Grace A, Zumhagen S, Seebohm G, Ortiz-Bonnin B, Rinné S, Sachse FB, Schulze-Bahr E, Decher N.

J Mol Cell Cardiol. 2015 Mar;80:186-95. doi: 10.1016/j.yjmcc.2015.01.002. Epub 2015 Jan 26.

PMID:
25633834
40.

Kv1.5 blockers preferentially inhibit TASK-1 channels: TASK-1 as a target against atrial fibrillation and obstructive sleep apnea?

Kiper AK, Rinné S, Rolfes C, Ramírez D, Seebohm G, Netter MF, González W, Decher N.

Pflugers Arch. 2015 May;467(5):1081-90. doi: 10.1007/s00424-014-1665-1. Epub 2014 Dec 17.

PMID:
25511502
41.

Klotho: a new trafficking modifier of Kv7.1/KCNE1 channels.

Strutz-Seebohm N, Wrobel E, Schulze-Bahr E, Seebohm G.

Channels (Austin). 2014;8(4):285. No abstract available.

42.

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5383-92. doi: 10.1073/pnas.1419553111. Epub 2014 Dec 1.

43.

Novel Kv7.1-phosphatidylinositol 4,5-bisphosphate interaction sites uncovered by charge neutralization scanning.

Eckey K, Wrobel E, Strutz-Seebohm N, Pott L, Schmitt N, Seebohm G.

J Biol Chem. 2014 Aug 15;289(33):22749-58. doi: 10.1074/jbc.M114.589796. Epub 2014 Jun 19.

44.

Bioelectric signaling regulates size in zebrafish fins.

Perathoner S, Daane JM, Henrion U, Seebohm G, Higdon CW, Johnson SL, Nüsslein-Volhard C, Harris MP.

PLoS Genet. 2014 Jan;10(1):e1004080. doi: 10.1371/journal.pgen.1004080. Epub 2014 Jan 16.

45.

Structural basis of PI(4,5)P2-dependent regulation of GluA1 by phosphatidylinositol-5-phosphate 4-kinase, type II, alpha (PIP5K2A).

Seebohm G, Wrobel E, Pusch M, Dicks M, Terhag J, Matschke V, Rothenberg I, Ursu ON, Hertel F, Pott L, Lang F, Schulze-Bahr E, Hollmann M, Stoll R, Strutz-Seebohm N.

Pflugers Arch. 2014 Oct;466(10):1885-97. doi: 10.1007/s00424-013-1424-8. Epub 2014 Jan 5.

46.

Genetic variation in the two-pore domain potassium channel, TASK-1, may contribute to an atrial substrate for arrhythmogenesis.

Liang B, Soka M, Christensen AH, Olesen MS, Larsen AP, Knop FK, Wang F, Nielsen JB, Andersen MN, Humphreys D, Mann SA, Huttner IG, Vandenberg JI, Svendsen JH, Haunsø S, Preiss T, Seebohm G, Olesen SP, Schmitt N, Fatkin D.

J Mol Cell Cardiol. 2014 Feb;67:69-76. doi: 10.1016/j.yjmcc.2013.12.014. Epub 2013 Dec 27.

PMID:
24374141
47.

A complex partnership: KCNQ1 and KCNE1.

Seebohm G.

Biophys J. 2013 Dec 3;105(11):2437-8. doi: 10.1016/j.bpj.2013.10.022. No abstract available.

48.

Pharmacological targeting in inherited arrhythmia syndromes.

Zumhagen S, Strutz-Seebohm N, Seebohm G, Schulze-Bahr E.

Curr Med Chem. 2014;21(11):1308-19. Review.

PMID:
24251569
49.

The linker pivot in Ci-VSP: the key to unlock catalysis.

Hobiger K, Utesch T, Mroginski MA, Seebohm G, Friedrich T.

PLoS One. 2013 Jul 29;8(7):e70272. doi: 10.1371/journal.pone.0070272. Print 2013.

50.

A common structural component for β-subunit mediated modulation of slow inactivation in different KV channels.

Strutz-Seebohm N, Henrion U, Schmitt N, Schulze-Bahr E, Seebohm G.

Cell Physiol Biochem. 2013;31(6):968-80. doi: 10.1159/000350115. Epub 2013 Jun 26.

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