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Items: 1 to 50 of 100

1.

Improving CRISPR-Cas9 Genome Editing Efficiency by Fusion with Chromatin-Modulating Peptides.

Ding X, Seebeck T, Feng Y, Jiang Y, Davis GD, Chen F.

CRISPR J. 2019 Feb;2:51-63. doi: 10.1089/crispr.2018.0036.

PMID:
31021236
2.

Targeted activation of diverse CRISPR-Cas systems for mammalian genome editing via proximal CRISPR targeting.

Chen F, Ding X, Feng Y, Seebeck T, Jiang Y, Davis GD.

Nat Commun. 2017 Apr 7;8:14958. doi: 10.1038/ncomms14958.

3.

Synthesis and evaluation of analogs of the phenylpyridazinone NPD-001 as potent trypanosomal TbrPDEB1 phosphodiesterase inhibitors and in vitro trypanocidals.

Veerman J, van den Bergh T, Orrling KM, Jansen C, Cos P, Maes L, Chatelain E, Ioset JR, Edink EE, Tenor H, Seebeck T, de Esch I, Leurs R, Sterk GJ.

Bioorg Med Chem. 2016 Apr 1;24(7):1573-81. doi: 10.1016/j.bmc.2016.02.032. Epub 2016 Feb 26.

PMID:
26935942
4.

CYP709B3, a cytochrome P450 monooxygenase gene involved in salt tolerance in Arabidopsis thaliana.

Mao G, Seebeck T, Schrenker D, Yu O.

BMC Plant Biol. 2013 Oct 28;13:169. doi: 10.1186/1471-2229-13-169.

5.

Discovery of novel Trypanosoma brucei phosphodiesterase B1 inhibitors by virtual screening against the unliganded TbrPDEB1 crystal structure.

Jansen C, Wang H, Kooistra AJ, de Graaf C, Orrling KM, Tenor H, Seebeck T, Bailey D, de Esch IJ, Ke H, Leurs R.

J Med Chem. 2013 Mar 14;56(5):2087-96. doi: 10.1021/jm3017877. Epub 2013 Mar 1.

6.

Catechol pyrazolinones as trypanocidals: fragment-based design, synthesis, and pharmacological evaluation of nanomolar inhibitors of trypanosomal phosphodiesterase B1.

Orrling KM, Jansen C, Vu XL, Balmer V, Bregy P, Shanmugham A, England P, Bailey D, Cos P, Maes L, Adams E, van den Bogaart E, Chatelain E, Ioset JR, van de Stolpe A, Zorg S, Veerman J, Seebeck T, Sterk GJ, de Esch IJ, Leurs R.

J Med Chem. 2012 Oct 25;55(20):8745-56. doi: 10.1021/jm301059b. Epub 2012 Oct 8.

PMID:
22963052
7.

A venom-derived neurotoxin, CsTx-1, from the spider Cupiennius salei exhibits cytolytic activities.

Kuhn-Nentwig L, Fedorova IM, Lüscher BP, Kopp LS, Trachsel C, Schaller J, Vu XL, Seebeck T, Streitberger K, Nentwig W, Sigel E, Magazanik LG.

J Biol Chem. 2012 Jul 20;287(30):25640-9. doi: 10.1074/jbc.M112.339051. Epub 2012 May 21.

8.

Biological and structural characterization of Trypanosoma cruzi phosphodiesterase C and Implications for design of parasite selective inhibitors.

Wang H, Kunz S, Chen G, Seebeck T, Wan Y, Robinson H, Martinelli S, Ke H.

J Biol Chem. 2012 Apr 6;287(15):11788-97. doi: 10.1074/jbc.M111.326777. Epub 2012 Feb 21.

9.

Pharmacological validation of Trypanosoma brucei phosphodiesterases as novel drug targets.

de Koning HP, Gould MK, Sterk GJ, Tenor H, Kunz S, Luginbuehl E, Seebeck T.

J Infect Dis. 2012 Jul 15;206(2):229-37. doi: 10.1093/infdis/jir857. Epub 2012 Jan 30.

10.
11.

Therapeutic potential of phosphodiesterase inhibitors in parasitic diseases.

Shakur Y, de Koning HP, Ke H, Kambayashi J, Seebeck T.

Handb Exp Pharmacol. 2011;(204):487-510. doi: 10.1007/978-3-642-17969-3_20. Review.

PMID:
21695653
12.

The exopolyphosphatase TbrPPX1 of Trypanosoma brucei.

Luginbuehl E, Kunz S, Wentzinger L, Freimoser F, Seebeck T.

BMC Microbiol. 2011 Jan 6;11:4. doi: 10.1186/1471-2180-11-4.

13.

Mitochondrial translation is essential in bloodstream forms of Trypanosoma brucei.

Cristodero M, Seebeck T, Schneider A.

Mol Microbiol. 2010 Nov;78(3):757-69. doi: 10.1111/j.1365-2958.2010.07368.x. Epub 2010 Sep 24.

14.

The N terminus of phosphodiesterase TbrPDEB1 of Trypanosoma brucei contains the signal for integration into the flagellar skeleton.

Luginbuehl E, Ryter D, Schranz-Zumkehr J, Oberholzer M, Kunz S, Seebeck T.

Eukaryot Cell. 2010 Oct;9(10):1466-75. doi: 10.1128/EC.00112-10. Epub 2010 Aug 6.

15.

Cupiennin 1a exhibits a remarkably broad, non-stereospecific cytolytic activity on bacteria, protozoan parasites, insects, and human cancer cells.

Kuhn-Nentwig L, Willems J, Seebeck T, Shalaby T, Kaiser M, Nentwig W.

Amino Acids. 2011 Jan;40(1):69-76. doi: 10.1007/s00726-009-0471-0. Epub 2010 Feb 7.

16.

Gene conversion transfers the GAF-A domain of phosphodiesterase TbrPDEB1 to one allele of TbrPDEB2 of Trypanosoma brucei.

Kunz S, Luginbuehl E, Seebeck T.

PLoS Negl Trop Dis. 2009 Jun 9;3(6):e455. doi: 10.1371/journal.pntd.0000455.

17.

Propidium iodide-based methods for monitoring drug action in the kinetoplastidae: comparison with the Alamar Blue assay.

Gould MK, Vu XL, Seebeck T, de Koning HP.

Anal Biochem. 2008 Nov 15;382(2):87-93. doi: 10.1016/j.ab.2008.07.036. Epub 2008 Aug 3.

PMID:
18722997
18.

Cyclic nucleotide-specific phosphodiesterases of Plasmodium falciparum: PfPDEalpha, a non-essential cGMP-specific PDE that is an integral membrane protein.

Wentzinger L, Bopp S, Tenor H, Klar J, Brun R, Beck HP, Seebeck T.

Int J Parasitol. 2008 Dec;38(14):1625-37. doi: 10.1016/j.ijpara.2008.05.016. Epub 2008 Jun 12.

PMID:
18590734
19.

Crystal structure of the Leishmania major phosphodiesterase LmjPDEB1 and insight into the design of the parasite-selective inhibitors.

Wang H, Yan Z, Geng J, Kunz S, Seebeck T, Ke H.

Mol Microbiol. 2007 Nov;66(4):1029-38. Epub 2007 Oct 17.

20.

Trypanosomes and mammalian sperm: one of a kind?

Oberholzer M, Bregy P, Marti G, Minca M, Peier M, Seebeck T.

Trends Parasitol. 2007 Feb;23(2):71-7. Epub 2006 Dec 14. Review.

PMID:
17174157
21.

The Trypanosoma brucei cAMP phosphodiesterases TbrPDEB1 and TbrPDEB2: flagellar enzymes that are essential for parasite virulence.

Oberholzer M, Marti G, Baresic M, Kunz S, Hemphill A, Seebeck T.

FASEB J. 2007 Mar;21(3):720-31. Epub 2006 Dec 13.

PMID:
17167070
22.

Cyclic nucleotide specific phosphodiesterases of Leishmania major.

Johner A, Kunz S, Linder M, Shakur Y, Seebeck T.

BMC Microbiol. 2006 Mar 8;6:25.

23.

The role of Trypanosoma brucei MRPA in melarsoprol susceptibility.

Alibu VP, Richter C, Voncken F, Marti G, Shahi S, Renggli CK, Seebeck T, Brun R, Clayton C.

Mol Biochem Parasitol. 2006 Mar;146(1):38-44. Epub 2005 Nov 18.

PMID:
16343658
24.

A FYVE-containing unusual cyclic nucleotide phosphodiesterase from Trypanosoma cruzi.

Kunz S, Oberholzer M, Seebeck T.

FEBS J. 2005 Dec;272(24):6412-22.

25.

Cyclic nucleotide specific phosphodiesterases of the kinetoplastida: a unified nomenclature.

Kunz S, Beavo JA, D'Angelo MA, Flawia MM, Francis SH, Johner A, Laxman S, Oberholzer M, Rascon A, Shakur Y, Wentzinger L, Zoraghi R, Seebeck T.

Mol Biochem Parasitol. 2006 Jan;145(1):133-5. Epub 2005 Oct 21. No abstract available.

PMID:
16280178
26.

A vector series for rapid PCR-mediated C-terminal in situ tagging of Trypanosoma brucei genes.

Oberholzer M, Morand S, Kunz S, Seebeck T.

Mol Biochem Parasitol. 2006 Jan;145(1):117-20. Epub 2005 Sep 29. No abstract available.

PMID:
16269191
27.

Molecular pharmacology of adenosine transport in Trypanosoma brucei: P1/P2 revisited.

Geiser F, Lüscher A, de Koning HP, Seebeck T, Mäser P.

Mol Pharmacol. 2005 Sep;68(3):589-95. Epub 2005 Jun 2.

PMID:
15933219
28.

cAMP signalling in the kinetoplastid protozoa.

Seebeck T, Schaub R, Johner A.

Curr Mol Med. 2004 Sep;4(6):585-99. Review.

PMID:
15357210
29.

Relationships between the major kinetoplastid paraflagellar rod proteins: a consolidating nomenclature.

Gadelha C, LeBowitz JH, Manning J, Seebeck T, Gull K.

Mol Biochem Parasitol. 2004 Jul;136(1):113-5. No abstract available.

PMID:
15138073
30.

TbPDE1, a novel class I phosphodiesterase of Trypanosoma brucei.

Kunz S, Kloeckner T, Essen LO, Seebeck T, Boshart M.

Eur J Biochem. 2004 Feb;271(3):637-47.

31.

Mechanisms of arsenical and diamidine uptake and resistance in Trypanosoma brucei.

Matovu E, Stewart ML, Geiser F, Brun R, Mäser P, Wallace LJ, Burchmore RJ, Enyaru JC, Barrett MP, Kaminsky R, Seebeck T, de Koning HP.

Eukaryot Cell. 2003 Oct;2(5):1003-8.

32.

Enhanced endothelial nitric oxide-synthase activity in mice infected with Trypanosoma brucei.

Viswambharan H, Seebeck T, Yang Z.

Int J Parasitol. 2003 Sep 15;33(10):1099-104.

PMID:
13129532
33.
34.

The regulatory subunit of a cGMP-regulated protein kinase A of Trypanosoma brucei.

Shalaby T, Liniger M, Seebeck T.

Eur J Biochem. 2001 Dec;268(23):6197-206.

35.

Genetic variants of the TbAT1 adenosine transporter from African trypanosomes in relapse infections following melarsoprol therapy.

Matovu E, Geiser F, Schneider V, Mäser P, Enyaru JC, Kaminsky R, Gallati S, Seebeck T.

Mol Biochem Parasitol. 2001 Sep 28;117(1):73-81.

PMID:
11551633
36.

cAMP-specific phosphodiesterase TbPDE1 is not essential in Trypanosoma brucei in culture or during midgut infection of tsetse flies.

Gong KW, Kunz S, Zoraghi R, Kunz Renggli C, Brun R, Seebeck T.

Mol Biochem Parasitol. 2001 Sep 3;116(2):229-32. No abstract available.

PMID:
11522356
37.

Drug resistance in Trypanosoma brucei spp., the causative agents of sleeping sickness in man and nagana in cattle.

Matovu E, Seebeck T, Enyaru JC, Kaminsky R.

Microbes Infect. 2001 Jul;3(9):763-70. Review.

PMID:
11489425
38.

Melarsoprol refractory T. b. gambiense from Omugo, north-western Uganda.

Matovu E, Enyaru JC, Legros D, Schmid C, Seebeck T, Kaminsky R.

Trop Med Int Health. 2001 May;6(5):407-11.

39.

cAMP signalling in Trypanosoma brucei.

Seebeck T, Gong K, Kunz S, Schaub R, Shalaby T, Zoraghi R.

Int J Parasitol. 2001 May 1;31(5-6):491-8. Review.

PMID:
11334934
40.
41.

Characterization of TbPDE2A, a novel cyclic nucleotide-specific phosphodiesterase from the protozoan parasite Trypanosoma brucei.

Zoraghi R, Kunz S, Gong K, Seebeck T.

J Biol Chem. 2001 Apr 13;276(15):11559-66. Epub 2000 Dec 27.

42.

Nucleoside diphosphate kinase of Trypanosoma brucei.

Hunger-Glaser I, Hemphill A, Shalaby T, Hänni M, Seebeck T.

Gene. 2000 Oct 31;257(2):251-7.

PMID:
11080591
43.

Infection of organotypic slice cultures from rat central nervous tissue with Trypanosoma brucei brucei.

Stoppini L, Buchs PA, Brun R, Muller D, Duport S, Parisi L, Seebeck T.

Int J Med Microbiol. 2000 Mar;290(1):105-13.

PMID:
11043987
44.

Cyclic AMP signaling in trypanosomatids.

Naula C, Seebeck T.

Parasitol Today. 2000 Jan;16(1):35-8. Review.

PMID:
10637587
45.

Inhibition of succinyl CoA synthetase histidine-phosphorylation in Trypanosoma brucei by an inhibitor of bacterial two-component systems.

Hunger-Glaser I, Brun R, Linder M, Seebeck T.

Mol Biochem Parasitol. 1999 May 15;100(1):53-9.

PMID:
10376993
46.

Histidine-phosphorylation of succinyl CoA synthetase from Trypanosoma brucei.

Hunger-Glaser I, Linder M, Seebeck T.

Mol Biochem Parasitol. 1999 May 15;100(1):43-52.

PMID:
10376992
47.

Phosphorylation of a major GPI-anchored surface protein of Trypanosoma brucei during transport to the plasma membrane.

Bütikofer P, Vassella E, Ruepp S, Boschung M, Civenni G, Seebeck T, Hemphill A, Mookherjee N, Pearson TW, Roditi I.

J Cell Sci. 1999 Jun;112 ( Pt 11):1785-95.

48.

Deletion of the genes for the paraflagellar rod protein PFR-A in Trypanosoma brucei is probably lethal.

Hunger-Glaser I, Seebeck T.

Mol Biochem Parasitol. 1997 Dec 1;90(1):347-51. No abstract available.

PMID:
9497059
49.

The Trypanosoma brucei autoantigen I/6 is an internally repetitive cytoskeletal protein.

Detmer E, Hemphill A, Müller N, Seebeck T.

Eur J Cell Biol. 1997 Apr;72(4):378-84.

PMID:
9127738
50.

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