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Items: 25


Extended Requirement of Granulocyte Colony-Stimulating Factor for Clozapine-Associated Neutropenia.

Leppla IE, Nucifora FC, Sedlak TW.

J Clin Psychopharmacol. 2019 Mar/Apr;39(2):169-172. doi: 10.1097/JCP.0000000000001017. No abstract available.


The glutathione cycle shapes synaptic glutamate activity.

Sedlak TW, Paul BD, Parker GM, Hester LD, Snowman AM, Taniguchi Y, Kamiya A, Snyder SH, Sawa A.

Proc Natl Acad Sci U S A. 2019 Feb 12;116(7):2701-2706. doi: 10.1073/pnas.1817885116. Epub 2019 Jan 28.


Assessing Brain Metabolism With 7-T Proton Magnetic Resonance Spectroscopy in Patients With First-Episode Psychosis.

Wang AM, Pradhan S, Coughlin JM, Trivedi A, DuBois SL, Crawford JL, Sedlak TW, Nucifora FC Jr, Nestadt G, Nucifora LG, Schretlen DJ, Sawa A, Barker PB.

JAMA Psychiatry. 2019 Jan 9. doi: 10.1001/jamapsychiatry.2018.3637. [Epub ahead of print]


Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study.

Sedlak TW, Nucifora LG, Koga M, Shaffer LS, Higgs C, Tanaka T, Wang AM, Coughlin JM, Barker PB, Fahey JW, Sawa A.

Mol Neuropsychiatry. 2018 May;3(4):214-222. doi: 10.1159/000487639. Epub 2018 Apr 17.


Oxidative stress and inflammation in schizophrenia.

Sawa A, Sedlak TW.

Schizophr Res. 2016 Sep;176(1):1-2. doi: 10.1016/j.schres.2016.06.014. Epub 2016 Jul 6. No abstract available.


Early postnatal GABAA receptor modulation reverses deficits in neuronal maturation in a conditional neurodevelopmental mouse model of DISC1.

Saito A, Taniguchi Y, Rannals MD, Merfeld EB, Ballinger MD, Koga M, Ohtani Y, Gurley DA, Sedlak TW, Cross A, Moss SJ, Brandon NJ, Maher BJ, Kamiya A.

Mol Psychiatry. 2016 Oct;21(10):1449-59. doi: 10.1038/mp.2015.203. Epub 2016 Jan 5.


Implications for reactive oxygen species in schizophrenia pathogenesis.

Koga M, Serritella AV, Sawa A, Sedlak TW.

Schizophr Res. 2016 Sep;176(1):52-71. doi: 10.1016/j.schres.2015.06.022. Epub 2015 Nov 15. Review.


Clinical utility of neuronal cells directly converted from fibroblasts of patients for neuropsychiatric disorders: studies of lysosomal storage diseases and channelopathy.

Kano S, Yuan M, Cardarelli RA, Maegawa G, Higurashi N, Gaval-Cruz M, Wilson AM, Tristan C, Kondo MA, Chen Y, Koga M, Obie C, Ishizuka K, Seshadri S, Srivastava R, Kato TA, Horiuchi Y, Sedlak TW, Lee Y, Rapoport JL, Hirose S, Okano H, Valle D, O'Donnell P, Sawa A, Kai M.

Curr Mol Med. 2015;15(2):138-45.


Role of apoptosis signal-regulating kinase 1 (ASK1) as an activator of the GAPDH-Siah1 stress-signaling cascade.

Tristan CA, Ramos A, Shahani N, Emiliani FE, Nakajima H, Noeh CC, Kato Y, Takeuchi T, Noguchi T, Kadowaki H, Sedlak TW, Ishizuka K, Ichijo H, Sawa A.

J Biol Chem. 2015 Jan 2;290(1):56-64. doi: 10.1074/jbc.M114.596205. Epub 2014 Nov 12.


DISC1 regulates trafficking and processing of APP and Aβ generation.

Shahani N, Seshadri S, Jaaro-Peled H, Ishizuka K, Hirota-Tsuyada Y, Wang Q, Koga M, Sedlak TW, Korth C, Brandon NJ, Kamiya A, Subramaniam S, Tomoda T, Sawa A.

Mol Psychiatry. 2015 Jul;20(7):874-9. doi: 10.1038/mp.2014.100. Epub 2014 Sep 16.


Oxidative stress and schizophrenia: recent breakthroughs from an old story.

Emiliani FE, Sedlak TW, Sawa A.

Curr Opin Psychiatry. 2014 May;27(3):185-90. doi: 10.1097/YCO.0000000000000054. Review.


Cognitive and motivational deficits together with prefrontal oxidative stress in a mouse model for neuropsychiatric illness.

Johnson AW, Jaaro-Peled H, Shahani N, Sedlak TW, Zoubovsky S, Burruss D, Emiliani F, Sawa A, Gallagher M.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12462-7. doi: 10.1073/pnas.1307925110. Epub 2013 Jul 9.


Behavioral effects of cocaine mediated by nitric oxide-GAPDH transcriptional signaling.

Xu R, Serritella AV, Sen T, Farook JM, Sedlak TW, Baraban J, Snyder SH, Sen N.

Neuron. 2013 May 22;78(4):623-30. doi: 10.1016/j.neuron.2013.03.021.


DISC1 Pathway in Brain Development: Exploring Therapeutic Targets for Major Psychiatric Disorders.

Kamiya A, Sedlak TW, Pletnikov MV.

Front Psychiatry. 2012 Mar 22;3:25. doi: 10.3389/fpsyt.2012.00025. eCollection 2012.


Glutathione is a physiologic reservoir of neuronal glutamate.

Koga M, Serritella AV, Messmer MM, Hayashi-Takagi A, Hester LD, Snyder SH, Sawa A, Sedlak TW.

Biochem Biophys Res Commun. 2011 Jun 17;409(4):596-602. doi: 10.1016/j.bbrc.2011.04.087. Epub 2011 Apr 24.


Constituents of bile, bilirubin and TUDCA, protect against oxidative stress-induced retinal degeneration.

Oveson BC, Iwase T, Hackett SF, Lee SY, Usui S, Sedlak TW, Snyder SH, Campochiaro PA, Sung JU.

J Neurochem. 2011 Jan;116(1):144-53. doi: 10.1111/j.1471-4159.2010.07092.x. Epub 2010 Dec 2.


The diverse functions of GAPDH: views from different subcellular compartments.

Tristan C, Shahani N, Sedlak TW, Sawa A.

Cell Signal. 2011 Feb;23(2):317-23. doi: 10.1016/j.cellsig.2010.08.003. Epub 2010 Aug 19. Review.


Cycling the wagons for biliverdin reductase.

Sedlak TW, Snyder SH.

J Biol Chem. 2009 Nov 13;284(46):le11; author reply le12. doi: 10.1074/jbc.L109.037119. No abstract available.


Bilirubin and glutathione have complementary antioxidant and cytoprotective roles.

Sedlak TW, Saleh M, Higginson DS, Paul BD, Juluri KR, Snyder SH.

Proc Natl Acad Sci U S A. 2009 Mar 31;106(13):5171-6. doi: 10.1073/pnas.0813132106. Epub 2009 Mar 13.


Messenger molecules and cell death: therapeutic implications.

Sedlak TW, Snyder SH.

JAMA. 2006 Jan 4;295(1):81-9.


Heme oxygenase-2 is activated by calcium-calmodulin.

Boehning D, Sedaghat L, Sedlak TW, Snyder SH.

J Biol Chem. 2004 Jul 23;279(30):30927-30. Epub 2004 Jun 2.


Bilirubin benefits: cellular protection by a biliverdin reductase antioxidant cycle.

Sedlak TW, Snyder SH.

Pediatrics. 2004 Jun;113(6):1776-82. Review. No abstract available.


Bax-mediated cell death by the Gax homeoprotein requires mitogen activation but is independent of cell cycle activity.

Perlman H, Sata M, Le Roux A, Sedlak TW, Branellec D, Walsh K.

EMBO J. 1998 Jul 1;17(13):3576-86.


Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.

Meijerink JP, Mensink EJ, Wang K, Sedlak TW, Slöetjes AW, de Witte T, Waksman G, Korsmeyer SJ.

Blood. 1998 Apr 15;91(8):2991-7.


Multiple Bcl-2 family members demonstrate selective dimerizations with Bax.

Sedlak TW, Oltvai ZN, Yang E, Wang K, Boise LH, Thompson CB, Korsmeyer SJ.

Proc Natl Acad Sci U S A. 1995 Aug 15;92(17):7834-8.

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