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Items: 1 to 50 of 127

1.

Author Correction: L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM.

Nature. 2019 Aug;572(7767):E5. doi: 10.1038/s41586-019-1350-9.

PMID:
31296937
2.

SLC1A5 glutamine transporter is a target of MYC and mediates reduced mTORC1 signaling and increased fatty acid oxidation in long-lived Myc hypomorphic mice.

Zhao X, Petrashen AP, Sanders JA, Peterson AL, Sedivy JM.

Aging Cell. 2019 Jun;18(3):e12947. doi: 10.1111/acel.12947. Epub 2019 Mar 25.

3.

LINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.

Simon M, Van Meter M, Ablaeva J, Ke Z, Gonzalez RS, Taguchi T, De Cecco M, Leonova KI, Kogan V, Helfand SL, Neretti N, Roichman A, Cohen HY, Meer MV, Gladyshev VN, Antoch MP, Gudkov AV, Sedivy JM, Seluanov A, Gorbunova V.

Cell Metab. 2019 Apr 2;29(4):871-885.e5. doi: 10.1016/j.cmet.2019.02.014. Epub 2019 Mar 7.

PMID:
30853213
4.

L1 drives IFN in senescent cells and promotes age-associated inflammation.

De Cecco M, Ito T, Petrashen AP, Elias AE, Skvir NJ, Criscione SW, Caligiana A, Brocculi G, Adney EM, Boeke JD, Le O, Beauséjour C, Ambati J, Ambati K, Simon M, Seluanov A, Gorbunova V, Slagboom PE, Helfand SL, Neretti N, Sedivy JM.

Nature. 2019 Feb;566(7742):73-78. doi: 10.1038/s41586-018-0784-9. Epub 2019 Feb 6. Erratum in: Nature. 2019 Aug;572(7767):E5.

5.

Regulation of Cellular Senescence by Polycomb Chromatin Modifiers through Distinct DNA Damage- and Histone Methylation-Dependent Pathways.

Ito T, Teo YV, Evans SA, Neretti N, Sedivy JM.

Cell Rep. 2018 Mar 27;22(13):3480-3492. doi: 10.1016/j.celrep.2018.03.002.

6.

Do senescence markers correlate in vitro and in situ within individual human donors?

Waaijer MEC, Gunn DA, van Heemst D, Slagboom PE, Sedivy JM, Dirks RW, Tanke HJ, Westendorp RGJ, Maier AB.

Aging (Albany NY). 2018 Feb 28;10(2):278-289. doi: 10.18632/aging.101389.

7.

Systemic Age-Associated DNA Hypermethylation of ELOVL2 Gene: In Vivo and In Vitro Evidences of a Cell Replication Process.

Bacalini MG, Deelen J, Pirazzini C, De Cecco M, Giuliani C, Lanzarini C, Ravaioli F, Marasco E, van Heemst D, Suchiman HED, Slieker R, Giampieri E, Recchioni R, Marcheselli F, Salvioli S, Vitale G, Olivieri F, Spijkerman AMW, Dollé MET, Sedivy JM, Castellani G, Franceschi C, Slagboom PE, Garagnani P.

J Gerontol A Biol Sci Med Sci. 2017 Aug 1;72(8):1015-1023. doi: 10.1093/gerona/glw185. Erratum in: J Gerontol A Biol Sci Med Sci. 2017 May 1;72(5):729.

8.

Mitochondria: Masters of Epigenetics.

Tatar M, Sedivy JM.

Cell. 2016 May 19;165(5):1052-1054. doi: 10.1016/j.cell.2016.05.021.

9.

Reorganization of chromosome architecture in replicative cellular senescence.

Criscione SW, De Cecco M, Siranosian B, Zhang Y, Kreiling JA, Sedivy JM, Neretti N.

Sci Adv. 2016 Feb 5;2(2):e1500882. doi: 10.1126/sciadv.1500882. eCollection 2016 Feb.

10.

The dark side of circulating nucleic acids.

Gravina S, Sedivy JM, Vijg J.

Aging Cell. 2016 Jun;15(3):398-9. doi: 10.1111/acel.12454. Epub 2016 Feb 22. Review.

11.

DNA damage markers in dermal fibroblasts in vitro reflect chronological donor age.

Waaijer ME, Croco E, Westendorp RG, Slagboom PE, Sedivy JM, Lorenzini A, Maier AB.

Aging (Albany NY). 2016 Jan;8(1):147-57.

12.

DNA Hypomethylation and Histone Variant macroH2A1 Synergistically Attenuate Chemotherapy-Induced Senescence to Promote Hepatocellular Carcinoma Progression.

Borghesan M, Fusilli C, Rappa F, Panebianco C, Rizzo G, Oben JA, Mazzoccoli G, Faulkes C, Pata I, Agodi A, Rezaee F, Minogue S, Warren A, Peterson A, Sedivy JM, Douet J, Buschbeck M, Cappello F, Mazza T, Pazienza V, Vinciguerra M.

Cancer Res. 2016 Feb 1;76(3):594-606. doi: 10.1158/0008-5472.CAN-15-1336. Epub 2016 Jan 15.

13.

Interventions to Slow Aging in Humans: Are We Ready?

Longo VD, Antebi A, Bartke A, Barzilai N, Brown-Borg HM, Caruso C, Curiel TJ, de Cabo R, Franceschi C, Gems D, Ingram DK, Johnson TE, Kennedy BK, Kenyon C, Klein S, Kopchick JJ, Lepperdinger G, Madeo F, Mirisola MG, Mitchell JR, Passarino G, Rudolph KL, Sedivy JM, Shadel GS, Sinclair DA, Spindler SR, Suh Y, Vijg J, Vinciguerra M, Fontana L.

Aging Cell. 2015 Aug;14(4):497-510. doi: 10.1111/acel.12338. Epub 2015 Apr 22. Review.

14.

Reduced expression of MYC increases longevity and enhances healthspan.

Hofmann JW, Zhao X, De Cecco M, Peterson AL, Pagliaroli L, Manivannan J, Hubbard GB, Ikeno Y, Zhang Y, Feng B, Li X, Serre T, Qi W, Van Remmen H, Miller RA, Bath KG, de Cabo R, Xu H, Neretti N, Sedivy JM.

Cell. 2015 Jan 29;160(3):477-88. doi: 10.1016/j.cell.2014.12.016. Epub 2015 Jan 22.

15.

Human Genomics. Sleeping dogs of the genome.

Gorbunova V, Boeke JD, Helfand SL, Sedivy JM.

Science. 2014 Dec 5;346(6214):1187-8. doi: 10.1126/science.aaa3177. No abstract available.

16.

Transcriptional landscape of repetitive elements in normal and cancer human cells.

Criscione SW, Zhang Y, Thompson W, Sedivy JM, Neretti N.

BMC Genomics. 2014 Jul 11;15:583. doi: 10.1186/1471-2164-15-583.

17.

A comparison of oncogene-induced senescence and replicative senescence: implications for tumor suppression and aging.

Nelson DM, McBryan T, Jeyapalan JC, Sedivy JM, Adams PD.

Age (Dordr). 2014 Jun;36(3):9637. doi: 10.1007/s11357-014-9637-0. Epub 2014 Mar 20.

18.

The effects of aging on the expression of Wnt pathway genes in mouse tissues.

Hofmann JW, McBryan T, Adams PD, Sedivy JM.

Age (Dordr). 2014 Jun;36(3):9618. doi: 10.1007/s11357-014-9618-3. Epub 2014 Feb 1.

19.

Why do we grow old: is it because our cells just wear out, we run out of cells (or both), and what can we do about it?

Sedivy JM, van Deursen JM.

Longev Healthspan. 2013 Apr 22;2(1):7. doi: 10.1186/2046-2395-2-7.

20.

Transposable elements become active and mobile in the genomes of aging mammalian somatic tissues.

De Cecco M, Criscione SW, Peterson AL, Neretti N, Sedivy JM, Kreiling JA.

Aging (Albany NY). 2013 Dec;5(12):867-83.

21.

Death by transposition - the enemy within?

Sedivy JM, Kreiling JA, Neretti N, De Cecco M, Criscione SW, Hofmann JW, Zhao X, Ito T, Peterson AL.

Bioessays. 2013 Dec;35(12):1035-43. doi: 10.1002/bies.201300097. Epub 2013 Oct 15.

22.

Probing the depths of cellular senescence.

Baker DJ, Sedivy JM.

J Cell Biol. 2013 Jul 8;202(1):11-3. doi: 10.1083/jcb.201305155. Epub 2013 Jul 1.

23.
24.

Genomes of replicatively senescent cells undergo global epigenetic changes leading to gene silencing and activation of transposable elements.

De Cecco M, Criscione SW, Peckham EJ, Hillenmeyer S, Hamm EA, Manivannan J, Peterson AL, Kreiling JA, Neretti N, Sedivy JM.

Aging Cell. 2013 Apr;12(2):247-56. doi: 10.1111/acel.12047. Epub 2013 Jan 30.

25.

Regulation of RKIP function by Helicobacter pylori in gastric cancer.

Moen EL, Wen S, Anwar T, Cross-Knorr S, Brilliant K, Birnbaum F, Rahaman S, Sedivy JM, Moss SF, Chatterjee D.

PLoS One. 2012;7(5):e37819. doi: 10.1371/journal.pone.0037819. Epub 2012 May 25.

26.

The number of p16INK4a positive cells in human skin reflects biological age.

Waaijer ME, Parish WE, Strongitharm BH, van Heemst D, Slagboom PE, de Craen AJ, Sedivy JM, Westendorp RG, Gunn DA, Maier AB.

Aging Cell. 2012 Aug;11(4):722-5. doi: 10.1111/j.1474-9726.2012.00837.x. Epub 2012 Jun 11.

27.

Postnatal liver growth and regeneration are independent of c-myc in a mouse model of conditional hepatic c-myc deletion.

Sanders JA, Schorl C, Patel A, Sedivy JM, Gruppuso PA.

BMC Physiol. 2012 Mar 7;12:1. doi: 10.1186/1472-6793-12-1.

28.

Suppression of Myc oncogenic activity by nucleostemin haploinsufficiency.

Zwolinska AK, Heagle Whiting A, Beekman C, Sedivy JM, Marine JC.

Oncogene. 2012 Jul 12;31(28):3311-21. doi: 10.1038/onc.2011.507. Epub 2011 Nov 14.

29.
30.

Kinetic profiling of the c-Myc transcriptome and bioinformatic analysis of repressed gene promoters.

Yap CS, Peterson AL, Castellani G, Sedivy JM, Neretti N.

Cell Cycle. 2011 Jul 1;10(13):2184-96. Epub 2011 Jul 1.

32.

Age-associated increase in heterochromatic marks in murine and primate tissues.

Kreiling JA, Tamamori-Adachi M, Sexton AN, Jeyapalan JC, Munoz-Najar U, Peterson AL, Manivannan J, Rogers ES, Pchelintsev NA, Adams PD, Sedivy JM.

Aging Cell. 2011 Apr;10(2):292-304. doi: 10.1111/j.1474-9726.2010.00666.x. Epub 2010 Dec 30.

33.

Proteomic profiling of Myc-associated proteins.

Agrawal P, Yu K, Salomon AR, Sedivy JM.

Cell Cycle. 2010 Dec 15;9(24):4908-21. Epub 2010 Dec 15.

34.

Epigenetic control of aging.

Muñoz-Najar U, Sedivy JM.

Antioxid Redox Signal. 2011 Jan 15;14(2):241-59. doi: 10.1089/ars.2010.3250. Epub 2010 Nov 22. Review.

35.

Widespread expression of the Supv3L1 mitochondrial RNA helicase in the mouse.

Paul E, Kielbasinski M, Sedivy JM, Murga-Zamalloa C, Khanna H, Klysik JE.

Transgenic Res. 2010 Aug;19(4):691-701. doi: 10.1007/s11248-009-9346-0. Epub 2009 Nov 25.

36.

How to learn new and interesting things from model systems based on "exotic" biological species.

Sedivy JM.

Proc Natl Acad Sci U S A. 2009 Nov 17;106(46):19207-8. doi: 10.1073/pnas.0911232106. Epub 2009 Nov 11. No abstract available.

37.

A link between the accumulation of DNA damage and loss of multi-potency of human mesenchymal stromal cells.

Alves H, Munoz-Najar U, De Wit J, Renard AJ, Hoeijmakers JH, Sedivy JM, Van Blitterswijk C, De Boer J.

J Cell Mol Med. 2010 Dec;14(12):2729-38. doi: 10.1111/j.1582-4934.2009.00931.x.

38.

Disruption of Supv3L1 damages the skin and causes sarcopenia, loss of fat, and death.

Paul E, Cronan R, Weston PJ, Boekelheide K, Sedivy JM, Lee SY, Wiest DL, Resnick MB, Klysik JE.

Mamm Genome. 2009 Feb;20(2):92-108. doi: 10.1007/s00335-008-9168-z. Epub 2009 Jan 15.

39.

Global regulation of nucleotide biosynthetic genes by c-Myc.

Liu YC, Li F, Handler J, Huang CR, Xiang Y, Neretti N, Sedivy JM, Zeller KI, Dang CV.

PLoS One. 2008 Jul 16;3(7):e2722. doi: 10.1371/journal.pone.0002722.

40.

Cellular senescence and organismal aging.

Jeyapalan JC, Sedivy JM.

Mech Ageing Dev. 2008 Jul-Aug;129(7-8):467-74. doi: 10.1016/j.mad.2008.04.001. Epub 2008 Apr 12. Review.

41.

Reconstructing networks of pathways via significance analysis of their intersections.

Francesconi M, Remondini D, Neretti N, Sedivy JM, Cooper LN, Verondini E, Milanesi L, Castellani G.

BMC Bioinformatics. 2008 Apr 25;9 Suppl 4:S9. doi: 10.1186/1471-2105-9-S4-S9.

42.

Aging by epigenetics--a consequence of chromatin damage?

Sedivy JM, Banumathy G, Adams PD.

Exp Cell Res. 2008 Jun 10;314(9):1909-17. doi: 10.1016/j.yexcr.2008.02.023. Epub 2008 Mar 12. Review.

43.

The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry.

Morrish F, Neretti N, Sedivy JM, Hockenbery DM.

Cell Cycle. 2008 Apr 15;7(8):1054-66. Epub 2008 Feb 8.

44.

The RKIP (Raf-1 Kinase Inhibitor Protein) conserved pocket binds to the phosphorylated N-region of Raf-1 and inhibits the Raf-1-mediated activated phosphorylation of MEK.

Rath O, Park S, Tang HH, Banfield MJ, Brady RL, Lee YC, Dignam JD, Sedivy JM, Kolch W, Yeung KC.

Cell Signal. 2008 May;20(5):935-41. doi: 10.1016/j.cellsig.2008.01.012. Epub 2008 Jan 24.

PMID:
18294816
45.

Signaling crossroads: the function of Raf kinase inhibitory protein in cancer, the central nervous system and reproduction.

Klysik J, Theroux SJ, Sedivy JM, Moffit JS, Boekelheide K.

Cell Signal. 2008 Jan;20(1):1-9. Epub 2007 Jul 12. Review.

46.

A proposal to sequence genomes of unique interest for research on aging.

de Magalhães JP, Sedivy JM, Finch CE, Austad SN, Church GM.

J Gerontol A Biol Sci Med Sci. 2007 Jun;62(6):583-4. No abstract available.

PMID:
17595413
47.

Microarray analysis of glial cells resistant to JCV infection suggests a correlation between viral infection and inflammatory cytokine gene expression.

Manley K, Gee GV, Simkevich CP, Sedivy JM, Atwood WJ.

Virology. 2007 Sep 30;366(2):394-404. Epub 2007 Jun 6.

48.
49.
50.

Correlation analysis reveals the emergence of coherence in the gene expression dynamics following system perturbation.

Neretti N, Remondini D, Tatar M, Sedivy JM, Pierini M, Mazzatti D, Powell J, Franceschi C, Castellani GC.

BMC Bioinformatics. 2007 Mar 8;8 Suppl 1:S16.

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